業績・研究発表

2002年以降(英文)

■REFERENCES

Furukawa K, Aoaygi Y, Hrada T, Enomoto H. The usefulness of prevention consolidation therapy of esophageal varices using argon plasma coagulation therapy. Hepatolgy Res. 23(3):220-225, 2002.

Aoyagi Y, Mita Y, Suda T, Kawai K, Kuroiwa T, Igarashi M, Kobayashi M, Waguri N, Asakura H. The fucosylation index of serum α-fetoprotein as useful prognostic factor in patients with hepatocellular carcinoma in special reference to chronological changes. Hepatolgy Res. 23(4):287-295, 2002.

Koyama Y, Katsuno Y, Miyoshi N, Hayakawa S, Mita T, Muto H, Isemura S, Aoyagi Y, Isemura M. Apoptosis-inducing activity of lectin isolated from the Mushroom Boletopsis leucomelas in U937 cells. Biosci. Biotechnol. Biochem. 66:784-789, 2002.

SudaT, Fujiyama A, Takimoto M, Igarashi M, Kuroiwa T, Waguri N, Kawai H, Mita Y, Aoyagi Y, Interchromosomal telomere length variation. Biochem Bioph Res Comm, 291:210-214, 2002.

Kozakai I, Itoh Y, Kuwano R, Aoyagi Y, Asakura H. Chemical deafferentiation of the nasal neuroepithelium profoundly reduces cholecystokinin gene expression in mouse olfactory bulb. Acta Medica et Biologica, 50:53-60, 2002.

Waguri N, Suda T, Kamura K, Aoyagi Y, Heterogeneous hepatic enhancement on CT angiography in idiopathic portal hypertension. Liver 22:276-280, 2002.

Kuroiwa T, Suda T, MD, Takahashi T, Hirono H, Natsui M, Motoyama M, Nomoto M, Aoyagi Y, Bile duct involvement in a case of autoimmune pancreatitis successfully treated with an oral steroid. Digestive Diseases & Science, 47:1810-1816, 2002.

Suzuki K, Ohkoshi S, Yano M, Ichida T, Takimoto M, Naitoh A, Mori S, Hata K, Igarashi K, Hara H, Ohta H, Soga K, Watanabe T, Kamimura T, Aoyagi Y. Sustained biochemical remission after interferon treatment may closely be related to the end of treatment biochemical response and associated with a lower incidence of hepatocarcinogenesis. Liver 23(3):143-147, 2003.

Yokota T, Suda T, Igarashi M, Kuroiwa T, Waguri N, Kawai K, Mita Y, Aoyagi Y, Telomere length variation and maintenance in hepatocarcinogenesis. Cancer 98(1):110-118, 2003.

Waguri N, Suda T, Nomoto M, Kawai H, Mita Y, Kuroiwa T, Igarashi M, Kobayashi M, Fukuhara Y, Aoyagi Y. Sensitive and specific detection of circulating cancer cells in patients with hepatocellular carcinoma; detection of human telomerase reverse transcriptase messenger RNA after immunomagnetic separation. Clin Cancer Res, 9(8):3004-3011, 2003.

Igarashi H, Aoyagi Y, Suda T, Mita Y, Kawai H, Studies on the correlation among the fucosylation index, concentration of α-fetoprotein and des-γ-carboxy prothrombin as prognostic indicators in hepatocellular carcinoma. Hepatolgy Res. 27(4): 280-288, 2003.

Gohsi S, Ohkoshi S, Ogata N, Takahashi T, Nomoto N, Ichida T, Aoyagi Y. A patient with chronic non-B, non-C hepatitis who developed liver cirrhosis and hepatocellular carcinoma over 14 years observation. Acta Medica et Biologica 51:111-116, 2003.

Igarashi M, Suda T, Hara H, Takimoto M, Nomoto M, Takahashi T, Okoshi S, Kawai H, Mita Y, Waguri N, Aoyagi Y. Interferon can block telomere erosion and in rare cases result in hepatocellular carcinoma development with telomeric repeat binding factor 1 overexpression in chronic hepatitis C. Clin Cancer Res, 9: 5264-5270, 2003.

Watanabe S, Suzuki K, Kawauchi Y, Yamagiwa S, Yoneyama H, Kawachi H, Okada Y, Shimizu F, Asakura H, Aoyagi Y. Kinetic analysis of the development of pancreatic lesions in mice infected with a murine retrovirus. Clin Immunol. 109(2): 212-23. 2003.

Matsuda Y, Ichida T, Genda T, Yamagiwa S, Aoyagi Y, Asakura H. Loss of p16 contributes to p27 sequestration by cyclin D(1)-cyclin-dependent kinase 4 complexes and poor prognosis in hepatocellular carcinoma. Clin Cancer Res. 9(9): 3389-96, 2003.

