業績・研究発表

2001年以前(英文)

■REFERENCES

Aoyagi Y, Ikenaka T, and Ichida F. Comparative chemical structures of human alpha-fetoprotein from fetal serum and from ascites fluid of a patient with hepatoma. Cancer Res., 37: 3663-3667, 1977.

Aoyagi Y. Ikenaka T. and Ichida F. Copper(II)-binding ability of human alpha-fetoprotein. Cancer Res., 38: 3483-3486, 1978.

Aoyagi Y, Ikenaka T, and Ichida F. Copper(II)-binding ability of human alpha-fetoprotein. Scand. J. Immunol., Vol. 8, Suppl. 8, 385-389, 1978.

Aoyagi Y, Ikenaka T. and Ichida F. alpha-Fetoprotein as a carrier protein in plasma and its bilirubin-binding ability. Cancer Res., 39:3571-3574, 1979.

Aoyagi Y, Ikenaka T. and Ichida F. Bilirubin-binding ability of human alpha-fetoprotein. Carcino-Embryonic Proteins, Vol. II, 287-290, 1979, Ed., F.G. Lehmann, Elsevier/North-Holland Biomedical Press.

Kojima N, Isemura M, Yosizawa Z, Ono T, Shinada S, Soga K, Aoyagi Y. and Ichida F. Distribution of fibronectin in fibrotic human livers at various states. Tohoku J. exp. Med., 135:403-412, 1981.

Aoyagi Y, Takahashi T, Odani S, Ogata K, Ono T. and Ichida F. Inhibitory effect of alpha-fetoprotein on protein synthesis in a reticulocyte lysate cell-free system. J. Biol. Chem., 257:9566-9569, 1982.

Aoyagi Y. and Ichida F. Measurement of differential affinity of alpha-fetoprotein with lectins in diagnosis of hepatocellular carcinoma. In Ten years of the Japan Medical Research Foundation, pp212-213, Japan Medical Foundation, University of Tokyo Press 1983.

Isemura, M., Satoh, N., Munakata, H., Aikawa, J., Ototani, N, Yosizawa, Z., Sakuma, A., Masuda, T., Aoyagi, Y. and Ichida, F. Glycosaminoglycans of human colonic mucosa and colonic adenocarcinoma. Tohoku J. exp. Med., 142:89-952, 1984.

Aoyagi Y, Suzuki Y, Isemura M, Soga K, Ozaki T. Ichida T, Inoue K, Sasaki H, and Ichida, F. Differential reactivity of alpha-fetoprotein with lectins and evaluation of its usefulness in the diagnosis of hepatocellular carcinoma. Gann, 75:809-815, 1984.

Isemura M, Munakata H, Kosakai M, Nomoto M, Aoyagi Y, Ichida F, Nagai H, Motomiya M. and Yosizawa Z. Extraction of fibronectin from human normal and cirrhotic livers. Tohoku J. exp. Med., 144:217-218, 1984.

Takahashi T, Aoyagi Y, Kamimura T, Ichida F. and Isemura M. Immunoelectron microscopic demonstration of fibronectin in normal and fibrotic livers. Pathology of Hepatic Fibrosis. 47-56, 1985, Eds., Hirayama, C. and Kivirikko, K.I. Elsevier Science Publishers. Aoyagi Y, Isemura M, Yosizawa Z, Suzuki Y, Sekine C, Ono T. and Ichida F. Fucosylation of serum alpha-fetoprotein in patients with primary hepatocellular carcinoma. Biochim Biophys Acta, 830:217-223, 1985.

Aoyagi Y, Isemura M, Suzuki Y, Sekine C, Soga K, Ozaki K. and Ichida F. Fucosylated alpha-fetoprotein as marker of early hepatocellular carcinoma. Lancet, ii:1353-1354, 1985.

Aoyagi Y, Isemura M, Suzuki Y, Sekine C, Soga K, Ozaki K. and Ichida F. Change in fucosylation of alpha-fetoprotein on malignant transformation of liver cells. Lancet, i:210, 1986.

Suzuki Y, Aoyagi Y, Muramatsu M, Isemura M. and Ichida F. Close topographical relationship in alpha-foetoprotein(AFP) between a lens culinaris binding glycan and the epitope recognized by AFP-reactive monoclonal antibody, 18H4. Brit J Cancer, 55:147-152, 1987.

