Division of Virology


Niigata University
Graduate school of medical and dental sciences


Last updated on Jun 6, 2016

Copyright 2014 Division of Virology | Japanese

Member

Masahiro Fujii
Professor

Masahiko Takahashi
Associate professor

Hiroki Kawamura
Research fellow

Yasufumi Kijima
Graduate student

Svetlana Pyatnickaya
Graduate student

Sergei Anisimov
Graduate student

Misako Tobimatsu
Technician and Secretary

Yuko Saito
Technician and Secretary

Projects

There are eight human tumor viruses, including hepatitis B virus and human papilloma virus, and they are associated with around 10-15 % of human cancers including hepatoma and cervical carcinoma. However, effective therapeutics against these malignancies are not available. We study the mechanism of leukemogenesis of adult T-cell leukemia (ATL) caused by human T-cell leukemia virus type 1 (HTLV-1), and object the understanding of the common and specific mechanisms of oncogenesis by the tumor viruses. Based on the study, we object the development of new therapeutics to ATL and other virus-associated malignancies.

Project#1
Molecular mechanism of HTLV-1-associated diseases
HTLV-1 is a causative retrovirus of ATL and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). We are interested in how HTLV-1 causes ATL and HAM/TSP. HTLV-1 encodes a viral oncoprotein Tax, playing central roles in HTLV-1 pathogenesis. We isolated several host proteins interacting with Tax, such as USP10, and found that it plays pivotal roles in cellular stress response as well as HTLV-1 pathology as shown below

Project#2
USP10 controls cellular stress response
USP10 is a component of stress granules (SG) induced by various stress agents including UV, oxidant (arsenate) and viral infection. We found that USP10 inhibits stress-induced reactive oxygen species (ROS) production and ROS-dependent apoptosis by forming SG. We are studying how USP10 control stress responses

Project#3
USP10 is a target molecule of arsenate induced apoptosis of leukemic cells
Arsenate is used for therapeutics against acute promyelocitic leukemia. In addition, arsenate showed a promising therapeutic effect against ATL. Nevertheless, the molecular mechanism of arsenate action has not been elucidated yet. We found that USP10 is a target molecule of arsenate to kill ATL cells and HTLV-1-transformed T-cell lines. Arsenate induced apoptosis of ATL cells more effectively than other human T-cell lines through inefficient function of USP10 in ATL. We are studying the molecular mechanism of USP10-mediated apoptosis inhibition. We are also searching the signaling pathway augmenting arsenate sensitivity to develop more effective ATL therapeutics.

Papers

2016

Higuchi M, Kawamura H, Matsuki H, Hara T, Takahashi M, Saito S, Saito K, Jiang S, Naito M, Kiyonari H, Fujii M.
USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells.
Stem Cell Reports, 7(6):1116-1129, (2016).

Mizuguchi M, Sasaki Y, Hara T, Higuchi M, Tanaka Y, Funato N, Tanaka N, Fujii M, Nakamura M.
Induction of Cell Death in Growing Human T-Cells and Cell Survival in Resting Cells in Response to the Human T-Cell Leukemia Virus Type 1 Tax.
PLoS One, 11(2):e0148217, (2016).

Motai Y, Takahashi M, Takachi T, Higuchi M, Hara T, Aoyagi Y, Terai S, Tanaka Y, Fujii M.
Human T-cell leukemia virus type 1 (HTLV-1) Tax1 oncoprotein but not HTLV-2 Tax2 induces the expression of OX40 ligand by interacting with p52/p100 and RelB.
Virus Genes, in press

2015

Maeda N, Ohashi T, Chagan-Yasutan H, Hattori T, Takahashi Y, Harigae H, Hasegawa H, Yamada Y, Fujii M, Maenaka K, Uede T.
Osteopontin-integrin interaction as a novel molecular target for antibody-mediated immunotherapy in adult T-cell leukemia.
Retrovirology, 12:99, (2015)

Ichikawa T, Nakahata S, Fujii M, Iha H, Morishita K.
Loss of NDRG2 enhanced activation of the NF-κB pathway by PTEN and NIK phosphorylation for ATL and other cancer development.
Sci Rep, 5:12841, (2015)