Yang XH, Kamura T, Ichida T, Yamamoto S, Yamagiwa S, Ozaki T, Takano T, Aoyagi Y. Late phase images in whole liver double phase CT during hepatic arteriography in the diagnosis of well-differentiated hepatocellular carcinomas. Acta Medica et Biologica 51:125-131, 2003.

Togashi T, Obata M, Aoyagi Y, Kominami R, Mishima Y. Two distinct methods analyzing chromatin structure using centrifugation and antibodies to modified histone H3: both provide similar chromatin states of the Rit1/Bcl11b gene. Biochem Bioph Res Comm, 313:489-495, 2004.

Takeda Y, Okoshi S, Suzuki K, Yano M, Gangemi J-D, Jay G, Asakura H, Aoyagi Y. Effect of Interferon arfa and cell cycle progression on translation mediated by hepatitis C virus 5' untranslated region: A study using a transgenic mouse model. J Viral Hepatitis. 11:33-44, 2004.

Hirono H, Ajioka Y, Watanabe H, Baba Y, Tozawa E, Nishikura K, Mukai G, Honma T, Aoyagi Y. Bidirectional gastric differentiation in cellular mucin phenotype (foveolar and pyloric) in serrated adenoma and hyperplastic polyp of the colorectum. Pathol Int. 54(6):401-7. 2004

Nakamura A, Suda T, Honma T, Takahashi T, Igarashi M, Waguri N, Kawai H, Mita Y, Aoyagi Y. Increased hTR expression during transition from adenoma to carcinoma is not associated with promoter methylation. Digestive Diseases & Science, 49:1504-1512, 2004.

Ishimoto Y, Tomiyama-Miyaji C, Watanabe H, Yokoyama H, Ebe K, Tsubata S, Aoyagi Y, Abo T. Age-dependent variation in the proportion and numer of intestinal lymphocyte subsets, especially natural killer T cells, double-positive CD4+ CD8+ cells and B220+ T cells, in mice. Immunology 113:371-377, 2004.

Ebe K, Tomiyama-Miyaji C, Yokoyama H, Ishimoto Y, Tsubata S, Nagura T, Li C, Bai X, Kawamura T, Watanabe H, Aoyagi Y, Abo T. Comparative characterization of double-positive CD4+CD8+ cells in the thymus and small intestine of mice. Biomed Res 25:201-207, 2004.

Kawamura T, Watanabe H, Aoyagi Y, Abo T. Comparative characterization of double-positive CD4+CD8+ cells in the thymus and small intestine of mice. Biomed Res 25:201-207, 2004.

Waguri N, Yoshimura A, Suda T, Yamamoto S, Kamura T, Igarashi M, Honma N, Takahashi T, Nomoto M, Yamamoto M, Aoyagi Y, Liver metastasis 30 years after enucleation of the left eyeball for choroidal melanoma. Hepatology Res. 30: 232-237, 2004.

Yokoyama H, Miyakawa R, Miyaji C, Tsukada C, Ishimoto Y, Kawamura H, Watanabe H, Aoyagi Y, Abo T. Estimation of cytotoxic lymphocytes against male H-Y antigens induced by two-step stimulations as CD8+NK1.1-TCRint and CD8+NK1.1+TCRint cell. Biomed Res 25:93-100, 2004.

Takamura M, Ichida T, Yokoyama J, Matsuda Y, Nomoto M, Aoyagi Y, Recurrence of hepatocellular carcinoma 102 months after successful eradication and removal of memberanous obstruction of the inferior vena cava. J Gastroenterol 39:681-684, 2004.

Tsuboi Y, Ichida T, Sugitani S, Genda T, Inayoshi J, Takamura M, Matsuda Y, Nomoto M, Aoyagi Y. Overexpression of extracellular signal-regulated protein kinase and its correlation with proliferation in human hepatocellular carcinoma. Liver Int. 2004 Oct;24(5):432-6.

Takamura M, Ichida T, Matsuda Y, Kobayashi M, Yamagiwa S, Genda T, Shioji K, Hashimoto S, Nomoto M, Hatakeyama K, Ajioka Y, Sakamoto M, Hirohashi S, Aoyagi Y. Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma. Cancer Lett. 2004 Aug 30;212(2):253-9.

Tamura Y, Maruyama M, Mishima Y, Fujisawa H, Obata M, Kodama Y, Yoshikai Y, Aoyagi Y, Niwa O, Schaffner W and Kominami R. Predisposition to mouse thymic lymphomas in response to ionizing radiation depends on variant alleles encoding metal-responsive transcription factor-1 (Mtf-1), Oncogene 24, 399-406, 2005.

Kubota T, Yoshikai Y, Tamura Y, Mishima Y, Aoyagi Y, Niwa O, Kominami R. Comparison of properties of spontaneous and radiation-induced mouse thymic lymphoma: role of Trp53 and radation. Radiation Res., 11:315-22, 2005.

