An RNA-binding protein, Qki5, regulates embryonic neural stem cells through pre-mRNA processing in cell adhesion signaling.

Hayakawa-Yano Y, Suyama S, Nogami M, Yugami M, Koya I, Furukawa T, Zhou L, Abe M, Sakimura K, Takebayashi H, Nakanishi A, Okano H, Yano M.

Genes Dev 31 (18): 1910-1925, 2017. [PubMed]

Hearing loss controlled by optogenetic stimulation of nonexcitable nonglial cells in the cochlea of the inner ear.

Sato MP, Higuchi T, Nin F, Ogata G, Sawamura S, Yoshida T, Ota T, Hori K, Komune S, Uetsuka S, Choi S, Masuda M, Watabe T, Kanzaki S, Ogawa K, Inohara H, Sakamoto S, Takebayashi H, Doi K, Tanaka KF, Hibino H.

Front Mol Neurosci 10: 300, 2017. [Open access]

A novel splice site mutation of myosin VI in mice leads to stereociliary fusion caused by disruption of actin networks in the apical region of inner ear hair cells.

Seki Y, Miyasaka Y, Suzuki S, Wada K, Yasuda SP, Matsuoka K, Ohshiba Y, Endo K, Ishii R, Shitara H, Kitajiri SI, Nakagata N, Takebayashi H, Kikkawa Y.

PLoS ONE 12: e0183477, 2017. [PubMed] [Open access]

Reduced proliferation of oligodendrocyte progenitor cells in the postnatal brain of dystonia musculorum mice.

Hossain MI, Horie M, Takebayashi H.

Neurochem Res in press [PubMed]

Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway.

Morizawa YM, Hirayama Y, Ohno N, Shibata S, Shigetomi E, Sui Y, Nabekura J, Sato K, Okajima F, Takebayashi H, Okano H, Koizumi S.

Nature Commun 8: 28, 2017. [PubMed] [Open access] [山梨大学プレスリリース]

Epidermal growth factor signals attenuate phenotypic and functional development of neocortical GABA neurons.

Namba H, Nagano T, Jodo E, Eifuku S, Horie M, Takebayashi H, Iwakura Y, Sotoyama H, Takei N, Nawa H.

J Neurochem 142: 886-900, 2017. [PubMed]

Oligodendrocyte precursor cells in the mouse optic nerve originate in the preoptic area.

Ono K, Yoshii K, Tominaga H, Gotoh H, Nomura T, Takebayashi H, Ikenaka K.

Brain Struct Funct 222: 2441-2448, 2017. [PubMed]

Independent tonotopy and thalamocortical projection patterns in two adjacent parts of the classical primary auditory cortex in mice.

Tsukano H, Horie M, Takahashi K, Hishida R, Takebayashi H, Shibuki K.

Neurosci Lett 637: 26-30, 2017. [PubMed] [Open access]

Histological detection of dynamic glial responses in the dysmyelinating Tabby-jimpy mutant brain.

Ikeda M, Hossain MI, Zhou L, Horie M, Ikenaka K, Horii A, Takebayashi H.

Anat Sci Int in press [PubMed]


Endoplasmic reticulum-localized transmembrane protein Dpy19L1 is required for neurite outgrowth.

Watanabe K, Bizen N, Sato N, Takebayashi H.

PLoS ONE 11: e0167985, 2016. [PubMed] [Open access]

Characterization of novel dystonia musculorum mutant mice: implications for central nervous system abnormality.

Horie M, Mekada K, Sano H, Kikkawa Y, Chiken S, Someya T, Saito K, Hossain MD, Nameta M, Abe K, Sakimura K, Ono K, Nambu A, Yoshiki A, Takebayashi H.

Neurobiol Dis 96: 271-283, 2016. [PubMed]

Biallelic variants in UBA5 link dysfunctional UFM1 ubiquitin-like modifier pathway to severe infantile-onset encephalopathy.

