Division of Microscopic Anatomy

Graduate School of Medical and Dental Sciences

Niigata University

To Medical School


Three-dimensional ultrastructure of cells and tissues
by scanning electron microscopy

Scanning electron microscopy (SEM) is useful for observing the surface topography of samples and has been used for analyzing the three-dimensional ultrastructure of cells and tissues.
 Recently, we also developed a real-time 3D SEM, which can obtain real-time stereo-images by using a beam tilting method. This technique is expected to be used not only for an imagingtool but also for a dissection tool in the field of microscopic anatomy.

Application of scanning probe microscopy
to biomedical studies

Various kinds of microscope using a probing tip have been introduced since the scanning tunneling microscope was invented in 1981, and now form a family of the scanning probe microscope (SPM). Among them, the atomic force microscope (AFM) has been widely used by biologists because this microscope has the advantage increating topographic images of the sample surface at high spatial resolution in various (vacuum, air and liquid) environments.