オートファジー、代謝と神経変性疾患

Autophagy, metabolism and neurodegeneration

  • 日本学術振興会 日中韓フォーサイト事業

    JSPS A3 Foresight Program

研究業績:2017年

  1. Kim TS, Shin YH, Lee HM, Kim JK, Choe JH, Jang JC, Um S, Jin HS, Komatsu M, Cha GH, Chae HJ, Oh DC, Jo EK.
    Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway.

    Sci Rep. 7(1):3431
  2. Yamaguchi J, Suzuki C, Nanao T, Kakuta S, Ozawa K, Tanida I, Saitoh T, Sunabori T, Komatsu M, Tanaka K, Aoki S, Sakimura K, Uchiyama Y.
    Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgenesis.

    Autophagy in press
  3. Koike M, Shibata M, Sunabori T, Yamaguchi J, Sakimura K, Komatsu M, Tanaka K, Uchiyama Y.
    Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7.

    Am J Pathol. 187(7):1586-1600
  4. Peng H, Yang J, Li G, You Q, Han W, Li T, Gao D, Xie X, Lee BH, Du J, Hou J, Zhang T, Rao H, Huang Y, Li Q, Zeng R, Hui L, Wang H, Xia Q, Zhang X, He Y, Komatsu M, Dikic I, Finley D, Hu R.
    Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation.

    Nat Microbiol. 2:17066
  5. Peng H, Yang J, Li G, You Q, Han W, Li T, Gao D, Xie X, Lee BH, Du J, Hou J, Zhang T, Rao H, Huang Y, Li Q, Zeng R, Hui L, Wang H, Xia Q, Zhang X, He Y, Komatsu M, Dikic I, Finley D, Hu R.
    Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.

    Cell Res. 27(5):657-674
  6. Ueno T, Komatsu M.
    Autophagy in the liver: functions in health and disease.

    Nat Rev Gastroenterol Hepatol. 14(3)170-184
  7. Ishimura R, Obata M, Kageyama S, Daniel J, Tanaka K, Komatsu M.
    A novel approach to assess the ubiquitin-fold modifier 1-system in cells.

    FEBS Lett. 591(1):196-204