Shigemura T, Shiohara M, Kato M, Furuta S, Kaneda K, Morishita K, Hasegawa H, Fujii M, Gorlach A, Koike K, Kamata T.
Superoxide-Generating Nox5α Is Functionally Required for the Human T-Cell Leukemia Virus Type 1-Induced Cell Transformation Phenotype.
J Virol, 89(17):9080-9089, (2015)

Hara T, Mizuguchi M, Fujii M, Nakamura M.
Kruppel-like factor 2 represses transcription of the telomerase catalytic subunit hTERT in human T cells.
J Biol Chem, 290(14):8758-8763, (2015).

Saito S, Kawamura T, Higuchi M, Kobayashi T, Yoshita-Takahashi M, Yamazaki M, Abe M, Sakimura K, Kanda Y, Kawamura H, Jiang S, Naito M, Yoshizaki T, Takahashi M, Fujii M.
RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells.
Eur J Immunol, 45(5):1512-1523, (2015).

Takachi T, Takahashi M, Takahashi-Yoshita M, Higuchi M, Obata M, Mishima Y, Okuda S, Tanaka Y, Matsuoka M, Saitoh A, Green PL, Fujii M.
Human T-cell leukemia virus type 1 Tax oncoprotein represses the expression of the BCL11B tumor suppressor in T-cells.
Cancer Sci, 106(4):461-465, (2015).

2014

Higuchi M, Takahashi M, Tanaka Y, Fujii M.
Downregulation of proapoptotic Bim augments IL-2-independent T-cell transformation by human T-cell leukemia virus type-1 Tax.
Cancer Med, 3(6):1605-1614.

Hara T, Jones MF, Subramanian M, Li XL, Ou O, Zhu Y, Yang Y, Wakefield LM, Hussain SP, Gaedcke J, Ried T, Luo J, Caplen NJ, Lal A.
Selective targeting of KRAS-Mutant cells by miR-126 through repression of multiple genes essential for the survival of KRAS-Mutant cells.
Oncotarget, 5(17):7635-7650, (2014).

Li XL, Lu X, Parvathaneni S, Bilke S, Zhang H, Thangavel S, Vindigni A, Hara T, Zhu Y, Meltzer PS, Lal A, Sharma S.
Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion.
Cell Cycle,13(15):2431-2445,(2014)

Li XL, Hara T, Choi Y, Subramanian M, Francis P, Bilke S, Walker RL, Pineda M, Zhu Y, Yang Y, Luo J, Wakefield LM, Brabletz T, Park BH, Sharma S, Chowdhury D, Meltzer PS, Lal A.
A p21-ZEB1 Complex Inhibits Epithelial-Mesenchymal Transition through the MicroRNA 183-96-182 Cluster.
Mol Cell Biol, 34(3):533-550, (2014).

2013

Takahashi M, Higuchi M, Makokha GN, Matsuki H, Yoshita M, Tanaka Y, Fujii M.
HTLV-1 Tax oncoprotein stimulates ROS production and apoptosis in T-cells by interacting with USP10.
Blood, 122(5):715-725.

Mizukoshi T, Komori H, Mizuguchi M, Abdelaziz H, Hara T, Higuchi M, Tanaka Y, Ohara Y, Funato N, Fujii M, Nakamura M.
Failure in activation of the NF-kB canonical pathway by human T-cell leukemia virus type 1 Tax in non-hematopoietic cell lines.
Virology, 443(2):226-235.

Makokha GN, Takahashi M, Higuchi M, Saito S, Tanaka Y, Fujii M.
Human T-cell leukemia virus type 1 Tax protein interacts with and mislocalizes the PDZ domain protein MAGI-1.
Cancer Science, 104(3):313-320.

Takahashi M, Higuchi M, Matsuki H, Yoshita M, Ohsawa T, Oie M, Fujii M.
Stress granules inhibit apoptosis by reducing reactive oxygen species production.
Mol Cell Biol, 33(4):815-829.

Matsuki H, Takahashi M, Higuchi M, Makokha GN, Oie M, Fujii M.
Both G3BP1 and G3BP2 contribute to stress granule formation.
Genes Cells, 18(2):135-146.

