{"id":4712,"date":"2021-07-07T11:59:25","date_gmt":"2021-07-07T02:59:25","guid":{"rendered":"http:\/\/www.med.niigata-u.ac.jp\/pub\/?p=4712"},"modified":"2021-07-07T18:07:48","modified_gmt":"2021-07-07T09:07:48","slug":"%e8%ab%96%e6%96%87%e3%81%8c%e5%85%ac%e9%96%8b%e3%81%95%e3%82%8c%e3%81%be%e3%81%97%e3%81%9f%ef%bc%88%e9%95%b7%e7%94%b0%e7%a7%80%e5%92%8c%e5%85%88%e7%94%9f%ef%bc%89","status":"publish","type":"post","link":"http:\/\/www.med.niigata-u.ac.jp\/pub\/2021\/07\/07\/%e8%ab%96%e6%96%87%e3%81%8c%e5%85%ac%e9%96%8b%e3%81%95%e3%82%8c%e3%81%be%e3%81%97%e3%81%9f%ef%bc%88%e9%95%b7%e7%94%b0%e7%a7%80%e5%92%8c%e5%85%88%e7%94%9f%ef%bc%89\/","title":{"rendered":"\u30d0\u30ed\u30ad\u30b5\u30d3\u30ebPA\u5909\u7570\u682a\u306e\u691c\u51fa\u6cd5\u306b\u3064\u3044\u3066\u306e\u8ad6\u6587\u304c\u516c\u958b\u3055\u308c\u307e\u3057\u305f\uff08\u9577\u7530\u79c0\u548c\u5148\u751f\uff09"},"content":{"rendered":"<p><a href=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2021\/07\/HP_\u30a2\u30a4\u30ad\u30e3\u30c3\u30c1\u753b\u50cf.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-4718\" src=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2021\/07\/HP_\u30a2\u30a4\u30ad\u30e3\u30c3\u30c1\u753b\u50cf-600x115.jpg\" alt=\"\" width=\"600\" height=\"115\" srcset=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2021\/07\/HP_\u30a2\u30a4\u30ad\u30e3\u30c3\u30c1\u753b\u50cf-600x115.jpg 600w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2021\/07\/HP_\u30a2\u30a4\u30ad\u30e3\u30c3\u30c1\u753b\u50cf.jpg 681w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/p>\n<p>\u9577\u7530\u79c0\u548c\u5148\u751f\u306e\u8ad6\u6587\u304c\u3001Antiviral Research\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u30d0\u30ed\u30ad\u30b5\u30d3\u30eb\u6295\u4e0e\u5f8c\u306b\u4e00\u5b9a\u7a0b\u5ea6\u51fa\u73fe\u3059\u308bPA\u5909\u7570\u682a\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0PCR\u3067\u8fc5\u901f\u306b\u691c\u51fa\u3059\u308b\u65b9\u6cd5\u306b\u3064\u3044\u3066\u306e\u8ad6\u6587\u3067\u3059\u3002<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33577807\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33577807\/<\/a><\/p>\n<div id=\"abstract\" class=\"abstract\">\n<h2 class=\"title\">Abstract<\/h2>\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<p>Baloxavir marboxil has been used for influenza treatment since March 2018 in Japan. After baloxavir treatment, the most frequently detected substitution is Ile38Thr in polymerase acidic protein (PA\/I38T), and this substitution reduces baloxavir susceptibility in influenza A viruses. To rapidly investigate the frequency of PA\/I38T in influenza A (H1N1)pdm09 and A (H3N2) viruses in clinical samples, we established a rapid real-time system to detect single nucleotide polymorphisms in PA, using cycling probe real-time PCR. We designed two sets of probes that were labeled with either 6-carboxyfluorescein (FAM) or 6-carboxy-X-rhodamine (ROX) to identify PA\/I38 (wild type strain) or PA\/I38T, respectively. The established cycling probe real-time PCR system showed a dynamic linear range of 10<sup>1<\/sup> to 10<sup>6<\/sup> copies with high sensitivity in plasmid DNA controls. This real-time PCR system discriminated between PA\/I38T and wild type viruses well. During the 2018\/19 season, 377 influenza A-positive clinical samples were collected in Japan before antiviral treatment. Using our cycling probe real-time PCR system, we detected no (0\/129, 0.0%) influenza A (H1N1)pdm09 viruses with PA\/I38T substitutions and four A (H3N2) (4\/229, 1.7%) with PA\/I38T substitution prior to treatment. In addition, we found PA\/I38T variant in siblings who did not received baloxavir treatment during an infection caused by A (H3N2) that afflicted the entire family. Although human-to-human transmission of PA\/I38T variant may have occurred in a closed environment, the prevalence of this variant in influenza A viruses was still limited. Our cycling probe-PCR system is thus useful for antiviral surveillance of influenza A viruses possessing PA\/I38T.