Sekine C, Aoyagi Y, Suzuki Y, Ichida F. The reactivity of alpha-1-antitrypsin with Lens culinaris agglutinin and its usefulness in the diagnosis of neoplastic diseases of the liver. Brit J Cancer, 56:371-375, 1987.

Aoyagi Y, Suzuki Y, Isemura M, Nomoto M, Sekine C, Igarashi K, and Ichida F. The fucosylation index of alpha-fetoprotein and its usefulness in the early diagnosis of hepatocellular carcinoma. Cancer, 61:769-774, 1988.

Munakata H, Hayashi N, Yamaguchi Y, Aoyagi Y, Ichida F. and Isemura M. Biochemical evidence for the local synthesis and retention of fibronectin in the tissue of human placenta. Int J Biochem, 20:113-116, 1988.

Odani S, Koide T, Ono T. and Aoyagi Y. Analysis of strongly acidic amino acids by the conventional amino acid analyzer: application to determination of protein-bound cysteine and glutathione. Analytical Biochemistry, 171:305-309, 1988.

Soga K, Nomoto M, Ichida T, Aoyagi Y, Ozaki T, and Ichida F. Clinical evaluation of transcatheter arterial embolization and one shot chemotherapy in hepatocellular carcinoma. Hepato-gastroenterol. 35:116-120, 1988.

Suzuki Y, Aoyagi Y, Muramatsu M, Igarashi K, Saitoh A, Oguro M, Isemura M, and Asakura H. A lectin-based monoclonal enzyme immunoassay to distinguish fucosylated and non-fucosylated alpha-fetoprotein molecular variants. Ann Clin Biochem, 27:121-128, 1990.

Aoyagi Y, Suzuki Y, Igarashi K, Saitoh A, Isemura M, Oguro M, Yokota T, Nomoto M. and Asakura H. The usefulness of the simultaneous determinations of glucosaminylation and fucosylation indices of alpha-fetoprotein in the differential diagnosis of neoplastic diseases of the liver. Cancer, 67:2390-2394, 1991.

Suzuki T, Watanabe K, Hirota M, Iwafuchi M, Ono T, Aoyagi Y, and Ito S. Establishment of a human hepatoblastoma model in athymic nude mice, producibility of fatty acid-binding protein, alpha-fetoprotein and alpha1-acid glycoprotein. Acta Pathol Jpn, 42:255-261, 1992.

Aoyagi Y, Saitoh A, Suzuki Y, Igarashi K, Oguro M, Yokota T, Mori S, Suda T, Isemura M, and Asakura, H. Fucosylation index of alpha-fetoprotein, a possible aid in early recognition of hepatocellular carcinoma in patients with cirrhosis. Hepatology, 17:50-52, 1993.

Saitoh A, Aoyagi Y, Oguro M, Igarashi K, Yokota T, Mori S, Suda T, Suzuki Y, Sekine C, Kamimura T. and Asakura H. Structural analysis on the sugar chains of alpha-1-antitrypsin from the patients with hepatocellular carcinoma. Int Hepatol Commun. 1:5-10, 1993.

Aoyagi Y, Suzuki Y, Igarashi K, Saitoh A, Oguro M, Yokota T, Mori S, Suda T, Isemura M. and Asakura H. Carbohydrate structures of human alpha-fetoprotein of patients with hepatocellular carcinoma: presence of fucosylated and non-fucosylated triantennary glycans. Brit J Cancer, 67:486-492, 1993.

Saitoh A, Aoyagi Y, and Asakura H. Structural analysis on the sugar chains of alpha-1-antitrypsin: Presence of fucosylated biantennary glycan in hepatocellular carcinoma. Arch Biochem Biophys, 303:281-287, 1993.

Aoyagi Y, Suzuki Y, Igarashi K, Yokota T, Mori S, Suda T, Isemura M. and Asakura H. Highly enhanced fucosylation of alpha-fetoprotein in patients with germ cell tumor. Cancer, 72:615-618, 1993.

Soga K, Arai F, Tsuruya T, Aikawa K, Toshima M, Shibasaki K. and Aoyagi, Y. Studies on factors affecting plasma PIVKA-II levels in hepatocellular carcinoma. Acta Medica et Biologica, 41:197-200, 1993.

Aoyagi Y. Molecular discrimination between alpha-fetoprotein from patients with hepatocellular carcinoma and nonneoplastic liver diseases by their carbohydrate structures. Invited Review Article. Int. J. Oncology, 4:369-383, 1994.