Imai M, Higuchi M, Kawamura H, Yoshita M, Takahashi M, Oie M, Matsuki H, Tanaka T, Aoyagi Y, Fujii M.
Human T cell leukemia virus type 2 (HTLV-2) Tax2 has a dominant activity over HTLV-1 Tax1 to immortalize human CD4+ T cells.
Virus Genes, 46(1):39-46.

2009

Higuchi M, Fujii M.
Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis.
Retrovirology, 6(1):117.

Shoji T, Higuchi M, Kondo R, Takahashi M, Oie M, Tanaka Y, Aoyagi Y, Fujii M.
Identification of a novel motif responsible for the distinctive transforming activity of human T-cell leukemia virus (HTLV) type 1 Tax1 protein from HTLV-2 Tax2.
Retrovirology, 6(1):83.

Mizuguchi M, Asao H, Hara T, Higuchi M, Fujii M, Nakamura M.
Transcriptional activation of the interleukin-21 and its receptor genes by human T-cell leukemia virus type 1 Tax in human T-cells.
J Biol Chem, 284(38):25501-25511.

Zhao T, Yasunaga JI, Satou Y, Nakao M, Takahashi M, Fujii M, Matsuoka M.
Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF-kB.
Blood, 113(12):2755-2764.

2008

Okajima M, Takahashi M, Higuchi M, Ohsawa T, Yoshida S, Yoshida Y, Oie M, Tanaka Y, Gejyo F, Fujii M.
Human T-cell leukemia virus type 1 Tax induces an aberrant clustering of the tumor suppressor Scribble through the PDZ domain binding motif dependent and independent interaction.
Virus Genes, 37(2):231-240.

Yoshida S, Higuchi M, Shoji T, Yoshita M, Ishioka K, Takahashi M, Oie M, Tanaka Y, Uchiyama M, Fujii M.
Knockdown of synapse-associated protein Dlg1 reduces syncytium formation induced by human T-cell leukemia virus type 1.
Virus Genes, 37(1):9-15.

Isogawa M, Higuchi M, Takahashi M, Oie M, Mori N, Tanaka Y, Aoyagi Y, Fujii M.
Rearranged NF-kappa B2 gene in an adult T-cell leukemia cell line.
Cancer Sci, 99(4):792-798.

Nakayama T, Hieshima K, Arao T, Jin Z, Nagakubo D, Shirakawa AK, Yamada Y, Fujii M, Oiso N, Kawada A, Nishio K, Yoshie O.
Aberrant expression of Fra-2 promotes CCR4 expression and cell proliferation in adult T-cell leukemia.
Oncogene. 27(23):3221-3232.

2006

Kondo R, Higuchi M, Takahashi M, Oie M, Tanaka Y, Gejyo F, Fujii M.
Human T-cell leukemia virus type 2 Tax protein induces interleukin 2-independent growth in a T-cell line.
Retrovirology, 3(1):88.

Ishioka K, Higuchi M, Takahashi M, Yoshida S, Oie M, Tanaka Y, Takahashi S, Xie L, Green P, Fujii M.
Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein.
Retrovirology, 3:71.

de la Fuente C, Gupta MV, Klase Z, Strouss K, Cahan P, McCaffery T, Galante A, Soteropoulos P, Pumfery A, Fujii M, Kashanchi F.
Involvement of HTLV-I Tax and CREB in aneuploidy: A bioinformatics approach.
Retrovirology, 3:43.

2005

Hall WW, Fujii M.
Deregulation of cell-signaling pathways in HTLV-1 infection.
Oncogene, 24:5965-5975.

Niinuma A, Higuchi M, Takahashi M, Oie M, Tanaka Y, Gejyo F, Tanaka N, Sugamura K, Xie L, Green PL, Fujii M.
Aberrant Activation of the Interleukin 2 Autocrine Loop through Nuclear Factor of Activated T cells by Nonleukemogenic Human T-cell Leukemia Virus Type 2 but not Leukemogenic Type 1 Virus.
J Virol, 79(18):11925-11934.

Tsubata C, Higuchi M, Takahashi M, Oie M, Tanaka Y, Gejyo F, Fujii M.
PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein is essential for the interleukin 2 independent growth induction of a T-cell line.
Retrovirology, 2(1):46.

