Saito A, Nagai R, Tanuma A, Hama H, Cho K, Takeda T, Yoshida Y, Toda T, Shimizu F, Horiuchi S, Gejyo F: Role of megalin in endocytosis of advanced glycation end products: implications for a novel protein binding to both megalin and advanced glycation end products. J Am Soc Nephrol, 14: 1123-1131, 2003.

Wada Y, Sato M, Saito A, Gejyo F: Infection-associated hemophagocytic syndrome in a diabetic patient undergoing chronic hemodialysis. Clin Exp Nephrol, 7: 163-166, 2003.

Saito A, Kazama JJ, Iino N, Cho K, Sato N, Yamazaki H, Oyama Y, Takeda T, Orlando RA, Shimizu F, Tabata Y, Gejyo F: Bioengineered implantation of megalin-expressing cells: A potential intracorporeal therapeutic model for uremic toxin protein clearance in renal failure. J Am Soc Nephrol, 14: 2025-2032, 2003.

Nagai M, Meerloo T, Takeda T and Farquhar MG: The adaptor protein ARH escorts megalin to and through endosomes. Mol Biol Cell, 14: 4984-4996, 2003.
Takeda T: Podocyte cytoskeleton is connected to the integral membrane protein podocalyxin through Na+/H+-exchanger regulatory factor 2 and ezrin. Clin Exp Nephrol, 7: 260-269, 2003.


Yamazaki H, Saito A, Ooi H, Kobayashi M, Mundel P, Gejyo F: Differentiation-induced cultured podocytes express endocytically active megalin, a Heymann nephritis antigen. Nephron Exp Nephrol, 96: 52-58, 2004.

Xie Y, Nishi S, Fukase S, Nakamura H, Chen X, Imai N, Sakatsume M, Saito A, Ueno M, Narita N, Yamamoto T, Gejyo F: Different type and localization of CD44 on surface membrane of regenerative renal tubular epithelial cells in vivo. Amer J Nephrol, 24: 188-197, 2004.

Hama H, Saito A, Takeda T, Tanuma A, Xie Y, Sato K, Kazama JJ, Gejyo F: Evidence indicating that renal tubular metabolism of leptin is mediated by megalin but not by the leptin receptors. Endocrinology, 145: 3935-3940, 2004.

Schmieder S, Nagai M, Orlando RA, Takeda T and Farquhar MG: Podocalyxin activates RhoA and induces actin reorganization through NHERF1 and ezrin in MDCK Cells. J Am Soc Nephrol, 15: 2289-2298, 2004.

Oyama Y, Takeda T, Hama H, Tanuma A, Iino N, Sato Kaseda R, Ma M, Yamamoto T, Fujii H, Kazama JJ, Odani S, Terada Y, Mizuta K, Gejyo F, Saito A: Evidence for megalin-mediated proximal tubular uptake of L-FABP, a carrier of potentially nephrotoxic molecules. Lab Invest, 85: 522-531, 2005.
Saito A, Takeda T, Sato K, Hama H, Tanuma A, Kaseda R, Suzuki Y, Gejyo F: Significance of proximal tubular metabolism of advanced glycation end products in kidney diseases. Ann N Y Acad Sci, 1043: 637-643, 2005.

Lehtonen S. Ryan JJ, Kudlicka K, Iino N, Zhou H and Farquhar MG: Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex. Proc Natl Acad Sci USA, 102: 9814-9819, 2005.

Saito A, Takeda T, Hama H, Oyama Y, Sato K, Tanuma A, Kaseda R, Ueno M, Nishi S, Ogasawara S, Gondaira F, Suzuki Y, Gejyo F: Role of megalin, a proximal tubular endocytotic receptor, in the pathogenesis of diabetic and metabolic syndrome-related nephropathies: protein metabolic overload hypothesis. Nephrology, Suppl 2: S26-31, 2005.


Saito A, Gejyo F: Current clinical aspects of dialysis-related amyloidosis in chronic dialysis patients. Ther Apher Dial, 10: 316-320, 2006.

Saeki T, Saito A, Hiura T, Yamazaki H, Emura I, Ueno M, Miyamura S, Gejyo F: Lymphoplasmacytic infiltration of multiple organs with immunoreactivity for IgG4: IgG4-related systemic disease. Intern Med, 45: 163-167, 2006.


