Third Department of Internal Medicine

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* Bibliographies



  1. Okoshi S, Takeda Y, Takimoto M, Shimotohno K, Asakura H, Jay G. Molecular dissection of hepatitis C virus expression. Intervirology 2001; 44: 21-8.
  2. Ito S, Nakazono K, Murasawa A, Mita Y, Hata K, Saito N, Kikuchi M, Yoshida K, Nakano M, Gejyo F. Development of fulminant hepatitis B (Precore variant mutant type) after the discontinuation of low-dose methotrexate therapy in a rheumatoid arthritid patient. Arthritis & Rheumatism 2001; 44: 339-42.
  3. Takahashi K, Takahashi T, Takahashi S, K Watanabe, Boku S, Matsui S, Arai F, Asakura H. Difference in quasispecies of the hypervariable region 1 of hepatitis C virus between alcoholic and non-alcoholic patients. J Gastroenterol Hepatol 2001; 16: 416-423.
  4. Casey CA, Nanji A, Cederbaum AI, Adachi M, Takahashi T. Alcoholic liver disease and apoptosis. Alcohol Clin Exp Res 2001; 25: 49S-53S.


  1. Yokota T, Suda T, Tsukioka S, Takahashi T, Honma T, Seki K, Matsuzawa J, Miura M, Aoyagi Y, Asakura H. The striking effect of hyperbaric oxygenation therapy in the management of chronic idiopathic intestinal pseudo-obstruction. Am J Gastroenterol 95: 285-288, 2000.
  2. Kawai H, Aoyagi Y, Nomoto M, Takizawa H, Suzuki Y, Hama A, Suda T, Takahashi T, Asakura H. Asymptomatic primary sclerosing cholangitis with marked hepatic fibrosis. Dig Dis Sci 45: 680-684, 2000
  3. Genda T, Sakamoto M, Ichida T, Asakura H Hirohashi S. Loss of cell-cell contact is induced by integrin-mediated cell-substratum adhesion in highly-motife and highly-metastatic hepatocellular carcinoma cells. Lab Invest 80(3): 387-394, 2000.
  4. Satoh T, Ichida T, Matsuda Y, Sugiyama M, Yonekura K, Ishikawa T, Asakura H. Interaction between hyaluronan and CD44 in the development of dimethylnitrosamine-induced liver cirrhosis, J Gastroenterol Hepatol, 15(4): 402-411, 2000.
  5. Takahashi T, So-Wan T, Kamimura T, Asakura H. Infiltrating polymorphonuclear leukocytes and apoptotic bodies derived from hepatocytes but not from ballooning hepatocytes containing Mallory bodies show nuclear DNA fragmentation in alcoholic hepatitis. Alcoholism: Clin Exp Res 24: 68S-73S, 2000
  6. Kawai H, Suda t, Aoyagi Y, Isokawa O, Mita Y, Waguri N, Kuroiwa T, Igarashi M , Tsukada K, Mori S, Shimizu T, Suzuki Y, Abe Y, Takahashi T, Nomoto M, Asakura H. Quantitative evaluation of genomic instability as a possible predictor for development of hepatocellular carcinoma: comparison of loss of heterozygosity and replication error. Hepatology 31: 1246-1250, 2000.
  7. Suzuki Y, Kobayashi M, Ishizuka K, Honma T, Hayashi S, Narisawa R, Asakura H. Inverted hyperplastic polyp diagnosed accurately by magnifying colonoscopy. Gastrointestinal Endoscopy 52: 115-118, 2000
  8. Ishikawa T, Ichida T, Matsuda Y, Sugitani S, Sugiyama M, Kato T, Miyazaki H, Asakura H. Expression of hepatic thrombopoietin mRNA in primary cultured hepatocytes and in rats with acute liver injury or bone marrow suppression with or without cirrhosis. J Gastroenterol Hepatol 15: 647-653, 2000
  9. Furukawa K, Takahashi T, Aoyagi Y, Naito A, Honma T, Sato E, Soga T, Tsukada H, Asakura H. Three-dimensional imaging of the radiological stereoscopic visualization of the pancreatic duct system by endoscopic retrograde pancreatography-helical computed tomography. Acta Med Biol 2000; 48: 59-64
  10. Kaizu H, Cho D, Matsuki A, Ohkoshi S, Nomoto M, Asakura H. γ-ray induced hepatocarcinogenesis in p53-deficient mice. Anticancer Res 2000; 20: 1545-1550.
  11. Matsuda Y. Microsatellite instability meets gallbladder cancer. (Editorial) J Gastroenterol 2000; 35: 798-799.
  12. Matsui S, Ichida T, Watanabe M, Sugitani S, Suda T, Takahashi T, Asakura H. Clinical features and etiology of hepatocellular carcinoma arising in patients with membranous obstruction of the inferior vena cava: in reference to hepatitits viral infection. J Gastroenterol Hepatol 2000; 15:1205-1211.
  13. Uchida M, Ichida T, Sato K, Yonekura K, Yamagiwa S, Sugahara S, Asakura H. Detection of intracellular interleukin-2 production in peripheral T lymphocytes by flow cytometry in patients with pancreatobiliary malignancies. J Gastroenterol Hepatol 2000; 15:1212-1218.
