{"id":51,"date":"2021-08-12T18:10:05","date_gmt":"2021-08-12T09:10:05","guid":{"rendered":"https:\/\/demo-niigata-u-car.polyworks.work\/?page_id=51"},"modified":"2021-10-15T10:49:47","modified_gmt":"2021-10-15T01:49:47","slug":"theme_arrhythmic","status":"publish","type":"page","link":"https:\/\/www.med.niigata-u.ac.jp\/car\/research\/theme_arrhythmic\/","title":{"rendered":"\u7814\u7a76\u30c6\u30fc\u30de - \u4e0d\u6574\u8108\u7814\u7a76\u30b0\u30eb\u30fc\u30d7"},"content":{"rendered":"
\r\n \r\n
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\u4e0d\u6574\u8108\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e<\/span><\/h2>\r\n
\r\n
\r\n
<\/dt>\r\n <\/dl>\r\n <\/div>\r\n

\r\n \u3000\u79c1\u305f\u3061\u306f\u69d8\u3005\u306a\u4e0d\u6574\u8108\u75be\u60a3\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u4e0d\u6574\u8108\u306e\u907a\u4f1d\u7684\u306a\u539f\u56e0\u3068\u3057\u3066\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u540c\u5b9a\u3055\u308c\u307e\u3059\u304c\u3001\u3053\u306e\u5909\u7570\u304c\u6765\u3059\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u6a5f\u80fd\u306e\u7570\u5e38\u3092\u57fa\u790e\u5b9f\u9a13\u3067\u8abf\u3079\u3066\u304d\u307e\u3057\u305f\u3002\u907a\u4f1d\u5b50\u5909\u7570\u3092\u542b\u3093\u3060\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u3092\u57f9\u990a\u7d30\u80de\u306b\u767a\u73fe\u3055\u305b\u3066\u3001\u30d1\u30c3\u30c1\u30af\u30e9\u30f3\u30d7\u6cd5\u3068\u3044\u3046\u65b9\u6cd5\u3092\u7528\u3044\u3066\u30a4\u30aa\u30f3\u96fb\u6d41\u3092\u8a08\u6e2c\u3057\u3001\u5909\u7570\u3092\u542b\u3093\u3067\u3044\u306a\u3044\u6b63\u5e38\u306a\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u306e\u96fb\u6d41\u3068\u6bd4\u8f03\u3059\u308b\u3053\u3068\u3067\u3001\u907a\u4f1d\u5b50\u5909\u7570\u304c\u4e0d\u6574\u8108\u3092\u767a\u751f\u3055\u305b\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3057\u307e\u3059\u3002\u6211\u3005\u306f\u9577\u5e74\u306b\u6e21\u3063\u3066QT\u5ef6\u9577\u75c7\u5019\u7fa4\u3084\u305d\u306e\u4ed6\u306e\u4e0d\u6574\u8108\u75be\u60a3\u306e\u907a\u4f1d\u7684\u80cc\u666f\u306b\u3064\u3044\u3066\u7814\u7a76\u3092\u884c\u3044\u3001\u591a\u304f\u306e\u65b0\u3057\u3044\u77e5\u898b\u3092\u6570\u591a\u304f\u5831\u544a\u3057\u3066\u304d\u307e\u3057\u305f\u30021-4<\/sup>\r\n <\/p>\r\n

\r\n \u3000\u907a\u4f1d\u5b50\u5909\u7570\u3092\u767a\u73fe\u3055\u305b\u305f\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u907a\u4f1d\u5b50\u5909\u7570\u304c\u5f15\u304d\u8d77\u3053\u3059\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u306e\u7570\u5e38\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u907a\u4f1d\u5b50\u5909\u7570\u306b\u3088\u308b\u6d3b\u52d5\u96fb\u4f4d\u306e\u7570\u5e38\u3084\u3001\u5fc3\u96fb\u56f3\u306e\u7570\u5e38\u3001\u5b9f\u969b\u306b\u30de\u30a6\u30b9\u3067\u767a\u75c7\u3059\u308b\u4e0d\u6574\u8108\u3084\u5fc3\u75be\u60a3\u306b\u3064\u3044\u3066\u3082\u8abf\u3079\u3066\u304d\u307e\u3057\u305f\u3002\u6700\u8fd1\u3067\u306f\u3001\u30ca\u30c8\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u907a\u4f1d\u5b50SCN5A\u306e\u5909\u7570\u3092\u767a\u73fe\u3055\u305b\u305f\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3057\u3066\u3001\u30ca\u30c8\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u306e\u5909\u7570\u304c\u3001\u6d1e\u4e0d\u5168\u75c7\u5019\u7fa4\u3001\u5fc3\u623f\u7d30\u52d5\u3001\u623f\u5ba4\u30d6\u30ed\u30c3\u30af\u306a\u3089\u3073\u306b\u5fc3\u5ba4\u983b\u62cd\u3068\u3044\u3063\u305f\u3042\u3089\u3086\u308b\u4e0d\u6574\u8108\u306b\u52a0\u3048\u3066\u62e1\u5f35\u578b\u5fc3\u7b4b\u75c7\u3092\u767a\u75c7\u3059\u308b\u65b0\u3057\u3044\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3057\u307e\u3057\u305f\u30025<\/sup>\r\n <\/p>\r\n

\r\n \u3000\u305d\u308c\u3089\u306e\u77e5\u898b\u3092\u65e5\u5e38\u8a3a\u7642\u306b\u3082\u5fdc\u7528\u3057\u3001\u901a\u5e38\u306f\u86cb\u767d\u306b\u7ffb\u8a33\u3055\u308c\u308b\u9818\u57df\u3068\u305d\u308c\u306b\u8fd1\u63a5\u3057\u305f\u9818\u57df\u306e\u307f\u3092\u5bfe\u8c61\u3068\u3057\u3066\u884c\u308f\u308c\u308b\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u3001\u30ca\u30c8\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u907a\u4f1d\u5b50\u306e\u975e\u7ffb\u8a33\u9818\u57df\u3067\u3042\u308b\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\u306b\u62e1\u3052\u69d8\u3005\u306a\u4e0d\u6574\u8108\u306e\u60a3\u8005\u3055\u3093\u306b\u5bfe\u3057\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001Brugada\u75c7\u5019\u7fa4\u3084\u65e9\u671f\u518d\u5206\u6975\u75c7\u5019\u7fa4\u3001\u6d1e\u4e0d\u5168\u75c7\u5019\u7fa4\u3084\u5fc3\u623f\u7d30\u52d5\u7b49\u3067\u3001SCN5A\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\u306e\u5909\u7570\u3092\u540c\u5b9a\u3057\u3001\u6a5f\u80fd\u89e3\u6790\u306b\u3088\u308a\u30ca\u30c8\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u3002\r\n <\/p>\r\n