Saito A: Role of proximal tubule cells in the intrarenal renin-angiotensin system. Gejyo F (Chief editor): Recent advances and new insight into the renin-angiotensin-aldosterone system in the kidney. Koko-do, Niigata, Japan, 24-28, 2007

Kaseda R, Iino N, Hosojima M, Takeda T, Hosaka K, Kobayashi A, Yamamoto K, Suzuki A, Kasai S, Suzuki Y, Gejyo F, Saito A: Megalin-mediated endocytosis of cystatin C in proximal tubule cells. Biochem Biophys Res Commun, 357: 1130-1134, 2007.

Saeki T, Nishi S, Ito T, Yamazaki H, Miyamura S, Emura S, Imai N, Ueno M, Saito A, Gejyo F: Renal lesions in IgG4-related systemic disease. Intern Med, 46: 1365-1372, 2007.

Tanuma A, Sato H, Takeda T, Hosojima M, Obayashi H, Hama H, Iino N, Hosaka K, Kaseda R, Imai N, Ueno M, Yamazaki M, Sakimura K, Gejyo F, Saito A: Functional characterization of a novel missense CLCN5 mutation causing alterations of proximal tubular endocytic machinery in Dent’s disease. Nephron Physiol, 104: 87-97, 2007.

Tanaka K, Ito M, Kodama M, Maruyama H, Hoyama M, Mitsuma W, Iino N, Hirono S, Okura Y, Gejyo F, Tanabe N and Aizawa Y: Longitudial change in renal function in patients with idiopathic dilated cardiomyopathy without renal insufficiency at initial diagnosis. Circ J, 71: 1927-1931, 2007.

Saito A, Iino N, Takeda T, Gejyo F: Role of megalin, a proximal tubular endocytic receptor, in calcium and phosphate homeostasis. Ther Apher Dial, Suppl 1: S23-S26, 2007.


Lehtonen S, Shah M, Nielsen R, Iino N, Ryan JJ, Zhou H and Farquhar MG: The endocytic adaptor protein ARH associates with motor and centrosomal proteins and is involved in centrosome assembly and cytokinesis. Mol Biol Cell, 19: 2949-2961, 2008.

Hosaka K, Kazama JJ, Yamamoto S, Iino N, Maruyama H, Saito A, Narita I: Alterations in serum phosphate levels predict the long-term response to intravenous calcitriol therapy in dialysis patients with secondary hyperparathyroidism. J Bone Miner Metab, 26: 85-190, 2008.

Motoyoshi Y, Matsusaka T, Saito A, Pastan I, Willnow TE, Mizutani S, Ichikawa I: Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria. Kidney Int, 74: 1262-1269, 2008.

Arai M, Mizuta K, Saito A, Hashimoto Y, Iwasaki S, Watanabe T, Mineta H: Localization of megalin in rat vestibular dark cells and endolymphatic sac epithelial cells. Acta Otolaryngol, 128: 627-633, 2008.

Hosaka K, Takeda T, Iino N, Hosojima M, Sato H, Kaseda R, Yamamoto K, Kobayashi A, Gejyo F, Saito A: Megalin and nonmuscle myosin heavy chain IIA interact with the adaptor protein Disabled-2 in proximal tubule cells. Kidney Int, 75: 1308-1315, 2009.

Hosojima M, Sato H, Yamamoto K, Kaseda R, Soma T, Kobayashi A, Suzuki A, Kabasawa H, Takeyama A, Ikuyama K, Iino N, Nishiyama A, Thekkumkara TJ, Takeda T, Suzuki Y, Gejyo F, Saito A: Regulation of megalin expression in cultured proximal tubule cells by angiotensin II type 1A receptor- and insulin-mediated signaling cross talk. Endocrinology, 150: 871-878, 2009.


Saeki T, Nishi S, Imai N, Ito T, Yamazaki H, Kawano M, Yamamoto M, Takahashi H, Matsui S, Nakada S, Origuchi T, Hirabayashi A, Homma N, Tsubata Y, Takata T, Wada Y, Saito A, Fukase S, Ishioka K, Miyazaki K, Masaki Y, Umehara H, Sugai S, Narita I: Clinicopathological characteristics of patients with IgG4-related tubulointerstitial nephritis. Kidney Int, 10: 1016-1023, 2010.

