教室業績集
Department of Physiology II
 

~2017~


Watabe T, Xu M, Watanabe M, Nabekura J, Higuchi T, Hori K, Sato MP, Nin F, Hibino H, Ogawa K, Masuda M, Tanaka KF.

Time-controllable Nkcc1 knockdown replicates reversible hearing loss in postnatal mice.

Sci Rep, (2017), 7, Article number:13605. Scientific Reports


Sato MP, Higuchi T, Nin F, Ogata G, Sawamura S, Yoshida T, Ota T, Hori K, Komune S, Uetsuka S, Choi S, Masuda M, Watabe T, Kanzaki S, Ogawa K, Inohara H, Sakamoto S, Takebayashi H,  Doi K, Tanaka KF, Hibino H.

Hearing loss controlled by optogenetic stimulation of nonexcitable nonglial cells in the cochlea of the inner ear.

Frontiers in Molecular Neuroscience, (2017), 10(300): 1-16.  Frontiers in Molecular Neuroscience


Ogata G, Ishii Y, Asai K, Sano Y, Nin F, Yoshida T, Higuchi T, Sawamura S, Ota T, Hori K, Maeda K, Komune S, Doi K, Takai M, Findlay I, Kusuhara H, Einaga Y, Hibino H.

A microsensing system for the in vivo real-time detection of local drug kinetics.

Nat Biomed Eng, (2017), 1: 654-666. Nat Biomed Eng, Behind the paper, News & Views


Nin F, Yoshida T, Murakami S, Ogata G, Uetsuka S, Choi S, Doi K, Sawamura S, Inohara H, Komune S, Kurachi Y, Hibino H.

Computer modeling defines the system driving a constant current crucial for homeostasis in the mammalian cochlea by integrating unique ion transports.

npj Systems Biology and Applications, (2017), 3, Article number:24. npj Systems Biology and Applications.


Yoshida T, Sawamura S, Ota T, Higuchi T, Ogata G, Hori K, Nakagawa T, Doi K, Sato MP, Nonomura Y, Horii A, Takahashi S, Komune S, Nin F, Hibino H.

Fibrocytes in the cochlea of the mammalian inner ear: their molecular architecture, physiological properties, and pathological relevance.

Medical Research Archives, (2017), 5(6): 1-16. Medical Research Archives.


Hibino H, Takai M, Noguchi H, Sawamura S, Takahashi Y, Sakai H, Shiku H.

An approach to the research on ion and water properties in the interphase between the plasma membrane and bulk extracellular solution.

J Physiol Sci, (2017), 67(4): 439-445. Pubmed


Choi S, Sato K, Ota T, Nin F, Muramatsu S, Hibino H.

Multifrequency swept optical coherence tomographic vibrometry in biological tissues.

Biomed Opt Express, (2017), 8(2): 608-621. Biomedical Optics Express


~2016~

Nin F, Yoshida T, Sawamura S, Ogata G, Ota T, Higuchi T, Murakami S, Doi K, Kurachi Y, Hibino H.

The unique electrical properties in an extracellular fluid of the mammalian cochlea; their functional roles, homeostatic processes, and pathological significance.

Pfluger Arch Eur J Physiol, (2016), 468(10): 1637-1649. Pubmed


Yoshida T, Nin F, Murakami S, Ogata G, Uetsuka S, Choi S, Nakagawa T, Inohara H, Komune S, Kurachi Y, Hibino H.

The unique ion permeability profile of cochlear fibrocytes and its contribution to establishing their positive resting membrane potential.

Pfluger Arch Eur J Physiol, (2016), 468(9): 1609-1619. Pubmed

*2017/03/22 Nin F, Yoshida T, Hibino H. ‘The positive resting membrane potential of non-excitable fibrocytes in the mammalian cochlea.’

   上記タイトルにてAtlas of Scienceに掲載。Atlas of Science


Miyasaka Y, Suzuki S, Yoshimoto S, Shitara H, Ohshiba Y, Okakura K, Seki Y, Tokano H, Kitamura K, Takada T, Shiroishi T, Hibino H, Kominami R, Yonekawa H, Kikkawa Y.

Heterozygous mutation of Ush1g/Sans in mice causes early-onset hearing loss, which is recovered by reconstituting the strain-specific mutation in Cdh23.

