{"id":5916,"date":"2023-05-02T13:43:59","date_gmt":"2023-05-02T04:43:59","guid":{"rendered":"http:\/\/www.med.niigata-u.ac.jp\/pub\/?p=5916"},"modified":"2023-05-02T13:43:59","modified_gmt":"2023-05-02T04:43:59","slug":"2023%e5%b9%b44%e6%9c%8828%e6%97%a5%e3%80%80%e6%8a%97%e3%82%a4%e3%83%b3%e3%83%95%e3%83%ab%e3%82%a8%e3%83%b3%e3%82%b6%e5%89%a4%e6%84%9f%e5%8f%97%e6%80%a7%e4%bd%8e%e4%b8%8b%e6%a0%aa%e8%aa%bf%e6%9f%bb","status":"publish","type":"post","link":"http:\/\/www.med.niigata-u.ac.jp\/pub\/2023\/05\/02\/2023%e5%b9%b44%e6%9c%8828%e6%97%a5%e3%80%80%e6%8a%97%e3%82%a4%e3%83%b3%e3%83%95%e3%83%ab%e3%82%a8%e3%83%b3%e3%82%b6%e5%89%a4%e6%84%9f%e5%8f%97%e6%80%a7%e4%bd%8e%e4%b8%8b%e6%a0%aa%e8%aa%bf%e6%9f%bb\/","title":{"rendered":"2023\u5e744\u670828\u65e5\u3000\u6297\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u5264\u611f\u53d7\u6027\u4f4e\u4e0b\u682a\u8abf\u67fb\u306e\u7d50\u679c"},"content":{"rendered":"<p>\u7d50\u679c\u306b\u3064\u3044\u3066<\/p>\n<p>2022\/23 \u30b7\u30fc\u30ba\u30f3\u4e2d\u306b\u30012023 \u5e74 4 \u6708 20 \u65e5\u6642\u70b9\u3067\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u69d8\u75be\u60a3\u60a3\u8005\u304b\u3089\u63a1\u53d6\u3055\u308c\u305f\u30b5\u30f3\u30d7\u30eb\u306f\u4ee5\u4e0b\u306e\u3068\u304a\u308a\u3067\u3059\u3002<\/p>\n<p>\u65e5\u672c\u306e\u5168\u56fd\u3068\u6c96\u7e04\u304b\u3089\u3001\u521d\u8a3a\u6642\u3067199\u4ef6\u306e\u30b5\u30f3\u30d7\u30eb\u3001\u518d\u8a3a\u6642\u306761\u4ef6\u306e\u30b5\u30f3\u30d7\u30eb\u3001\u30d0\u30ed\u30ad\u30b5\u30d3\u30eb\u6295\u4e0e\u5f8c\u306b40\u4ef6\u306e\u30b5\u30f3\u30d7\u30eb\u304c\u53ce\u96c6\u3055\u308c\u307e\u3057\u305f\uff08\u88681\uff09\u3002<a href=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_1-cropped.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-medium wp-image-5911\" src=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_1-cropped-600x288.jpg\" alt=\"\" width=\"600\" height=\"288\" srcset=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_1-cropped-600x288.jpg 600w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_1-cropped-1024x492.jpg 1024w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_1-cropped-768x369.jpg 768w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_1-cropped-1536x737.jpg 1536w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_1-cropped.jpg 1908w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/p>\n<p>\u30b5\u30a4\u30af\u30ea\u30f3\u30b0\u30d7\u30ed\u30fc\u30d6\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0PCR \u306b\u3088\u308b PA\/I38T \u5909\u7570\u306e\u691c\u51fa\u7d50\u679c\u3092\u4ee5\u4e0b\u306b\u793a\u3057\u307e\u3059 (\u8868 2)\u3002<a href=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-medium wp-image-5912\" src=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_2-600x450.jpg\" alt=\"\" width=\"600\" height=\"450\" srcset=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_2-600x450.jpg 600w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_2-1024x768.jpg 1024w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_2-768x576.jpg 768w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_2-1536x1152.jpg 1536w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_2.jpg 2000w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/p>\n<p>PA\/I38T\u5909\u7570\u304c\u3042\u3063\u305f\u75c7\u4f8b\u306e\u5272\u5408\u306f\u6b21\u306e\u3068\u304a\u308a\u3067\u3059\u3002<\/p>\n<p>A(H1N1)pdm09 \u3067\u306f\u30011 \u4ef6\u4e2d\u3001\u30d0\u30ed\u30ad\u30b5\u30d3\u30eb\u6295\u4e0e\u524d\u53ca\u3073\u5f8c\u306e\u30b5\u30f3\u30d7\u30eb\u3067 PA\/I38T \u5909\u7570\u306f\u691c\u51fa\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f (0.0%)\u3002 A(H3N2) \u3067\u306f\u3001\u6295\u4e0e\u524d\u306e\u30b5\u30f3\u30d7\u30eb\u306e\u3046\u3061\u3001176\u4ef6\u4e2d 1 \u4ef6(0.6%)\u3067PA\/I38\u5909\u7570\u304c\u691c\u51fa\u3055\u308c\u307e\u3057\u305f\u3002 \u30d0\u30ed\u30ad\u30b5\u30d3\u30eb\u6cbb\u7642\u5f8c\u306e\u30b5\u30f3\u30d7\u30eb\u3067\u306f\u300138 \u4ef6\u4e2d 3 \u4ef6\u304b\u3089 PA\/I38T \u5909\u7570(7.9%) \u304c\u691c\u51fa\u3055\u308c\u307e\u3057\u305f\u3002 \u518d\u8a3a\u6642\u306eRT-PCR\u967d\u6027\u4ef6\u6570\u306b\u57fa\u3065\u3044\u3066\u983b\u5ea6\u3092\u8a08\u7b97\u3059\u308b\u3068\u300117.6\uff05\u306b\u306a\u308a\u307e\u3057\u305f\uff08\u518d\u8a3a\u6642\u306e17\u4ef6\u306eRT-PCR\u967d\u6027\u30b5\u30f3\u30d7\u30eb\u306e\u3046\u30613\u4ef6\u306ePA \/ I38T\u5909\u7570\uff09\u3002<\/p>\n<p>\u30b5\u30d6\u30bf\u30a4\u30d7\u304c\u5224\u5b9a\u3067\u304d\u306a\u304b\u3063\u305fA\u578b\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306e\u3046\u3061\u3001\u30d0\u30ed\u30ad\u30b5\u30d3\u30eb\u6295\u4e0e\u524d\u306e\u691c\u4f537\u4ef6\u3067\u306f\u3001PA\/I38T\u5909\u7570\u306f\u691c\u51fa\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6 B \u306f\u691c\u51fa\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3010PA\u907a\u4f1d\u5b50\u89e3\u6790\u3011<\/p>\n<p>A(H3N2) \u3067\u306f\u300136 \u4ef6\u306e\u30d0\u30ed\u30ad\u30b5\u30d3\u30eb\u6295\u4e0e\u5f8c\u81e8\u5e8a\u30b5\u30f3\u30d7\u30eb\u306e\u3046\u3061 \u30011 \u4ef6\u3067 PA\/I38M\u3001\u304a\u3088\u3073 2\u4ef6\u3067 I38T \u7f6e\u63db (13.0%) \u304c\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u306b\u3088\u3063\u3066\u691c\u51fa\u3055\u308c\u307e\u3057\u305f (\u8868 3)\u3002<a href=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-medium wp-image-5913\" src=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_3-600x450.jpg\" alt=\"\" width=\"600\" height=\"450\" srcset=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_3-600x450.jpg 600w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_3-1024x768.jpg 1024w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_3-768x576.jpg 768w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_3-1536x1152.jpg 1536w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_3.jpg 2000w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a>\u5206\u6bcd\u3092\u30d0\u30ed\u30ad\u30b5\u30d3\u30eb\u6295\u4e0e\u7fa4\u304b\u3064 NGS \u304c\u6210\u529f\u3057\u305f 7 \u4ef6\u306e\u30b5\u30f3\u30d7\u30eb\u306b\u3057\u305f\u5834\u5408\u3001PA \u5909\u7570\u306e\u691c\u51fa\u983b\u5ea6\u306f 42.8% \u3067\u3057\u305f\u3002<\/p>\n<p>\u3010NA\u907a\u4f1d\u5b50\u89e3\u6790\u3011<\/p>\n<p>A(H3N2)\u306b\u304a\u3044\u3066\u3001\u30ce\u30a4\u30e9\u30df\u30cb\u30c0\u30fc\u30bc\u963b\u5bb3\u85ac(NAI)\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u308bNA\u5909\u7570\u682a\u306f\u3001\u6b21\u4e16\u4ee3\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u306b\u3088\u308a\u3001\u6295\u4e0e\u524d\u306e\u691c\u4f53(0\/103)\u304a\u3088\u3073\u3001\u30aa\u30bb\u30eb\u30bf\u30df\u30d3\u30eb\u6295\u4e0e\u5f8c\u306e\u691c\u4f53(0\/13)\u306e\u3069\u3061\u3089\u3067\u3082\u691c\u51fa\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\uff08\u88684\uff09\u3002<a href=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_4.