Higuchi M, Matsuda T, Mori N, Yamada Y, Horie R, Watanabe T, Takahashi M, Oie M, Fujii M.
Elevated expression of CD30 in adult T-cell leukemia cell lines. Possible role in constitutive NF-kB activation.
Retrovirology, 2(1):29.

Kawakami H, Tomita M, Matsuda T, Ohta T, Tanaka Y, Fujii M, Hatano M, Tokuhara T, Mori N.
Transcriptional activation of survivin through the NF-kB pathway by human T-cell leukemia virus type I Tax.
Int J Cancer, 115(6):967-974.

Jen KY, Higuchi M, Cheng J, Li J, Wu LY, Li YF, Lin HL, Chen Z, Gurtsevitch V, Fujii M, Saku T.
Nucleotide sequences and functions of the Epstein-Barr virus latent membrane protein 1 genes isolated from salivary gland lymphoepithelialcarcinomas.
Virus Genes, 30(2):223-235.

2004

Tetsuka T, Higuchi M, Fukushi M, Watanabe A,Takizawa S, Oie M, Gejyo F, Fujii M.
Visualization of a Functional KSHV Episome-Maintenance Protein LANA in Living Cells.
Virus Genes, 29(2):175-182, (2004).

Ohashi M, Sakurai M, Higuchi M, Mori N, Fukushi M, Oie M, Coffey RJ,Yoshiura K, Tanaka Y, Uchiyama M, Hatanaka M, Fujii M.
Human T-cellLeukemia Virus Type 1 Tax Oncoprotein Induces and Interacts with a Multi-PDZ Domain Protein, MAGI-3.
Virology, 320(1):52-62, (2004).

Hirata A, Higuchi M, Niinuma A, Ohashi M, Fukushi M, Oie M, Akiyama T, Tanaka Y, Gejyo F, Fujii M.
PDZ Domain-Binding Motif of Human T-cell Leukemia Virus Type 1 Tax Oncoprotein Augments the Transforming Activity in a Rat Fibroblast Cell Line.
Virology, 318(1):327-336, (2004).

2003

Fukushi M, Higuchi M, Oie M, Kasolo F, Ichiyama K, Yamamoto M, Katano H, Sata T, Fujii M.
Latency-associated nuclear antigen of Kaposi’s sarcoma-associated herpesvirus interacts with human myeloid cell nuclear differentiation antigen induced by interferon alpha
Virus Genes, 27(3):237-247, (2003).

Dewan MZ, Terashima K, Taruishi M, Hasegawa H, Ito M, Tanaka Y, Mori N, Sata T, Koyanagi Y, Maeda M, Kubuki Y, Okayama A, Fujii M, Yamamoto N.
Rapid Tumor Formation of Human T-Cell Leukemia Virus Type1-Infected Cell Lines in Novel NOD-SCID/gammac(null) Mice: Suppression by an Inhibitor against NF-kappaB.
J Virol, 77(9):5286-5294, (2003).

Mori N, Fujii M.
Aberrant transcription through NF-kB/Rel and AP-1 in adult T-cell leukemia.
Gann Monograph on Cancer Research, Vol.50, 73-92, (2003).

2002

Shinohara H, Fukushi M, Higuchi M, Oie M, HoshiO, Ushiki T, Hayashi J, Fujii M.
Chromosome binding site of latency-associated nuclear antigen of Kaposi’s sarcoma-associated herpesvirus is essential for persistent episome maintenance and is functionally substituted by histone H1.
J Virol, 76:12917-12924, (2002).

Takahashi T, Higuchi M, Fukushi M, Oie M, Ito M, Fujii M.
Homotypic cell-cell adhesion induced by human T-cell leukemia virus type 1 Tax protein in T-cell lines.
Virology, 302:132-143, (2002).

Mori N, Yamada Y, Ikeda S, Yamasaki Y, Tsukasaki K, Tanaka Y, Tomonaga M, Yamamoto N, Fujii M.
Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I infected T-cell lines and primary adult T-cell leukemia cells.
Blood, 100:1828-1834, (2002).