Hum Mol Genet, (2016), 25(10): 2045-2059. Pubmed


~2015~

Choi S, Maruyama Y, Suzuki T, Nin F, Hibino H, Sasaki O.

Wide-field heterodyne detection method for two-dimensional surface vibration measurement.

Optics Communications, (2015), 356: 343-349. Optics Communications


Choi S, Watanabe T, Suzuki T, Nin F, Hibino H, Sasaki O.

Multifrequency swept common-path en-face OCT for wide-field measurement of interior surface vibrations in thick biological tissues.

Optics Express, (2015), 23(16): 21078-21089.  Optics Express


Uetsuka S*, Ogata G*, Nagamori S*, Isozumi N, Nin F, Yoshida T, Komune S, Kitahara T, Kikkawa Y, Inohara H, Kanai Y, Hibino H.

Molecular architecture of the stria vascularis membrane transport system, which is essential for physiological function of the mammalian cochlea.

European Journal of Neuroscience, (2015), 42: 1984-2002. [*: equal contributors] Pubmed

*2016/07/18 World Biomedical Frontiersに掲載。World Biomedical Frontiers


Yoshida T, Nin F, Ogata G, Uetsuka S, Kitahara T, Inohara H, Akazawa K, Komune S, Kurachi Y, Hibino H.

NKCCs in the fibrocytes of the spiral ligament are silent on the unidirectional K+-transport that controls the electrochemical properties in

the mammalian cochlea.

Pfluger Arch Eur J Physiol, (2015), 467(7): 1577-1589. Pubmed


Fujita A, Inanobe A, Hibino H, Nielsen S, Ottersen OP, Kurachi Y. 

Clustering of Kir4.1 at specialized compartments of the lateral membrane in ependymal cells of rat brain. 

Cell Tissue Res, (2015), 359(2): 627-634. Pubmed


~2014~

Yamaguchi S, Tanimoto A, Otsuguro K, Hibino H, Ito S.

Negatively-charged amino acids near and in transient receptor potential (TRP) domain of TRPM4 are one determinant of its Ca2+ sensitivity.

 J Biol Chem, (2014), 289(51): 35265-35282. Pubmed


~2013~

Adachi N, Yoshida T, Nin F, Ogata G, Yamaguchi S, Suzuki T, Komune S, Hisa Y, Hibino H#, Kurachi Y#.

The mechanism underlying maintenance of the endocochlear potential by the K+ -transport system in the fibrocytes of the inner ear.

Journal of Physiology (London), (2013), 591(18): 4459-4472. [#: equal corresponding authors] Pubmed


~2012~

Ogata G, Stradleigh TW, Partida GJ, Ishida AT.

Dopamine and Full-Field Illumination Activate D1 and D2-D5-Type Receptors in Adult Rat Retinal Ganglion Cells.

The Journal of Comparative Neurology, (2012), 520(17): 4032–4049. Pubmed


Partida GJ, Stradleigh TW, Ogata G, Godzdanker I, Ishida AT.

Thy1 associates with the cation channel subunit HCN4 in adult rat retina.

Invest Ophthalmol Vis Sci, (2012), 53(3): 1696-1703. Pubmed


Nin F, Reichenbach T, Fisher J, Hudspeth AJ.

Contribution of active hair bundle motility to nonlinear amplification in the mammalian cochlea.

Proc Natl Acad Sci USA, (2012), 109(51): 21076-21080. Pubmed


Fisher J, Nin F, Reichenbach T, Uthaiah R, Hudspeth AJ.

The special pattern of cochlear amplification.

Neuron, (2012), 76(5): 989-997. Pubmed


Nin F, Hibino H#, Murakami S, Suzuki T, Hisa Y, Kurachi Y#.

A computational model of a circulation current that controls electrochemical properties in the mammalian cochlea.

Proc Natl Acad Sci USA, (2012), 109(23): 9191-9196. [#: equal corresponding authors] Pubmed


Reichenbach T, Stefanovic A, Nin F, Hudspeth AJ.

Waves on Reissner’s membrane: A mechanism for the propagation of otoacoustic emissions from the cochlea.

Cell Reports, (2012), 1(4), 374-384. Pubmed


~2011~

Stradleigh TW, Ogata G, Partida GJ, Oi H, Greenberg KP, Krempely KS, Ishida AT.

