分子生物学分野

School of medicine, Niigata University

JAPANESE

2012 Publication

  1. McMahon J, Huang X, Yang J, Komatsu M, Yue Z, Qian J, Zhu X, Huang Y.
    Impaired autophagy in neurons after disinhibition of mammalian target of rapamycin and its contribution to epileptogenesis.

    J Neurosci 32:15704-15714.
  2. Tashiro Y, Urushitani M, Inoue H, Koike M, Uchiyama Y, Komatsu M, Tanaka K, Yamazaki M, Abe M, Misawa H, Sakimura K, Ito H, Takahashi R.
    Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis.

    J Biol Chem 287:42984-42994.
  3. Inoue K, Rispoli J, Kaphzan H, Klann E, Chen EI, Kim J, Komatsu M, Abeliovich A.
    Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.

    Mol Neurodegener 7:48.

  4. Kageyama S, Komatsu M.
    Impaired G1-Arrest, Autophagy, and Apoptosis in Atg7-Knockout Mice.

    Circ Res. 111:962-964.
  5. Reggiori F, Komatsu M, Finley K, Simonsen A.
    Selective types of autophagy.

    Int J Cell Biol. doi:10.1155/2012/156272.
  6. Mijaljica D, Nazarko TY, Brumell JH, Huang WP, Komatsu M, Prescott M, Simonsen A, Yamamoto A, Zhang H, Klionsky DJ, Devenish RJ.
    Receptor protein complexes are in control of autophagy.

    Autophagy. 8:1-5.
  7. Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, Yamamoto M.
    Keap1 degradation by autophagy for the maintenance of redox homeostasis.

    Proc Natl Acad Sci U S A. 109:13561-13566.
  8. Jiang M, Wei Q, Dong G, Komatsu M, Su Y, Dong Z.
    Autophagy in proximal tubules protects against acute kidney injury.

    Kidney Int. doi: 10.1038/ki.2012.261.
  9. Komatsu M, Kageyama S, Ichimura Y.
    p62/SQSTM1/A170: Physiology and pathology.
    Pharmacol Res. doi.org/10.1016/j.phrs.2012.07.004.

  10. Reggiori F, Komatsu M, Finley K, Simonsen A.
    Autophagy: more than a nonselective pathway.

    Int J Cell Biol. doi:10.1155/2012/219625
  11. Komatsu M.
    Liver autophagy: physiology and pathology.
    J Biochem. 152:5-15.

  12. Friedman LG, Lachenmayer ML, Wang J, He L, Poulose SM, Komatsu M, Holstein GR, Yue Z.
    Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain.
    J Neurosci. 32:7585-7593.

  13. Fukada H, Yamashina S, Izumi K, Komatsu M, Tanaka K, Ikejima K, Watanabe S.
    Suppression of autophagy sensitizes Kupffer cells to endotoxin.

    Hepatol Res. doi: 10.1111/j.1872-034X.2012.01024.x.
  14. Quan W, Kim HK, Moon EY, Kim SS, Choi CS, Komatsu M, Jeong YT, Lee MK, Kim KW, Kim MS, Lee MS.
    Role of hypothalamic proopiomelanocortin neuron autophagy in the control of appetite and leptin response.

    Endocrinology. 153:1817-1126.

  15. Coupé B, Ishii Y, Dietrich MO, Komatsu M, Horvath TL, Bouret SG.
    Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation.

    Cell Metab. 15:247-255.

  16. Tanida I, Yamasaki M, Komatsu M, Ueno T.
    The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation.

    Autophagy. 8:88-97.

  17. Igusa Y, Yamashina S, Izumi K, Inami Y, Fukada H, Komatsu M, Tanaka K, Ikejima K, Watanabe S.
    Loss of autophagy promotes murine acetaminophen hepatotoxicity.

    J Gastroenterol. 47:433-443.

  18. Quan W, Hur KY, Lim Y, Oh SH, Lee JC, Kim KH, Kim GH, Kim SW, Kim HL, Lee MK, Kim KW, Kim J, Komatsu M, Lee MS.
    Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice.
    Diabetologia. 55:392-403.

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