Tsuchiya A, Heike T, Fujino H, Shiota M, Umeda K, Yoshimoto M, Matsuda Y, Ichida T, Aoyagi Y, Nakahata T. Long-term extensive expansion of mouse hepatic stem/progenitor cells in a novel serum-free culture system. Gastroenterology, 128(7):2089-104, 2005.

Soga K, Shibasaki K, Aoyagi Y, Effect of interferon on incidence of hepatocellular carcinoma in patients with chronic hepatitis C. Hepato-Gasroenterology 52: 1154- 1158, 2005.

Matsuda Y, Yamagiwa S, Takamura M, Honda Y, Ishimoto Y, Ichida T, Aoyagi Y. Overexpressed Id-1 is associated with a high risk of hepatocellular carcinoma development in patients with cirrhosis without transcriptional repression of p16. Cancer 104(5):1037-44, 2005.

Watanabe K, Takahashi T, Takahashi S, Okoshi S, Ichida T, Aoyagi Y. Comparative study of genotype B and C hepatitis B virus-induced chronic hepatitis in relation to the basic core promoter and precore mutations. J Gastroenterol Hepatol. 20(3):441-9, 2005.

Sato Y, Yamamoto S, Oya H, Nakatsuka H, Kobayashi T, Takeishi T, Hirano K, Hara Y, Watanabe T, Waguri N, Suda T, Ichida T, Aoyagi Y, Hatakeyama K. Preoperative human-telomerase reverse transcriptase mRNA in peripheral blood and tumor recurrence in living-related liver transplantation for hepatocellular carcinoma. Hepatogastroenterology, 52(65):1325-1388, 2005.

Honma T, Sugimura K, Asakura H, Matsuzawa J, Suzuki K, Kobayashi M, Aoyagi Y. Leukocytapheresis is effective in inducing but not in maintaining remission in ulcerative colitis. Clin Gastroenterol, 39(10):886-90, 2005.

Tsubata S, Ebe K, Kawamura T, Ishimoto Y, Tomiyama-Miyaji C, Watanabe H, Sekikawa H, Aoyagi Y, Abo T. Protection against malaria by anti-erythropoietin antibody due to suppression of erythropoiesis in the liver and at other sites. Immunol Cell Biol. 2005;83(6):638-42.

Takamura M, Narisawa R, Maruyama Y, Yokoyama J, Fukuhara Y, Kawai H, Yamagiwa S, Sato Y, Matsuda Y, Sugimura K, Ichida T, Aoyagi Y. A primary follicular lymphoma of the duodenum treated successfully with radiation therapy. Intern Med. 2006; 45(5):309-11.

Wakai T, Shirai Y, Suda T, Yokoyama N, Sakata J, Cruz PV, Kawai H, Matsuda Y, Watanabe M, Aoyagi Y, Hatakeyama K. Long-term outcomes of hepatectomy vs percutaneous ablation for treatment of hepatocellular carcinoma < or =4 cm. World J Gastroenterol. 2006; 28;12(4):546-52.

Kamimura K, Oosaki A, Sugahara S, Mori S. (2008) Survival of three nonocclusive mesenteric ischemia patients following early diagnosis by multidetector row computed tomography and prostaglandin E1 treatment. Intern Med 47:2001-2006.

Tsuboi Y, Ohkoshi S, Yano M, Suzuki K, Tsubata SS, Ishihara K, Ichida T, Sugitani S, Shibazaki K, Aoyagi Y. Common clinicopathological features of the patients with chronic hepatitis B virus infection who developed hepatocellular carcinoma after seroconversion to anti-HBs--a consideration of the pathogenesis of HBV-induced hepatocellular carcinoma and a strategy to inhibit it. Hepatogastroenterology. 2006 Jan-Feb;53(67):110-4.

Kawauchi Y, Suzuki K, Watanabe S, Yamagiwa S, Yoneyama H, Han GD, Palaniyandi SS, Veeraveedu PT, Watanabe K, Kawachi H, Okada Y, Shimizu F, Asakura H, Aoyagi Y, Narumi S. Role of IP-10/CXCL10 in the progression of pancreatitis-like injury in mice after murine retroviral infection. Am J Physiol Gastrointest Liver Physiol. 2006 Aug;291(2):G345-54.

Yano M, Ohkoshi S, Suzuki K, Ito S, Wakabayashi H, Sugiyama M, Watanabe T, Maeda H, Hatakeyama SA, Hatano T, Kobayashi Y, Takei S, Kohjiro H, Tsuboi Y, Takahashi T, Ishikawa T, Kamimura T, Ichida T, Aoyagi Y. Absence of pretreatment markers that predict the emergence of YMDD mutants during lamivudine treatment--the results of a prospective multi-center study. Hepatogastroenterology. 2006 Jan-Feb;53(67):124-7.

