大学院生(修士課程・博士課程)
募集中
ミトコンドリアやオートファジーに興味のある方は、ぜひご連絡ください。
問い合わせ先:神吉(かんき)
kanki<at>med.niigata-u.ac.jp
025-227-2156












主要論文(筆頭著者又は責任著者が研究室所属者のもの)
 年  論文  リンク
2017  Yamashita SI, Kanki T. How autophagy eats large mitochondria: Autophagosome formation coupled with mitochondrial fragmentation. Autophagy. 2017 ;13(5):980-981.  
 2017  Yamashita SI, Kanki T. Detection of Hypoxia-Induced and Iron Depletion-Induced Mitophagy in Mammalian Cells. Methods Mol Biol. 2017  
 2017  Furukawa K, Kanki T. Mitophagy in Yeast: A Screen of Mitophagy-Deficient Mutants. Methods Mol Biol. 2017  
 2016  Yamashita SI, Jin X, Furukawa K, Hamasaki M, Nezu A, Otera H, Saigusa T, Yoshimori T, Sakai Y, Mihara K, Kanki T. Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy. J Cell Biol. 2016 ;215(5):649-665.  
2015   Hirota Y, Yamashita S, Kurihara Y, Jin X, Aihara M, Saigusa T, Kang D, Kanki T. Mitophagy is primarily due to alternative autophagy and requires MAPK1 and MAPK14 signaling pathways. Autophagy 2015 ;11(2):332-43  
2014  Kanki T, Furukawa K, Yamashita SI. Mitophagy in yeast: Molecular mechanisms and physiological role. Biochim Biophys Acta. In Press  
2014 Aihara M, Jin X, Kurihara Y, Yoshida Y, Matsushima Y, Oku M, Hirota Y, Saigusa T, Aoki Y, Uchiumi T, Yamamoto T, Sakai Y, Kang D, Kanki T. Tor and the Sin3-Rpd3 complex regulate expression of the mitophagy receptor protein Atg32 in yeast. J Cell Sci. 2014;127:3184-96   
2014 Kanki T, Okamoto K. Assays for Autophagy II: Mitochondrial Autophagy. Methods Mol Biol. 2014;1163:165-73.  
2013 Kanki T, Kurihara Y, Jin X, Goda T, Ono Y, Aihara M, Hirota Y, Saigusa T, Aoki Y, Uchiumi T, Kang D. Casein kinase 2 is essential for mitophagy. EMBO Rep. 2013: 14(9): 788-94  
2012 Kurihara Y, Kanki T, Aoki Y, Hirota Y, Saigusa T, Uchiumi T, Kang D. Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast. J Biol Chem. 2012;287(5):3265-72  
 2012 Hirota Y, Kang D, Kanki T. The physiological role of mitophagy: new insights into phosphorylation events. Int J Cell Biol. 2012; 2012:354914.  
2011 Aoki Y, Kanki T, Hirota Y, Kurihara Y, Saigusa T, Uchiumi T, Kang D. Phosphorylation of Ser114 on Atg32 mediates mitophagy. Mol Biol Cell. 2011;22(17):3206-17.  
 2011 Kanki T, Klionsky D, Okamoto K. Mitochondria autophagy in yeast. Antioxid Redox Signal. 2011;14(10):1989-2001.  
2010 Kanki T. Nix, a receptor protein for mitophagy in mammals. Autophagy. 2010;6(3):433-5.  
2010 Kanki T, Klionsky DJ. The molecular mechanism of mitochondria autophagy in yeast. Mol Microbiol. 2010;75(4):795-800.  
2010 Kanki T, Wang K, Klionsky DJ. A genomic screen for yeast mutants defective in mitophagy Autophagy. 2010;6(2):278-80.  
2009 Kanki T, Klionsky DJ. Atg32 is a tag for mitochondria degradation in yeast. Autophagy. 2009;5(8):1201-2.  
2009 Kanki T, Wang K, Baba M, Bartholomew CR, Lynch-Day MA, Du Z, Geng J, Mao K, Yang Z, Yen WL, Klionsky DJ. A genomic screen for yeast mutants defective in selective mitochondria autophagy. Mol Biol Cell. 2009;20(22):4730-8.  
2009 Kanki T, Wang K, Cao Y, Baba M, Klionsky DJ. Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell. 2009;17(1):98-109.  
2009  Kanki T, Kang D, Klionsky DJ. Monitoring mitophagy in yeast: the Om45-GFP processing assay. Autophagy. 2009;5(8):1186-9.  
2009 Kanki T, Klionsky DJ. Mitochondrial abnormalities drive cell death in Wolfram syndrome 2. Cell Res. 2009;19(8):922-3.  
2008  Kanki T, Klionsky DJ. Mitophagy in yeast occurs through a selective mechanism. J Biol Chem. 2008;283(47):32386-93.  


