研究業績

学術論文・総説

2022年

  1. Fujisaki T , Saito K , Kikuchi T , Kondo E. : The prolyl hydroxylase OGFOD1 promotes cancer cell proliferation by regulating the expression of cell cycle regulators.

    FEBS Lett. 2022 Dec 4. doi: 10.1002/1873-3468.14547. Online ahead of print.

  2. Herik Rodrigo AG, Tomonobu N, Yoneda H, Kinoshita R, Mitsui Y, Sadahira T, Terawaki SI, Gohara Y, Gede Yoni Komalasari NL, Jiang F, Murata H, Yamamoto KI, Futami J, Yamauchi A, Kuribayashi F, Inoue Y, Kondo E, Toyooka S, Nishibori M, Watanabe M, Nasu Y, Sakaguchi M. : Toll-like receptor 4 promotes bladder cancer progression upon S100A8/A9 binding, which requires TIRAP-mediated TPL2 activation.

    Biochem Biophys Res Commun. 2022 Dec 17;634:83-91. doi: 10.1016/j.bbrc.2022.09.116. Epub 2022 Oct 6.

  3. Tomonobu N, Kinoshita R, Wake H, Inoue Y, Ruma I-M W, Suzawa K, Gohara Y, Komalasari NLGY, Jiang F, Murata H, Yamamoto K, Sumardika IW, Chen Y, Futami J, Yamauchi A, Kuribayashi F, Kondo E, Toyooka S, Nishibori M, Sakaguchi M.: Histidine-rich Glycoprotein suppresses the S100A8/A9-mediated organotropic metastasis of melanoma cells.

    Int. J. Mol. Sci. 2022, 23, 10300. https://doi.org/10.3390/ijms231810300 (registering DOI)

  4. Fukushima H, Kato T, Furusawa A, Okada R, Wakiyama H, Furumoto H, Okuyama S, Kondo E, Choyke PL, Kobayashi H.: Intercellular adhesion molecule-1-targeted near-infrared photoimmunotherapy of triple-negative breast cancer. Cancer Sci. 2022 Jun 20. doi: 10.1111/cas.15466. Online ahead of print.

  5. Yokoyama Y, Iioka H, Horii A, Kondo E. Crumbs3 is expressed in oral squamous cell carcinomas and promotes cell migration and proliferation by affecting RhoA activity.

    Oncol Lett. 2022 Jun;23(6):173. doi: 10.3892/ol.2022.13293. Epub 2022 Apr 13.

2021年

  1. Kondo E, Iioka H, Saito K. Tumor-homing peptide and its utility for advanced cancer medicine.

    Cancer Sci. 2021;112:2118–2125 doi: 10.1111/cas.14909.

  2. Saito K, Mitsui A, Sumardika IW, Yokoyama Y, Sakaguchi M, Kondo E. PLOD2-driven IL-6/STAT3 signaling promotes the invasion and metastasis of oral squamous cell carcinoma via activation of integrin β1.

    Int J Oncol. 2021 Jun;58(6):29. doi: 10.3892/ijo.2021.5209. Epub 2021 Apr 23.

2020年

  1. 近藤英作：「PDCはがん治療展開の新たなカードとなりえるか？」

    ゲノム医療時代のがん-分子標的薬と診断薬研究-実験医学増刊号 Vol.38(15):191(2637)-197(2643), 2020 ISSN0288-5514

  2. 近藤英作：「ペプチド医薬による新たながん治療創出へのチャレンジ （PDC はがん治療革新の一手となりえるか？）」Drug delivery System（日本DDS学会誌） Vol.35(3) :222-228, 2020 ISSN 0913-5006 CODEN:DDSYEI

  3. Ueki Y, Saito K, Iioka H, Sakamoto I, Kanda Y, Sakaguchi M, Horii A, Kondo E. PLOD2 is essential to functional activation of integrin β1 for invasion/metastasis in head and neck squamous cell carcinomas.

    iScience 23, 100850　February 21, 2020 https://doi.org/10.1016/j.isci.2020.100850

2019年

  1. Saito K, Iioka H, Maruyama S, Sumardika IW, Sakaguchi M and Kondo E. PODXL1 promotes metastasis of the pancreatic ductal adenocarcinoma by activating the C5aR/C5a axis from the tumor microenvironment.

    Neoplasia 2019 Nov 20;21(12):1121-1132. doi: 10.1016/j.neo.2019.09.003. 