<\/p>\n<\/div>\n<p><strong class=\"sub-title\"> Keywords: <\/strong> Antiviral susceptibility; Baloxavir marboxil; Cycling probe real-time PCR; Influenza virus; PA\/I38T substitution.<\/p>\n<\/div>\n<p id=\"copyright\" class=\"copyright\">Copyright \u00a9 2021 Elsevier B.V. All rights reserved.<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2021\/07\/\u9577\u7530\u5148\u751f\u8ad6\u6587.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-4753\" src=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2021\/07\/\u9577\u7530\u5148\u751f\u8ad6\u6587-566x600.jpg\" alt=\"\" width=\"566\" height=\"600\" srcset=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2021\/07\/\u9577\u7530\u5148\u751f\u8ad6\u6587-566x600.jpg 566w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2021\/07\/\u9577\u7530\u5148\u751f\u8ad6\u6587.jpg 737w\" sizes=\"auto, (max-width: 566px) 100vw, 566px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u9577\u7530\u79c0\u548c\u5148\u751f\u306e\u8ad6\u6587\u304c\u3001Antiviral Research\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002 \u30d0\u30ed\u30ad\u30b5\u30d3\u30eb\u6295\u4e0e\u5f8c\u306b\u4e00\u5b9a\u7a0b\u5ea6\u51fa\u73fe\u3059\u308bPA\u5909\u7570\u682a\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0PCR\u3067\u8fc5\u901f\u306b\u691c\u51fa\u3059\u308b\u65b9\u6cd5\u306b\u3064\u3044\u3066\u306e\u8ad6\u6587\u3067\u3059\u3002 https:\/\/pubmed.nc<a href=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/2021\/07\/07\/%e8%ab%96%e6%96%87%e3%81%8c%e5%85%ac%e9%96%8b%e3%81%95%e3%82%8c%e3%81%be%e3%81%97%e3%81%9f%ef%bc%88%e9%95%b7%e7%94%b0%e7%a7%80%e5%92%8c%e5%85%88%e7%94%9f%ef%bc%89\/\"> &#8230;\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":4718,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1,3],"tags":[],"class_list":["post-4712","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-blog"],"jetpack_featured_media_url":"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2021\/07\/HP_\u30a2\u30a4\u30ad\u30e3\u30c3\u30c1\u753b\u50cf.jpg","jetpack_shortlink":"https:\/\/wp.me\/ph72WZ-1e0","jetpack-related-posts":[{"id":6246,"url":"http:\/\/www.med.niigata-u.ac.jp\/pub\/2024\/10\/17\/2022-2023%e5%b9%b4%e3%82%b7%e3%83%bc%e3%82%ba%e3%83%b3%e3%81%ae%e6%97%a5%e6%9c%ac%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%82%a4%e3%83%b3%e3%83%95%e3%83%ab%e3%82%a8%e3%83%b3%e3%82%b6%e3%82%b5%e3%83%bc-2\/","url_meta":{"origin":4712,"position":0},"title":"2022-2023\u5e74\u30b7\u30fc\u30ba\u30f3\u306e\u65e5\u672c\u306b\u304a\u3051\u308b\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30b5\u30fc\u30d9\u30a4\u30e9\u30f3\u30b9\uff082024\u5e7410\u670817\u65e5\u66f4\u65b0\uff09","author":"public-health","date":"2024\u5e7410\u670817\u65e5","format":false,"excerpt":"2022-2023\u5e74\u30b7\u30fc\u30ba\u30f3\u306e\u65e5\u672c\u306b\u304a\u3051\u308b\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u6d41\u884c\u682a\u3068\u6297\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u85ac\u611f\u53d7\u6027\u4f4e\u4e0b\u682a\u8abf\u67fb\u306e\u2026","rel":"","context":"What\u2019s 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