![\"\"](\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2025\/08\/\u30b9\u30e9\u30a4\u30c91-1-338x600.jpg\")
<\/a><\/p>\n\u89e3\u6790\u5bfe\u8c61\u306e\u5927\u534a\u306f\u3001\u73fe\u5728\u306e\u30ef\u30af\u30c1\u30f3\u682aA\/Victoria\/4897\/2022\uff08IVR-238\uff09\u304c\u5c5e\u3059\u308b5a.2a.1\uff08D\uff09\u7cfb\u7d71\u3068\u306f\u7570\u306a\u308b\u30015a.2a\uff08C.1.9\uff09\u7cfb\u7d71\u306b\u5206\u985e\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306f\u3001\u7279\u306bC.1.9.3\u30b5\u30d6\u30af\u30ec\u30fc\u30c9\u306b\u5c5e\u3057\u3001\u4e16\u754c\u7684\u306b\u6d41\u884c\u3057\u3066\u3044\u308b\u682a\u3068\u4e00\u81f4\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u4e00\u65b9\u3067\u3001\u30ef\u30af\u30c1\u30f3\u682a\u3068\u540c\u30585a.2a.1\uff08D\uff09\u7cfb\u7d71\u306b\u5206\u985e\u3055\u308c\u308b\u691c\u4f53\u3082\u3001\u5c11\u6570\u306a\u304c\u3089\u691c\u51fa\u3055\u308c\u307e\u3057\u305f\u3002
\n\u307e\u305f\u3001\u30ce\u30a4\u30e9\u30df\u30cb\u30c0\u30fc\u30bc\uff08NA\uff09H275Y\u5909\u7570\u3092\u6709\u3059\u308b3\u691c\u4f53\u306f\u3001\u3044\u305a\u308c\u3082HA\u7cfb\u7d71\u6a39\u4e0a\u3067\u540c\u4e00\u306e\u30af\u30ec\u30fc\u30c9\u306b\u96c6\u7d04\u3059\u308b\u50be\u5411\u3092\u307f\u305b\u3066\u3044\u308b\u305f\u3081\u3001\u4eca\u5f8c\u3001NA\u907a\u4f1d\u5b50\u306e\u8a73\u7d30\u306a\u89e3\u6790\u3092\u5b9f\u65bd\u3059\u308b\u4e88\u5b9a\u3067\u3059\u3002<\/p>\n
Overview of Influenza Circulating Strains and Antiviral Drug-Resistant Strains in Japan During the 2024-2025 Season (As of September 25, 2025)
\nBetween October 2024 and September 25, 2025, we conducted a study in Japan to monitor circulating influenza strains and the emergence of antiviral resistance. The study focused on detecting substitutions in the PA gene associated with reduced susceptibility to baloxavir and substitutions in the NA gene associated with reduced susceptibility to neuraminidase inhibitors, including oseltamivir.<\/p>\n
Participating Medical Institutions and Sample Collection
\nOutpatient medical institutions in seven prefectures participated in this study. Upper respiratory tract samples were collected as initial samples from patients who visited these institutions with suspected influenza symptoms (influenza-like illness, ILI), such as fever, cough, sore throat, and fatigue. These patients were confirmed positive for influenza A or B using rapid diagnostic tests (RDTs). For patients treated with baloxavir, upper respiratory tract samples were also collected during follow-up visits 3\u20137 days after treatment. All clinical specimens were sent to Niigata University for influenza virus detection, subtype determination, and PA and NA substitution detection using real-time PCR(RT-PCR), Sanger sequencing, and next-generation sequencing (NGS).<\/p>\n
Initial Sample Results
\nOf the 114 samples collected at the initial visit, 69 (60.5%) were identified as influenza A(H1N1)pdm09, 29 (25.4%) as A(H3N2), 11 (9.6%) as B\/Victoria, and 3 (2.6%) as influenza B of undetermined lineage. No A\/B co-infections were detected. Two samples (1.8%) were RT-PCR negative (Table 1).<\/p>\n
Detection of PA\/I38T Substitution in Pre-Treatment Samples
\nCycling probe RT-PCR was performed to detect the PA\/I38T substitution in influenza A samples collected prior to treatment. The PA\/I38T substitution was not detected in any of the 69 A(H1N1)pdm09 or 29 A(H3N2) samples (detection rate: 0%) (Table 2-1).<\/p>\n
Follow-Up Samples After Baloxavir Treatment
\nAmong nine patients treated with baloxavir (all A(H1N1)pdm09), upper respiratory tract samples were collected 3\u20137 days post-treatment. PA\/I38T substitutions were not detected in any of these samples by cycling probe RT-PCR (detection rate: 0%). Of these, one was classified as a susceptible strain without the PA\/I38T substitution, and eight were PCR-negative (Table 2-1).<\/p>\n
Whole-Genome Analysis Using Next-Generation Sequencing (NGS)
\nWhole-genome sequencing was conducted to investigate resistance-associated substitutions in the PA and NA genes.