Mori N, Fujii M, Hinz M, Nakayama K, Yamada Y, Ikeda S, Yamasaki Y, Tanaka Y, Tomonaga M, Kashanchi F, Yamamoto N.
Activation of cyclin D1 and D2 promoters by human T-cell leukemia virus type I Tax proteinis associated with interleukin-2 independent growth in T cells.
Int J Cancer, 99:378-385, (2002).

Endo K, Hirata A, Iwai K, Sakurai M, Fukushi M,Oie M, Higuchi M, Hall WW, Gejyo F, Fujii M.
Human T-cell Leukemia Virus(HTLV) Type 2 Tax Protein Transforms a Rat Fibroblast Cell Line but Less Efficiently than HTLV-1 Tax.
J Virol, 76:2648-2653, (2002).

Maruyama S, Hao N, Cheng J, Horino K, Ohnishi M, Fukushi M, Fujii M, Saku T.
Castleman's disease of the buccal mucosa: report of a case and review of the literature of head and neck cases.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 93(3):305-310, (2002).

Higuchi M, Kieff E, Izumi KM.
The Epstein-Barrvirus latent membrane protein 1 putative Janus kinase 3 (JAK3) binding domain does not mediate JAK3 association or activation in B-lymphoma or lymphoblastoid cell lines.
J Virol, 76(1):455-459, (2002).

2000

Mori N, Fujii M, Yamamoto N.
Aberration in signal transduction pathway in human T-cell leukemia virus type I-infected T cells.
Acta Medica Nagasakiensia, 45:1-8, (2000).

Fujii M, Iwai K, Oie M, Fukushi M, Yamamoto N, Kannagi M, Mori N.
Activation of oncogenic transcription factor AP-1 in T-cells infected with Human T-cell Leukemia Virus Type 1.
AIDS Res Hum Retroviruses, 16(16):1603-1606, (2000).

1999

Mori N, Yamamoto N, Fujii M.
Activation of Nuclear Factor kappa B transcription factor by human T-cell leukemia virus type I.
Acta Med Biol, vol.47:85-96, (1999).

Santiago F, Clark E, Chong S, Molina C, Mozafari F,Mahieux R, Fujii M, Azimi N, Kashanchi F.
Transcriptional Up-Regulationof the Cyclin D2 Gene and Acquisition of New Cyclin-Dependent Kinase Partnersin Human T-Cell Leukemia Virus Type 1-Infected Cells.
J Virol, 73(12):9917-9927, (1999).

Ohashi T, Hanabuchi S, Kato H, Koya Y, Takemura F, Hirokawa K, Yoshiki T, Tanaka Y, Fujii M, Kannagi M.
Induction of ATL-like lymphoproliferative diseases and its inhibition by adoptive immunotheray in T-cell deficient nude rats inoculated with syngeneic HTLV-I-immortalized cells.
J Virol, 73(7):6031-6040, (1999).

Tsukahara T, Kannagi M, Ohashi T, Kato H, Arai M,Nunez G, Iwanaga Y, Yamamoto N, Ohtani K, Nakamura M, Fujii M.
Induction of Bcl-x(L) expression by human T-cell leukemia virus type 1 Tax through NF-kappaB in apoptosis-resistant T-cell transfectants with Tax.
J Virol, 73(10):7981-7987, (1999).

Koya Y, Ohashi T, Kato H, Ohashi T, Hanabuchi S, Tsukahara T, Takemura F, Etoh K, Matusoka M, Fujii M, Kannagi M.
Establishment of a seronegative HTLV-I-carrier state in rats inoculated with asyngeneic HTLV-I-immortalized T cell line.
J Virol, 73(8):6436-6443, (1999).

Nakamura N, Fujii M, Tsukahara T, Arai M, Ohashi T, Kannagi M, Yamamoto N.
Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells.
Oncogene, 18(17):2667-2675, (1999).

Mori N, Fujii M, Ikeda S, Yamada Y, Tomonaga M, Ballard D, Yamamoto N.
Constitutive activation of NF-kB in primary adult T-cell leukemia cells.
Blood, 93(7):2360-2368, (1999).