  14. Ichida T. Editorial; Does brain damage (hepatic encephalopathy) improve without any complication and sequellae after liver transplantation? Int Med 2000; 39(11): 871-872.
  15. Yonekura K, Ichida T, Sato K, Yamagiwa S, Uchida M, Sugahara S, Ito S, Abo T, Asakura H. Liver infiltrating CD56 positive T lymphocytes in hepatitis C virus infection. Liver 2000; 20(5); 357-365.
  16. Yamagiwa S, Ichida T, Sato K, Sugahara S, Yonekura K, Uchida M, Uehara K, Katoh M, Satoh H, Abo T, Asakura H. Liposome-encapsulated OK-432 specifically and sustainedly induced hepatic NK cells and intermediate T cell receptor cells. J Gastroenterol Hepatol 2000; 15: 542-549.
  17. Suzuki A, Sugimura K, Ohtsuka K, Hasegawa K, Suzuki K, Ishizuka T, Mochizuki T, Honma T, Narisawa R, Asakura H. Fas/Fas ligand expression and characteristics of primed CD45RO+ T cells in the inflamed mucosa of ulcerative colitis. Scand J Gastroenterol 2000; 35: 1278-1283.
  18. Sato F, Yamazaki H, Ataka K, Mashima I, Suzuki K, Takahashi T, Umezu H, Gejyo F. Malignant peritoneal mesothelioma associated with deep vein thrombosis following radiotherapy for seminoma of the testis. Int Med 2000;39: 920-4.


  1. Ichida T. Morphological aspects of hepatic sinusoidal walls in reperfusion injury after liver preservation for liver transplantation. Liver Diseases and Hepatic Sinusoidal Cells 307-317, 1999
  2. Sugahara S, Shimizu T, Yoshida Y, Aiba T, Yamagiwa S, Asakura H, Abo T. Extrathymic derivation of gut lymphocytes in parabiotic mice. Immunology 96:57-65, 1999
  3. Matsuda Y, Ichida T, Matsuzawa J, Sugimura K, Asakura H. p16INK4 is inactivated by extensive CpG methylation in human hepatocellular carcinoma. Gastroenterology 116:394-400, 1999
  4. Asakura H. Proinflammatory cyrokines in IBD. J Gastroenterol 34:149-151,1999
  5. Takizawa H, Narisawa R, Asakura H. Jejunal invasion of pheochromocytoma pathologically confirmed by endoscopic biopsy. Am J Med Sci 317:63-66,1999.
  6. Ishikawa T, Ichida T, Ishimoto Y, Yokoyama J, Nomoto M, Ebe Y, Usuda H, Naito M, Asakura H. Complete remission of multiple hepatocellular carcinomas associated with hepatitis C virus-related decompensated liver cirrhosis by oral administration of enteric-coated tegafur/uracil. Am J Gastroenterol 94:1682-1685, 1999.
  7. Suda T, Ohkoshi S, Aoyagi Y, Fujimaki T, Narisawa R, Nomoto M, Kamimura T, Tanaka K, Asakura H. A pregnant case of severe acute hepatitis type C successfully treated with natural interferon-alpha and showing no evidence of a maternal transmission of HCV to the newborn. Acta Med Biol 47:75-80, 1999.
  8. Murai M, Yoneyama H, Harada A, Yi Z, Vestergaard C, Guo B, Suzuki K, Asakura H, Matsushima K. Active participation of CCR5+CD8+ T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease. J Clin Invest 104:49-57, 1999.
  9. Isokawa O, Suda T, Aoyagi Y, Kawai H, Takahashi T, Nomoto M, Mita Y, Igarashi H, Asakura H. Reduction of telomeric repeats as a possible predictor for depvelopment of hepatocellular carcinoma: convenient evaluation by slot-blot analysis. Hepatology 30:408-412, 1999.
  10. Oyanagi Y, Takahashi T, Matsui S, Takahashi S, Boku S, Takahashi K, Furukawa K, Arai F, Asakura H. Enhanced expression of interleukin-6 in chronic hepatitis C. Liver 19:464-472, 1999.
  11. Ichida T, Yamagiwa S, Sato K, Sugahara S, Uehara K, Ishikawa T, Katoh M, Satoh H, Asakura H. Clinical significance of liposome-encapsulated OK-432 injection with simultaneous interventional radiological treatment of hepatocellular carcinoma based on experimental analysis of liver-associated lymphocytes. In: Frontiers in Hepatology. Progress in Hepatocellular Carcinoma Treatment. Eds by Okita K. Springer-Verlag Tokyo, 2000, pp40-48.
  12. Naitoh A, Aoyagi Y, Asakura H. Highly enhanced fucosylation of serum glycoproteins in patients with hepatocellular carcinoma. J Gastroenterol Hepatol 14: 436-445, 1999.
  13. Sato Y, Sugimura K, Mochizuki T, Honma T, Suriki H, Tashiro K, Ishizuka K, Narisawa R, Ichida T, Van Thiel D, Asakura H. Regional differences on production of chemokines in gastric mucosa between Helicobacter pylori-positive duodenal ulcer and gastric ulcer. Dig Dis Sci 44(12): 2390-2396, 1999
  14. Genda T, Sakamoto M, Ichida T, Asakura H, Kojiro M, Narumiya S, Hirohashi S. Cell motility mediated by Rho and Rho-associated protein kinase plays a critical role on intrahepatic metastasis of human hepatocellular carcinoma. Hepatology 30, 1027-1036, 1999.