  2. Iioka H, Saito K, Kondo E. Crumbs3 regulates the expression of glycosphingolipids on the plasma membrane to promote colon cancer cell migration.

    Biochem. Biophys. Res. Commun. 2019 Nov 5;519(2):287-293. doi: 10.1016/j.bbrc.2019.08.161. Epub 2019 Sep 26.

  3. Chen Y, Sumardika IW, Tomonobu N, Kinoshita R, Inoue Y, Iioka H, Mitsui Y, Saito K, Ruma IMW, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Kubo M, Putranto EW, Murakami T, Liu M, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M. Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness.

    Neoplasia 2019 May 14;21(7):627-640. doi: 10.1016/j.neo.2019.04.006. 

  4. Mitsui Y, Tomonobu N, Watanabe M, Kinoshita R, Sumardika W, Youyi C, Murata H, Yamamoto KI, Sadahira T, Rodrigo AGH, Takamatsu H, Araki K, Yamauchi A, Yamamura M, Fujiwara H, Inoue Y, Futami J, Saito K, Iioka H, Kondo E, Nishibori M, Toyooka S, Yamamoto Y, Nasu Y, Sakaguchi M. Upregulation of mobility in pancreatic cancer cells by secreted S100A11 through activation of surrounding fibroblasts.

    Oncol. Res. 2019 Apr 17. doi: 10.3727/096504019X15555408784978.

  5. Iioka H, Saito K, Sakaguchi M, Tachibana T, Homma K, Kondo E. Crumbs3 is a critical factor that regulates invasion and metastasis of colon adenocarcinoma via the specific interaction with FGFR1.

    Int. J. Cancer 2019 Apr 13. doi: 10.1002/ijc.32336.

  6. Chen Y, Sumardika IW, Tomonobu N, Winarsa Ruma IM, Kinoshita R, Kondo E, Inoue Y, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Liu M, Futami J, Sasai K, Katayama H, Kubo M, Putranto EW, Hibino T, Sun B, Nishibori M, Toyooka S, Sakaguchi M. Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion.

    Cancer Lett. 2019 Mar 21;452:178-190. doi: 10.1016/j.canlet.2019.03.023.

  7. Takamatsu H, Yamamoto KI, Tomonobu N, Murata H, Inoue Y, Yamauchi A, Sumardika IW, Youyi C, Kinoshita R, Yamamura M, Fujiwara H, Mitsui Y, Araki K, Futami J, Saito K, Iioka H, Ruma IMW, Putranto EW, Nishibori M, Kondo E, Yamamoto Y, Toyooka S, Sakaguchi M. Extracellular S100A11 plays a critical role in spread of the fibroblast population in pancreatic Cancers.

    Oncol. Res. 2019 Mar 8. doi: 10.3727/096504018X15433161908259. 

  8. Sumardika IW, Chen Y, Tomonobu N, Kinoshita R, Ruma IMW, Sato H, Kondo E, Inoue Y, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Putranto EW, Hibino T, Nishibori M, Toyooka S, Sakaguchi M. Neuroplastin-β mediates S100A8/A9-induced lung cancer disseminative progression

    Mol. Carcinog. 2019 Feb 5. doi: 10.1002/mc.22987. 

  9.  Takata K, Saito K, Maruyama S, Miyata-Takata T, Iioka H, Okuda S, Ling Y, Karube K, Miki Y, Maeda Y, Yoshino T, Steidl C, Kondo E. Identification of TRA-1-60-positive cells as a potent refractory population in follicular lymphomas.

    Cancer Sci. 2019 Jan;110(1):443-457. doi: 10.1111/cas.13870.

2018年

  1. Kinoshita R, Sato H, Yamauchi A, Takahashi Y, Inoue Y, Sumardika IW, Chen Y, Tomonobu N, Araki K, Shien K, Tomida S, Torigoe H, Namba K, Kurihara E, Ogoshi Y, Murata H, Yamamoto KI, Futami J, Putranto EW, Ruma IMW, Yamamoto H, Soh J, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M. Newly developed anti-S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis

    Int. J. Cancer 2018 Nov 10. doi: 10.1002/ijc.31982. 