Iwanaga Y, Tsukahara T., Ohashi T, Tanaka Y, Arai1 M, Nakamura M, Ohtani K, Koya Y, Kannagi M, Yamamoto N, Fujii M.
Human T-cell leukemia virus type 1 Tax protein abrogates interleukin 2 dependence in a mouse T-cell line.
J Virol, 73(2):1271-1277, (1999).

Ohashi T, Kubo M, Kato H, Iwamoto A, Takahashi H, Fujii M, Kannagi M.
Role of class I major histocompatibility complex-restricted and -unrestricted suppression of human immunodeficiency virus type 1 (HIV-1) replication by CD8+ T lymphocytes.
J Gen Virol, 80(Pt 1):209-216, (1999).

1998

Kato H, Koya Y, Ohashi T, Hanabuchi S, Takemura F, FujiiM, Tsujimoto H, Hasegawa A, Kannagi M.
Oral administration of human T-cell leukemia virus type 1 induces immune unresponsiveness with persistent infection in adult rats.
J Virol, 72(9):7289-7293, (1998).

Ohashi T, Arai M, Kato H, Kubo M, Fujii M, Yamamoto N, Iwamoto A, Kannagi M.
High SDF-1 expression in HIV-1 carriers does not correlate with CD8+ T cell-mediated suppression of viral replication.
Virology, 244(2):467-472, (1998).

Arai M, Kannagi M, Matsuoka M, Sato T, Yamamoto N, Fujii M.
Expression of FAP-1 (Fas-associated phosphatase) and resistance to Fas-mediated apoptosis in T-cell lines derived from human T-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis.
AIDS Res Hum Retroviruses, 14(3):261-267, (1998).

Arai M, Ohashi T, Yamamoto N, Kannagi M, Fujii M.
Human T-cell leukemia virus type 1 Tax protein induces the expression of lymphocyte chemoattractant SDF-1/PBSF..
Virology, 241(2):298-303, (1998).

1997

Kannagi M, Nakamura T, Akari H, Kuroda MJ, Fujii M, Oka S, Iwamoto A, Kurata T, Higashi D, Harada S.
Dual phasic suppression ofviral replication following de novo human immunodeficiency virus type 1 (HIV-1) infection in lymphocytes of asymptomatic HIV-1 carriers.
Leukemia, 11:545-547, (1997).

Kishi S, Saijyo S, Arai M, Karasawa S, Ueda S, KannagiM, Iwakura Y, Fujii M, Yonehara S.
Resistance to fas-mediated apoptosis of peripheral T cells in human T lymphocyte virus type I (HTLV-I) transgenicmice with autoimmune arthropathy.
J Exp Med, 186(1):57-64, (1997).

Fujii M, Minamino T, Nomura M, Miyamoto K,Tanaka J, Seiki M.
v-Rel activates the proto-oncogene c-jun promoter: a correlation with its transforming activity.
Leukemia, 11:402-404, (1997).

Kubo M, Ohashi T, Fujii M, Oka S, Iwamoto A,Harada S, Kannagi M.
Abrogation of in vitro suppression of human immunodeficiency virus type 1 (HIV-1) replication mediated by CD8+ T lymphocytes of asymptomatic HIV-1 carriers by staphylococcal enterotoxin B and phorbol esters through induction of tumor necrosis factor alpha.
J Virol, 71(10):7560-7566, (1997).

Matsumoto K, Shibata H, Fujisawa JI, Inoue H, Hakura A, Tsukahara T, Fujii M.
Human T-cell leukemia virus type 1 Tax protein transforms rat fibroblasts via two distinct pathways.
J Virol, 71(6):4445-4451, (1997).

1996

Fujii M, Minamino T, Nomura M, Miyamoto K,Tanaka J, Seiki M.
Selective activation of the proto-oncogene c-jun promoter by the transforming protein of v-Rel.
Oncogene, 12(10):2193-2202, (1996).

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Niigata University
Graduate school of medical and dental sciences
Division of Virology


1-757 Asahimachi-dori,
Chuo-ku, Niigata-shi,
Niigata JAPAN 951-8510

Phone: +81-25-227-2115
Fax: +81-25-227-0763
fujiimas @ med.niigata-u.ac.jp

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