  15. Iino S, Sato S, Kumada H, Toda G, Ishii H, Miyake K, Hino K, Ichida T, Akahane Y, Kiyosawa K, Kobayashi K, Hayashi N, Kuroki T, Tsuji T, Sata M, Sakai T, Yano M. Involvement of GBV-C/HGV in liver diseases in Japan. Hepatology Research 13: 153-159, 1999.
  16. Ogata N. Fujii K. Takigawa S. Nomoto M. Ichida T. Asakura H. Novel patterns of amino acid mutations in the hepatitis B virus polymerase in association with resistance to lamivudine therapy in japanese patients with chronic hepatitis B. Journal of Medical Virology. 59(3):270-6, 1999.
  17. Nussler AK. Vergani G. Gollin SM. Dorko K. Morris SM Jr. Demetris AJ. Nomoto M. Beger HG. Strom SC. Isolation and characterization of a human hepatic epithelial-like cell line (AKN-1) from a normal liver. In Vitro Cellular & Developmental Biology. Animal. 35(4):190-7, 1999.
  18. Yamagiwa S, Seki S, Shirai K, Yoshida Y, Watanabe H, and Abo T. Development of intraepithelial T lymphocytes in the intestine of irradiated SCID mice by adult liver hematopoietic stem cells from normal mice. J Hepatol 30: 681-688, 1999.
  19. Asakura H, Suzuki A, Ohtsuka K, Hasegawa K, Sugimura K. Gut-associated lymphoid tissues in ulcerative colitis. JPEN J Parenter Enteral Nutr 1999; 23(5): S25-S28.


  1. Funakoshi K, Sugimura K, Anezaki K, Bannai K, Ishizuka K, Asakura H: Spectrum of cytokine gene expression in intestinal mucosal lesions of Crohn's disease and ulcerative colitis. Digestion 59:73-78, 1998
  2. Suda T, Isokawa O, Aoyagi Y, Nomoto M, Tsukada K, Shimizu T, Suzuki Y, Naito A, Igarashi H, Yanagi M, Takahashi T, Asakura H. Quantitation of telomerase activity in hepatocellular carcinoma: A possible aid for a prediction of recurrent diseases in the remnant liver. Hepatology 27:402-406 1998
  3. Sugiyama M, Ichida T, Sato T, Ishikawa T, Matsuda Y, Asakura H. Expression of activin A is increased in cirrhotic and fibrotic rat livers. Gastroenterology 114:550-558, 1998
  4. Itoh S, Ichida T, Yoshida T, Hayakawa A, Uchida M, Tashiro-Itoh T, Matsuda Y, Ishihara K, Asakura H. Autoantibodies against a 210kDa glycoprotein of the nuclear pore complex as a prognostic marker in patients with primary biliary cirrhosis. J Gastroenterol Hepatol 13:257-265, 1998
  5. Mita Y, Aoyagi Y, Yanagi M, Suda T, Suzuki Y, Asakura H. The usefullness of determining des-gamma-carboxy prothrombin by sensitive enzyme immunoassay in the early diagnosis of patients with hepatocellular carcinoma. Cancer 82:1643-1648, 1998
  6. Anezaki K, Asakura K, Honma T, Ishizuka K, Funakoshi K, Tsukada Y, Narisawa R. Correlations between interleukin-8, and myeloperoxidase or lumonol-dependent chemiluminescence in inflamed mucosa of ulcerative colitis. Internal Medicine 37:253-258, 1998
  7. Hasegawa K, Seki S, Yamagiwa S, Sato K, Sugahara S, Hiraide H, Asakura H, Abo T. Involvement of IL-2Rbetha+ T cells in graft-versusu-host disease of the liver and intestine across mutant MHC class I or class II barrier. Biomedical Research 19:9-19, 1998
  8. Enomoto H, Watanabe H, Nishikura K, Umezawa H, Asakura H. Topographic distribution of Helicobacter pylori in the resected stomach. Eur J Gastroenterol Hepatol 10:473-478, 1998
  9. Mori S, Aoyagi Y, Yanagi M, Suzuki Y, Asakura H. Serum N-acetylglucosaminyltransferase III activities in hepatocellular carcinoma. J Gastroenterol Hepatol 13:610-619, 1998
  10. Ichida T, Sato K, Uchida M, Yamagiwa S, Yonekura K, Sugimura K, Sugahara S, Ishihara K, Asakura H. Treatment of symptomatic primary biliary cirrhosis with lymphocytapheresis: a preliminary clinical trial. Hepatology Research 11:41-48, 1998
  11. Furukawa K, Takahashi T, Arai F, Matsushima K, Asakura H. Enhanced mucosal expression of interleukin-6 mRNA but not of interleukin-8 mRNA at the margin of gastric ulcer in Helicobacter pylori-positive gastritis. J Gastroenterol 33:625-633, 1998
  12. Arai F, Takahashi T, Furukawa K, Matsushima K, Asakura H. Mucosal expression of interleukin-6 and interleukin-8 messenger RNA in ulcerative colitis and in Crohn's disease. Dig Dis Sci 43(9):2071-2079, 1998
  13. Sugitani S, Sakamoto M, Ichida T, Genda T, Asakura H, Hirohashi S. Hyperplastic foci reflect the risk of multicentric development of human hepatocellular carcinoma. J Hepatol 28:1045-1053, 1998
  14. Aoyagi Y, Isokawa O, Suda T, Watanabe M, Suzuki Y, Asakura H. The fucosylation index of alpha-fetoprotein as a possible prognostic indicator for patients with hepatocellular carcinoma. Cancer 83:2076-2082, 1998
  15. Tanaka Y, Ichida T, Nomoto M, Matsuda Y, Asakura H. Areas of sinusoidal surface hepatocyte nuclear predominance in type C chronic hepatitis. Liver 18:383-390, 1998.