\r\n \u3000\u5f93\u6765\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u65b9\u6cd5\u3067\u306f\u3001\u907a\u4f1d\u5b50\u3054\u3068\u306eDNA\u914d\u5217\u3092\u4e00\u3064\u305a\u3064\u8abf\u3079\u308b\u305f\u3081\u3001\u975e\u5e38\u306b\u591a\u304f\u306e\u624b\u9593\u3068\u6642\u9593\u3092\u8981\u3057\u307e\u3057\u305f\u3002\u8fd1\u5e74\u3001\u7d0430\u5104\u5bfe\u306e\u30d2\u30c8\u306eDNA\u914d\u5217\u3059\u3079\u3066\u3092\u308f\u305a\u304b\u6570\u65e5\u4ee5\u5185\u306b\u8abf\u3079\u3089\u308c\u308b\u6b21\u4e16\u4ee3\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u6cd5\u304c\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u306f\u4e0d\u6574\u8108\u5206\u91ce\u306e\u4e2d\u3067\u65e5\u672c\u56fd\u5185\u3067\u3082\u6700\u3082\u65e9\u3044\u6642\u671f\u304b\u3089\u65b0\u3057\u3044\u539f\u56e0\u907a\u4f1d\u5b50\u3092\u767a\u898b\u3059\u308b\u305f\u3081\u306b\u6b21\u4e16\u4ee3\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u6cd5\u3092\u6d3b\u7528\u3057\u3001\u3053\u308c\u307e\u3067\u306bQT\u5ef6\u9577\u75c7\u5019\u7fa4\u3084Brugada\u75c7\u5019\u7fa4\u306e\u65b0\u305f\u306a\u907a\u4f1d\u5b50\u306b\u5909\u7570\u3092\u540c\u5b9a\u3057\u3066\u304d\u307e\u3057\u305f\u30026<\/sup>\r\n <\/p>\r\n

\r\n \u3000\u3088\u308a\u30d2\u30c8\u306b\u8fd1\u3044\u4e0d\u6574\u8108\u75be\u60a3\u306e\u30e2\u30c7\u30eb\u3068\u3057\u3066\u4e2d\u578b\u52d5\u7269\u3092\u7528\u3044\u3066\u306e\u7814\u7a76\u3092\u884c\u3063\u3066\u304d\u307e\u3057\u305f\u3002QT\u5ef6\u9577\u75c7\u5019\u7fa4\u306fTorsade de Pointes\u3068\u3044\u3046\u7279\u5fb4\u7684\u306a\u591a\u5f62\u6027\u5fc3\u5ba4\u983b\u62cd\u3092\u767a\u75c7\u3057\u307e\u3059\u304c\u3001\u3053\u306e\u5fc3\u5ba4\u983b\u62cd\u306e\u767a\u751f\u3068\u6301\u7d9a\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u4e0d\u6574\u8108\u767a\u75c7\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u305d\u306e\u4e88\u77e5\u30fb\u4e88\u9632\u306e\u305f\u3081\u3001\u4e2d\u578b\u52d5\u7269\u3092\u7528\u3044\u3066\u7279\u7570\u7684\u306a\u5fc3\u81d3\u8868\u9762\u304a\u3088\u3073\u5fc3\u7b4b\u5185\u306e\u96fb\u6c17\u751f\u7406\u73fe\u8c61\u3068\u50ac\u4e0d\u6574\u8108\u6027\u306e\u95a2\u9023\u6027\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u307e\u305f\u5fc3\u81d3\u8868\u9762\u304a\u3088\u3073\u5fc3\u7b4b\u5185\u306e\u96fb\u6c17\u751f\u7406\u7684\u7570\u5e38\u3068\u4f53\u8868\u5fc3\u96fb\u56f3\u306e\u7a2e\u3005\u306e\u95a2\u9023\u6027\u3092\u660e\u3089\u304b\u306b\u3057\u81e8\u5e8a\u4f8b\u306b\u304a\u3051\u308b\u4e0d\u6574\u8108\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u306b\u5bc4\u4e0e\u3057\u3066\u304d\u307e\u3057\u305f\u30027-10<\/sup>\u3000\u5fc3\u5ba4\u7d30\u52d5\u306f\u5fc3\u81d3\u7a81\u7136\u6b7b\u306e\u539f\u56e0\u3068\u306a\u308b\u6700\u91cd\u75c7\u306e\u4e0d\u6574\u8108\u3067\u3059\u304c\u3001\u767a\u75c7\u3084\u7dad\u6301\u306e\u6a5f\u69cb\u306f\u5341\u5206\u306b\u306f\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u73fe\u5728\u306f\u690d\u8fbc\u307f\u578b\u9664\u7d30\u52d5\u5668\uff08ICD\uff09\u306b\u3088\u308b\u5bfe\u75c7\u7642\u6cd5\u304c\u4e3b\u306b\u884c\u308f\u308c\u307e\u3059\u3002\u6211\u3005\u306f\u5171\u540c\u7814\u7a76\u8005\u3068\u306e\u4e2d\u578b\u52d5\u7269\u3092\u7528\u3044\u305f\u7814\u7a76\u3067\u3001\u5fc3\u5ba4\u7d30\u52d5\u306e\u767a\u75c7\u3084\u7dad\u6301\u3001\u518d\u767a\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u5fc3\u5ba4\u5185\u306e\u89e3\u5256\u5b66\u7684\u90e8\u4f4d\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u540c\u90e8\u4f4d\u306b\u5bfe\u3057\u3066\u30ab\u30c6\u30fc\u30c6\u30eb\u30a2\u30d6\u30ec\u30fc\u30b7\u30e7\u30f3\u306e\u624b\u6cd5\u3092\u9069\u5fdc\u3059\u308b\u3053\u3068\u3067\u3001\u5fc3\u5ba4\u7d30\u52d5\u306e\u767a\u75c7\u81ea\u4f53\u3092\u6291\u5236\u3059\u308b\u6839\u6cbb\u6cbb\u7642\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\r\n <\/p>\r\n

