論文

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Expansion of the population of double negative CD4-8- Tab-cells in the liver is a common feature of autoimmune mice. J. Immunol. 147: 2907-2912, 1991. 10) Watanabe, H., Ohtsuka, K., Kimura, M., Ikarashi, Y., Ohmori, K., Kusumi, A., Ohteki, T., Seki, S. and Abo, T. Details of an isolation method for hepatic lymphocytes in mice. J. Immunol. Methods 146: 145-154, 1992. 11) Abo, T. Extrathymic differentiation of T lymphocytes and its biological function. Biomed. Res. 13: 1-39, 1992. 12) Okuyama, R., Abo, T., Seki, S., Ohteki, T., Sugiura, K., Kusumi, A. and Kumagai, K. Estrogen administration activates extrathymic T cell differentiation in the liver. J. Exp. Med. 175: 661-669, 1992. 13) Kimura, M., Watanabe, H. and Abo, T. Selective activation of extrathymic T cells in the liver by glycyrrhizin. Biotherapy 5: 167-176, 1992. 14) Abo, T., Kusumi, A., Seki, S., Ohteki, T., Sugiura, K., Masuda, T., Rikiishi, H., Iiai, T. and Kumagai, K. Activation of extrathymic T cells in the liver and reciprocal inactivation of intrathymic T cells by bacterial stimulation. Cell. Immunol. 142: 125-136, 1992. 15) Ohteki, T., Okuyama, R., Seki, S., Abo, T., Sugiura, K., Kusumi, A., Ohmori, T, Watanabe, H. and Kumagai, K. Age-dependent increase of extrathymic T cells in the liver and their appearance in the periphery of older mice. J. Immunol. 149: 1562-1570, 1992. 16) Kusumi, A., Abo, T., Masuda, T., Sugiura, K., Seki, S., Ohteki, T., Okuyama, R. and Abo, T. Lymphotoxin activates hepatic T cells and simultaneously induces profound thymic atrophy. Immunology 77: 177-184, 1992. 17) Tsuchida, M., Iiai, T., Watanabe, H. and Abo, T. Relative resistance of intermediate TCR cells to anti-CD3 mAb in mice in vivo and their partial functional characterization. Cell. Immunol. 145: 78-90, 1992. 18) Iiai, T., Watanabe, H., Seki, S., Sugiura, K., Hirokawa, K., Utsuyama, M., Takahashi-Iwanaga, H., Iwanaga, T., Ohteki, T. and Abo, T. Ontogeny and development of extrathymic T cells in mouse liver. Immunology 77: 556-563, 1992. 19) Sato, Y., Tsukada, K., Iiai, T., Ohmori, K., Yoshida, K., Muto, T., Watanabe, H., Matsumoto, Y. and Abo, T. Activation of extrathymic T cells in the liver during liver regeneration following partial hepatectomy. Immunology 78: 86- 91, 1993. 20) Ohteki, T., Abo, T., Kusumi, A., Sasaki, T., Shibata, S., Seki, S. and Kumagai, K. Age-associated increase of CD5+B cells in the liver of autoimmune NZB/WF1 mice. Microbiol. Immunol. 37: 221-228, 1993. 21) Ohmori, K., Iiai, T., Watanabe, H., Tanaka, T., Miyasaka, M. and Abo, T. Activation of extrathymic T cells in the liver of mice bearing syngeneic tumors. Biomed. Res. 14: 65-79, 1993. 22) Tsuchida, M., Hashimoto, M., Abo, T., Miyamura, H., Hirano, T. and Eguchi, S. CD5+B cells in the thymus of patients with myasthenia gravis. Biomed. Res. 14: 19-25, 1993. 23) Funahashi, I., Watanabe, H., Abo, T., Indo, K. and Miyaji, H. Tumour inhibition in mice by glycosylated recombinant human lymphotoxin analysis of tumour-regional mononuclear cells involved with its action. Brit. J. Cancer 67: 447- 455, 1993. 24) Abo, T. Extrathymic pathways of T-cell differentiation: A primitive and fundamental immune system. Microbiol. Immunol. 