Saito A, Sato H, Iino N, Takeda T: Molecular mechanisms of receptor-mediated endocytosis in the renal proximal tubular epithelium. J Biomed Biotechnol, ID: 403272 doi: 10.1155/2010/403272, 2010.


Saito A, Kaseda R, Hosojima M, Sato H: Proximal tubule cell hypothesis for cardiorenal syndrome in diabetes. Int J Nephrol, ID: 957164 doi: 10.4061/2011/957164, 2011.

Saito A, Sato H, Iino N, Takeda T: Physiology and pathophysiology of megalin-mediated endocytosis in renal proximal tubule cells. In: Advances in Medicine and Biology Research, Vol. 14 ISBN: 978-1-61761-930-4 Leon V. Berhardt (Editor), Nova Science Publishers, Inc., 2011.

Tanimura A, Yamada F, Saito A, Ito M, Kimura T, Anzai N, Horie D, Yamamoto H, Miyamoto K, Taketani Y, Takeda E: Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis. J Med Invest, 58: 140-147, 2011.

Takeyama A, Sato H, Soma-Nagae T, Kabasawa H, Suzuki A, Yamamoto-Kabasawa K, Hosojima M, Kaneko R, Higuchi F, Kaseda R, Ogasawara S, Narita I, Saito A: Megalin is downregulated via LPS-TNF-α-ERK1/2 signaling pathway in proximal tubule cells. Biochem Biophys Res Commun, 407: 108-112, 2011.

Kaseda R, Hosojima M, Sato H, Saito A: Role of megalin and cubilin in the metabolism of vitaminD3. Ther Apher Dial, Suppl 1: 14-17, 2011.

Saito A, Hosojima M, Sato H: Hormonal Actions and Interactions in Proximal Tubule Cells Associated with the Development of Chronic Kidney Disease. In: Basic and Clinical Endocrinology Up-to-Date, ISBN 978-953-307-340-8, Edited by Fulya Akin, InTech, 2011.


Ogasawara S, Hosojima M, Kaseda R, Kabasawa H, Yamamoto-Kabasawa K, Kurosawa H, Sato H, Iino N, Takeda T, Suzuki Y, Narita I, Yamagata K, Tomino Y, Gejyo F, Hirayama Y, Sekine S, Saito A: Significance of urinary full-length and ectodomain forms of megalin in patients with type 2 diabetes. Diabetes Care, 35: 1112-1118, 2012.

Matsusaka T, Niimura F, Shimizu A, Pastan I, Saito A, Kobori H, Nishiyama A, Ichikawa I: Liver angiotensinogen is the primary source of renal angiotensin II. J Am Soc Nephrol, 23: 1181-1189, 2012.

Hara M, Yamagata K, Tomino Y, Saito A, Hirayama Y, Ogasawara S, Sekine S, Yan K: Urinary podocalyxin is an early marker for podocyte injury in patients with diabetes: Establishment of a highly sensitive enzyme-linked immunosorbent assay to detect urinary podocalyxin. Diabetologia, 55: 2913-2919, 2012.


Kubota M, Watanabe R, Kabasawa H, Iino N, Saito A, Kumagai T, Fujimura S, Kadowaki M: Rice protein ameliorates progression of diabetic nephropathy in Goto-Kakizaki rats with high-sucrose feeding. Br J Nutr, 10: 1211-1219, 2013.


Tsuchida Y, Kaneko Y, Otsuka T, Goto K, Saito A, Yamamoto K, Yamamoto T, Narita I: Upregulation of prolactin receptor in proximal tubular cells was induced in cardiac dysfunction model mice. Clin Exp Nephrol, 18: 65-74, 2014.

Miyazaki Y, Shimizu A, Pastan I, Taguchi K, Naganuma E, Suzuki T, Hosoya T, Yokoo T, Saito A, Miyata T, Yamamoto M, Matsusaka T: Keap1 inhibition attenuates glomerulosclerosis. Nephrol Dial Transplant, 29: 783-791, 2014.