  16. Ishikawa T, Ichida T, Matsuda Y, Sugitani S, Sugiyama M, Kato T, Miyazaki H, Asakura H. Reduced expression of thrombopoietin is involved in thrombocytopenia in human and rat liver cirrhosis. J Gastroenterol Hepatol 13:907-913, 1998
  17. Waguri N, Ichida T, Fujimaki R, Ishikawa T, Nomoto M, Asakura H, Nakamaru T, Saitoh A, Arakawa M, Saitoh K, Takahashi K. Case report: Fibrosing cholestatic hepatitis after living related-donor renal transplantation. J Gastroenterol Hepatol 13:1133-1137, 1998
  18. Ohishi K, Mita T, Odani S, Takahashi T, Aoyagi Y, Munakata H, Tada K, Isemura S, Hsu C-C, Isemura M. Bilirubin binding activity of cytokeratin 18 isolated from the porcine liver. Cell Structure and Function 23:325-331, 1988
  19. Sugahara S, Kuwano Y, Sato K, Hasegawa K, Yamagiwa S, Kawamura T, Yoshida Y, Asakura H, Abo T. Oligoclonality of TCRint cells with a low diversity of TCR complementarity-determining region 3 in mice with graft-versus-host disease. Scand J Immunol 48:592-604, 1998
  20. Yoneyama H, Harada A, Imai T, Baba M, Yoshie O, Zhang Y, Higashi H, Murai M, Asakura H, Matsushima K. Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice. J Clin Invest 102:1933-1941, 1998
  21. Yamashiki M. Kosaka Y. Nishimura A. Watanabe S. Nomoto M. Ichida F. Analysis of serum cytokine levels in primary biliary cirrhosis patients and healthy adults. Journal of Clinical Laboratory Analysis. 12(2):77-82, 1998.
  22. Yamashiki M. Kosaka Y. Nishioka J. Tameda Y. Takase K. Watanabe S. Kaito M. Nishimura A. Suzuki H. Nomoto M. Flow cytometric analysis of IL-6 receptors on peripheral lymphocytes in patients with primary biliary cirrhosis. Journal of Clinical Laboratory Analysis. 12(2):83-7, 1998.
  23. Yamagiwa S, Sugahara S, Shimizu T, Iwanaga T, Yoshida Y, Honda S, Watanabe H, Suzuki K, Asakura H and Abo T. The primary site of CD4-8-B220+ abT cells in lpr mice - the appendix in normal mice. J Immunol 160: 2665-2674, 1998.


  1. Kuwana K, Ichida T, Kamimura T, Ohkoshi S, Ogata N, Harada T, Endoh K, Asakura H. Risk factors and the effect of interferon therapy in the development of hepatocellular carcinoma: A multivariate analysys in 343 patients. J Gastroenterol Hepatol 12:149-155, 1997
  2. Miyazaki Y, Mitsuma T, Ichida T, Odazima H, Ishihara K, Asakura H. Amplification of BCR protein associated with oncogenesis in human hepatocellular carcinoma. Dig Dis Sci 42:927-937, 1997
  3. Matsuda Y, Matsumoto K, Yamada A, Ichida T, Asakura H, Komoriya Y, Nishiyama E, Nakamura T. Preventive and therapeutic effects in rats of hepatocyte growth factor infusion on liver fibrosis/cirrhosis. Hepatology 26:81-89, 1997
  4. Suzuki K, Narita T, Yui R, Ohtsuka K, Inada S, Kimura T, Okada Y, Makino M, Mizuochi T, Asakura H, Fujiwara M. Induction of intestinal lesions in nu/nu mice induced by transfer of lymphocytes from syngeneic mice infected with murine retrovirus. Gut 41:221-228, 1997
  5. Shintani N, Nakajima T, Nakakubo H, Nagai H, Kagitani Y, Takizawa H, Asakura H. Intravenous immunoglobulin(IVIG) treatment of experimental colitis induced by dextran sulfate sodium in rats. Clin Exp Immunol 108:340-345, 1997
  6. Matsui S, Takahashi T, Oyanagi Y, Takahashi S, Boku S, Takahashi K, Furukawa K, Arai F, Asakura H. Expression, localization and alternative splicing pattern of fibronectin messenger RNA in fibrotic human liver and hepatocellular carcinoma. J Hepatol 27:843-853, 1997
  7. Motoyama H. A luminol-enhanced chemiluminescence study on the gastric mucosa with portal hypertensive gastropathy. Acta Med Biol 45:121-126, 1997.