Honma N, Genda T, Matsuda Y, Yamagiwa S, Takamura M, Ichida T, Aoyagi Y. MEK/ERK signaling is a critical mediator for integrin-induced cell scattering in highly metastatic hepatocellular carcinoma cells. Lab Invest. 2006 Jul;86(7):687-96.

Hanawa T, Suzuki K, Kawauchi Y, Takamura M, Yoneyama H, Han GD, Kawachi H, Shimizu F, Asakura H, Miyazaki J, Maruyama H, Aoyagi Y. Attenuation of mouse acute colitis by naked hepatocyte growth factor gene transfer into the liver. J Gene Med. 2006 May;8(5):623-35. Yang XH, Yamagiwa S, Ichida T, Matsuda Y, Sugahara S, Watanabe H, Sato Y, Abo T, Horwitz DA, Aoyagi Y. Increase of CD4+ CD25+ regulatory T-cells in the liver of patients with hepatocellular carcinoma. J Hepatol. 2006 Aug;45(2):254-62.

Oya H, Sato Y, Yamamoto S, Nakatsuka H, Kobayashi T, Hara Y, Waguri N, Suda T, Aoyagi Y, Hatakeyama K.Comparison between human-telomerase reverse transcriptase mRNA and alpha-fetoprotein mRNA as a predictive value for recurrence of hepatocellular carcinoma in living donor liver transplantation.Transplant Proc. 2006 Dec;38(10):3636-9.

Maruyama M, Yamamoto T, Kohara Y, Katsuragi Y, Mishima Y, Aoyagi Y, Kominami R. Mtf-1 lymphoma-susceptibility locus affects retention of large thymocytes with high ROS levels in mice after gamma-irradiation. Biochem Biophys Res Commun. 2007 2;354(1):209-15.

Kamimura K, Kobayashi M, Narisawa R, Watanabe H, Sato Y, Honma T, Sekine A, Aoyagi Y. Collagenous gastritis: A case report and endoscopic and pathologic evaluation of the nodularity of Gastric Mucosa. Dig. Dis. Sci., 2007; 52(4):995-1000.

Kamimura K, Mishima Y, Obata M, Endo T, Aoyagi Y, Kominami R. Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages. Oncogene 2007 30;26(40):5840-50.

Takamura M, Matsuda Y, Yamagiwa S, Tamura Y, Honda Y, Suzuki K, Ichida T, Aoyagi Y. An inhibitor of c-Jun NH2-terminal kinase, SP600125, protects mice from D-galactosamine/lipopolysaccharide-induced hepatic failure by modulating BH3-only proteins. Life Sci. 2007 Mar 13;80(14):1335-44.

Takamura M, Ichida T, Ohkoshi S, Tsubata S, Osaki A, Aoyagi T, Nomoto M, Uehara K, Terada H, Aoyagi Y. Decompensated lamivudine-resistant Hepatitis B virus related cirrhosis treated successfully with adefovir dipivoxil allowin surgery for hepatocellular carcinoma. Intern Med. 2007; 46(7): 367-371.

Suda T, Liu D. Hydrodynamic Gene Delivery: Its Principles and Applications. Mol Ther 2007; 15: 2063-2069.

Suda T, Gao X, Stolz DB, Liu D. Structural impact of hydrodynamic injection on mouse liver. Gene Ther 2007; 14: 129-137.

Tsuchiya A, Heike T, Baba S, Fujino H, Umeda K, Matsuda Y, Nomoto M, Ichida T, Aoyagi Y, Nakahata T. Long-term culture of postnatal mouse hepatic stem/progenitor cells and their relative developmental hierarchy. Stem Cells. 2007;25:895-902.

Honda Y, Yamagiwa S, Matsuda Y, Takamura M, Ichida T, Aoyagi Y. Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis. J Hepatol. 2007;47(3):404-11

Yano M, Ikeda M, Abe KI, Dansako H, Ohkoshi S, Aoyagi Y, Kato N. Comprehensive Analysis of the Effects of Ordinary Nutrients on Hepatitis C Virus RNA Replication in Cell Culture. Antimicrob Agents Chemother. 2007 ;51(6):2016-27.

Kobayashi M, Kuroiwa T, Suda T, Tamura Y, Kawai H, Igarashi M, Fukuhara Y, Aoyagi Y. Fucosylated fraction of alpha-fetoprotein, L3, as a useful prognostic factor in patients with hepatocellular carcinoma with special reference to the low concentration of serum alpha-fetoprotein. Hepatol Res. 2007;37(11):914-22.