37: 247-258, 1993. 25) Koyamada, N., Ohteki, T., Abo, T., Fukumori, T., Ohkouchi, N., Satomi, S., Taguchi, Y., Kusumi, A., Mori, S. and Kumagai, K. Induction of specific tolerance by heptic double-negative CD4-8- abT cells of mice immunized with allogeneic cells via the portal vein in vitro. Cell. Immunol. 149: 107-116, 1993. 26) Matsumoto, Y., Hanawa, H., Tsuchida, M. and Abo, T. In situ inactivation of infiltrating T cells in the central nervous system with autoimmune encephalomyelitis. The role of astrocytes. Immunology 79: 381-390, 1993. 27) Hanawa, H., Tsuchida, M., Matsumoto, Y., Watanabe, H., Abo, T., Sekikawa, H., Kodama, M., Zhang, S. Izumi, T. and Shibata, A. Characterization of T cells infiltrating the heart in rats with experimental autoimmune myocarditis. Their similarity to extrathymic T cells in mice and the site of proliferation. J. Immunol. 150: 5682-5695, 1993. 28) Watanabe, H., Iiai, T., Kimura, M., Ohtsuka, K., Tanaka, T., Miyasaka, M., Tsuchida, M., Hanawa, H. and Abo, T. Characterization of intermediate TCR cells in the liver of mice with respect to their unique IL-2R expression. Cell Immunol. 149: 331-342, 1993. 29) Abo, T., Watanabe, H. and Sekikawa, H. Multiplicity of sites for extrathymic T-cell differentiation. Acta Medica Biol. 41: 59-79, 1993. 30) Kimura, M., Watanabe, H., Ohtsuka, K., Iiai, T., M. Tsuchida, Sato, S. and Abo, T. Radioresistance of intermediate TCR cells and their localization in the body of mice revealed by irradiation. Microbiol. Immunol. 37: 641-652, 1993. 31) Watanabe, H., Ohtsuka, K., Obata, Y., Iiai, T., Kimura, M., Takahashi, T., Hirokawa, K., Utsuyama, M. and Abo, T. Generalized expansion of extrathymic T cells in various immune organs of TL-transgenic mice. Biomed. Res. 14: 273- 288, 1993. 32) Tomita, Y., Watanabe, H., Kobayashi, H., Nishiyama, T., Tsuji, S., Imai, K., Abo, T., Fujiwara, M. and Sato, S. Expression of intercellular adhesion molecule-1 on transitional cell cancer. Am. J. Pathol. 143: 191-198, 1993. 33) Sato, Y., Tsukada, K., Matsumoto, Y. and Abo, T. Interferon-g inhibits liver regeneration by stimulating major histocompatibility complex class II antigen expression by regenerating liver. Hepatology 18: 340-346, 1993. 34) Tsuchida, M., Matsumoto, Y., Hirahara, H., Hanawa, H., Tomiyama, K. and Abo, T. Preferential distribution of Vb 8.2-positive T cells in the central nervous system of rats with myelin basic protein-induced autoimmune encephalomyelitis. Eur. J. Immunol. 23: 2399-2406, 1993. 35) Sato, K., Ohtsuka, K., Watanabe, H., Asakura, H. and Abo, T. 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Similarities and differences between extrathymic T cells residing in mouse liver and intestine. Cell. Immunol. 153: 52-66, 1994. 40) Matsumoto, Y., Tsuchida, M., Hanawa, H. and Abo, T. Successful prevention and treatment of autoimmune encephalomyelitis by short-term administration of anti-T-cell receptor ab antibody. Immunology 81: 1-7, 1994. 41) Abo, T., Watanabe, H., Iiai, T., Kimura, M., Ohtsuka, K., Sato, K., Ogawa, M., Hirahara, H., Hashimoto, S., Sekikawa, H. and Seki, S. Extrathymic pathways of T-cell differentiation in the liver and other organs. Int. Reviews Immunol. 11: 61-102, 1994. 