Muona M, Ishimura R, Laari A, Ichimura Y, Linnankivi T, Keski-Filppula R, Herva R, Rantala H, Paetau A, Poyhonen M, Obata M, Uemura T, Karhu T, Bizen N, Takebayashi H, McKee S, Parker MJ, Akawi N, McRae J, Hurles ME, the DDD Study, Kuismin O, Kurki MI, Anttonen A-K, Tanaka K, Palotie A, Waguri S, Lehesjoki A-E, Komatsu M.

Am J Hum Genet 99: 683-694, 2016. [PubMed] [Open access] [新潟大学プレスリリース]

Characteristic microglial features in patients with hereditary diffuse leukoencephalopathy with spheroids.

Tada M, Konno T, Tada M, Tezuka T, Miura T, Mezaki N, Okazaki KI, Arakawa M, Itoh K, Yamamoto T, Yokoo H, Yoshikura N, Ishihara K, Horie M, Takebayashi H, Toyoshima Y, Naito M, Onodera O, Nishizawa M, Takahashi H, Ikeuchi T, Kakita A.

Ann Neurol 80: 554-565, 2016. [PubMed]

Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.

Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp JL, Kritzik M, Sicklick JK, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek MA, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T.

Nature 534: 407-411, 2016. [PubMed]

Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sclerosis: Evidence for clinico-pathologic subtypes.

Takeuchi R, Tada M, Shiga A, Toyoshima Y, Konno T, Sato T, Nozaki H, Kato T, Horie M, Shimizu H, Takebayashi H, Onodera O, Nishizawa M, Kakita A, Takahashi H.

Acta Neuropathol Commun 4: 61, 2016. [PubMed] [Open access]

Musashi mediates translational repression of the Drosophila hypoxia inducible factor.

Bertolin AP, Katz MJ, Yano M, Pozzi B, Acevedo JM, Blanco-Obregon D, Gandara L, Sorianello E, Kanda H, Okano H, Srebrow A, Wappner P.

Nucleic Acids Res 44: 7555-7567, 2016. [PubMed]

Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells.

Ichiyanagi N, Fujimori K, Yano M, Ishihara-Fujisaki C, Sone T, Akiyama T, Okada Y, Akamatsu W, Matsumoto T, Ishikawa M, Nishimoto Y, Ishihara Y, Sakuma T, Yamamoto T, Tsuiji H, Suzuki N, Warita H, Aoki M, Okano H.

Stem Cell Rep 6: 496-510, 2016. [PubMed]

Quantitative map of multiple auditory cortical regions with a stereotaxic fine-scale atlas of the mouse brain.

Tsukano H, Horie M, Hishida R, Takahashi K, Takebayashi H, Shibuki K.

Sci Rep 29: 22315, 2016. [PubMed] [Open access]

The dorsoventral boundary of the germinal zone is a specialized niche for the generation of cortical oligodendrocytes during a restricted temporal window.

Naruse M, Ishino Y, Kumar A, Ono K, Takebayashi H, Yamaguchi M, Ishizaki Y, Ikenaka K, Hitoshi S.

Cereb Cortex 26: 2800-2810, 2016. [PubMed]


Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex.

Shinmyo Y, Riyadh MA, Ahmed G, Naser IB, Hossain M, Takebayashi H, Kawasaki H, Ohta K, Tanaka H.

Nature Commun 6: 10232, 2015. [PubMed] [Open access] [金沢大学プレスリリース]

Oligodendrogenesis in the fornix of adult mouse brain; the effect of LPS-induced inflammatory stimulation.

Fukushima S, Nishikawa K, Furube E, Muneoka S, Ono K, Takebayashi H, Miyata S.

Brain Res 1627: 52-69, 2015. [PubMed]

Specific distribution of non-phosphorylated neurofilaments characterizing each subfield in the mouse auditory cortex.

Horie M, Tsukano H, Takebayashi H, Shibuki K.

Neurosci Lett 606: 182-187, 2015. [PubMed]

Acute reduction of neuronal RNA binding Elavl2 protein and Gap43 mRNA in mouse hippocampus after kainic acid treatment.