Igarashi K, Aoyagi Y, Ohkoshi S, Yokota T, Mori S, Suda T, Kamimura T, and Asakura H. Sequence analysis of the proximal promoter region of the human alpha-fetoprotein gene in hepatocellular carcinoma. Cancer letters, 76:93-99, 1994.

Suda T, Ozawa T, Aoyagi Y, Mori S, Watanabe M, Tsukada Y, Kamimura T. and Asakura H. Nutritional support through percutaneous transhepatic internal drainage route in common bile duct cancer. J Gastroenterol Hepatol, 9:524-526, 1994.

Tsukada Y, Motoyama H, Akiyama N, Honma T, Narisawa R, Tsukada K, Aoyagi Y. and Asakura H. Gastric mucosal lesions in patients with chronic liver diseases. Gastrointestinal Functions: Regulation and Disturbance, 12:31-38, 1994.

Aoyagi Y. Carbohydrate-based measurement on alpha-fetoprotein in the early diagnosis of hepatocellular carcinoma. Mini-Review. Glycoconjugate Journal, 12: 194-199, 1995.

Tsuchida K. Aoyagi Y. Odani S. Mita T. and Isemura M. Isolation of a noble collagen-binding protein from the mushroom, Hypsizigus marmoreus which inhibits the Lewis lung carcinoma cell adhesion to type IV collagen. J Biol Chem, 270: 1481-1484, 1995.

Suzuki Y, Aoyagi Y, Naitoh A, Isokawa O, Igarashi H, Yanagi M, Suda T, Mori S, and Asakura H. Microheterogeneity analysis of serum transferrin before and after therapies to hepatocellular carcinoma. Int Hepatol Commun, 4:109-194, 1995.

Hirota S, Kudo S, Hosobe S, Kobayashi T, Himori M, Ikeda M, Takemoto Y, Nomoto M, Aoyagi Y and Asakura H. p53 Immunoreactive stain and early colorectal adenocarcinomas. Eur J Cancer, 31A:2220-2222, 1995.

Hirota S. Nomoto M. Hosobe S. Aoyagi Y. and Asakura H. Mucin in primary liver carcinoma: combined hepatocellular-cholangiocarcinoma or variant hepatocellular carcinoma. The Canadian J Gastroenterology, 10:12-16, 1996.

Aoyagi Y, Oguro M, Yanagi Y, Mita Y, Suda S, Suzuki Y, Hata K, Ichii, K, and Asakura H. Clinical significance of simultaneous determinations of alpha-fetoprotein and des-gamma-carboxy prothrombin in monitoring recurrence of patients with hepatocellular carcinoma. Cancer, 77:1781-1786, 1996. Suzuki Y, Aoyagi Y, Mori S, Suda T, Yanagi M, and Asakura H. Microheterogeneity of serum transferrin in the diagnosis of hepatocellular carcinoma. J Gastroenterol Hepatol, 11:358-365, 1996.

Aoyagi Y, Mori S, Naitoh A, Yanagi M, Suzuki Y, Suda T, Isokawa O, Igarashi, H, Takahashi T, Isemura M, and Asakura H. Alpha-fetoprotein producing renal cell carcinoma with the increased activity of N-acetylglucosaminyltransferase III, Nephron, 74:409-414, 1996.

Furukawa K, Aoyagi Y, Arai F, Matsuzawa J, Ookoshi S, Takahashi T, Narisawa R, Kamimura T and Asakura H. A case of acute hepatitis E after a trip to Nepal and India. Acta Medica et Biologica, 44:103-105, 1996.

Aoyagi Y. and Asakura H. Lectins for detection of altered glycosylation of circulating glycoproteins: alpha-1-antitrypsin. In: Rhodes JM and Milton JD Eds. Methods in Molecular Medicine, Lectin Methods and Protocols, Chapter16, pp1-7, Humana Press Inc. Totowa, NJ, 1996.

Saitoh A, Aoyagi Y, Mori S, Suda T, Suzuki Y, Sekine C and Asakura, H. Measurement of the fucosylated sugar chains of serum alpha-1-antitrypsin:The relationship between reactivity with Lens culinaris agglutinin and HPLC analysis of the pyridylaminated sugar chains. Acta Medica et Biologica, 45:11-14, 1997.

