1. Research Summary

The vascular system comprises blood vessels and lymphatic vessels. It is a lifeline in our body, which play distinct but cooperative role in fluid homeostasis. Defective vascular development is associated with pathological conditions. The aim of our research is to clarify how these vessels are developmentally formed and how pathological conditions can be regulated. We are particularly interested in lymphatic vascular development and pathological conditions caused by developmental defect or aging.

2. Research Subjects

• Lymphatic vascular development and regulation of fluid homeostasis in the mouse.
• Blood vessel-derived factors regulating lymphatic vascular patterning.
• Transcription factors in endothelial cells during blood and lymphatic vascular formation and maintenance.
• Angiocrine factors secreted through endothelial-to-mesenchymal transition during inflammation and cancer progression.

Please see the Pharmacology website for a detailed description of our research.