  8. Saitoh A, Aoyagi Y, Mori S, Suda T, Suzuki Y, Sekine C, Asakura H. Measurement of the fucosylated sugar chains of serum α1-antitrypsin: The relationship between reactivity with lens culinaris agglutinin and HPLC analysis of the pyridylaminated sugar chains. Acta Med Biol 45:11-14, 1997.
  9. Aoyagi Y, Asakura H. Lectins for detection of altered glycosylation of circulating glycoproteins. Methods in Molecular Medicine Vol. 9. Edited by Rhodes JM, Milton JD. Humata Press Inc. Totowa, NJ, USA, 1997, pp207-214.
  10. Tashiro-Itoh T, Ichida T, Matsuda Y, Satoh T, Sugiyama M, Tanaka Y, Ishikawa T, Itoh S, Nomoto M, Asakura H. Metallothionein expression and concentrations of copper and zinc are associated with tumor differentiation in hepatocellular carcinoma. Liver 17:300-306
  11. Natsui M, Kawasaki K, Takizawa H, Hayashi S, Matsuda Y, Sugimura K, Seki K, Narisawa R, Sendo F, Asakura H. Selective depletion of neutrophils by amonoclonal antibody, RP-3, suppresses dextran sulphate sodium-induced colitis in rats. J Gastroenterol Hepatol 12:801-808, 1997
  12. Ueda H, Ohkoshi S, Kim C-M, et al. A transgenic mouse model of HBV related hepatocellular carcinoma. Liver Cancer, Okuda K and Tabor E, Eds. Churchill Livingstone, New York, 1997, pp201-211.
  13. Ogata N. Zanetti AR. Yu M. Miller RH. Purcell RH. Infectivity and pathogenicity in chimpanzees of a surface gene mutant of hepatitis B virus that emerged in a vaccinated infant. Journal of Infectious Diseases. 175(3):511-23, 1997.
  14. Yamashiki M. Kosaka Y. Kondo I. Nomoto M. Impaired cytokine production by peripheral T lymphocytes in low responders to hepatitis B vaccination [letter]. Clinical Science. 92(5):527-8, 1997.
  15. Sugitani A. Bauer AJ. Reynolds JC. Halfter WM. Nomoto M. Starzl TE. Todo S. The effect of small bowel transplantation on the morphology and physiology of intestinal muscle: a comparison of autografts versus allografts in dogs. Transplantation. 63(2):186-94, 1997.


  1. Hirota S, Nomoto M, Hosobe S, Aoyagi Y, Asakura H: Mucin in primary liver carcinomas: Combined hepatocellular-cholangiocarcinoma or variant hepatocellular carcinoma. Can J Gastroenterol 10(1):12-16, 1996
  2. Aoyagi Y, Mori S, Naitoh A, Yanagi M, Suzuki Y, Suda T, Isokawa O, Igarashi H, Takahashi T, Isemura M, Asakura H: Alpha-fetoprotein-producing renal cell carcinoma with increased activity of N-acetylglucosaminyl-transferase V. Nephron 74:409-414, 1996
  3. Aoyagi Y, Oguro M, Yanagi M, Mita Y, Suda T, Suzuki Y, Hata K, Ichii K, Asakura H: Clinical significance of simultaneous determinations of alpha-fetoprotein and des-gamma-carboxy prothrombin in monitoring recurrence in patients with hepatocellular carcinoma. Cancer 77:1781-1786, 1996
  4. Suzuki Y, Aoyagi Y, Mori S, Suda T, Naitoh A, Isokawa O, Yanagi M, Igarashi H, Asakura H:Microheterogeneity of serum transferrin in the diagnosis of hepatocellular carcinoma. J Gastroenterol Hepatol 11:358-365, 1996
  5. Suda T, Mishima Y, Takayanagi K, Asakura H, Odani S, Kominami R: A novel activity of HMG domains: promotion of the triple-stranded complex formation between CNA containing (GGA/TCC)11 and d(GGA)11 oligonucleotides. Nuc Acid Res 24:4733-4740, 1996
  6. Ichida T, Sugitani S, Sato T, Matsuda Y, Sugiyama M, Yonekura K, Ishikawa T, Asakura H. Localization of hyaluronan in human liver sinusoids: a histochemical study using hyaluronan-binding protein. Liver 16:365-371, 1996
  7. Ichida T, VanThiel DH, Hassanein T. The medical management of hepatocellular carcinoma(HCC) in Japan: A review with implications for HCC seen in the West. Hepato-Gastroenterology 43:1575-1583, 1996
  8. Ichida F, Tsuji T, Omata M, Ichida T, Inoue K, Kamimura T, Yamada G, Hino K, Yokosuka O, Suzuki H. New Inuyama classification; new criteria for histological assessment of chronic hepatitis. Int Hepatol Commun 6:112-119, 1996
  9. Aoyagi Y, et al: Lectins for detection of altered glycosylation of circulating glycoproteins: alpha-1-antitrypsin. In: Rhodes JM and Milton JD eds. Methods in Molecular Medicine, Lectin Methods and Protocols. Chapter 16. Humana Press Inc. Totowa, NJ 1996, pp1-7.
  10. Ichida T. Multimodality treatment of hepatocellular carcinoma. In: Update on hepatobiliary diseases 1996. Edited by Lam, KSK, Paumgarten G, Wang B. Kluwer Academic Publ., 1996, pp222-238.