Colocalization of HCN channel subunits in rat retinal ganglion cells.

The Journal of Comparative Neurology, (2012), 519(13): 2546–2573. Pubmed


長谷川功、赤石隆夫(2011)

発言ポイント制の導入による双方向性授業システム、

新潟大学教育研究年報16


香田徹、日比野浩、任書晃、倉智嘉久、入野俊夫、鵜木祐史、鈴木陽一、牧勝弘、津崎実、森周司、(編集者 香田・森)

日本音響学会 内耳有毛細胞機能の分子生物学的基盤とそのモデル 

音響サイエンスシリーズ3「聴覚モデル」 58-100, 2011 コロナ社, 東京(233頁)


~2010~

Ogata G, Natsume K, Ishizuka S, Hayashi H.

The spike-timing-dependent plasticity function based on a brain sequential lerning system using a recurrent neuronal network.

JAMRIS special issue, (2010), 4(2): 25-30. JAMRIS


Hibino H, Nin F, Tsuzuki C, Kurachi Y.

How is the highly positive endocochlear potential formed? The specific architecture of the stria vascularis and the roles of the ion-transport apparatus.

Pflugers Arch - Eur J Physiol, (2010), 459(4): 521-533. Pubmed


Hibino H, Inanobe A, Furutani K, Murakami S, Findlay I, Kurachi Y.

Inwardly rectifying potassium channels: their structure, function and physiological roles.

Physiol Rev, (2010), 90(1): 291-366.  Pubmed


~2009~

Hayashida Y*, Varela Rodríguez C*, Ogata G*, Partida GJ*, Oi H, Stradleigh TW, Lee SC, Felipe Colado A, Ishida AT.

Inhibition of adult rat retinal ganglion cells by D1-type dopamine receptor activation,

Journal of Neuroscience, (2009), 29(47) : 15001-15016. Pubmed


山口賢一、山田貴穂、長谷川功

前脳GABAA受容体とバゾプレッシン分泌

生体の科学 60(5): 378-379,2009.


~2008~

Yamaguchi K, Yamada T.

Roles of forebrain GABA receptors in controlling vasopressin secretion and related phenomena under basal and hyperosmotic circumstances in conscious rats.

Brain Research Bulletin, (2008), 77(1): 61-69. Pubmed


Nin F*, Hibino H*, Doi K, Suzuki T, Hisa Y, Kurachi Y.

The endocochlear potential depends on two K+ diffusion potentials and an electrical barrier in the stria vascularis of the inner ear.

Proc Natl Acad Sci USA, (2008), 105(5):1751-1756. [*: equal contributors] Pubmed


~2007~

Hibino H, Kurachi Y.

Distinct detergent-resistant membrane microdomains (lipid-rafts) respectively harvest K+ and water transport systems in brain astroglia.

Eur J Neurosci, (2007), 26(9):2539-2555. Pubmed


~2006~

Ogata G, Natsume K.

Synchronization process of neurons depends on giant EPSP of hippocampal pyramidal cells,

Journal of Signal Processing, RISP, (2006), 10(6): 399-406. JSP


Ogata G, Natsume K.

Dependence of neuronal synchronization process on the giant EPSP pattern of hippocampal pyramidal cells,

Journal of Signal Processing, RISP, (2006), 10(4): 239-242. JSP


Yamaguchi K, Yamada T.

Involvement of anteroventral third ventricular AMPA/kainate receptors in both hyperosmotic and hypovolemic AVP secretion in conscious rats.

Brain Research Bulletin, (2006), 71(2): 183-192. Pubmed


Hibino H, Kurachi Y.

Molecular and physiological bases of the K+ circulation in the mammalian inner ear.

Physiology (Bethesda), (2006), 21:336-345. Pubmed


Shibata T, Hibino H, Doi K, Suzuki T, Hisa Y, Kurachi Y.

Gastric type H+,K+-ATPase in the cochlear lateral wall is critically involved in formation of the endocochlear potential.

Am J Physiol; Cell Physiol, (2006), 291(5):C1038-1048. Pubmed


~2005~

Yamaguchi K, Watanabe K.

Anteroventral third ventricular N-methyl-D-aspartate receptors, but not metabotropic glutamate receptors are involved in hemorrhagic AVP secretion.

Brain Research Bulletin, (2005), 66(1): 59-69.