  2. Kinoshita R, Sato H, Yamauchi A, Takahashi Y, Inoue Y, Sumardika IW, Chen Y, Tomonobu N, Araki K, Shien K, Tomida S, Torigoe H, Namba K, Kurihara E, Ogoshi Y, Murata H, Yamamoto KI, Futami J, Putranto EW, Winarsa Ruma IM, Yamamoto H, Soh J, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M. exSSSRs (extracellular S100 Soil Sensor Receptors)-Fc fusion proteins work as prominent decoys to S100A8/A9-induced lung tropic cancer metastasis.

    Int. J. Cancer 2018 Oct 26. doi: 10.1002/ijc.31945. 

  3. Kanda Y, Takeuchi A, Ozawa M, Kurosawa Y, Kawamura T, Bogdanova D, Iioka H, Kondo E, Kitazawa Y, Ueta H, Matsuno K, Kinashi T, Katakai T. Visualizing the Rapid and Dynamic Elimination of Allogeneic T Cells in Secondary Lymphoid Organs.

    J. Immunol. 2018 Aug 1;201(3):1062-1072. doi: 10.4049/jimmunol.1700219. Epub 2018 Jun 20.

  4. Saito K, Sakaguchi M, Maruyama S, Iioka H, Putranto EW, Sumardika IW, Tomonobu N, Kawasaki T, Homma K, Kondo E. Stromal mesenchymal stem cells facilitate pancreatic cancer progression by regulating specific secretory molecules through mutual cellular interaction.

    J. Cancer 2018 Jul 30;9(16):2916-2929. doi: 10.7150/jca.24415. eCollection 2018.

  5. Ruma IMW, Kinoshita R, Tomonobu N, Inoue Y, Kondo E, Yamauchi A, Sato H, Sumardika IW, Chen Y, Yamamoto KI, Murata H, Toyooka S, Nishibori M, Sakaguchi M. Embigin Promotes Prostate Cancer Progression by S100A4-Dependent and-Independent Mechanisms.

    Cancers (Basel) 2018 Jul 23;10(7). pii: E239. doi: 10.3390/cancers10070239.

  6. Muhammad K, Rudolf R, Pham DAT, Klein-Hessling S, Takata K, Matsushita N, Ellenrieder V, Kondo E*, Serfling E*. Induction of Short NFATc1/αA Isoform Interferes with Peripheral B Cell Differentiation. (*はcorresponding author)

    Front. Immunol. 2018 Jan 24;9:32. doi: 10.3389/fimmu.2018.00032. eCollection 2018.

2017年

  1. Sumardika IW,  Youyi C,  Kondo E,  Inoue Y,  Ruma IMW,  Murata H,  Kinoshita R,  Yamamoto KI,  Tomida S,  Shien K,  Satoh H,  Yamauchi A,  Futami J,  Putranto EW,  Hibino T,  Toyooka S,  Nishibori M,  Sakaguchi M. ß-1,3-galactosyl-O-glycosyl-glycoprotein ß-1,6-N-acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility.

    Oncol. Res. 2017 Sep 18. doi: 10.3727/096504017X15031557924123. [Epub ahead of print]

  2. Maeda A, Ando H, Ura T, Muro K, Aoki M, Saito K, Kondo E, Takahashi S, Ito Y, Mizuno Y, and Fujimura A. Differences in Urinary Renal Failure Biomarkers in Cancer Patients Initially Treated with Cisplatin.

    Anticancer Res. 2017 Sep;37(9):5235-5239.

  3. Wada T, Sumardika IW, Saito S, Ruma IM, Kondo E, Shibukawa M, Sakaguchi M. Identification of a novel component leading to anti-tumor activity besides the major ingredient cordycepin in Cordyceps militaris extract.

    J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2017 Sep 1;1061-1062:209-219. doi: 10.1016/j.jchromb.2017.07.022. Epub 2017 Jul 19.

2016年

  1. Matsushita N, Suzuki M, Ikebe E, Nagashima S, Inatome R, Asano K, Tanaka M, Matsushita M, Kondo E, Iha H, Yanagi S. Regulation of B cell differentiation by the ubiquitin-binding protein TAX1BP1.

    Sci. Rep. 2016 Aug 12;6:31266. doi: 10.1038/srep31266.

  2. Saho S, Satoh H, Kondo E, Inoue Y, Yamauchi A, Murata H, Kinoshita R, Yamamoto KI, Futami J, Putranto EW, Ruma IM, Sumardika IW, Youyi C, Suzawa K, Yamamoto H, Soh J, Tomida S, Sakaguchi Y, Saito K, Iioka H, Huh NH, Toyooka S, Sakaguchi M. Active Secretion of Dimerized S100A11 Induced by the Peroxisome in Mesothelioma Cells.

