HOME Activities Laboratory Medicine

1.Research Summary

In the field of laboratory medicine, research activities on laboratory medicine and preventive medicine are conducted. We work on understanding the significance and characteristics of laboratory tests, systematic analysis on the management of laboratories and developing new methodologies of clinical laboratory medicine in collaboration with the Clinical Laboratory Division in the Niigata University Medical & Dental Hospital. In the field of preventive medicine, epidemiological researches to identify risk factors for arteriosclerotic diseases have been conducted.

2.Research Groups

  • Laboratory Medicine Group
  • Preventive Medicine Group

3-1.Laboratory Medicine Group

Research subjects

Research on the mechanism of HbA1c fluctuations

Research on predictability of heart rate variability

Research on the collective synchronization of the nervous system

Development of a noise removal technique for processing an image comprising faint signals

Research on procedures for quality control of laboratory examinations

Mathematical modeling and analyses for dimisishing queues in laboratories

3-2.Preventive Medicine Group

Research subjects

Epidemiological research to identify risk factors for arteriosclerosis in a Japanese population

Research on susceptibility to oxidation of low-density lipoprotein and the development of arteriosclerosis

Development of a mathematical model of lipid metabolism

4.Research Results

[Area] Laboratory medicine

[Research subject] Development of a noise removal technique for processing an image comprising faint signals

When observing FISH images of chromosomes using a super-high-resolution microscope (such as SNOM/AFM), observed brightness is so weak as signals of each pixel comprise only a few photons; thus, an obtained image is covered with noise due to stochastic perturbations (Poisson noise). In order to estimate the true brightness distribution from such an image. we developed a new image processing procedure by applying the uniformity test of the Poisson distribution and acquired patents for it in Japan and in the US [Photographs].