Kamimura K, Ohi H, Kubota T, Okazuka K, Yoshikai Y, Wakabayashi Y, Aoyagi Y, Mishima Y, Kominami R. Haploinsufficiency of Bcl11b for suppression of lymphomagenesis and thymocyte development. Biochem Biophys Res Commun. 2007;355(2):538-42.

Aiba T, Takahashi T, Suzuki K, Okoshi S, Nomoto M, Uno K, Aoyagi Y. Liver injury induced by a Japanese herbal medicine, sairei-to (TJ-114, Bupleurum and Hoelen Combination, Chai-Ling-Tang) R1. J Gastroenterol Hepatol. 2007;22(5):762-3.

Suzuki K, Kawauchi Y, Palaniyandi SS, Veeraveedu PT, Fujii M, Yamagiwa S, Yoneyama H, Han GD, Kawachi H, Okada Y, Ajioka Y, Watanabe K, Hosono M, Asakura H, Aoyagi Y, Narumi S. Blockade of interferon-gamma-inducible protein-10 attenuates chronic experimental colitis by blocking cellular trafficking and protecting intestinal epithelial cells. Pathol Int. 2007 Jul;57(7):413-20.

Tsuboi K, Takamura M, Sato Y, Yokoyama H, Takeuchi M, Igarashi M, Kondo D, Omori K, Ogawa A, Takeyama A, Koyama Y, Ajioka Y, Aoyagi Y. Severe acute pancreatitis as an initial manifestation of primary hyperparathyroid adenoma in a pediatric patient. Pancreas. 2007 Jul;35(1):100-1.

Yamazaki K, Ohkoshi S, Maruyama M, Aoki YH, Yano M, Kurita S, Suzuki K, Matsuda Y, Sugimura K, Aoyagi Y. Early upsurge in anti-HBs titer possibly caused by the immunomodulative, not by the mutagenetic effect of interferon and ribavirin. Hepatol Res. 2007;37(6):477-81.

Hokari M, Matsuda Y, Wakai T, Shirai Y, Sato M, Tsuchiya A, Takamura M, Yamagiwa S, Suzuki K, Ohkoshi S, Ichida T, Kawachi H, Aoyagi Y Tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 potentates the anchorage-independent growth of human hepatoma HepG2 cells. Life Sci. 2007, 81:336-345.

Nakamura J, Kobayashi K, Toyabe S, Aoyagi Y, Akazawa K. The cost-effectiveness of the new protocol reflecting rapid virologic response to peginterferon alpha-2b and ribavirin for chronic hepatitis C. Eur J Gastroenterol Hepatol. 2007 Sep;19(9):733-9.

Yamazaki K, Suzuki K, Ohkoshi S, Yano M, Kurita S, Aoki Y, Toba K, Takamura M, Yamagiwa S, Matsuda Y, Aoyagi Y. Temporal treatment with interferon-b prevents hepatocellular carcinoma in hepatitis B virus-X gene transgenic mice. J Hepatol. 2007,(48)255-265.

Oshima T, Kawasaki T, Ohashi R, Hasegawa G, Jiang S, Umezu H, Aoyagi Y, Iwanari H, Tanaka T, Hamakubo T, Kodama T, Naito M. Downregulated P1 promoter-driven hepatocyte nuclear factor-4α expression in human colorectal carcinoma is a new prognostic factor against liver metastasis. Pathology International 2007, (57):82-90.

Sakamoto N, Tanabe Y, Yokota T, Saitoh K, Sekine-Osajima Y, Nakagawa M, Itsui Y, Tasaka M, Sakurai Y, Cheng-Hsin C, Yano M, Ohkoshi S, Aoyagi Y, Maekawa S, Enomoto N, Kohara M, Watanabe M, Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA. J Gastroenterol Hepatol. 2008 Sep;23(9):1437-47.

Tsuchiya A, Heike T, Baba S, Fujino H, Umeda K, Matsuda Y, Nomoto M, Ichida T, Aoyagi Y, Nakahata T.Sca-1+ endothelial cells (SPECs) reside in the portal area of the liver and contribute to rapid recovery from acute liver disease.Biochem Biophys Res Commun. 2008 ,(365)595-601

Isogawa M, Higuchi M, Takahashi M, Oie M, Mori N, Tanaka Y, Aoyagi Y, Fujii M. Rearranged NF-kappa B2 gene in an adult T-cell leukemia cell line. Cancer Sci. 2008 Apr;99(4):792-8.

Kamimura K, Oosaki A, Sugahara S, Mori S, Morita T, Kimura K. (2008) Eosinophilic esophagitis: a case report. Effective treatment with systemic corticosteroids for the relapse of the disease. Clin J Gastroenterol 1:46-51.

Suda T, Suda K, Liu D. Computer-assisted Hydrodynamic Gene Delivery. Mol Ther 2008; 16: 1098-1104.