  11. Iguchi S. Toba K. Fuse I. Wada Y. Maruyama S. Takahashi M. Koike T. Nomoto M. Shibata A. Aizawa Y. Severe cryoglobulinemia in a patient with asymptomatic hepatitis C virus infection. Internal Medicine. 35(9):712-6, 1996
  12. Nemoto A. Krajack A. Suzuki T. Takeyoshi I. Hamada N. Nomoto M. Zhang S. Zhu Y. Starzl TE. Todo S. Glutamine metabolism of intestine grafts: influence of mucosal injury by prolonged preservation and transplantation. Transplantation Proceedings. 28(5):2545-6, 1996
  13. Zhang S. Takeyoshi I. Nomoto M. Zhu Y. Nemoto A. Hamada N. Todo S. Evaluation of solutions for canine small bowel preservation. Transplantation Proceedings. 28(5):2612-3, 1996
  14. Hamada N. Zhang S. Nomoto M. Zhu Y. Nemoto A. Kawashima Y. Starzl TE. Todo S. Lazaroid U74006F for canine small bowel preservation. Transplantation Proceedings. 28(5):2607-8, 1996
  15. Kobayashi Y. Galvao FH. Nomoto M. Murase N. Takeyoshi I. Starzl TE. Todo S. Influence of graft perfusion pressure on graft viability after small bowel preservation and transplantation. Transplantation Proceedings. 28(5):2598-9, 1996
  16. Sugitani A. Reynolds JC. Nomoto M. Starzl TE. Todo S. Intestinal neurons in acute and chronic rejection after small bowel transplantation in dogs. Transplantation Proceedings. 28(5):2543, 1996
  17. Toyama Y. Murase N. Galvao FH. Sakamoto T. Nomoto M. Starzl TE. Todo S. Prolonged small bowel graft survival using photochemotherapy and low-dose FK 506. Transplantation Proceedings. 28(5):2506-7, 1996
  18. Tanaka M. Murase N. Ye Q. Miyazaki W. Nomoto M. Miyazawa H. Manez R. Toyama Y. Demetris AJ. Todo S. Starzl TE. Effect of anticomplement agent K76 COOH on hamster-to-rat and guinea pig-to-rat heart xenotransplantation. Transplantation. 62(5):681-8, 1996
  19. Yamashiki M. Nishimura A. Nomoto M. Suzuki H. Kosaka Y. Herbal medicine 'Sho-saiko-to' induces tumour necrosis factor-alpha and granulocyte colony-stimulating factor in vitro in peripheral blood mononuclear cells of patients with hepatocellular carcinoma. Journal of Gastroenterology & Hepatology. 11(2):137-42, 1996
  20. Tanaka M. Murase N. Nomoto M. Demetris AJ. Todo S. Starzl TE. Tacrolimus (FK 506)-dependent tolerance after liver and heart xenotransplantation: inhibition of humoral response and acceptance of donor organs. Transplantation Proceedings. 28(2):679-80, 1996
  21. Yamagiwa S, Kuwano Y, Hasegawa K, Sato K, Ohtsuka K, Iiai T, Tomiyama K, Watanabe H, Sugahara S, Seki S, Asakura H, and Abo T. Existence of a small population of IL-2Rbhi TCRint cells in SCG and MRL-lpr/lpr mice which produce normal Fas mRNA and Fas molecules from the lpr gene. Eur J Immunol 26: 1409-1416, 1996.


  1. Ichida T, Matsunami H, Kawasaki S, Makuuchi M, Harada T, Ito S, and Asakura H. Living related-donor liver transplantation from adult to adult for primary biliary cirrhosis. Ann Inter Med 122(4):275-6,1995
  2. Ohkoshi S, Tawaraya H, Kuwana K, Harada T, Watanabe M, Higuchi S, Kojima H, Kamimura T, and Asakura H. A retrospective study of hepatitis C virus carriers in a local endemic town in Japan-A possible presence of asymptomatic carrier-. Dig Dis Sci 40(2):465-71,1995
  3. Ohtsuka K, Sato K, Watanabe H, Kimura M, Asakura H, and Abo T. Unique orderof the lymphocyte subset induction in the liver and intestine of mice during listeria monocytogenes infection. Cellular Immunology 161:112-24,1995
  4. Ichida T, Shibasaki K, Muto Y, Sato S, Watanabe A, and Ichida F. Clinical study of an enteral branched-chain amino acid solution in decompensated liver cirrhosis with hepatic encephalopathy. Nutrition(suppl) 11(2):238-44,1995
  5. Tawaraya H, Ohkoshi S, Kuwana K, Watanabe M, Kamimura T, and Asakura H. Epidemiologic survery and genetic analysis of endemic hepatitis C virus infection in a Japanese town with a high prevalence of hepatitis B virus carriers. J Med Virolo 45(4):367-72,1995
  6. Tashiro T, Sato H, Takahashi T, Genda T, Sugitani S, Yoshida T, Funakoshi K, Tsukada Y, Narisawa R, Nomoto M, Kamimura T, Asakura H, Ohta T, and Watanabe H. Non-secretory alpha chain disease involving stomach, small intestin and colon. Internal Medicine 34(4):255-60,1995