Ohtsuka T, Yano M, Okano H.

Biochem Biophys Res Commun 466: 46-51, 2015. [PubMed]

Somatic mutations in the MTOR gene cause focal cortical dysplasia type IIb.

Nakashima M, Saitsu H, Takei N, Tohyama J, Kato M, Kitaura H, Shiina M, Shirozu H, Masuda H, Watanabe K, Ohba C, Tsurusaki Y, Miyake N, Zheng Y, Sato T, Takebayashi H, Ogata K, Kameyama S, Kakita A, Matsumoto N.

Ann Neurol 78: 375-386, 2015. [PubMed]

Delineation of a frequency-organized region isolated from the mouse primary auditory cortex.

Tsukano H, Horie M, Bo T, Uchimura A, Hishida R, Kudoh M, Takahashi K, Takebayashi H, Shibuki K.

J Neurophysiol 113: 2900-2920, 2015. [PubMed] [Open access]

Expression of the Olig gene family in the developing mouse inner ear.

Kanaya E, Okano T, Yoshida A, Katsuno T, Takabayashi H, Ito J, Yamamoto N.

Gene Expr Patterns 17: 79-86, 2015. [PubMed]

Alternative role of HuD splicing variants in neuronal differentiation.

Hayashi S, Yano M, Igarashi M, Okano HJ, Okano H.

J Neurosci Res 93: 399-409, 2015. [PubMed]

Impaired clustered protocadherin-α (cPcdh-α) leads to aggregated retinogeniculate terminals and impaired visual acuity in mice.

Meguro R, Hishida R, Tsukano H, Yoshitake K, Imamura R, Tohmi M, Kitsukara T, Hirabayashi T, Yagi T, Takebayashi H, Shibuki K.

J Neurochem 133: 66-72, 2015. [PubMed] [Open access]


Disruption of actin-binding domain-containing dystonin protein causes dystonia musculorum in mice.

Horie M, Watanabe K, Bepari AK, Nashimoto J, Araki K, Sano H, Chiken S, Nambu A, Ono K, Ikenaka K, Kakita K, Yamamura K, Takebayashi H*.

Eur J Neurosci 40: 3458-3471, 2014. [PubMed]

Olig3 is not involved in the ventral patterning of spinal cord.

Liu Z, Hu X, Huang C, Zheng K, Takebayashi H, Cao C, Qiu M.

PLoS One 28: e111076, 2014. [PubMed] [Open access]

Development of the prethalamus is crucial for thalamocortical projection formation and is regulated by Olig2.

Ono K, Clavairoly A, Nomura T, Gotoh H, Uno A, Armant O, Takebayashi H, Zhang Q, Shimamura K, Itohara S, Parras CM, Ikenaka K.

Development 14: 2075-2084, 2014. [PubMed] [Open access]

Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum.

Seto Y, Nakatani T, Masuyama N, Taya S, Kumai M, Minaki Y, Hamaguchi A, Inoue YU, Inoue T, Miyashita S, Fujiyama T, Yamada M, Chapman H, Campbell K, Magnuson MA, Wright CV, Kawaguchi Y, Ikenaka K, Takebayashi H, Ishiwata S, Ono Y, Hoshino M.

Nature Commun 5: 3337, 2014. [PubMed]


Age-related deterioration of cortical responses to slow FM sounds in the auditory belt region of adult C57BL/6 mice.

Tsukano H, Horie M, Honma Y, Ohga S, Hishida R, Takebayashi H, Takahashi S, Shibuki K.
Neurosci Lett 556: 204-209, 2013. [PubMed]

Auditory cortical areas activated by slow frequency-modulated sounds in mice.
Honma Y, Tsukano H, Horie M, Ohshima S, Tohmi M, Kubota Y, Takahashi K, Hishida R, Takahashi S, Shibuki K.
PLoS One 17: e68113, 2013. [PubMed] [Open access]

Dual compartments of the ventral division of the medial geniculate body projecting to the core region of the auditory cortex in C57BL/6 mice.