著書、日本語総説など
 年  論文  リンク
2017 神吉智丈 Parkinに依存しないマイトファジー 最新医学・第72巻・第2号  
2017  古川 健太郎, 神吉 智丈 酵母におけるマイトファジーの分子機構と生理的役割  化学と生物 Vol.54 pp266-272  
 2016  神吉智丈 Digestシリーズ -オートファジー:その発見から未解決問題まで-Vol.4 「選択的オートファジー」MSD Vol.42 2016年9月号  
 2014  Yusuke Kukrihara and Tomotake Kanki, Atg32 Confers Selective Mitochondrial Sequestration as a Cargo for Autophagy. M.A. Hayat (ed) Autophagy Volume 4. 163-174.  
2014 神吉智丈 ミトコンドリアオートファジー-ミトコンドリア恒常性維持機構- 新潟医学雑誌 第127巻 第12号 645-648  
2014 神吉智丈 マイトファジー:ミトコンドリアを選択的に分解する機構 新潟県医師会報 No.754  
2011 神吉智丈、康東天 マイトファジー~基礎から臨床応用まで~ 医学のあゆみ 2011 238巻 4号 342-3  
2011 廣田有子、青木義政、神吉智丈 オートファジーによるミトコンドリア分解機構 生化学 2011 83巻 2号 126-30  
2009 神吉智丈 ミトコンドリアオートファジーの分子機構 福岡医学雑誌 2009 100巻 9号 291-297  


共同研究による成果
 年  論文  リンク
 2016  Akabane S, Matsuzaki K, Yamashita S, Arai K, Okatsu K, Kanki T, Matsuda N, Oka T. Constitutive Activation of PINK1 Protein Leads to Proteasome-mediated and Non-apoptotic Cell Death Independently of Mitochondrial Autophagy. J Biol Chem. 2016 ;291(31):16162-74  
 2013  Matsuda T, Kanki T, Tanimura T, Kang D, Matsuura ET. Effects of overexpression of mitochondrial transcription factor A on lifespan and oxidative stress response in Drosophila melanogaster. Biochem Biophys Res Commun. 2013;430(2):717-21.  
2013  Uchiumi T, Tanamachi H, Kuchiwaki K, Kajita M, Matsumoto S, Yagi M, Kanki T, Kang D. Mutation and functional analysis of ABCC2/multidrug resistance protein 2 in a Japanese patient with Dubin-Johnson syndrome. Hepatol Res. 2013;43(5):569-75.  
2013  Fang J, Uchiumi T, Yagi M, Matsumoto S, Amamoto R, Saito T, Takazaki S, Kanki T, Yamaza H, Nonaka K, Kang D. Protein instability and functional defect by mutations of dihydroorotate dehydrogenase with Miller syndrome patients. Biosci Rep. 2012: 32(6): 631-9  
2012 Yagi M, Uchiumi T, Takazaki S, Okuno B, Nomura M, Yoshida SI, Kanki T, Kang D. p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability. Nucleic Acids Res. 2012;40(19):9717-37  
2012 Matsumoto S, Uchiumi T, Saito T, Yagi M, Takazaki S, Kanki T, Kang D. Localization of mRNAs encoding human mitochondrial oxidative phosphorylation proteins. Mitochondrion. 2012;12(3):391-8.  
2012 Matsumoto S, Uchiumi T, Tanamachi H, Saito T, Yagi M, Takazaki S, Kanki T, Kang D. Ribonucleoprotein Y-box-binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNA. Biochem J. 2012;443(2):573-84.  
2012 Klionsky DJ. et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012;8(4):445-544.  




copyright©2015 Kanki Lab. all rights reserved
新潟大学大学院医歯学総合研究科