Kobyashi M, Suda T, Hashiba M, Nagasaki K, Adachi A, Nomoto M, Arakawa M, Aoyagi Y. Regular Exercise Improves Insulin Sensitivity, Physical Activity, and Psychosocial Status in Patients with Chronic Liver Diseases Acta Medica Biologica 2008; 56: 1-9.

Yamagiwa S, Matsuda Y, Ichida T, Honda Y, Takamura M, Sugahara S, Ishikawa T, Ohkoshi S, Sato Y, Aoyagi Y. Sustained response to interferon-alpha plus ribavirin therapy for chronic hepatitis C is closely associated with increased dynamism of intrahepatic natural killer and natural killer T cells. Hepatol Res. 2008 Jul;38(7):664-72.

Nakamura J, Toyabe SI, Aoyagi Y, Akazawa K. Economic impact of extended treatment with peginterferon alpha-2a and ribavirin for slow hepatitis C virologic responders. J Viral Hepat. 2008 Apr;15(4):293-9.

Nakamura J, Terajima K, Aoyagi Y, Akazawa K. Cost-effectiveness of the national screening program for hepatitis C virus in the general population and the high-risk groups. Tohoku J Exp Med. 2008 May;215(1):33-42.

Ohkoshi S, Yoshimura A, Yamamoto S, Yano M, Kurita S, Yamazaki K, Aoki Y, Yamagiwa S, Wakabayashi H, Sugiyama M, Takahashi T, Ishikawa T, Matsuda Y, Ichida T, Kamimura T, Aoyagi Y. Sucessful treatment with lamivudine may correlate with reduction of serum ferritin levels in the patients with chronic hepatitis and liver cirrhosis type B. Hepatol Int 2008 2:382-387.

Kamimura K, Liu D. Physical approaches for nucleic acid delivery to liver. AAPS J 2008;10 :589-595.

Kurita S, Ohkoshi S, Yano M, Yamazaki K, Suzuki K, Aoki YH, Matsuda Y, Wakai T, Shirai Y, Ichida T, Aoyagi Y. Progression of hypermethylation of the p16(INK4A) gene from normal liver to nontumorous liver and hepatocellular carcinoma: an evaluation using quantitative PCR analysis. Dig Dis Sci. 2009 Jan;54(1):80-8.

Suda T, Kamimura K, Kubota T, Tamura Y, Igarashi M, Kawai H, Aoyagi Y, Liu D. Progress toward liver-based gene therapy. Hepatol Res. 2009 Apr;39(4):325-40.

Takahashi T, Koike T, Hashimoto S, Miura T, Nakamura J, Yamada S, Miura T, Yanagi M, Yamazaki K, Okoshi S, Aoyagi Y. A case of lamivudine-sensitive de novo acute hepatitis B induced by rutuximab with the CHOP regimen for diffuse large B cell lymphoma. Hepatol Int 2009 Mar;3(1):316-22. 2009.

Tamura Y Yamagiwa S, Aoki Y, Kurita S, Suda T, Ohkoshi S, Nomoto M, Aoyagi Y. Serum alpha-fetoprotein levels during and after interferon therapy and the development of hepatocellular carcinoma in patients with chronic hepatitis C. Dig Dis Sci. 2009 Nov; 54(11):2530-7.

Kamimura K, Suda T, Xu W, Zhang G, Liu D. Image-guided, Lobe-specific Hydrodynamic Gene Delivery to Swine Liver. Mol Ther 2009; 17: 491-9.

Watanabe T, Soga K, Hirono H, Hasegawa K, Shibasaki K, Kawai H, Aoyagi Y. Features of hepatocellular carcinoma in cases with autoimmune hepatitis and primary biliary cirrhosis. World J Gastroenterol. 2009 Jan 14;15(2):231-9.

Sato M, Takamura M, Sato Y, Yokoyama H, Nozawa Y, Masui Y, Miida H, Hashimoto T, Ito M, Aoyagi Y. Drug-induced acute pancreatitis associated with 22-oxacalcitriol ointment for treatment of psoriasis. JOP. 2009 Mar 18;10(3):336-7.

Yano M, Ikeda M, Abe KI, Kawai Y, Kuroki M, Mori K, Dansako H, Ariumi Y, Ohkoshi S, Aoyagi Y, Kato N. Oxidative stress induces anti-hepatitis C virus status via the activation of extracellular signal-regulated kinase. Hepatology. 2009 Sep;50(3):678-88.

Tsuchiya A, Kamimura H, Takamura M, Yamagiwa S, Matsuda Y, Sato Y, Nomoto M, Ichida T, Aoyagi Y. Clinicopathological analysis of CD133(+) and NCAM(+) human hepatic stem/progenitor cells in damaged livers and hepatocellular carcinomas. Hepatol Res. 2009 Nov;39(11):1080-90.