  7. Takizawa H, Shintani N, Natsui M, Sasakawa T, Nakakubo T, Nakajima T, and Asakura H. Activated immunocompetent cells in rat colitis mucosa induced by dextrain sulfate sodium and not complete but prtial suppression of colitis by FK506. Digestion 56:259-64,1995
  8. Aoyagi Y. Carbohydrated-based measurements on alpha-fetoprotein in the early diagnosis of hepatocellular carcinoma. Glycoconjugate Journal 12:194-9,1995
  9. Suda T, Mishima Y, Asakura H, and Kominami R. Formation of a parallel-stranded DNA homoduplex by d(GGA) repeat oligonucleotides. Nucl Acid Res 23(18):3771-7,1995
  10. Sasakawa T, Takizawa H, Bannai H, Narisawa R, and Asakura H. Activated CD4+ and CD8+ cells in the colonic mucosa of Ul cerative colitis patients: Their relationship to HLA-DR antigen expression on the colonic epithelium and serum soluble CD25 levels. Digestion 56:516-22,1995
  11. Suzuki Y, Aoyagi Y, Naitoh A, Isokawa O, Igarashi H, Yanagi M, Suda T, Mori S, Asakura H. Microheterogeneity analysis of serum transferrin before and after therapies to hepatocellular carcinoma. Int Hepatol Commun 4:190-194, 1995
  12. Hirota S, Kudo S, Hosobe S, Kobayashi T, Himori M, Ikeda M, Takemoto Y, Nomoto M, Aoyagi Y, Asakura H: p53 immunoreactive stain and early colorectal adenocarcinomas. Eur J Cancer 31A:2220-2222, 1995
  13. Takizawa H, Asakura H, Sasakawa T, Bannai H, Nomoto M. Immunological studies of the mucosa in colitis induced by sodium dextran sulfate i rats. Advances in Mucosal Immunology Mestecky I et al eds, Plenum Press, New York, 1995, pp1383-1387
  14. Asakura H. Inflammatory bowel disease and arthropathy. Asian Medical Journal 38(5):225-230, 1995
  15. Asakura H, Sugimura K. HLA, antineutrophil cytoplasmic autoantibody and heterogeneity in ulcerative colitis. Gastroenterology 108:597-599, 1995
  16. Ogata N. Genetic variation of hepatitis B virus: Biological characterization of a fulminant hepatitis-related mutant and an immunization-resistant mutant. Progress in Liver Study 21:27-34, 1995
  17. Ogata N. Genetic variation of hepatitis C virus: Discovery of the molecular evolution with a hypervariable region. Progress in Liver Study 21:35-40, 1995
  18. Matsuda Y, Matsumoto K, Ichida T, Nakamura T. Hepatocyte growth factor suppresses the onset of liver cirrhosis and abrogates lethal hepatic dysfunction in rats. J Biochem 118:643-649, 1995
  19. Funakoshi K, Sugimura K, Sasakawa T, Bannai H, Anezaki K, Ishizuka K, Yoshida K, Narisawa R, Asakura H. Study of cytokines in ulcerative colitis. J Gastroenterol 30[Suppl VIII]:61-63, 1995
  20. Tanaka M. Murase N. Miyazawa H. Ye Q. Manez R. Todo S. Demetris AJ. Nomoto M. Miyazaki W. Starzl TE. Effect of anticomplement agent K-76 COOH in hamster-to-rat and guinea pig-to-rat xenotransplantation. Transplantation Proceedings. 27(1):275-6, 1995.

*   1994

  1. Aoyagi Y: Molecular discrimination between alpha-fetoprotein from patients with hepatocellular carcinoma and non-neoplastic liver diseases by their carbohydrate structures(Review). Int J Oncol 4:369-83,1994
  2. Watanabe M, Okoshi S, Tawaraya H, Miyajima T, Shimotori K, Kamimura T, Asakura H, Hepatitis C viral markers in patients who received blood that was positive for hepatitis C virus core antibody, with genetic evidence of hepatitis C virus transmission. Transfusion 34:125-9,1994
  3. Igarashi K, Aoyagi Y, Okoshi S, Yokota T, Mori S, Suda T, Kamimura T, Asakura H, Sequence analysis of the proximal promoter region of the human α-fetoprotein gene in hepatocellular carcinoma. Cancer Letters 76:93-9,1994
  4. Ogata N, Miller RH, Ishak KG, Zanetti AR, Purcell RH. Genetic and biological characterization of two hepatitis B virus variants: A precore mutant implication in fulminant hepatitis and a surface mutant resistant to immunoprophylaxis. Viral Hepatitis and Liver Disease 238-42,1994
  5. Takahashi T, Isemura M, Nakamura T, Matsui S, Oyanagi Y, Asakura H, Immunolocalization of a fibronectin-binding proteoglycan (PG-P1) immunologically related to HSPG2/perlecan in nomal and fibrotic human liver. J Hepatol 21:500-8,1994
  6. Tsukada Y, Motoyama H, Akiyama N, Honma T, Narisawa R, Tsukada K, Aoyagi Y, Asakura H, Gastric mucosal lesions in patients with chronic liver disease. Excepta Medica 12:31-8,1994
  7. Kobayashi M, Watanabe H, Ajioka Y, Honma H, Asakura H. Proliferating cell nuclear antigen/cyclin expression in small adenomas of the large intestine in relation to size and macroscopic appearance. J Gastroentetol 29:139-46,1994