    Cancer Microenviron. 2016 Dec;9(2-3):93-105. doi: 10.1007/s12307-016-0185-2. Epub 2016 Jun 22.

  3. Saito K, Iioka H, Kojima C, Ogawa M, Kondo E. Peptide-based tumor inhibitor encoding mitochondrial p14(ARF) is highly efficacious to diverse tumors.

    Cancer Sci. 2016 Sep;107(9):1290-301. doi: 10.1111/cas.12991. Epub 2016 Aug 4.

  4. Ruma IM, Putranto EW, Kondo E, Murata H, Watanabe M, Huang P, Kinoshita R, Futami J, Inoue Y, Yamauchi A, Sumardika IW, Youyi C, Yamamoto K, Nasu Y, Nishibori M, Hibino T, Sakaguchi M. MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-κB and ROS formation upon ligand binding.

    Clin. Exp. Metastasis 2016 Aug;33(6):609-27. doi: 10.1007/s10585-016-9801-2. Epub 2016 May 5.

  5. Kuwahara K, Yamamoto-Ibusuki M, Zhang Z, Phimsen S, Gondo N, Yamashita H, Takeo T, Nakagata N, Yamashita D, Fukushima Y, Yamamoto Y, Iwata H, Saya H, Kondo E, Matsuo K, Takeya M, Iwase H, Sakaguchi N. GANP protein encoded on human chromosome 21/mouse chromosome 10 is associated with resistance to mammary tumor development. Cancer Sci. 2016 Apr;107(4):469-77. doi: 10.1111/cas.12883. Epub 2016 Feb 9.

2015年

  1. Higa M, Katagiri C, Shimizu-Okabe C, Tsumuraya T, Sunagawa M, Nakamura M, Ishiuchi S, Takayama C, Kondo E, Matsushita M.: Identification of a novel cell-penetrating peptide targeting human glioblastoma cell lines as a cancer-homing transporter.
    Biochem. Biophys. Res. Commun. 2015 Feb 6;457(2):206-12. doi: 10.1016/j.bbrc.2014.12.089. Epub 2015 Jan 3.

2014年

  1. Muhammad K, Alrefai H, Marienfeld R, Pham DA, Murti K, Patra AK, Avots A, Bukur V, Sahin U,Kondo E, Klein-Hessling S, Serfling E.: NF-κB factors control the induction of NFATc1 in B lymphocytes.
    Eur. J. Immunol. doi: 10.1002/eji.201444756., 2014 Sep 1. [Epub ahead of print]

  2. Nakata S, Tanaka H, Ito Y, Hara M, Fujita M, Kondo E, Kanemitsu Y, Yatabe Y, Nakanishi H.: Deficient HER3 expression in poorly-differentiated colorectal cancer cells enhances gefitinib sensitivity.
    Int. J. Oncol. Oct;45(4):1583-93, 2014

  3. Ruma IMW, Putranto EW, Kondo E, Watanabe R, Saito K, Inoue Y, Yamamoto K, Nakata S,Kaihata M, Murata H and Sakaguchi M.: Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells.
    Int. J. Oncol. Jul;45(1):209-18, 2014

  4. Saito K, Sakaguchi M, Iioka H, Matsui M, Nakanishi H, Huh NH and Kondo E.: Coxsackie and adenovirus receptor is a critical regulator for the survival and growth of oral squamous carcinoma cells.
    Oncogene Mar 6;33(10):1274-86, 2014

  5. Yusa A, Toneri T, Masuda T, Ito S, Yamamoto S, Okochi M, Kondo N, Iwata H, Yatabe Y, Ichinosawa Y, Kinuta S, Kondo E, Honda H, Arai F, Nakanishi H. : Development of a New Rapid Isolation Device for Circulating Tumor Cells (CTCs) Using 3D Palladium Filter and Its Application for Genetic Analysis.
    PLoS ONE Feb 11;9(2):e88821., 2014

  6. 近藤英作：「腫瘍組織に吸収されるペプチド～癌の新しい医療技術」 G.I. Research (Journal of Gastrointestinal Research) 特集 消化器腫瘍の分子イメージング22(1), 17-23, 2014