Shoji T, Higuchi M, Kondo R, Takahashi M, Oie ,M Tanaka Y, Aoyagi Y Fujii M. Identification of a novel motif responsible for the distinctive transforming activity of human T-cell leukemia virus (HTLV) type 1 Tax1 protein from HTLV-2 Tax2. Retrovirology 2009, 6:83doi:10. 1186/1742-4690-6-83 Published: 17 September 2009.

Yoshikawa S, Zen Y, Fujii T, Sato Y, Ohta T, Aoyagi Y, Nakanuma Y Characterization of CD133+ parenchymal cells in the liver: histology and culture.World J Gastroenterol. 2009 Oct 21;15(39):4896-906.

Michitaka K, Nishiguchi S, Aoyagi Y, Hiasa Y, Tokumoto Y, Onji M; The Japan Etiology of Liver Cirrhosis Study Group. Etiology of liver cirrhosis in Japan: a nationwide survey. J Gastroenterol. 2009 Sep 30. [Epub ahead of print]

Tsuchiya A, Imai M, Kamimura H, Togashi T, Watanabe K, Seki K, Ishikawa T, Ohta H, Yoshida T, Kamimura T. Successful treatment of multiple lung metastases of hepatocellular carcinoma by combined chemotherapy with docetaxel, cisplatin and tegafur/uracil. World J Gastroenterol 2009 April 14; 15(14): 1779-1781.

Tsuchiya A, Kubota T, Takizawa K, Yamada K, Wakai T, Matsuda Y, Honma T, Watanabe M, Shirai Y, Maruyama H, Nomoto M, Aoyagi Y. Successful Treatment in a Case of Massive Hepatocellular Carcinoma with Paraneoplastic Syndrome. Case reports in gastroenterology 2009;3:105-110.

Kamimura K, Zhang G, Liu D. Image-guided, Intravascular Hydrodynamic Gene Delivery to Skeletal Muscle in Pigs. Mol Ther 2010;18(1):93-100.

Tamura Y, Igarashi M, Suda T, Wakai T, Shirai Y, Umemura T, Tanaka T, Kakizaki S, Takagi H, Hiasa Y, Onji M, Aoyagi Y. Fucosylated fraction of alpha-fetoprotein as a predictor of prognosis in patients with hepatocellular carcinoma after curative treatment. Dig Dis Sci. 2010 Jul;55(7):2095-101.

Takamura M, Yamagiwa S, Wakai T, Tamura Y, Kamimura H, Kato T, Tsuchiya A, Matsuda Y, Shirai Y, Ichida T, Ajioka Y, Aoyagi Y. Loss of liver-intestine cadherin in human intrahepatic cholangiocarcinoma promotes angiogenesis by up-regulating metal-responsive transcription factor-1 and placental growth factor. Int J Oncol. 2010 Jan;36(1):245-54.

Korita P, Wakai T, Shirai Y,Matsuda Y, Sakata J, Takamura M, Yano M, Sanpei A, Aoyagi Y, Hatakeyama K, Ajioka Y. Multidrug resistance-associated protein 2 determines the efficacy of cisplatin in patients with hepatocellular carcinoma. Oncology Reports 2010 Apr;23(4):965-72.

Kamimura K, Oosaki A, Sugahara S, Mori S, Moroda T, Satoh O, Morita T, Kimura K, Kamura T, Nomoto M, Aoyagi Y. (2010) Malignant potential of hepatic angiomyolipoma: case report and literature review. Clin J Gastroenterol 3:104-110.

Ohkoshi S, Yamagiwa S, Yano M, Takahashi H, Aoki YH, Matsuda Y, Aoyagi Y Very-Low-Dose Pegylated Interferon a2a Plus Ribavirin Therapy for Advanced Liver Cirrhosis Type C: A Possible Therapeutic Alternative without Splenic Intervention. Case Rep Gastroenterol. 2010 Jul 28;4(2):261-266.

Kobayashi M, Narisawa R, Sato Y, Takeuchi M, Aoyagi Y Self-limiting risk of metachronous gastric cancers after endoscopic resection. Dig Endosc. 2010 Jul;22(3):169-73.

Osaki A, Kubota T, Suda T, Igarashi M, Nagasaki K, Tsuchiya A, Yano M, Tamura Y, Takamura M, Kawai H, Yamagiwa S, Kikuchi T, Nomoto M, Aoyagi Y. Shear wave velocity is a useful marker for managing nonalcoholic steatohepatitis. World J Gastroenterol. 2010 Jun 21;16(23):2918-25.

Tamura Y, Igarashi M, Kawai H, Suda T, Satomura S, Aoyagi Y. Clinical Advantage of Highly Sensitive On-Chip Immunoassay for Fucosylated Fraction of Alpha-Fetoprotein in Patients with Hepatocellular Carcinoma. Dig Dis Sci. 2010 Dec;55(12):3576-83. Epub 2010 Apr 21.