\n-Initial samples: NGS analysis was successful in 71 samples, 57 A(H1N1)pdm09, 10 A(H3N2), and 4 B\/Victoria (Tables 2-2 and 4).
\n-Follow-up samples: NGS analysis was conducted in 13 follow-up samples, 9 following baloxavir treatment and 4 following oseltamivir treatment (Tables 2-2 and 4).<\/p>\n
PA Gene Analysis
\n-Initial samples: No PA gene substitutions associated with reduced susceptibility to baloxavir were detected in any of the 71 samples (57 A(H1N1)pdm09, 10 A(H3N2), 4 B\/Victoria) (Table 2-2).
\n-Follow-up samples: NGS analysis was performed on 9 follow-up samples after baloxavir treatment (all A(H1N1)pdm09). Of these, only 1 sample yielded analyzable sequence data, and no baloxavir resistance-associated PA substitutions were detected (detection rate: 0%).<\/p>\n
Pending Analyses
\nAs of now, substitution detection in the PA gene using Sanger sequencing has not yet been conducted.<\/p>\n
NA Gene Analysis
\n-Initial samples: Among the 71 samples analyzed, oseltamivir resistance\u2013associated substitutions were detected in 4 A(H1N1)pdm09 samples: one sample had the NA\/S247N substitution, and three had the NA\/H275Y substitution (detection rate: 7.0%) (Table 4). Variant calling showed that these substitutions were present at high proportions (>99%) in each sample. No such substitutions were detected in A(H3N2) or B\/Victoria samples.<\/p>\n
-Follow-up samples: Of the 4 follow-up samples after oseltamivir treatment (all A(H1N1)pdm09), NGS analysis yielded analyzable data for 3. Among these, resistance-associated NA substitutions were detected in 2 samples. The detection rate was 50.0% when calculated based on all 4 samples, and 66.6% when calculated based on the 3 analyzable samples. One sample carried the NA\/N295S substitution, and another retained the NA\/S247N substitution that had already been detected in the initial sample from the same patient. Variant calling revealed a substitution frequency of 18.7% for NA\/N295S and 99.6% for NA\/S247N.<\/p>\n
Phylogenetic Tree Analysis of HA gene
\nA phylogenetic analysis of the HA gene of A(H1N1)pdm09 viruses detected in Japan since October 2024 was conducted (Figure 1).
\nMost of the sequenced viruses belonged to the 5a.2a (C.1.9) clade, which is distinct from the 2024\u20132025 vaccine strain A\/Victoria\/4897\/2022 (IVR-238) that falls under clade 5a.2a.1 (D). The majority of strains were classified within the globally prevalent C.1.9.3 subclade. A small number of strains were also identified within the same 5a.2a.1 (D) clade as the vaccine strain.
\nNotably, the three samples with the NA\/H275Y substitution are likely to cluster within the same HA clade, suggesting a possible genetic linkage. Further analysis of the corresponding NA genes is planned.<\/p>\n","protected":false},"excerpt":{"rendered":"
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…\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":6424,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1,3,11],"tags":[],"class_list":["post-6422","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-blog","category-influenzasearch"],"jetpack_featured_media_url":"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2025\/09\/\u30b9\u30e9\u30a4\u30c91-1.jpg","jetpack_shortlink":"https:\/\/wp.me\/ph72WZ-1FA","jetpack-related-posts":[{"id":6461,"url":"http:\/\/www.med.niigata-u.ac.jp\/pub\/2025\/12\/25\/2025%e5%b9%b412%e6%9c%884%e6%97%a5%e3%80%80%e6%8a%97%e3%82%a4%e3%83%b3%e3%83%95%e3%83%ab%e3%82%a8%e3%83%b3%e3%82%b6%e5%89%a4%e6%84%9f%e5%8f%97%e6%80%a7%e4%bd%8e%e4%b8%8b%e6%a0%aa%e8%aa%bf%e6%9f%bb\/","url_meta":{"origin":6422,"position":0},"title":"2025\u5e7412\u67084\u65e5\u3000\u6297\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u5264\u611f\u53d7\u6027\u4f4e\u4e0b\u682a\u8abf\u67fb\u306e\u7d50\u679c","author":"public-health","date":"2025\u5e7412\u670825\u65e5","format":false,"excerpt":"2025-2026\u5e74\u30b7\u30fc\u30ba\u30f3\u306e\u65e5\u672c\u306b\u304a\u3051\u308b\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u6d41\u884c\u682a\u3068\u6297\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u85ac\u611f\u53d7\u6027\u4f4e\u4e0b\u682a\u8abf\u67fb\u306e\u2026","rel":"","context":"What\u2019s 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