![\"\"](\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/02\/21-22_\u30b9\u30e9\u30a4\u30c93-600x262.jpg\")
<\/a><\/p>\nHA\u907a\u4f1d\u5b50\u306e\u89e3\u6790\u306e\u7d50\u679c\u3001\u3053\u306e4\u4ef6\u306e\u30a6\u30a4\u30eb\u30b9\u306fWHO\u30af\u30ec\u30fc\u30c93C.2a1b.2a.2\u306b\u5c5e\u3057\u30012022\/23\u5e74\u5317\u534a\u7403\u30ef\u30af\u30c1\u30f3\u682aA\/Darwin\/6\/2021\u3068\u907a\u4f1d\u5b50\u7684\u306b\u8fd1\u7e01\u306e\u30a6\u30a4\u30eb\u30b9\u3067\u3057\u305f\u30022022\u5e748\u6708\u9803\u306b\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u3067\u6d41\u884c\u3057\u305f\u30a6\u30a4\u30eb\u30b9\u3068\u3082\u975e\u5e38\u306b\u8fd1\u3044HA\u907a\u4f1d\u5b50\u914d\u5217\u3092\u6301\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n
Abstract: Four A\/H3N2 detected during the 2021\/22 season were all susceptible to anti-influenza drugs, baloxavir and neuraminidase inhibitors.<\/p>\n
Results of the 2021\/2022 Influenza Anti-Influenza Drug Susceptibility Investigation conducted by Division of International Health, Niigata University are reported.<\/p>\n
From October 2021 to the end of September 2022, 14 medical facilities nationwide participated to the study, we and received a total of 16 samples from influenza-like illness patients. Only pre-treatment samples were collected and no second visit samples after treatment were received.Firstly SARS-CoV-2 was screened by Real-time PCR, and then influenza was detected using real-time PCR and viral isolation.As a result, four cases of influenza A (4\/16, 25%) were detected, all of which were A\/H3N2.No influenza A\/H1N1pdm09 or B was detected.<\/p>\n
SARS-CoV-2 were detected in 7 of the 12 cases collected from January to March 2022.Four samples collected from July to early August 2022 turned out to be influenza A\/H3N2.<\/p>\n
Next-generation sequencing was performed on the clinical specimens from the four cases that were determined to be A\/H3N2, and a whole-virus sequencing analysis was implemented.No substitutions in polymerase gene (PA\/E23K, PA\/I38X, etc.) causing decreased susceptibility to baloxavir were found in any of the four A\/H3N2 viruses, suggesting that they were susceptible to baloxavir.No substations in neuraminidase gene (NA\/Q136K, NA\/N294S, NA\/R292K, etc.) causing decreased susceptibility to neuraminidase inhibitors were not observed in any of the four A\/H3N2 viruses, suggesting that they are also susceptible to neuraminidase inhibitors.<\/p>\n
As a result, the number of viruses that confer reduced susceptibility was 0.0% (0\/4) for both baloxavir and neuraminidase inhibitors.<\/p>\n
HA gene analysis showed that the four A\/H3N2 viruses belonged to WHO clade 3C.2a1b.2a.2 and were genetically related to the 2022\/23 Northern Hemisphere vaccine strain A\/Darwin\/6\/2021. They are also very similar to the viruses that circulated in Australia around August 2022.<\/p>\n","protected":false},"excerpt":{"rendered":"
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…\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":5847,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1,3,11],"tags":[],"class_list":["post-5843","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-blog","category-influenzasearch"],"jetpack_featured_media_url":"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/02\/21-22_\u30b9\u30e9\u30a4\u30c92.jpg","jetpack_shortlink":"https:\/\/wp.me\/ph72WZ-1wf","jetpack-related-posts":[{"id":6294,"url":"http:\/\/www.med.niigata-u.ac.jp\/pub\/2025\/01\/23\/2024-2025%e5%b9%b4%e3%82%b7%e3%83%bc%e3%82%ba%e3%83%b3%e3%81%ae%e6%97%a5%e6%9c%ac%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%82%a4%e3%83%b3%e3%83%95%e3%83%ab%e3%82%a8%e3%83%b3%e3%82%b6%e6%b5%81%e8%a1%8c\/","url_meta":{"origin":5843,"position":0},"title":"2025\u5e741\u670817\u65e5\u3000\u6297\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u5264\u611f\u53d7\u6027\u4f4e\u4e0b\u682a\u8abf\u67fb\u306e\u7d50\u679c","author":"public-health","date":"2025\u5e741\u670823\u65e5","format":false,"excerpt":"2024-2025\u5e74\u30b7\u30fc\u30ba\u30f3\u306e\u65e5\u672c\u306b\u304a\u3051\u308b\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u6d41\u884c\u682a\u3068\u6297\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u85ac\u611f\u53d7\u6027\u4f4e\u4e0b\u682a\u8abf\u67fb\u306e\u2026","rel":"","context":"What\u2019s 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