Yamamoto T, Morita S, Go R, Obata M, Katsuragi Y, Fujita Y, Maeda Y, Yokoyama M, Aoyagi Y, Ichikawa H, Mishima Y, Kominami R. Clonally expanding thymocytes having lineage capability in gamma-ray-induced mouse atrophic thymus. Int J Radiat Oncol Biol Phys. 2010 May 1;77(1):235-43.

Aoyagi T, Takahashi M, Higuchi M, Oie M, Tanaka Y, Kiyono T, Aoyagi Y, Fujii M. The PDZ domain binding motif (PBM) of human T-cell leukemia virus type 1 Tax can be substituted by heterologous PBMs from viral oncoproteins during T-cell transformation. Virus Genes. 2010 Apr;40(2):193-9.

Mizuno KI, Kudo SE, Ohtsuka K, Hamatani S, Wada Y, Inoue H, Aoyagi Y. Narrow-Banding Images and Structures of Microvessels of Colonic Lesions. Dig Dis Sci. 2010 Dec 28. [Epub ahead of print]

Kawai H, Nomoto M, Suda T, Kamimura K, Tsuchiya A, Tamura Y, Yano M, Takamura M, Igarashi M, Wakai T, Yamagiwa S, Matsuda Y, Ohkoshi S, Kurosaki I, Shirai Y, Okada M, Aoyagi Y Multicentric occurrence of hepatocellular carcinoma with nonalcoholic steatohepatitis World J Hepatol 2011 January 27; 3(1): 15-23

Tsuchiya A, Kanefuji T, Suda T, Aoyagi T, Osaki A, Togashi T, Kawauchi Y, Fushiki M, Watanabe G, Hirota M, Nomoto M, Ajioka Y, Aoyagi Y. Alpha-fetoprotein-producing adenocarcinoma in which the metastatic route was determined from calcified lesions. Clin J Gastroenterol 2011; 4: 89-94.

Aoki YH, Ohkoshi S, Yamagiwa S, Yano M, Takahashi H, Waguri N, Igarashi K, Sugitani S, Takahashi T, Ishikawa T, Kamimura T, Wakabayashi H, Watanabe T, Matsuda Y, Nomoto M, Aoyagi Y. Characterization of elevated alanine aminotransferase levels during pegylated-interferon α-2b plus ribavirin treatment for chronic hepatitis C. Hepatol Res. 2011 Feb;41(2):118-25.

Abe S, Nagasaka K, Hirayama Y, Kozuka-Hata H, Oyama M, Aoyagi Y, Obuse C, Hirota T. The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II. Genes Dev. 2011 Apr 15;25(8):863-74.

Tsuchiya A, Kamimura H, Tamura Y, Takamura M, Yamagiwa S, Suda T, Nomoto M, Aoyagi Y. Hepatocellular carcinoma with progenitor cell features distinguishable by the hepatic stem/progenitor cell marker NCAM. Cancer Lett. 2011 Jun 11. [Epub ahead of print]

Kobayashi M, Takeuchi M, Ajioka Y, Hashimoto S, Sato A, Narisawa R, Aoyagi Y. Mucin phenotype and narrow-band imaging with magnifying endoscopy for differentiated-type mucosal gastric cancer. J Gastroenterol. 2011 Jun 11. [Epub ahead of print]

Takeuchi M, Kobayashi M, Hashimoto S, Narisawa R, Aoyagi Y. Usefulness of magnifying narrow band imaging for assessing lateral tumor extent of early gastric cancer: a case report. Dig Endosc. 2011 May;23 Suppl 1:86-8.

Kamimura K, Suda T, Zhang G, Liu D. (2011) Advances in Gene Delivery SystemsPharmaceutical Medicine in Press.

Aoyagi Y, Tamura Y, Suda T, EDITORIAL,History and recent progress in evaluation of the fucosylated alpha-fetoprotein fraction, J Gastroenterol Hepatol, 2011 in press.

Kamimura H, Yamagiwa S, Tsuchiya A, Takamura M, Matsuda Y, Ohkoshi S, Inoue M, Wakai T, Shirai Y, Nomoto M, Aoyagi Y. Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence. J. Hepatol. 2011 (in press)

Mireen Friedrich-Rust, Julia Nierhoff, Monica Lupsor, Ioan Sporea, Carmen Fierbinteanu-Braticevici, Deike Strobel, Hirokazu Takahashi, Masato Yoneda, Takeshi Suda, Stefan Zeuzem, and Eva Herrmann. Performance of Acoustic Radiation Force Impulse-Imaging for the staging of liver fibrosis: a pooled meta-analysis. J Viral Hep. 2011 in press.

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