\r\n \u30002017\u5e74\u304b\u3089\u306f\u4e0d\u6574\u8108\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u89e3\u660e\u306e\u305f\u3081\u306e\u624b\u6cd5\u3068\u3057\u3066\u3001\u65b0\u305f\u306b\u5149\u5b66\u30de\u30c3\u30d4\u30f3\u30b0\u30b7\u30b9\u30c6\u30e0\u3092\u5c0e\u5165\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u5fc3\u81d3\u306e\u96fb\u6c17\u6d3b\u52d5\u30923\u6b21\u5143\u7684\u306b\u9ad8\u7cbe\u5ea6\u306b\u8a18\u9332\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u3001\u7279\u306b\u5fc3\u623f\u7d30\u52d5\u3084\u5fc3\u5ba4\u7d30\u52d5\u306a\u3069\u306e\u8907\u96d1\u306a\u8208\u596e\u69d8\u5f0f\u3092\u6301\u3064\u4e0d\u6574\u8108\u306e\u691c\u8a0e\u304c\u9032\u5c55\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u5149\u5b66\u30de\u30c3\u30d4\u30f3\u30b0\u306b\u306f\u4e2d\u578b\u52d5\u7269\u306e\u5fc3\u81d3\u304c\u4e3b\u306b\u7528\u3044\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u4f7f\u7528\u3059\u308b\u6a5f\u5668\u306e\u6027\u80fd\uff08\u611f\u5ea6\uff09\u306e\u9650\u754c\u304c\u3042\u3063\u305f\u305f\u3081\u3067\u3059\u304c\u3001\u5f53\u79d1\u3067\u306f\u30de\u30a6\u30b9\u306e\u5fc3\u81d3\uff08\u5fc3\u5ba4\u3001\u5fc3\u623f\uff09\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5149\u5b66\u30de\u30c3\u30d4\u30f3\u30b0\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u30de\u30a6\u30b9\u3067\u306f\u907a\u4f1d\u5b50\u6539\u5909\u304c\u6bd4\u8f03\u7684\u5bb9\u6613\u306b\u3067\u304d\u308b\u3053\u3068\u304b\u3089\u3001\u4e0a\u8a18\u306e\u3088\u3046\u306a\u907a\u4f1d\u5b50\u7570\u5e38\u306b\u8d77\u56e0\u3059\u308b\u4e0d\u6574\u8108\u75be\u60a3\u306e\u75c5\u614b\u3084\u3001\u907a\u4f1d\u5b50\u7570\u5e38\u306b\u57fa\u3065\u304f\u5fc3\u75be\u60a3\u306b\u5408\u4f75\u3057\u305f\u4e0d\u6574\u8108\u306e\u53ef\u8996\u5316\u3001\u89e3\u6790\u304c\u53ef\u80fd\u3068\u306a\u308a\u3001\u591a\u304f\u306e\u77e5\u898b\u3092\u5f97\u3089\u308c\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\r\n <\/p>\r\n <\/div>\r\n \r\n

\r\n

\u907a\u4f1d\u5b50\u8a3a\u65ad<\/span><\/h2>\r\n

\r\n \u3000\u5fc3\u81d3\u306e\u6a5f\u80fd\u4f4e\u4e0b\u3084\u62e1\u5927\u3001\u80a5\u5927\u306a\u3069\u306e\u5668\u8cea\u7684\u306a\u7570\u5e38\u3092\u4f34\u308f\u306a\u3044\u4e0d\u6574\u8108\u306e\u591a\u304f\u306f\u907a\u4f1d\u6027\u306e\u75be\u60a3\u3067\u3059\u3002\u73fe\u5728\u307e\u3067\u306bQT\u5ef6\u9577\u75c7\u5019\u7fa4\u3001Brugada\u75c7\u5019\u7fa4\u3001\u65e9\u671f\u518d\u5206\u6975\u75c7\u5019\u7fa4\u3001\u7279\u767a\u6027\u5fc3\u5ba4\u7d30\u52d5\u3001\u30ab\u30c6\u30b3\u30e9\u30df\u30f3\u611f\u53d7\u6027\u591a\u5f62\u6027\u5fc3\u5ba4\u983b\u62cd\u3001QT\u77ed\u7e2e\u75c7\u5019\u7fa4\u3001\u5fc3\u623f\u7d30\u52d5\u3001\u6d1e\u4e0d\u5168\u75c7\u5019\u7fa4\u3001\u623f\u5ba4\u30d6\u30ed\u30c3\u30af\u3068\u3044\u3063\u305f\u4e0d\u6574\u8108\u3067\u539f\u56e0\u3068\u306a\u308b\u907a\u4f1d\u5b50\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\r\n <\/p>\r\n

\r\n
\r\n
<\/dt>\r\n <\/dl>\r\n <\/div>\r\n

\r\n \u3000\u5f53\u79d1\u3067\u306f\u3001QT\u5ef6\u9577\u75c7\u5019\u7fa4\u306e\u907a\u4f1d\u5b50\u8a3a\u65ad\u304c\u533b\u7642\u5236\u5ea6\u306b\u3088\u3063\u3066\u4fdd\u967a\u9069\u5fdc\u3068\u306a\u308b\u4ee5\u524d\u304b\u3089\u907a\u4f1d\u5b50\u8a3a\u65ad\u3092\u884c\u3063\u3066\u3001\u60a3\u8005\u3055\u3093\u306b\u6709\u7528\u306a\u60c5\u5831\u3092\u63d0\u4f9b\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u4e0d\u6574\u8108\u306e\u539f\u56e0\u3068\u306a\u308b\u907a\u4f1d\u5b50\u60c5\u5831\u304c\u5224\u660e\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u60a3\u8005\u3055\u3093\u500b\u3005\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u907a\u4f1d\u5b50\u60c5\u5831\u306b\u5fdc\u3058\u305f\u6cbb\u7642\u6cd5\u306e\u9078\u629e\u3084\u4e0d\u6574\u8108\u767a\u4f5c\u3092\u304d\u305f\u3059\u5371\u967a\u6027\u306e\u5224\u65ad\u3092\u884c\u3046\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u4e0d\u6574\u8108\u306f\u6642\u306b\u7a81\u7136\u6b7b\u306e\u539f\u56e0\u3068\u306a\u308b\u75be\u60a3\u3067\u3059\u304c\u3001\u60a3\u8005\u3055\u3093\u306e\u5bb6\u65cf\u306e\u907a\u4f1d\u5b50\u3092\u8abf\u3079\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u307e\u3060\u75c5\u6c17\u3092\u767a\u75c7\u3057\u3066\u3044\u306a\u3044\u65b9\u304c\u4e0d\u6574\u8108\u3092\u767a\u75c7\u3059\u308b\u5371\u967a\u6027\u3092\u77e5\u308b\u3053\u3068\u3082\u3067\u304d\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u540c\u3058\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u3092\u6301\u3064\u3054\u5bb6\u65cf\u3082\u3001\u6ce8\u610f\u6df1\u3044\u7d4c\u904e\u89b3\u5bdf\u3084\u4e88\u9632\u7684\u306a\u6cbb\u7642\u306e\u5fc5\u8981\u6027\u306a\u3069\u3092\u4e88\u6e2c\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\r\n <\/p>\r\n