De S, Kuwahara S, Saito A: The endocytic receptor megalin and its associated proteins in proximal tubule epithelial cells. Membranes, 4: 333-355, 2014

Seki T, Asanuma K, Asao R, Nonaka K, Sasaki Y, Oliva Trejo JA, Kurosawa H, Hirayama Y, Horikoshi S, Tomino Y, Saito A: Significance of urinary full-length megalin in patients with IgA nephropathy. PLoS ONE, 9(12): e114400, 2014.


Yamamoto-Kabasawa K, Hosojima M, Yata Y, Saito M, Tanaka N, Tanaka J, Tanabe N, Narita I, Arakawa M, Saito A: Benefits of a 12-week lifestyle modification program including diet and resistance exercise on albuminuria in diabetic Japanese populations. Clinical and Experimental Nephrology, 19: 1076-89, 2015.


Kubota M, Watanabe R, Yamaguchi M, Hosojima M, Saito A, Fujii M, Fujimura S, Kadowaki M: Rice endosperm protein slows progression of fatty liver and diabetic nephropathy in Zucker diabetic fatty rats. Br J Nutr. 2016 Oct 11:1-10, 2016.

Kuwahara S, Hosojima M,Kaneko R,Aoki H,Nakano D,Sasagawa T,Kabasawa H,Kaseda R,Yasukawa R,Ishikawa T,Suzuki A,Sato H,Kageyama S,Tanaka T,Kitamura N,Narita I,Komatsu M,Nishiyama A,Saito A: Megalin-Mediated Tubuloglomerular Alterations in High-Fat Diet-Induced Kidney Disease. J Am Soc Nephrol, 27: 1996-2008, 2016.

Hosojima M, Kaseda R, Kondo H, Fujii M, Kubota M, Watanabe R, Tanabe N, Kadowaki M, Suzuki Y, Saito A: Beneficial effects of rice endosperm protein intake in Japanese men with risk factors for metabolic syndrome: a randomized, crossover clinical trial. BMC Nutrition, 2: 25, doi:10.1186/s40795-016-0065-7, 2016.

Kawakami T, Fujikawa A, Ishiyama Y, Hosojima M, Saito A, Kubota M, Fujimura S, Kadowaki M: Protective effect of composite earthworm powder against diabetic complications via increased fibrinolytic function and improvement of lipid metabolism in ZDF rats. Biosci Biotechnol Biochem, 80: 1980-1989, 2016.


Suruda C, Tsuji S, Yamanouchi S, Kimata T, Nguyen HT, Kurosawa H, Hirayama Y, Tsukaguchi H, Saito A, Kaneko K: Decreased urinary excretion of the ectodomain form of megalin (A-megalin) in children with OCRL gene mutations. Pediatr Nephrol, 32: 621-625, 2017.

Goto S, Ookawara S, Saito A: Differences in the adsorption of nafamostat mesilate between polyester-polymer alloy and polysulfone membranes. J Artif Organs, 20: 138-144, doi: 10.1007/s10047-016-0937-2, 2017.

Hori Y, Aoki N, Kuwahara S, Hosojima M, Kaseda R, Goto S, Iida T, De S, Kabasawa H, Kaneko R, Aoki H, Tanabe Y, Kagamu H, Narita I, Kikuchi T, Saito A: Megalin Blockade with Cilastatin Suppresses Drug-Induced Nephrotoxicity. J Am Soc Nephrol, 28: 1783-1791, 2017

De S, Kuwahara S, Hosojima M, Ishikawa T, Kaseda R, Sarkar P, Yoshioka Y, Kabasawa H, Iida T, Goto S, Toba K, Higuchi Y, Suzuki Y, Hara M, Kurosawa H, Narita I, Hirayama Y, Ochiya T, Saito A: Exocytosis-Mediated Urinary Full-Length Megalin Excretion Is Linked With the Pathogenesis of Diabetic Nephropathy. Diabetes, 66: 1391-1404, 2017.

Sato H, Hosojima M, Ishikawa T, Aoki K, Okamoto T, Saito A, Tsuchida M: Glucose variability based on continuous glucose monitoring assessment is associated with postperspective complications after cardiovascular surgery. Ann Thorac Cardiovasc Surg, doi: 10.5761/atcs.oa.17-00045, in press.