分子生物学分野

新潟大学大学院医歯学総合研究科

ENGLISH

2011年 研究業績

洋雑誌

  1. Mizushima N, Komatsu M.
    Autophagy: renovation of cells and tissues.
    Cell. vol. 147, 728-741. Review
  2. Isogai S, Morimoto D, Arita K, Unzai S, Tenno T, Hasegawa J, Sou YS, Komatsu M, Tanaka K, Shirakawa M, Tochio H.
    Crystal structure of the ubiquitin-associated (UBA) domain of p62 and its interaction with ubiquitin.
    J Biol Chem. vol. 286.31864-31874
  3. Komatsu M.
    Potential role of p62 in tumor development.
    Autophagy. vol. 7. 1088-1090
  4. Ezaki J, Matsumoto N, Takeda-Ezaki M, Komatsu M, Takahashi K, Hiraoka Y, Taka H, Fujimura T, Takehana K, Yoshida M, Iwata J, Tanida I, Furuya N, Zheng DM, Tada N, Tanaka K, Kominami E, Ueno T.
    Liver autophagy contributes to the maintenance of blood glucose and amino acid levels.
    Autophagy.7.727-736
  5. Asano T, Komatsu M, Yamaguchi-Iwai Y, Ishikawa F, Mizushima N, Iwai K.
    Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells.
    Mol Cell Biol. 10.2040-2052
  6. Ch'en IL, Tsau JS, Molkentin JD, Komatsu M, Hedrick SM.
    Mechanisms of necroptosis in T cells.
    J Exp Med. 208.633-641
  7. Ushio H, Ueno T, Kojima Y, Komatsu M, Tanaka S, Yamamoto A, Ichimura Y, Ezaki J, Nishida K, Komazawa-Sakon S, Niyonsaba F, Ishii T, Yanagawa T, Kominami E, Ogawa H, Okumura K, Nakano H.
    Crucial role for autophagy in degranulation of mast cells.
    J Allergy Clin Immunol. 127.1267-1276.e6
  8. Inami Y, Waguri S, Sakamoto A, Kouno T, Nakada K, Hino O, Watanabe S, Ando J, Iwadate M, Yamamoto M, Lee MS, Tanaka K, Komatsu M.
    Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.
    J Cell Biol. vol 18 275-284.
  9. Takamura A, Komatsu M, Hara T, Sakamoto A, Kishi C, Waguri S, Eishi Y, Hino O, Tanaka K, Mizushima N.
    Autophagy-deficient mice develop multiple liver tumors.
    Genes Dev. vol 15. 795-800.
  10. Cheng HC, Kim SR, Oo TF, Kareva T, Yarygina O, Rzhetskaya M, Wang C, During M, Talloczy Z, Tanaka K, Komatsu M, Kobayashi K, Okano H, Kholodilov N, Burke RE.
    Akt suppresses retrograde degeneration of dopaminergic axons by inhibiton of macroatuophagy.
    J Neurosci.vol. 31, 2125-2135.
  11. Ha BH, Jeon YJ, Shin SC, Tatsumi K, Komatsu M, Tanaka K, Watson CM, Wallis G, Chung CH, Kim EE.
    Structure of ubiquitin-fold modifier 1-specific protease UfSP2.
    J Biol Chem.vol. 286, 10248-10257.
  12. Fujishima Y, Nishiumi S, Masuda A, Inoue J, Nguyen NM, Irino Y, Komatsu M, Tanaka K, Kutsumi H, Azuma T, Yoshida M.
    Autophagy in the intestinal epithelium reduces endotoxin-induced inflammatory responses by inhibiting NF-κB activation.
    Arch Biochem Biophys. vol 506. 223-235.
  13. Pei Y, Chen ZP, Ju HQ, Komatsu M, Ji YH, Liu G, Guo CW, Zhang YJ, Yang CR, Wang YF, Kitazato K.
    Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro.
    Biochem Biophys Res Commun. vol 405, 186-191.
  14. Tatsumi K, Yamamoto-Mukai H, Shimizu R, Waguri S, Sou YS, Sakamoto A, Taya C, Shitara H, Hara T, Chung CH, Tanaka K, Yamamoto M, Komatsu M.
    The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice.
    Nat Commn. vol. 181.
  15. Inoue D, Kubo H, Taguchi K, Suzuki T, Komatsu M, Motohashi H, Yamamoto M.
    Inducible disruption of autophagy in the lung causes airway hyper-responsiveness.
    Biochem Biophys Res Commun. vol 405, 13-18.
  16. Ichimura Y, Komatsu M.
    Pathophysiological role of autophagy: lesson from autophagy-deficient mouse models.
    Exp Anim. vol 60. 329-345.

和雑誌

  1. 高村聡、小松雅明、水島昇:オートファジー欠損は多発性肝腫瘍を発症する,細胞工学 HOTPRESS, vol. 30, 1186-1187.
  2. 一村義信,小松雅明:オートファジーの選択基質p62の生理機能,内分泌・糖尿病・代謝内科,vol. 33, 371-376.
  3. 小松雅明:オートファジーの破綻と肝疾患発症機構,実験医学,vol. 29, 2101-2107.
  4. 小松雅明:ユビキチンシステムとオートファジーのクロストーク,実験医学 増刊,vol. 29, 182-187.
  5. 辰巳加奈子、小松雅明:赤血球産生に必要不可欠なユビキチン様タンパク質修飾システム,細胞工学 HOTPRESS,vol. 33, 646-647.
  6. 一村義信、小松雅明:オートファジー関連疾患,Surgery Frontier,vol. 18, 32-39.
  7. 一村義信、小松雅明:オートファジー,モデル動物利用マニュアル「生物機能モデルと新しいリソース・リサーチツール」, 221-229.

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