\r\n \u3000\u60a3\u8005\u3055\u3093\u306e\u907a\u4f1d\u5b50\u8a3a\u65ad\u3092\u884c\u3046\u3068\u3068\u3082\u306b\u3001\u79c1\u305f\u3061\u4e0d\u6574\u8108\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u65b0\u3057\u3044\u539f\u56e0\u907a\u4f1d\u5b50\u3092\u898b\u3064\u3051\u3066\u533b\u5b66\u306e\u767a\u5c55\u306b\u8ca2\u732e\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u307e\u3067\u306b\u69d8\u3005\u306a\u4e0d\u6574\u8108\u75c7\u5019\u7fa4\u306b\u304a\u3044\u3066\u7d0460\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u304c11<\/sup>\u3001\u305d\u306e\u3046\u3061\u306e1\u5272\u7a0b\u5ea6\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u306e\u767a\u898b\u306b\u79c1\u305f\u3061\u306e\u30b0\u30eb\u30fc\u30d7\u304c\u95a2\u308f\u3063\u3066\u304d\u307e\u3057\u305f\u300212-15<\/sup>\r\n <\/p>\r\n <\/div>\r\n \r\n

\r\n

\u4e0d\u6574\u8108\u306e\u65b0\u3057\u3044\u85ac\u7269\u7642\u6cd5\u306e\u958b\u767a<\/span><\/h2>\r\n
\r\n
\r\n
<\/dt>\r\n <\/dl>\r\n <\/div>\r\n

\r\n \u3000\u9069\u5207\u306a\u85ac\u7269\u6cbb\u7642\u306b\u3088\u308a\u4e0d\u6574\u8108\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u65e5\u5e38\u751f\u6d3b\u3092\u9001\u3063\u3066\u3044\u308b\u60a3\u8005\u3055\u3093\u304c\u591a\u304f\u3044\u308b\u4e00\u65b9\u3001\u4e2d\u306b\u306f\u85ac\u5264\u304c\u52b9\u304d\u306b\u304f\u3044\u3001\u3042\u308b\u3044\u306f\u305d\u306e\u52b9\u679c\u304c\u4e0d\u5b89\u5b9a\u306a\u96e3\u6cbb\u6027\u306e\u4e0d\u6574\u8108\u60a3\u8005\u3055\u3093\u3082\u3044\u3089\u3063\u3057\u3083\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u69d8\u3005\u306a\u4e0d\u6574\u8108\u306b\u5bfe\u3059\u308b\u591a\u7a2e\u591a\u69d8\u306a\u85ac\u5264\u306e\u52b9\u679c\u3092\u7814\u7a76\u3057\u3001\u65b0\u3057\u3044\u85ac\u7269\u7642\u6cd5\u3092\u958b\u767a\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u5f53\u79d1\u306f\u7279\u306b\u5fc3\u5ba4\u7d30\u52d5\u30fb\u5fc3\u5ba4\u983b\u62cd\u3068\u3044\u3063\u305f\u6700\u3082\u91cd\u75c7\u306a\u5fc3\u5ba4\u6027\u4e0d\u6574\u8108\u306e\u85ac\u7269\u7642\u6cd5\u3067\u56fd\u969b\u7684\u306a\u696d\u7e3e\u3092\u3042\u3052\u3066\u3044\u307e\u3059\u3002\u69d8\u3005\u306a\u7a2e\u985e\u306e\u6297\u4e0d\u6574\u8108\u85ac\u304c\u5fc3\u5ba4\u983b\u62cd\u3092\u505c\u6b62\u3055\u305b\u308b\u52b9\u679c\u3092\u6bd4\u8f03\u3057\u3001\u4e0d\u6574\u8108\u767a\u4f5c\u3092\u8d77\u3053\u3057\u305f\u6551\u6025\u60a3\u8005\u3055\u3093\u3078\u306e\u6709\u52b9\u306a\u6cbb\u7642\u6cd5\u3092\u89e3\u660e\u3057\u307e\u3057\u305f\u300216<\/sup>\u3000\u307e\u305f\u3001\u4e3b\u306b\u5fc3\u5ba4\u983b\u62cd\u306e\u6cbb\u7642\u306b\u7528\u3044\u3089\u308c\u308b\u8907\u6570\u306e\u6297\u4e0d\u6574\u8108\u85ac\u306e\u7b2c\u2161\u76f8\u81e8\u5e8a\u8a66\u9a13\u306b\u95a2\u308f\u308a\u6297\u4e0d\u6574\u8108\u85ac\u306e\u958b\u767a\u306b\u643a\u308f\u3063\u3066\u3044\u307e\u3059\u3002\u30bd\u30bf\u30ed\u30fc\u30eb\u306e\u52b9\u679c\u5224\u5b9a\u6cd5\u3084\u3001\u30d9\u30d7\u30ea\u30b8\u30eb\u306e\u5fc3\u5ba4\u983b\u62cd\u3078\u306e\u6709\u7528\u6027\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u307e\u3057\u305f\u300217-20<\/sup>\u3000\u4ed6\u306b\u3082\u30cb\u30d5\u30a7\u30ab\u30e9\u30f3\u30c8\u30fb\u30e1\u30ad\u30b7\u30ec\u30c1\u30f3\u306e\u4f75\u7528\u7642\u6cd5\u3084\u3001QT\u5ef6\u9577\u75c7\u5019\u7fa4\u306b\u4f34\u3046\u591a\u5f62\u6027\u5fc3\u5ba4\u983b\u62cd\u306b\u5bfe\u3059\u308b\u30e9\u30f3\u30b8\u30aa\u30ed\u30fc\u30eb\u306e\u6709\u52b9\u6027\u7b49\u3001\u591a\u6570\u306e\u7d4c\u9a13\u304b\u3089\u6709\u52b9\u306a\u6cbb\u7642\u6cd5\u3092\u89e3\u660e\u3057\u5831\u544a\u3057\u3066\u304d\u307e\u3057\u305f\u300221,22<\/sup>\r\n <\/p>\r\n

