{"id":5781,"date":"2022-11-04T16:42:11","date_gmt":"2022-11-04T07:42:11","guid":{"rendered":"http:\/\/www.med.niigata-u.ac.jp\/pub\/?p=5781"},"modified":"2022-11-04T16:42:11","modified_gmt":"2022-11-04T07:42:11","slug":"%e3%80%90%e8%ab%96%e6%96%87%e3%80%91%e6%88%91%e5%a6%bb%e3%81%95%e3%82%93%ef%bc%9aduration-of-fever-and-symptoms-in-influenza-infected-children-treated-with-baloxavir-marboxil-during-the-2019-2","status":"publish","type":"post","link":"http:\/\/www.med.niigata-u.ac.jp\/pub\/2022\/11\/04\/%e3%80%90%e8%ab%96%e6%96%87%e3%80%91%e6%88%91%e5%a6%bb%e3%81%95%e3%82%93%ef%bc%9aduration-of-fever-and-symptoms-in-influenza-infected-children-treated-with-baloxavir-marboxil-during-the-2019-2\/","title":{"rendered":"\u3010\u8ad6\u6587\u3011\u6211\u59bb\u3055\u3093\uff1aDuration of fever and symptoms in influenza-infected children treated with baloxavir marboxil during the 2019\u20132020 season in Japan and detection of influenza virus with the PA E23K substitution."},"content":{"rendered":"<p>\u5927\u5b66\u9662\u751f\u306e\u6211\u59bb\u594e\u592a\u3055\u3093\u306e\u8ad6\u6587\u306e\u7d39\u4ecb\u3067\u3059\u3002<\/p>\n<p>Wagatsuma, K., R. Saito, I. Chon, W. W. Phyu, K. Fujio, T. Kawashima, I. Sato, T. Saito, M. Minato, N. Kodo, E. Suzuki, Y. Ono, H. Masaki, Y. Shirahige, A. Kitano, H. Hamabata, S. Yuyang, L. Jiaming &amp; H. Watanabe.<\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0166354222000791\">Duration of fever and symptoms in influenza-infected children treated with baloxavir marboxil during the 2019\u20132020 season in Japan and detection of influenza virus with the PA E23K substitution.<\/a><\/p>\n<p>Antiviral Res. 2022 May;201:105310. doi: 10.1016\/j.antiviral.2022.105310; PMID:\u00a035358601<\/p>\n<p>2019-20\u5e74\u30b7\u30fc\u30ba\u30f3\u306e\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u60a3\u8005\u3055\u3093\u3067\u3001\u6297\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u85ac\u3067\u3042\u308b\u30d0\u30ed\u30ad\u30b5\u30d3\u30eb\u3068\u30aa\u30bb\u30eb\u30bf\u30df\u30d3\u30eb\u306e\u6cbb\u7642\u52b9\u679c\u306b\u3064\u3044\u3066\u6bd4\u8f03\u3057\u3001\u3055\u3089\u306b\u30d0\u30ed\u30ad\u30b5\u30d3\u30eb\u3068\u30ce\u30a4\u30e9\u30df\u30cb\u30c0\u30fc\u30bc\u963b\u5bb3\u5264\u306b\u5bfe\u3059\u308b\u8010\u6027\u682a\uff08\u85ac\u5264\u611f\u53d7\u6027\u4f4e\u4e0b\u682a\uff09\u3092\u691c\u7d22\u3057\u307e\u3057\u305f<\/p>\n<p><a href=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2022\/11\/1-s2.0-S0166354222000791-gr2_lrg-scaled.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-medium wp-image-5782\" src=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2022\/11\/1-s2.0-S0166354222000791-gr2_lrg-533x600.jpg\" alt=\"\" width=\"533\" height=\"600\" srcset=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2022\/11\/1-s2.0-S0166354222000791-gr2_lrg-533x600.jpg 533w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2022\/11\/1-s2.0-S0166354222000791-gr2_lrg-909x1024.jpg 909w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2022\/11\/1-s2.0-S0166354222000791-gr2_lrg-768x865.jpg 768w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2022\/11\/1-s2.0-S0166354222000791-gr2_lrg-1364x1536.jpg 1364w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2022\/11\/1-s2.0-S0166354222000791-gr2_lrg-1819x2048.jpg 1819w\" sizes=\"auto, (max-width: 533px) 100vw, 533px\" \/><\/a><\/p>\n<p>Highlights<br \/>\n\u2022An observational study compared fever and symptom duration between baloxavir- and oseltamivir-treated influenza patients.<\/p>\n<p>\u2022Children (n = 159, aged &lt;19 years) infected with A(H1N1)pdm09 or B\/Victoria-lineage during 2019\u20132020 in Japan were analyzed.