Exercise

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Exercise 1	Nov. 27
Slide	Observation	Sketch
Normal rat kidney (HE)	*Cortex/glomerulus/medulla *Nephron/collecting duct (proximal, Henle, distal)	Glomerulus: epithelial, endothelial, mesangial cells
Normal rat kidney (PAM)	*GBM/TBM/Bowman's /mesangial matrix	GBM, Mesangial matrix
Anti-GBM Glomerulonephritis Day 6 (HE, PAM)	*Glomerular enlargement *Glomerular hypercellularity *Tubular changes: hypertrophy, casts, droplets *Insterstitial changes: leukocyte infiltration, edema	Endocapillary proliferation (mononuclear cells>>PMN) Crescent

Exercise 2	Nov. 28
Slide	Observation	Sketch
Normal human kidney (PAS)	*Cortex/glomerulus/medulla *Nephron/collecting duct (proximal, Henle, distal)	Glomerulus: epithelial, endothelial, mesangial cells
Focal segmental glomerulosclerosis (HE, PAM)	Normal glemeruli in superficial cortex and abnormal glomeruli in juxatamedullary cortex No hypercellularity Tubular changes:hypertrophy, casts, droplets	Adhesion to Bowman's capsule Sclerotic glomerular lesion
Membranous nephropathy (HE, PAM)	*Glomerular capillary wall thickening (HE) No hypercellularity	Spike formation No increase of mesangial matrix

Exercise 3	Nov. 29
Slide	Observation	Sketch
IgA Nephropathy (PAS)	*Mesanigal proliferative (mesangial cell and matrix) lesion *Tubular atrophy, casts, TBM thickening *Interstitial fibrosis and mononuclear cell infiltration	Mesangial proliferative lesion Glomerular scar
Membranoproliferative glomerulonephritis (HE, PAM)	*Mesangial proliferative lesion *Glomerular sclerosis (scar, obsolescent glomerulus) *Tubular atrophy, casts, TBM thickening *Interstitial fibrosis and mononuclear cell infiltration	Double contour of GBM Adhesion to Bowman's

Exercise 4	Dec. 4
Slide	Observation	Sketch
Diabetic Nephropathy (HE, PAM)	*Diffuse lesion Increase of mesangial matrix GBM thickening *Nodular lesion *Fibrin cap, capsular drop?* *Hyaline degeneration of afferent and efferent arterioles *Tubular atrophy, interstitial fibrosis and mononuclear cell infiltration *Glomerular scar	Nodular lesion Fibrin Cap Hyaline degeneration
Lupus Nephritis (HE, PAM)	*Mesangial proliferative lesion *Wire-loop lesion, hyaline thrombus *Crescentic or scaring glomeruli *Fibrinoid degeneration of interlobular arteries *Tubular atrophy, casts, TBM thickening *Interstitial fibrosis and mononuclear cell infiltration	Mesangial cell proliferation and matrix increase Wire-loop

Exercise 5	Dec. 5
Slide	Observation	Sketch
Wilms' Tumor (HE)	*Normal and tumor tissue Blastema, epithlial, mesenchymal appearance	Tubule-, Glomerulus-, striated muscle-like
Grawitz's Tumor (HE)	*Normal and tumor tissue *Clear cell and dark cell	Alveolar pattern with blood vessels