\r\n \u3000\u6700\u8fd1\u3067\u306f\u3001\u907a\u4f1d\u6027\u4e0d\u6574\u8108\u75c7\u5019\u7fa4\u306e\u4e2d\u3067\u3001\u81f4\u6b7b\u6027\u304c\u9ad8\u3044\u30ab\u30c6\u30b3\u30e9\u30df\u30f3\u611f\u53d7\u6027\u5fc3\u5ba4\u983b\u62cd\u306b\u5bfe\u3059\u308b\u52b9\u679c\u7684\u306a\u65b0\u3057\u3044\u85ac\u7269\u7642\u6cd5\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u300223<\/sup>\u3000\u3053\u306e\u6cbb\u7642\u306e\u958b\u767a\u306f\u3001\u5f53\u79d1\u901a\u9662\u4e2d\u306e\u91cd\u75c7\u306a\u60a3\u8005\u3055\u3093\u3078\u306e\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u3092\u89e3\u660e\u3059\u308b\u305f\u3081\u306b\u958b\u59cb\u3055\u308c\u307e\u3057\u305f\u3002\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3092\u4f7f\u3063\u3066\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u3092\u958b\u767a\u3057\u3001\u5b9f\u969b\u306e\u60a3\u8005\u3055\u3093\u3078\u81e8\u5e8a\u5fdc\u7528\u3057\u73fe\u5728\u3067\u306f\u4e16\u754c\u3067\u3053\u306e\u6cbb\u7642\u6cd5\u304c\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4ed6\u306b\u3082\u5b9f\u9a13\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u3001\u5fc3\u623f\u306e\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3092\u6291\u5236\u3059\u308b\u6cbb\u7642\u6cd5\u3092\u7814\u7a76\u3057\u3066\u304d\u307e\u3057\u305f\u300224<\/sup>\r\n <\/p>\r\n

\r\n \u3000\u85ac\u7269\u7642\u6cd5\u306e\u307f\u306a\u3089\u305a\u3001\u30ab\u30c6\u30fc\u30c6\u30eb\u30a2\u30d6\u30ec\u30fc\u30b7\u30e7\u30f3\u3084\u690d\u8fbc\u307f\u30c7\u30d0\u30a4\u30b9\u6cbb\u7642\u306a\u3069\u306e\u975e\u85ac\u7269\u7642\u6cd5\u306e\u9818\u57df\u306b\u304a\u3044\u3066\u3082\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u305f\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u5fc3\u5ba4\u7d30\u52d5\u3067\u306f\u3001\u4e00\u90e8\u306e\u7279\u5b9a\u306e\u75c5\u614b\u3092\u9664\u3044\u3066\u3053\u308c\u307e\u3067\u6709\u52b9\u306a\u6839\u6cbb\u6cbb\u7642\u306f\u78ba\u7acb\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u5f53\u79d1\u3067\u306f\u5fc3\u5ba4\u7d30\u52d5\u306e\u767a\u75c7\u3084\u7dad\u6301\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u5fc3\u5185\u306e\u9818\u57df\u3092\u6a19\u7684\u3068\u3057\u305f\u5fc3\u5ba4\u7d30\u52d5\u30a2\u30d6\u30ec\u30fc\u30b7\u30e7\u30f3\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u305f\u7814\u7a76\u3092\u6d77\u5916\u5171\u540c\u7814\u7a76\u65bd\u8a2d\u3068\u9032\u3081\u3066\u3044\u307e\u3059\u300225<\/sup>\u3000\u305d\u3057\u3066\u3001\u540c\u6cbb\u7642\u306e\u81e8\u5e8a\u5fdc\u7528\u3092\u76ee\u6307\u3057\u305f\u5927\u578b\u52d5\u7269\u30e2\u30c7\u30eb\u3067\u306e\u57fa\u790e\u8a66\u9a13\u306b\u3088\u308a\u3001\u672c\u6cbb\u7642\u306e\u6709\u52b9\u6027\u3001\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u57fa\u790e\u30c7\u30fc\u30bf\u3092\u63c3\u3048\u3066\u3044\u307e\u3059\u3002\r\n <\/p>\r\n <\/div>\r\n \r\n

\r\n

\u81e8\u5e8a\u7814\u7a76<\/span><\/h2>\r\n
\r\n
\r\n
<\/dt>\r\n <\/dl>\r\n <\/div>\r\n