2013年

  1. Ito A, Ito Y, Matsushima S, Tsuchida D, Ogasawara M, Hasegawa J, Misawa K, Kondo E, Kaneda N, Nakanishi H.: New whole-body multimodality imaging of gastric cancer peritoneal metastasis combining fluorescence imaging with ICG-labeled antibody and MRI in mice.
    Gastric Cancer 2013 Nov 28. [Epub ahead of print]

  2. Matsuyama M, Tanaka H, Inoko A, Goto H, Yonemura S, Kobori K, Hayashi Y, Kondo E, Itohara S, Izawa I, Inagaki M.: Defect of mitotic vimentin phosphorylation causes microophthalmia and cataract via aneuploidy and senescence in lens epithelial cells.
    J. Biol. Chem. 2013 Oct 18. [Epub ahead of print]

  3. Murakami H, Ito S, Tanaka H, Kondo E, Kodera Y, Nakanishi H.: Establishment of new intraperitoneal paclitaxel-resistant gastric cancer cell lines and comprehensive gene expression analysis.
    Anticancer Res. 2013 Oct;33(10):4299-307.

  4. Saito K, Takigawa N, Ohtani N, Iioka H, Tomita Y, Ueda R, Fukuoka J, Kuwahara K, Ichihara E, Kiura K and Kondo E.: Anti-tumor impact of p14ARF on gefitinib-resistant non-small cell lung cancers.
    Mol. Cancer Ther. 12:1616-1628, 2013. (※Highlights of the issue.)

2012年

  1. Tcherniuk S, Fiser A-L, Derouazi M, Toussaint B, Wang Y, Wojtal I, Kondo E, Szolajska E, Chroboczek J.: Certain protein transducing agents convert translocated proteins into cell killers.
    Acta Biochimica Polonica 2012;59(3):433-9. Epub 2012 Sep 3.

  2. Karube K, Tsuzuki S, Yoshida N, Arita K, Liu F, Kondo E, Ko YH, Ohshima K, Nakamura S, Kinoshita T, Seto M.: Lineage-specific growth inhibition of NK cell lines by FOXO3 in association with Akt activation status.
    Exp. Hematol. 2012 Aug 21. [Epub ahead of print]

  3. Ohta M, Abe A, Ohno F, Hasegawa Y, Tanaka H, Maseki S, Kondo E, Kurita K, Nakanishi H.: Positive and negative regulation of podoplanin expression by TGF-β and histone deacetylase inhibitors in oral and pharyngeal squamous cell carcinoma cell lines.
    Oral Oncol. 2012 Jul 25. [Epub ahead of print]

  4. Kondo E, Saito K, Tashiro Y, Kamide K, Uno S, Furuya T, Mashita M, Nakajima K, Tsumuraya T, Kobayashi N, Nishibori M, Tanimoto M, Matsushita M.: Tumour lineage-homing cell-penetrating peptides as anticancer molecular delivery systems.
    Nature Commun. 3:951-963, July17, 2012.

  5. Murakami H, Nakanishi H, Tanaka H, Ito S, Misawa K, Ito Y, Ikehara Y, Kondo E and Kodera Y.: Establishment and characterization of novel gastric signet-ring cell and non signet-ring cell, poorly-differentiated adenocarcinoma cell lines with low and high malignant potential.
    Gastric Cancer Mar 27. [Epub ahead of print], 2012.

  6. Maseki S, Ijichi K, Tanaka H, Fujii M, Hasegawa Y, Ogawa T, Murakami S, Kondo E and Nakanishi H.: Acquisition of EMT phenotype in the gefitinib-resistant cells of a head and neck squamous cell carcinoma cell line through Akt/GSK-3β/snail signaling pathway.
    Br. J. Cancer Mar 13 ;106(6):1196-20, 2012.

  7. Fujii M, Toyoda T, Nakanishi H, Yatabe Y, Sato A, Matsudaira Y, Ito H, Murakami H, Kondo Y, Kondo E, Hida T, Tsujimura T, Osada H and Sekido Y.; TGF-・ synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth.
    J. Exp. Med. Mar 12;209(3):479-94. 2012.

  8. 近藤英作, 中島喜一郎.: 「細胞膜透過ペプチドを応用した医療技術展開へのアプローチ」. 遺伝子医学MOOK 21号「最新ペプチド合成技術とその創薬研究への応用」, 2012.

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