42) Hirahara, H., Ogawa, M., Kimura, M., Iiai, T., Tsuchida, M., Hanawa, H., Watanabe, H. and Abo, T. Glucocorticoid independence of acute thymic involution induced by lymphotoxin and estrogen. Cell. Immunol. 153: 401-411, 1994. 43) Iiai, T., Watanabe, H., Iwamoto, T., Nakashima I. and Abo, T. Predominant activation of extrathymic T cells during melanoma development of metallothionein/ret transgenic mice. Cell. Immunol. 153: 412-427, 1994. 44) Matsumoto, Y., Tsuchida, M., Hanawa, H. and Abo, T. T cell receptor peptide therapy　for autoimmune encephalomyelitis: stronger immunization is necessary for effective vaccination. Cell. Immunol. 153: 468-478, 1994. 45) Tsuchida, M., Hirahara, H., Matsumoto, Y., Abo, T. and Eguchi, S. Induction of specific unresponsiveness to cardiac allograft by short-term administration of anti-T cell receptor ab antibody. Transplantation 57: 256-262, 1994. 46) Tsuchida, M., Hanawa, H., Hirahara, H., Watanabe, H., Matsumoto, Y., Sekikawa, H. and Abo, T. Identification of CD4-8- abT cells with extrathymic properties in the subarachnoid space of rats with experimental autoimmune encephalomyelitis. A possible route by which effector cells invade the lesion. 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Induction of unique populations of hepatic T cells in mice during infection with Toxocara canis. Jap. J. Parasitol. 44: 382-390, 1995. 77) Abo, T., Watanabe, H., Sato, K., Iiai, T., Moroda, T., Takeda, K. and Seki, S. Extrathymic T cells stand at an intermediate phylogenetic position between natural killer cells and thymus-derived T cells. Natural Immunity. 14: 173-187, 1995. 78) Hanawa, H., Inomata, T., Sekikawa, H., Abo, T., Kodama, M., Izumi T. and Shibata, A. Analysis of heart-infiltrating T cell clonotypes in experimental autoimmune myocarditis. Circ. Res. 78: 118-125, 1996. 79) Hasegawa, K., Ohtsuka, K., Shimizu, F., Kawachi, Y., Nakayama, M., Sato, K., Yamagiwa, S., Asakura, H. and Abo, T. Induction of NK cells and intermediate TCR cells with protective ability form viral infectious death, at the early phase of herpes virus infection. Biomed. Res. 17: 67-79, 1996. 80) Nakayama, M., Ohtsuka, K., Sato, K., Hasegawa, K., Yamagiwa, S., Sakai, K. and Abo, T. 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Kinetics of organ-associated natural killer cells and intermediate CD3 cells during pulmonary and hepatic granulomatous inflammation induced by mycobacterial cord factor. Microbiol. Immunol. 40: 651-658, 1996. 92) Tada, T., Yamamura, S., Kuwano, Y. and Abo T. Level of myelopoiesis in the bone marrow is influenced by intestinal flora. Cell. Immunol. 173: 155-161, 1996. 93) Watanabe, H., Miyaji, C., Makino, M. and Abo, T. Therapeutic effects of glycyrrhizin in mice infected with LP-BM5 murine retrovirus and mechanisms involved in the prevention of disease progression. Biotherapy 9: 209-220, 1996. 94) Nakayama, M., Ohtsuka, K., Sato, K., Hasegawa, K., Osman, Y. and Abo, T. Activation by estrogen of the number and function of self-reactive forbidden T cell clones in intermediate T-cell receptor cells. Cell Immunol. 172: 163-171, 1996. 95) Yamamura, S., Arai, K., Toyabe, S., Takahashi, E. H. and Abo, T. 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