\r\n \u3000\u5f53\u79d1\u3067\u306f\u3001\u4e0d\u6574\u8108\u306e\u30ab\u30c6\u30fc\u30c6\u30eb\u30a2\u30d6\u30ec\u30fc\u30b7\u30e7\u30f3\u6cbb\u7642\u306b\u65e9\u671f\u304b\u3089\u53d6\u308a\u7d44\u307f\u3001\u3053\u308c\u307e\u3067\u591a\u304f\u306e\u4e0d\u6574\u8108\u306e\u60a3\u8005\u3055\u3093\u306e\u8a3a\u7642\u3092\u884c\u3063\u3066\u307e\u3044\u308a\u307e\u3057\u305f\u300226<\/sup>\u3000\u60a3\u8005\u3055\u3093\u304b\u3089\u79c1\u305f\u3061\u304c\u5b66\u3093\u3060\u3053\u3068\u3092\u81e8\u5e8a\u7814\u7a76\u3068\u3057\u3066\u767a\u8868\u3057\u3001\u4eca\u5f8c\u306e\u8a3a\u7642\u3084\u533b\u5b66\u306e\u767a\u5c55\u306b\u5f79\u7acb\u3066\u3066\u304d\u307e\u3057\u305f\u3002\u4f8b\u3048\u3070\u3001\u5fc3\u7b4b\u6897\u585e\u3084\u5fc3\u7b4b\u75c7\u3068\u3044\u3063\u305f\u5fc3\u7b4b\u306e\u7570\u5e38\u3092\u304d\u305f\u3059\u75be\u60a3\u306f\u81f4\u6b7b\u6027\u306e\u5fc3\u5ba4\u7d30\u52d5\u3084\u5fc3\u5ba4\u983b\u62cd\u3092\u5408\u4f75\u3059\u308b\u6700\u5927\u306e\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u5fc3\u75be\u60a3\u306b\u4f34\u3046\u5fc3\u5ba4\u983b\u62cd\u306e\u7279\u5fb4\u3084\u30a2\u30d6\u30ec\u30fc\u30b7\u30e7\u30f3\u6cbb\u7642\u306b\u3064\u3044\u3066\u591a\u304f\u306e\u77e5\u898b\u3092\u767a\u8868\u3057\u3001\u6cbb\u7642\u6cd5\u306a\u3069\u306b\u3064\u3044\u3066\u60c5\u5831\u3092\u767a\u4fe1\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u8fd1\u5e74\u3001\u5fc3\u623f\u7d30\u52d5\u306b\u5bfe\u3059\u308b\u30a2\u30d6\u30ec\u30fc\u30b7\u30e7\u30f3\u6cbb\u7642\u304c\u9032\u6b69\u3057\u3066\u3044\u307e\u3059\u3002\u5fc3\u623f\u7d30\u52d5\u306f\u52d5\u60b8\u306a\u3069\u306e\u81ea\u899a\u75c7\u72b6\u3084\u5fc3\u4e0d\u5168\u306e\u539f\u56e0\u3068\u306a\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u5fc3\u623f\u5185\u306b\u751f\u3058\u305f\u8840\u6813\u306b\u3088\u308b\u8133\u6897\u585e\u306e\u5371\u967a\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u3001\u5fc3\u539f\u6027\u8133\u585e\u6813\u75c7\u306e\u4e88\u9632\u306b\u306f\u6297\u51dd\u56fa\u7642\u6cd5\u3068\u3088\u3070\u308c\u308b\u8840\u6db2\u3092\u56fa\u307e\u308a\u306b\u304f\u304f\u3057\u3066\u8840\u6813\u306e\u5f62\u6210\u3092\u9632\u3050\u6cbb\u7642\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u306f\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u307e\u305f\u306f\u3001\u76f4\u63a5\u578b\u7d4c\u53e3\u6297\u51dd\u56fa\u85ac\uff08DOAC\uff09\u304c\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002DOAC\u306f\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u306b\u6bd4\u3079\u3066\u3001\u4f5c\u7528\u6642\u9593\u304c\u77ed\u3044\u3082\u306e\u306e\u8133\u6897\u585e\u4e88\u9632\u52b9\u679c\u304c\u540c\u7b49\u304b\u512a\u308c\u3001\u51fa\u8840\u6027\u526f\u4f5c\u7528\u304c\u5c11\u306a\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u512a\u308c\u305f\u6709\u52b9\u6027\u3092\u793a\u3059\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u306f\u660e\u3089\u304b\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u5f53\u79d1\u306e\u81e8\u5e8a\u7814\u7a76\u306b\u3088\u308a\u3001\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u306b\u6bd4\u3079\u76f4\u63a5\u578b\u7d4c\u53e3\u6297\u51dd\u56fa\u85ac\uff08DOAC\uff09\u670d\u7528\u4f8b\u3067\u306f\u8840\u7ba1\u640d\u50b7\u6642\u306e\u6b63\u5e38\u306a\u6b62\u8840\u53cd\u5fdc\u304c\u7dad\u6301\u3055\u308c\u6613\u3044\u3053\u3068\u3001\u307e\u305f\u3001DOAC\u3092\u5b9a\u671f\u7684\u306b\u5185\u670d\u3057\u305f\u5834\u5408\u305d\u306e\u8840\u4e2d\u6fc3\u5ea6\u306b\u95a2\u308f\u3089\u305a\u30c8\u30ed\u30f3\u30d3\u30f3\u7523\u751f\u304c\u6291\u5236\u3055\u308c\u3001\u305d\u306e\u4f5c\u7528\u306f\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u306b\u6bd4\u3079\u3066\u5f31\u3044\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3053\u3068\u3067\u3001DOAC\u306e\u6709\u52b9\u6027\u3092\u88cf\u4ed8\u3051\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u300227<\/sup>\u3000\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u4eca\u5f8c\u306e\u5fc3\u539f\u6027\u8133\u585e\u6813\u75c7\u4e88\u9632\u6cbb\u7642\u306e\u767a\u5c55\u306b\u7e4b\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001DOAC\u306e\u7a2e\u985e\u306b\u3088\u3063\u3066\u306f\u7d99\u7d9a\u5185\u670d\u4e0b\u306e\u51dd\u56fa\u80fd\u306b\u76f8\u9055\u304c\u3042\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u5341\u5206\u306a\u691c\u8a3c\u306b\u306f\u81f3\u3063\u3066\u3044\u306a\u3044\u73fe\u72b6\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u3053\u3067\u5f53\u79d1\u3067\u306f\u3001\u5fc3\u623f\u7d30\u52d5\u306b\u5bfe\u3059\u308b\u30ab\u30c6\u30fc\u30c6\u30eb\u30a2\u30d6\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u53d7\u3051\u3089\u308c\u308b\u60a3\u8005\u3055\u3093\u306b\u3054\u5354\u529b\u3044\u305f\u3060\u3044\u3066\u3001\u4e8b\u524d\u306b\u7a2e\u985e\u306e\u7570\u306a\u308bDOAC\u3092\u5185\u670d\u3057\u3066\u3044\u305f\u3060\u304d\u3001\u30ab\u30c6\u30fc\u30c6\u30eb\u4fb5\u8972\u306e\u524d\u5f8c\u306b\u63a1\u8840\u3092\u884c\u3044\u8840\u6db2\u4e2d\u306e\u6b62\u8840\u7269\u8cea\u306e\u5909\u5316\u3092\u8a55\u4fa1\u3059\u308b\u7121\u4f5c\u70ba\u6bd4\u8f03\u7814\u7a76\u3092\u591a\u65bd\u8a2d\u5171\u540c\u3067\u884c\u3063\u3066\u3044\u307e\u3059\u3002\r\n <\/p>\r\n

\r\n \u3000\u81ea\u5df1\u6297\u4f53\u306e1\u3064\u3067\u3042\u308b\u6297\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6297\u4f53\uff08AMA\uff09\u306f\u809d\u81d3\u306e\u75c5\u6c17\u3067\u3042\u308b\u539f\u767a\u6027\u80c6\u6c41\u6027\u80c6\u7ba1\u708e\u3084\u4e00\u90e8\u306e\u7b4b\u75be\u60a3\u306b\u95a2\u9023\u3059\u308b\u6297\u4f53\u3067\u3059\u304c\u3001AMA\u3092\u3082\u3064\u65b9\u306e\u4e2d\u306b\u306f\u5fc3\u6a5f\u80fd\u969c\u5bb3\u3084\u4e0d\u6574\u8108\u306a\u3069\u5fc3\u75be\u60a3\u3092\u5408\u4f75\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u3001\u4e0a\u5ba4\u6027\u4e0d\u6574\u8108\u306e\u5408\u4f75\u304c\u591a\u3044\u53ef\u80fd\u6027\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001AMA\u304c\u4e0d\u6574\u8108\u75be\u60a3\u3001\u7279\u306b\u81f4\u6b7b\u7684\u3068\u306a\u308a\u5f97\u308b\u5fc3\u5ba4\u6027\u4e0d\u6574\u8108\u306e\u5371\u967a\u56e0\u5b50\u3068\u306a\u308b\u306e\u304b\u306f\u4e0d\u660e\u3067\u3057\u305f\u3002\u5f53\u79d1\u3067\u306f\u3053\u306e\u75be\u60a3\u306b\u3064\u3044\u3066\u3001\u5f53\u9662\u306e\u8c4a\u5bcc\u306a\u75c7\u4f8b\u306e\u4e2d\u304b\u3089\u306e\u8abf\u67fb\u3001\u306a\u3089\u3073\u306b\u524d\u5411\u304d\u8abf\u67fb\u3092\u884c\u3044AMA\u3068\u5fc3\u5ba4\u6027\u4e0d\u6574\u8108\u306e\u95a2\u9023\u6027\u306b\u3064\u3044\u3066\u89e3\u660e\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\r\n <\/p>\r\n