  8. Suda T, Ozawa T, Aoyagi Y, Mori S, Watanabe M, Tsukada Y, Kamimura T, Asakura H, Nutritional support through percutaneous transphepatic internal drainage route in common bile duct cancer. J Gastroenterol Hepatol 9:524-6,1994
  9. Sato K, Otsuka K, Hasegawa K, Hashimoto S, Abo T, Kamimura T, Asakura H, Increase in the proportion of CD56+T cells in patients with chronic type C hepatitis after treatment with α-interferon. Int Hepatol Communications 2:398-402,1994
  10. Hashikura Y, Makuuchi M, Kawasaki S, Matsunami H, Ikegami T, Nakazawa Y, Kiyosawa K, Ichida T, Successful living-related partial liver transplantation to an adult patient. Lancet 343(8907):1233-4,1994
  11. Tsuchida K, Aoyagi Y, Odani S, Mita T, Isemura M, Isolation of a novel collagenbinding protein from the mushroom, Hypsizigus marmoreus, which inhibits the lewis lung carcinoma cell adhesion to type IV collagen. J Biol Chem 270(4):1481-4,1994
  12. Asakura H, Yoshioka M. Cholera toxin and diarrhea. J Gastroenterol Hepatol 9:186-193, 1994
  13. Asakura H, Honma T, Narisawa R. Endoscopy and Crohn's disease: Endoscopic approach to the pathogenesis of Crohn's disease. Dig Endsc 6(2):205-212, 1994
  14. Zhu Y. Zhang S. Nomoto M. Doria C. Ikoma A. Suzuki T. Hamamoto I. Todo S. Vascular versus luminal flushing for preservation of canine small bowel. Transplantation Proceedings. 26(3):1471-2, 1994.


*   1993

  1. Saito A, Aoyagi Y, Oguro M,Igarashi K, Yokota T, Mori S, Suda T, Suzuki Y,Sekine C, Kamimura T, Asakura H, Structural analysis on the sugar chains of α1-antitrypsin from patients with hepatocellular carcinoma. Int Hepatology Communications 1:5-10,1993
  2. Sugimura K,Asakura H, Analysis of genes within the HLA region affecting susceptibility to ulcerative colitis. Hum Immunol 36:112-8,1993
  3. Saito A, Aoyagi Y,Asakura H, Structural analysis on the sugar chains of human α1-antitrypsin: Presence of fucosylated biantennary glycan in hepatocellular carcinoma. Arch Blochem Blophys 303(2):281-7,1993
  4. Aoyagi Y, Saitoh A, Suzuki Y, Igarashi K, Oguro M, Yokota T, Mori S, Suda T, Isemura M, Asakura H: Fucosylation index of α-fetoprotein, a possible aid in the early recognition of hepatocellular carcinoma in patients with cirrhosis. Hepatology 17(1):50-52, 1993
  5. Takahashi T, Lasker JM, Rosman AS, Lieber CS: Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA. Hepatology 17(2):236-45,1993
  6. Tsutsumi M, Lasker JM, Takahashi T, Lieber CS: In vivo induction of hepatic P-4520 E1 by ethanol: role of increased enzyme synthesis. Arch Blochem Blophys 304(1):209-18,1993
  7. Okoshi S, Watanabe M, Kuwana K, Tawaraya H, Kamikura T, Asakura H, Clinical evaluation of the antibody against core protein of hepatitis C virus. Gastroenterologia Japonica 28(5):80-3,1993
  8. Aoyagi Y, Suzuki Y, Igarashi K, Yokota T, Mori S, Suda T, Naito A, Isemura M, Asakura H, Highly enhanced fucosylation of α-Fetoprotein of patients with germ cell tumor. Cancer 72(2):616-8,1993
  9. Saito A, Aoyagi Y, Asakura H, Structural analysis on the sugar chains of human α1-Antitrypsin: Presence of fucosylated biantennary glycan in hepatocellular carcinoma. Arch Blochem Blophys 303(2):281-7,1993
  10. Ichida T, Orthototopic liver transplantation for hepatocellular carcinoma in Japan, J. Tokyo Woman's medical college 63(suppl):93-8,1993
  11. Ogata N, Ostberg L, Ehrlich PH, Wong DC, Miller RH, Purcell RH: Markedly prolonged incubation period of hepatitis B in a chimpanzee passively immunized with a human monoclonal antibody to the a determinant of hepatitis B surface antigen. Proc Natl Acad Sci USA 90:3014-3018, 1993
  12. Aoyagi Y, Suzuki Y, Igarashi K, Saitoh A, Oguro M, Yokota T, Mori S, Suda T, Isemura M, Asakura H: Carbohydrate structures of human α-fetoprotein of patients with hepatocellular carcinoma: Presence of fucosylated and non-fucosylated triantennary glycans. Br J Cancer 67:486-492, 1993
  13. Ogata N, Miller R, Ishak K, Purcell R: The complete nucleotide sequence of a precore mutant of hepatitis B virus implicated in fulminant hepatitis and its biological characterization in chimpanzees. Virology 194:263-276, 1993

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