Suda T, Isokawa O, Aoyagi Y, Nomoto M, Tsukada K, Shimizu T, Suzuki Y, Naitoh A, Igarashi H, Yanagi M, Takahashi T, Asakura H. Quantitation of telomerase activity in hepatocellular carcinoma: A possible aid for a prediction of recurrent disease in the remnant liver. Hepatology, 27:402-406, 1998.

Mita Y, Aoyagi Y, Yanagi M, Suda T, Suzuki Y, Asakura H. Usefulness of sensitive determination of des-gamma-carboxy prothrombin in the early diagnosis of patients with hepatocellular carcinoma Cancer, 82:1643-1648, 1998.

Mori S, Aoyagi Y, Yanagi M, Suzuki Y, Asakura H. N-acetylglucosaminyl-transferase III activities in hepatocellular carcinoma. J Gastroenterol Hepatol. 13:610-619, 1998.

Soga K, Watanabe T, Aikawa K, Toshima M, Shibasaki K. and Aoyagi Y. Serum des-gamma-carboxy prothrombin level by a modified enzyme immunoassay method in hepatocellular carcinoma-Significance of des-gamma-carboxy prothrombin in small hepatocellular carcinoma. Hepato-Gasroenterology, 45:1737-1741, 1998.

Aoyagi Y, Isokawa O, Suda T, Watanabe M, Suzuki Y, Asakura H, The fucosylation index of alpha-fetoprotein as a possible prognostic indicator for patients with hepatocellular carcinoma. Cancer, 83:2076-2082, 1998.

Ohishi K, Mita T, Odani S, Takahashi T, Aoyagi Y, Munakata H, Tada K, Isemura S, Hsu CC, Isemura M. Bilirubin binding activity of cytokeratin 1 isolated from the porcine liver. Cell Structure and Function, 23: 325-331, 1998.

Takizawa H, Natsui M, Aoyagi Y, Asakura H. Pancreatitis in ulcerative colitis: A case report of improved stricture of the main pancreatic duct. J Clin Gastroenterology, 28:74-76, 1999.

Saeki K, Sano M, Miyase T, Nakamura Y, Hara Y, Aoyagi Y, Isemura M. Apoptosis-inducing activity of polyphenol compounds derived from tea catechins in human histiolytic lymphoma U937 cells. Biosci Biotechnol Biochem, 63(3): 585-587, 1999.

Naitoh A, Aoyagi Y, Asakura H. Highly enhanced fucosylation of serum glycoproteins in patients with hepatocellular carcinoma, correlation of the fucosylations between alpha-fetoprotein, alpha-1-antitrypsin and transferrin. J Gastroenterol Hepatol. 14:432-441, 1999.

Shoji Y, Aoyagi Y, Kawakami T, Isemura S, Isemura M. Cell adhesion activity for murine carcinoma cells of a wheat germ 55kDa protein with binding affinity for animal extracellular matrix proteins. Biochim Biophys Acta, 1426:498-504, 1999.

Suda T, Aoyagi Y. A pregnant case of severe acute hepatitis type C: Successfully treated with natural interferon alpha and no evidence of maternal transmission of HCV to the new born. Acta Medica et Biologica, 47:75-80, 1999.

Baba K, Takahashi Y, Aoyagi Y, Odani, S. The amino acid sequence of a lamprey (Entosphenus japonicus) liver fatty acid-binding protein identified its close relationship to cardiac fatty acid-bindingproteins of Mammalia. Comparative Biochemistry and Physiology, 123:223-228, 1999.

Isokawa O, Suda T, Aoyagi Y, Kawai H, Takahashi T, Tsukada K, Shimizu T, Nomoto M, Igarashi H, Yanagi M, Suzuki Y, Asakura H. Reduction of telomeric repeat as a possible predictor for development of hepatocellular carcinoma; convenient evaluation by slot-blot analysis. Hepatology, 30:408-412, 1999.

Furukawa K, Yokoyama A, Sato K, Horikawa K, Kurita Y, Aoyagi Y. Aberrant systemic arterial supply to the non-sequestrated lung: A case repor. Acta Medica et Biologica, 47:121-124, 1999.

Yokota T, Suda T, Tsukioka S, Takahashi T, Honma T, Seki K, Matsuzawa J, Miura M, Aoyagi Y, Asakura H. The striking effect of hyperbaric oxygenation therapy in the management of chronic idiopathic intestinal pseudo-obstruction. Am J Gastroenterol, 95:285-288, 2000.