\r\n \u3000\u7279\u767a\u6027\u5fc3\u5ba4\u7d30\u52d5\u306e\u75be\u60a3\u6982\u5ff5\u3067\u3042\u308b\u65e9\u671f\u518d\u5206\u6975\u75c7\u5019\u7fa4\u304c\u5927\u304d\u306a\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u307e\u3059\u304c\u3001\u5f53\u79d1\u306f1985\u5e74\u3053\u306e\u65b0\u3057\u3044\u75c5\u614b\u3092\u5831\u544a\u3057\u300128<\/sup>\u3000\u5fc3\u5ba4\u7d30\u52d5\u306e\u8a98\u5f15\u3068\u306a\u308b\u5c40\u6240\u8208\u596e\u306e\u30a2\u30d6\u30ec\u30fc\u30b7\u30e7\u30f3\u6cbb\u7642\u3092\u884c\u3063\u3066\u304d\u307e\u3057\u305f\u300229<\/sup>\u3000\u304f\u308f\u3048\u3066\u3001\u5f53\u79d1\u3067\u306f\u5168\u56fd\u306e\u4e0d\u6574\u8108\u8a3a\u7642\u306b\u3042\u305f\u3063\u3066\u3044\u308b\u65bd\u8a2d\u306e\u5354\u529b\u3092\u5f97\u3066\u3001\u5fc3\u5ba4\u7d30\u52d5\u3092\u304d\u305f\u3059\u65e9\u671f\u518d\u5206\u6975\u75c7\u5019\u7fa4\u306b\u3064\u3044\u3066\u3001\u305d\u306e\u81e8\u5e8a\u50cf\u3084\u5fc3\u96fb\u56f3\u306e\u7279\u5fb4\u3001\u539f\u56e0\u907a\u4f1d\u5b50\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u3055\u3089\u306b\u4e0d\u6574\u8108\u767a\u75c7\u306e\u5371\u967a\u56e0\u5b50\u3092\u540c\u5b9a\u3057\u300112,30<\/sup>\u3000Brugada\u75c7\u5019\u7fa4\u3084QT\u5ef6\u9577\u75c7\u5019\u7fa4\u3068\u3044\u3063\u305f\u4ed6\u306e\u907a\u4f1d\u6027\u4e0d\u6574\u8108\u75c7\u5019\u7fa4\u306e\u81e8\u5e8a\u7684\u306a\u7279\u5fb4\u3082\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u307e\u3057\u305f\u300231-36<\/sup>\u3000\u307e\u305f\u3001\u6700\u8fd1\u3067\u306f\u65e9\u671f\u518d\u5206\u6975\u6240\u898b\u304c\u3001\u7279\u767a\u6027\u5fc3\u5ba4\u7d30\u52d5\u306e\u307f\u306a\u3089\u305a\u5fc3\u623f\u7d30\u52d5\u306e\u767a\u75c7\u306b\u3082\u95a2\u9023\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u300237<\/sup>\u3000\u65e9\u671f\u518d\u5206\u6975\u306f\u5065\u5e38\u4eba\u306e3-11%\u306b\u8a8d\u3081\u3089\u308c\u308b\u5fc3\u96fb\u56f3\u6240\u898b\u3067\u3059\u304c\u3001\u3053\u306e\u6240\u898b\u304c\u5fc3\u623f\u7d30\u52d5\u767a\u75c7\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u8a8d\u8b58\u3055\u308c\u305f\u3053\u3068\u306b\u3088\u308a\u3001\u4eca\u5f8c\u306e\u5fc3\u623f\u7d30\u52d5\u6cbb\u7642\u306e\u767a\u5c55\u306b\u7e4b\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u5fc3\u5ba4\u7d30\u52d5\u3092\u304d\u305f\u3059Brugada\u75c7\u5019\u7fa4\u306b\u304a\u3051\u308b\u96fb\u6c17\u751f\u7406\u5b66\u7684\u306a\u7279\u5fb4\u306b\u3064\u3044\u3066\u3082\u7814\u7a76\u3092\u9032\u3081\u3066\u304a\u308a\u3001\u53f3\u5ba4\u6d41\u51fa\u8def\u306b\u304a\u3051\u308b\u30d7\u30ed\u30b0\u30e9\u30e0\u523a\u6fc0\u306b\u5bfe\u3059\u308b\u5c40\u6240\u4f1d\u5c0e\u306e\u6319\u52d5\u306e\u5dee\u7570\u306b\u3088\u308a\u5fc3\u5ba4\u7d30\u52d5\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3067\u304d\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u300238,39<\/sup>\r\n <\/p>\r\n