~2004~

Ogata G, Yoshimatsu S, Natsume K.

Involvement of intracellular Ca2+/Calmodulin kinase activation network in the induction of bicuculline-induced epileptic

discharges in hippocampal slices and Brain informatics simulator HIPPO-STATION,

International Congress Series, (2004), Vol. 1269, Brain-Inspired IT I, ELSEVIER, pp. 81-84.


Yamaguchi K, Watanabe K.

Pursuit of roles for metabotropic glutamate receptors in the anteroventral third ventricular region in regulating vasopressin secretion and cardiovascular function in conscious rats.

Brain Research Bulletin, (2004), 63(4): 321-329. 


Lesage F*, Hibino H*, Hudspeth AJ.

Association of β-catenin with the α subunit of neuronal large-conductance Ca2+ activated K+ channels.

Proc Natl Acad Sci USA, (2004), 101(2):671-675. [*: equal contributors]


~2003~

Yamaguchi K, Hama H.

A study on the mechanism by which sodium nitroprusside, a nitric oxide donor, applied to the anteroventral third ventricular region provokes facilitation of vasopressin secretion in conscious rats.

Brain Research, (2003), 968: 35-43


Hibino H, Pironkova R, Onwumere O, Rousset M, Charnet P, Hudspeth AJ, Lesage F.

Direct interaction with a nuclear protein and regulation of gene silencing by a variant of the Ca2+ channel β4 subunit.

Proc Natl Acad Sci USA, (2003), 100(1): 307-312.


~2002~

Akaishi T.

Scrotal skin temperature affects the activity of the hypothalamic magnocellular neurons in the rat.

Acta Medica et Biologica, (2002), 50 pp.171-176.


Yamaguchi K, Watanabe K.

Contribution of N-methyl-D-aspartate receptors in the anteroventral third ventricular region to vasopressin secretion, but not to cardiovascular responses  provoked by hyperosmolality and prostaglandin E2 in conscious rats.

Brain Research Bulletin, (2002), 58 (3): 301-309.


Hibino H, Pironkova R, Onwumere O, Vologodskaia M, Hudspeth AJ, Lesage F.

RIM-binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage gated Ca2+ channels.

Neuron, (2002), 34(3): 411-423.


~2000~

Hibino H, Inanobe A, Tanemoto M, Fujita A, Doi K, Kubo T, Hata Y, Takai Y, Kurachi Y.

Anchoring proteins confer G protein-sensitivity to an inward-rectifier K+ channel through GK domain.

EMBO J, (2000), 19(1): 78-83.


~1999~

Akaishi T. & Homma S.

Responses to osmotic stimulation of putative vasopressin and oxytocin neurons in supraoptic nucleus of ovariectomized rats.

Acta Medica et Biologica, (1999), 47: 1-8


Hibino H, Horio Y, Fuijta A, Inanobe A, Doi K, Gotow T, Uchiyama Y, Kubo T, Kurachi Y.

Expression of an inwardly rectifying K+ channel, Kir4.1, in the satellite cells of rat cochlear ganglia.

Am J Physiol; Cell Physiol, (1999), 277(4): C638-C644.


~1997~

Hibino H, Horio Y, Inanobe A, Doi K, Ito M, Yamada M, Gotow T, Uchiyama Y, Kawamura M, Kubo T, Kurachi Y.

An ATP-dependent inwardly rectifying potassium channel, KAB-2 (Kir4.1), in cochlear stria vascularis of inner ear: its specific subcellular localization and correlation with the formation of endocochlear potential.

J Neurosci, (1997), 17(12):4711-4721.


~1992~

Akaishi T & Homma S.

Hypothalamic osmoregulation for vasopressin release in streptozotocin-diabetic rats in vivo and in vitro.

Brain Research, (1992), 569: 86-92.


~1990~

Akaishi T & Sakuma Y.

Estrogen induced moduration of hypothalamic osmoregulation in the female rat.

Am. J. Physiol (Reg. Integ. Comp. Physiol.), (1990), 258: R924-929


山口 賢一  第9章「レニン・アンギオテンシン」

廣重力、佐藤昭夫編 「新生理科学大系第20巻.内分泌・自律機能調節の生理学」,

医学書院, 総頁 460頁中 108~122頁を担当, 1990.5