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-medium wp-image-5914\" src=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_4-600x450.jpg\" alt=\"\" width=\"600\" height=\"450\" srcset=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_4-600x450.jpg 600w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_4-1024x768.jpg 1024w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_4-768x576.jpg 768w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_4-1536x1152.jpg 1536w, http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/05\/report-04.2023-ver2_Page_4.jpg 2000w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/p>\n<p>Summary of Results.<br \/>\nDuring 2022\/23 season, samples collected from influenza-like-illness patients as of April 20, 2023 were as below:<\/p>\n<p>From main island of Japan and Okinawa 199 samples were collected at the first visit, 61 samples at the second visit, 40 samples after baloxavir treatment (Table 1).<\/p>\n<p>&nbsp;<\/p>\n<p>The results of the detection of PA\/I38T substation by cycling probe real-time PCR are shown below (Table 2).<\/p>\n<p>The percentage of patients with PA\/I38T substitution was:<br \/>\nIn A(H1N1)pdm09, no PA\/I38T variant in pre- and post-treatment samples was detected out of 1 sample (0.0%). In A(H3N2), among pre-treatment samples 1 PA\/I38T variant (0.6%) was detected out of 176 samples. Among post baloxavir-treatment samples, 3 PA\/I38T variants (7.9%) were detected out of 38 samples. If the frequency is calculated based on RT-PCR-positives at the second visit, it became 17.6% (3 PA\/I38T variants out of 17 RT-PCR-positive samples at the second visit).<\/p>\n<p>In unsubtyped influenza A, pre-treatment samples were 0 positive (0%) PA\/I38T variant out of 11 specimens.<\/p>\n<p>Influenza B was not detected.<\/p>\n<p>&nbsp;<\/p>\n<p>[PA gene analysis]<\/p>\n<p>In A(H3N2), one PA\/I38M, and two I38T substitutions (13.0%) out of 23 paired baloxavir-treated clinical sample was detected by next-generation sequencing (Table 3). If the denominator is based on 7 samples with successful NGS in the baloxavir-treated group, the frequency of PA variant was 42.8%.<\/p>\n<p>&nbsp;<\/p>\n<p>[NA gene analysis]<\/p>\n<p>No substitution in NA gene which confer reduced sensitivity to NAIs was found by next-generation sequencing either in pre-treatment samples (0\/103) or post-oseltamivir-treated samples (0\/13) (Table 4).<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7d50\u679c\u306b\u3064\u3044\u3066 2022\/23 \u30b7\u30fc\u30ba\u30f3\u4e2d\u306b\u30012023 \u5e74 4 \u6708 20 \u65e5\u6642\u70b9\u3067\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u69d8\u75be\u60a3\u60a3\u8005\u304b\u3089\u63a1\u53d6\u3055\u308c\u305f\u30b5\u30f3\u30d7\u30eb\u306f\u4ee5\u4e0b\u306e\u3068\u304a\u308a\u3067\u3059\u3002 \u65e5\u672c\u306e\u5168\u56fd\u3068\u6c96\u7e04\u304b\u3089\u3001\u521d\u8a3a\u6642\u3067199\u4ef6\u306e\u30b5\u30f3\u30d7\u30eb\u3001\u518d\u8a3a\u6642\u306761\u4ef6\u306e\u30b5\u30f3\u30d7<a href=\"http:\/\/www.med.niigata-u.ac.jp\/pub\/2023\/05\/02\/2023%e5%b9%b44%e6%9c%8828%e6%97%a5%e3%80%80%e6%8a%97%e3%82%a4%e3%83%b3%e3%83%95%e3%83%ab%e3%82%a8%e3%83%b3%e3%82%b6%e5%89%a4%e6%84%9f%e5%8f%97%e6%80%a7%e4%bd%8e%e4%b8%8b%e6%a0%aa%e8%aa%bf%e6%9f%bb\/\"> 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