<\/p>\n<p>\u2022Fever duration was likely shorter with baloxavir than oseltamivir, with no clear differences between the two groups.<\/p>\n<p>\u2022No patients with polymerase acidic (PA) protein-substituted viruses were identified prior to baloxavir treatment.<\/p>\n<p>\u2022One case (1.5%) of A(H1N1)pdm09 with a PA\/E23K substitution was detected after baloxavir treatment.<\/p>\n<p>&nbsp;<\/p>\n<p>-\u89b3\u5bdf\u7814\u7a76\u306b\u3088\u308a\u3001\u30d0\u30ed\u30ad\u30b5\u30d3\u30eb\u3068\u30aa\u30bb\u30eb\u30bf\u30df\u30d3\u30eb\u3092\u6295\u4e0e\u3057\u305f\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u60a3\u8005\u306e\u767a\u71b1\u3068\u75c7\u72b6\u306e\u6301\u7d9a\u6642\u9593\u3092\u6bd4\u8f03\u3057\u305f\u3002<\/p>\n<p>-2019\uff5e2020\u5e74\u306b\u65e5\u672c\u3067A(H1N1)pdm09\u307e\u305f\u306fB\/\u30d3\u30af\u30c8\u30ea\u30a2\u7cfb\u306b\u611f\u67d3\u3057\u305f\u5c0f\u5150\uff08n=159\u300119\u6b73\u672a\u6e80\uff09\u3092\u89e3\u6790\u5bfe\u8c61\u3068\u3057\u305f\u3002<\/p>\n<p>-\u767a\u71b1\u671f\u9593\u306f\u30aa\u30bb\u30eb\u30bf\u30df\u30d3\u30eb\u3088\u308a\u30d0\u30ed\u30ad\u30b5\u30d3\u30eb\u306e\u65b9\u304c\u77ed\u304b\u3063\u305f\u3068\u601d\u308f\u308c\u3001\u4e21\u7fa4\u9593\u306b\u660e\u78ba\u306a\u5dee\u306f\u306a\u304b\u3063\u305f\u3002<\/p>\n<p>-\u30d0\u30ed\u30ad\u30b5\u30d3\u30eb\u6295\u4e0e\u524d\u306b\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u9178\u6027\uff08PA\uff09\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5909\u7570\u3057\u305f\u30a6\u30a4\u30eb\u30b9\u3092\u6709\u3059\u308b\u60a3\u8005\u306f\u78ba\u8a8d\u3055\u308c\u306a\u304b\u3063\u305f\u3002<\/p>\n<p>-\u30d0\u30ed\u30ad\u30b5\u30d3\u30eb\u6295\u4e0e\u5f8c\u306bPA\/E23K\u5909\u7570\u3092\u6709\u3059\u308bA(H1N1)pdm09\u304c1\u4f8b\uff081.5\uff05\uff09\u691c\u51fa\u3055\u308c\u305f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5927\u5b66\u9662\u751f\u306e\u6211\u59bb\u594e\u592a\u3055\u3093\u306e\u8ad6\u6587\u306e\u7d39\u4ecb\u3067\u3059\u3002 Wagatsuma, K., R. Saito, I. Chon, W. W. Phyu, K. Fujio, T. Kawashima, I. Sato, T. Saito, <a href=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/2022\/11\/04\/%e3%80%90%e8%ab%96%e6%96%87%e3%80%91%e6%88%91%e5%a6%bb%e3%81%95%e3%82%93%ef%bc%9aduration-of-fever-and-symptoms-in-influenza-infected-children-treated-with-baloxavir-marboxil-during-the-2019-2\/\"> &#8230;\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":5782,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1,3],"tags":[],"class_list":["post-5781","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-blog"],"jetpack_featured_media_url":"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2022\/11\/1-s2.0-S0166354222000791-gr2_lrg-scaled.jpg","jetpack_shortlink":"https:\/\/wp.me\/ph72WZ-1vf","jetpack-related-posts":[{"id":5552,"url":"http:\/\/www.med.niigata-u.ac.jp\/pub\/2022\/03\/28\/2022%e3%80%80%e8%8b%b1%e6%96%87international-journal\/","url_meta":{"origin":5781,"position":0},"title":"2022\u3000\u82f1\u6587International Journal","author":"public-health","date":"2022\u5e743\u670828\u65e5","format":false,"excerpt":"Wagatsuma K, Yoshioka S, Yamazaki S, Sato R, WW Ph\u2026","rel":"","context":"What\u2019s New","block_context":{"text":"What\u2019s New","link":"http:\/\/www.med.niigata-u.ac.jp\/pub\/category\/news\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":6096,"url":"http:\/\/www.med.niigata-u.ac.jp\/pub\/2024\/01\/18\/2024%e3%80%80%e8%8b%b1%e6%96%87international-journal\/","url_meta":{"origin":5781,"position":1},"title":"2024\u3000\u82f1\u6587International Journal","author":"public-health","date":"2024\u5e741\u670818\u65e5","format":false,"excerpt":"Keita Wagatsuma. 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