Shoji Y, Isemura M, Muto H, Isemura S, Aoyagi Y. Isolation of a 41-kDa protein with cell adhesion activity for animal tumor cells from the Mushroom Hypsizigus marmoreus by affinity chromatography with type IV collagen immobilized on agarose. Biosci. Biotechnol. Biochem. 64: 775-780, 2000.

Mita Y, Aoyagi Y, Suda T, Asakura H, Plasma fucosyltransferase activity in patients with hepatocellular carcinoma, with special reference to correlation with fucosylated species of alpha-fetoprotein. J Hepatology, 32: 946-954, 2000.

Kawai H, Aoyagi Y, Nomoto M, Takizawa H, Suzuki Y, Hama A, Suda T, Takahashi T, Asakura H, Asymptomatic primary sclerosing cholangitis with marked hepatic fibrosis. Digestive Diseases & Science, 45: 680-684, 2000.

Takizawa H, Suzuki Y, Aoyagi Y, Asakura H. A case with diffuse narrowing of the main pancreatic duct successfully treated by steroid therapy. Digestive Endoscopy, 12:199-203, 2000.

Saitoh T, Mochizuki T, Suda T, Aoyagi Y, Tsukada Y, Narisawa N, Asakura H, Elevation of TFF1 (pS2) gene expression during healing of gastric ulcer at 'non-ulcerated' sites in the stomach: Semi-quantification using single tube method of polymerase chain reaction. J Gastroenterol Hepatol. 15:604-609, 2000.

Kawai H, Suda T, Aoyagi Y, Isokawa O, Mita Y, Waguri N, Kuroiwa T, Igarashi M, Tsukada K, Mori S, Shimizu T, Suzuki Y, Abe Y, Takahashi T, Nomoto M, Asakura H. Quantitative evaluation of genomic instability as a possible predictor of hepatocellular carcinoma: comparison of loss of heterozygosity and replication error. Hepatology, 31:1246-1250, 2000.

Furukawa K, Takahashi T, Aoyagi Y, Naito A, Honma T, Sato E, Soga T, Tsukada H, Asakura H.Three dimensional imaging by the endoscopic retrograde pancreatography, Helical computed tomography (ERP-HCT) for the radiological stereoscopic visualization of the pancreatic duct system. Acta Medica et Biologica, 48:58-64, 2000.

Hayakawa S, Kimura T, Saeki K, Koyama Y, Aoyagi Y, Noro T, Nakamura Y, Isemura M. Apoptosis-inducing activity of high molecular weight fractions of tea extracts. Biosci. Biotechnol. Biochem. 65:459-462, 2001.

Odani S, Baba K, Tsuchida Y, Aoyagi Y, Wakui S, Takahashi Y. Hepatic fatty acid-binding proteins of a Teleost, Lateolabrax japonicus, the primary structures and location of a disulfide bond. J Biochem, 129:69-76, 2001.

Shoji Y, Mita T, Isemura M, Mega T, Hase S, Isemura S, Aoyagi Y. A fibronectin-binding protein from rice bran with cell adhesion activity for animal tumor cells. Biosci. Biotechnol. Biochem. 65:1181-1186, 2001.

Seki K, Suda T, Aoyagi Y, Sugawara S, Natsui M, Motoyama H, Shirai Y, Sekine T, Kawai H, Mita Y, Waguri N, Kuroiwa T, Igarashi M, Asakura H. Diagnosis of pancreatic adenocarcinoma by detection of hTERT mRNA in pancreatic juice with sample qualification. Clin Cancer Res. 7:1976-1981, 2001.

Asakura H, Aoyagi Y, Nakazawa S. Eds. Trend in Gastroenterology and Hepatology, Springer-Verlag Tokyo 2001.

Furukawa K, Hrada T, AoaygiY. Successful endoscopic sphincoterotomy using a papillotome tipped with a balloon for cases of choledocholithiasis complicated by duodenal diverticula. Am J Gastroenterol, 96:3215-3216, 2001.

Yanagi M, Aoyagi Y, Suda T, Mita Y, Asakura H. N-acetylglucosaminyl-transferase V as a possible aid for the evaluation of tumor invasiveness in patients with hepatocellular carcinoma. J Gastroenterol Hepatol. 16:1282-1289, 2001.

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