Horie M, Tsukano H, Hishida R, Takebayashi H, Shibuki K.
Neurosci Res 76: 207-212, 2013. [PubMed]

Olig2-lineage cells preferentially differentiate into oligodendrocytes but fail to survive in the chronic demyelinating lesion.
Shimizu T, Tanaka KF, Takebayashi H, Higashi M, Ono K, Hitoshi S, Ikenaka K.
J Neurosci Res 91: 178-186, 2013. [PubMed]

Neuroanatomical study on the tecto-suprageniculate-dorsal auditory cortex pathway in the rat.

Horie M*, Meguro R, Hoshino K, Ishida N, Norita M.
Neuroscience 228: 382-394, 2013. [PubMed]


Identification of optogenetically activated striatal medium spiny neurons by Npas4 expression.

Bepari AK#, Sano H#, Tamamaki N, Nambu A, Tanaka KF*, Takebayashi H*.

PLoS One 7: e52783, 2012. [# co-first authors] [PubMed] [Open access]

Nx2.2+ progenitors generate somatic motoneurons in the chick spinal cord.

Gotoh H, Ono K, Nomura T, Takebayashi H, Harada H, Nakamura H, Ikenaka K.

PLoS One 7: e51581, 2012. [PubMed] [Open access]

Visualization of odor-induced neuronal activity by immediate early gene expression.

Bepari AK, Watanabe K, Yamaguchi M, Tamamaki N, Takebayashi H*.
BMC Neurosci 13: 140, 2012. [PubMed] [Open access] Most viewd article (^^)v

Subventricular Zone-Derived Oligodendrogenesis in Injured Neonatal White-matter in Mice Enhanced by a Nonerythropoietic EPO Derivative.

Kako E, Kaneko N, Aoyama M, Hida H, Takebayashi H, Ikenaka K, Asai K, Togari H, Sobue K, Sawamoto K.
Stem Cells 30: 2234-2247, 2012. [PubMed]

Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche.
Lee DA, Bedont JL, Wang H, Song J, Miranda-Angulo A, Takiar V, Charubhumi V, Balordi F, Takebayashi H, Aja S, Ford E, Fishell G, Blackshaw S.
Nature Neurosci 15: 700-702, 2012. [PubMed]

Role of motoneuron-derived neurotrophin 3 in survival and axonal projection of sensory neurons during neural circuit formation.
Usui N, Watanabe K, Ono K, Tomita K, Tamamaki N, Ikenaka K, Takebayashi H*.
Development 139: 1125-1132, 2012. [PubMed] In this Issueに取り上げられました

A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors.
Shinohara R, Thumkeo D, Kamijo H, Kaneko N, Sawamoto K, Watanabe K, Takebayashi H, Kiyonari H, Ishizaki T, Furuyashiki T, Narumiya S.
Nature Neurosci 15: 373-380, 2012. [PubMed] [News]


Dpy19l1, a multi-transmembrane protein, regulates radial migration of glutamatergic neurons in the developing cerebral cortex.
Watanabe K*, Takebayashi H*, Bepari AK, Esumi S, Yanagawa Y, Tamamaki N.
Development 138: 4979-4990, 2011. [PubMed] [Open access]

Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia.
Thumkeo D, Shinohara R, Watanabe K, Takebayashi H, Toyoda Y, Tohyama K, Ishizaki T, Furuyashiki T, Narumiya S.
PLoS One 6: e25465, 2011. [PubMed] [Open access]

Olig2-lineage cells generate GABAergic neurons in the prethalamic nuclei, including the zona incerta, ventral lateral geniculate nucleus and reticular thalamic nucleus.
Inamura N, Ono K, Takebayashi H, Zalc B, Ikenaka K.
Dev Neurosci 33: 118-129, 2011. [PubMed]

Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis.
Guo F, Meada Y, Ma J, Delgado M, Sohn J, Miers L, Ko EM, Bannerman P, Xu J, Wang Y, Zhou C, Takebayashi H, Pleasure D.
J Neurosci 31: 11914-11928, 2011. [PubMed] [Open access] [UC Davis News]

Evidence for the spontaneous production but massive programmed cell death of new neurons in the subcallosal zone of the adult mouse brain.
Kim WR, Chun SK, Kim TW, Kim H, Ono K, Takebayashi H, Ikenaka K, Oppenheim RW, Sun W.
Eur J Neurosci 33: 599-611, 2011. [PubMed]

Genetically-defined lineage tracing of Nkx2.2-expressing cells in chick spinal cord.
Goto H, Ono K, Takebayashi H, Harada H, Nakamura H, Ikenaka K.
Dev Biol 349: 504-511, 2011. [PubMed]


Origin of new glial cells in the intact and injured adult spinal cord.
Barnabe-Heider F, Goritz C, Sabelstrom H, Takebayashi H, Pfrieger FW, Meletis K, Frisen J.
Cell Stem Cell 7: 470-482, 2010. [PubMed]

Direct synaptic connections between superior colliculus afferents and thalamo-insular projection neurons in the feline suprageniculate nucleus: A double-labeling study with WGA-HRP and kainic acid.
Hoshino K, Horie M, Nagy A, Berenyi A, Benedek D, Norita M.
Neurosci Res 66: 7-13, 2010. [PubMed]


Origin of oligodendrocytes in the optic nerve; Old and new problem.

Ono K, Hirahara Y, Gotoh H, Nomura T, Takebayashi H, Yamada H, Ikenaka K.

Neurochemical Research in press [PubMed]

BPAG1 in muscles: structure and function in skeletal, cardiac and smooth muscle.

Horie M, Yoshioka N, Takebayashi H.

Semin Cell Dev Biol 69: 26-33, 2017. [PubMed]

Reconsidering Tonotopic Maps in the Auditory Cortex and Lemniscal Auditory Thalamus in Mice.

Tsukano H, Horie M, Ohga S, Takahashi K, Kubota Y, Hishida R, Takebayashi H, Shibuki K.

Frontiers in Neural Circuits 11:14, 2017. [PubMed] [Open access]

RNA regulation went wrong in neurodevelopmental disorders: The example of Msi/Elavl RNA binding proteins.

Yano M, Hayakawa-Yano Y, Okano H.

Int J Dev Neurosci 55: 124-130, 2016. [PubMed]

Oligodendrocyte generation during mouse development.

Takebayashi H, Ikenaka K.

Glia 63: 1350-1356, 2015. [PubMed]

RNA-binding protein research with transcriptome-wide technologies in neural development.

Yano M*, Ohtsuka T, Okano H.

Cell Tissue Res 359: 135-144, 2015. [PubMed] [Open access]

Olig2 transcription factor in the developing and injured forebrain: cell lineage and glial development.

Ono K, Takebayashi H, Ikenaka K.

Mol Cells 27: 397-401, 2009. [PubMed]


ジストニア様の運動症状と感覚神経変性を示すdystonia musculorumマウスの病態解析
生化学 89 (5): 756-760, 2017.

栗山桃奈、吉岡望、加畑雄大、牛木辰男、吉木淳、Thomas J Sproule、阿部理一郎、竹林浩秀
新潟医学会雑誌 131巻11号 印刷中

新潟医学会雑誌 129: 491-497, 2015.

神経化学 53: 41-46, 2014.

ヒト脳病理切片におけるin situ hybridization 法を利用したニューロンおよびグリア細胞の同定
新潟医学会雑誌 128: 625-634, 2014.

竹林浩秀、堀江正男、Asim K Bepari、渡辺啓介、目黒玲子
新潟医学会雑誌 127: 291-297, 2013.

新潟県医師会報 744: 1-4, 2012.

熊本医学会ニューズレター 第9号: 2011.

神経化学 47 (1): 10-18, 2008.

細胞工学 22 (4): 406-411, 2003.