\r\n \u3000\u5fc3\u81d3\u4f1d\u5c0e\u969c\u5bb3\u3092\u5408\u4f75\u3059\u308b\u91cd\u75c7\u5fc3\u4e0d\u5168\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u65b9\u6cd5\u306e\u4e00\u3064\u3068\u3057\u3066\u5fc3\u81d3\u518d\u540c\u671f\u7642\u6cd5\uff08CRT\uff09\u3068\u3044\u3046\u30c7\u30d0\u30a4\u30b9\u6cbb\u7642\u304c\u884c\u308f\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u5fc3\u7b4b\u6897\u585e\u3084\u62e1\u5f35\u578b\u5fc3\u7b4b\u75c7\u306a\u3069\u306b\u4ee3\u8868\u3055\u308c\u308b\u75be\u60a3\u3067\u306f\u3001\u5fc3\u7b4b\u969c\u5bb3\u304c\u9032\u884c\u3059\u308b\u3068\u5fc3\u4e0d\u5168\u3068\u547c\u3070\u308c\u308b\u72b6\u614b\u306b\u81f3\u308a\u3001\u80ba\u3046\u3063\u8840\u3084\u6d6e\u816b\u3001\u81d3\u5668\u969c\u5bb3\u3092\u304d\u305f\u3057\u307e\u3059\u3002\u5fc3\u7b4b\u969c\u5bb3\u306e\u9032\u884c\u306f\u523a\u6fc0\u4f1d\u5c0e\u306e\u969c\u5bb3\u3092\u4f75\u767a\u3059\u308b\u3053\u3068\u3067\u5fc3\u53ce\u7e2e\u306b\u5927\u304d\u306a\u305a\u308c\u3092\u751f\u3058\u3001\u3055\u3089\u306a\u308b\u5fc3\u81d3\u6a5f\u80fd\u4f4e\u4e0b\u306e\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u3088\u3046\u306a\u72b6\u614b\u3092\u6253\u958b\u3059\u308b\u305f\u3081\u306b\u3001\u7279\u6b8a\u306a\u30da\u30fc\u30b9\u30e1\u30fc\u30ab\u30fc\u3092\u5229\u7528\u3057\u3066\u523a\u6fc0\u4f1d\u5c0e\u3092\u88dc\u6b63\u3059\u308b\u3053\u3068\u3067\u5fc3\u81d3\u6a5f\u80fd\u306e\u6539\u5584\u3092\u306f\u304b\u308b\u6cbb\u7642\u304cCRT\u3068\u547c\u3070\u308c\u307e\u3059\u3002\u3053\u306e\u6cbb\u7642\u6cd5\u306f\u3001\u5fc3\u623f\u30fb\u53f3\u5fc3\u5ba4\u30fb\u5de6\u5fc3\u5ba4\u5074\u306e\u51a0\u72b6\u9759\u8108\u306b\u30da\u30fc\u30b9\u30e1\u30fc\u30ab\u30fc\u30ea\u30fc\u30c9\u3092\u624b\u8853\u3067\u914d\u7f6e\u3057\u3001\u81f3\u9069\u306a\u30bf\u30a4\u30df\u30f3\u30b0\u3067\u96fb\u6c17\u523a\u6fc0\u3059\u308b\u3053\u3068\u3067\u884c\u308f\u308c\u307e\u3059\u3002\u3053\u306e\u6cbb\u7642\u306b\u3088\u308a\u5fc3\u81d3\u306e\u53ce\u7e2e\u3092\u518d\u3073\u9069\u5207\u306b\u540c\u671f\u3055\u305b\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u624b\u8853\u306f\u3001\u73fe\u5728\u3067\u306f\u3059\u3079\u3066\u9759\u8108\u3092\u7d4c\u7531\u3057\u305f\u65b9\u6cd5\u3067\u8a8d\u53ef\u3092\u5f97\u305f\u65bd\u8a2d\u3067\u884c\u3046\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u3001\u6700\u3082\u6cbb\u7642\u304c\u52e7\u3081\u3089\u308c\u308b\u60a3\u8005\u3055\u3093\u306f\u3001\u6700\u9069\u306a\u85ac\u7269\u6cbb\u7642\u304c\u884c\u308f\u308c\u3066\u3044\u308b\u306b\u3082\u95a2\u308f\u3089\u305a\u4e2d\u7b49\u5ea6\u4ee5\u4e0a\u306e\u5fc3\u4e0d\u5168\u72b6\u614b\u306b\u3042\u308a\u3001\u5de6\u5ba4\u6a5f\u80fd\u306e\u4e2d\u7b49\u5ea6\u4ee5\u4e0a\u306e\u969c\u5bb3\u304c\u3042\u308a\u3001\u5fc3\u96fb\u56f3\u306b\u304a\u3044\u3066\u5fc3\u5ba4\u306e\u4f1d\u5c0e\u969c\u5bb3\u3092\u6301\u3064\u6d1e\u8abf\u5f8b\u306e\u65b9\u3067\u3059\u3002\u6700\u8fd1\u3067\u306f\u660e\u3089\u304b\u306a\u4f1d\u5c0e\u969c\u5bb3\u3092\u6301\u3064\u8efd\u75c7\u306e\u5fc3\u4e0d\u5168\u60a3\u8005\u306b\u3082\u6709\u52b9\u6027\u304c\u793a\u3055\u308c\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u3053\u306eCRT\u3092\u53d7\u3051\u305f\u60a3\u8005\u3055\u3093\u306e\u4e2d\u3067\u3001\u5fc3\u4e0d\u5168\u304c\u6539\u5584\u3057\u306a\u3044\u5834\u5408\u308230%\u307b\u3069\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u91cd\u75c7\u306e\u5fc3\u4e0d\u5168\u60a3\u8005\u3055\u3093\u306b\u304a\u3044\u3066\u3001CRT\u6cbb\u7642\u306e\u6709\u52b9\u6027\u304c\u5f97\u3089\u308c\u306a\u3044\u5834\u5408\u306b\u306f\u3001\u75c5\u72b6\u3084\u751f\u547d\u4e88\u5f8c\u306b\u95a2\u308f\u308b\u5927\u304d\u306a\u554f\u984c\u3068\u306a\u308a\u307e\u3059\u3002CRT\u306e\u6709\u52b9\u6027\u3092\u5c11\u3057\u3067\u3082\u6539\u5584\u3059\u308b\u76ee\u7684\u3067\u3001\u6211\u3005\u306e\u65bd\u8a2d\u3067\u306f\u30da\u30fc\u30b7\u30f3\u30b0\u7642\u6cd5\u306e\u9078\u629e\u30fb\u8abf\u6574\u306b\u3064\u3044\u3066\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u300240<\/sup>\r\n <\/p>\r\n

\r\n \u3000\u4e0d\u6574\u8108\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u60a3\u8005\u3055\u3093\u306b\u6700\u5148\u7aef\u306e\u77e5\u8b58\u3068\u6280\u8853\u3092\u7528\u3044\u305f\u8a3a\u7642\u3092\u884c\u3044\u3001\u8a3a\u7642\u3067\u5f97\u305f\u77e5\u898b\u3092\u767a\u4fe1\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u57fa\u790e\u5b9f\u9a13\u3084\u81e8\u5e8a\u8a66\u9a13\u3001\u60a3\u8005\u3055\u3093\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u306e\u89e3\u6790\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u3053\u308c\u307e\u3067\u306e\u81e8\u5e8a\u4e0a\u306e\u4e0d\u660e\u70b9\u3092\u89e3\u6c7a\u3059\u308b\u3053\u3068\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u57fa\u790e\u7814\u7a76\u3084\u907a\u4f1d\u5b50\u691c\u67fb\u3001\u81e8\u5e8a\u7814\u7a76\u306e\u6210\u679c\u3092\u518d\u3073\u60a3\u8005\u3055\u3093\u306b\u9084\u5143\u3057\u3001\u60a3\u8005\u3055\u3093\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u75c5\u6c17\u3084\u4f53\u8cea\u306e\u500b\u6027\u306b\u5408\u308f\u305b\u305f\u533b\u7642\u3092\u884c\u3044\u3001\u533b\u5b66\u306e\u767a\u5c55\u306b\u8ca2\u732e\u3067\u304d\u308c\u3070\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\r\n <\/p>\r\n <\/div>\r\n \r\n

\r\n

\u5f15\u7528\u6587\u732e<\/span><\/h4>\r\n
    \r\n
  1. Yamashita F, Horie M, Kubota T, Yoshida H, Yumoto Y, Kobori A, Ninomiya T, Kono Y, Haruna T, Tsuji K, Washizuka T, Takano M, Otani H, Sasayama S, Aizawa Y. Characterization and subcellular localization of kcnq1 with a heterozygous mutation in the c terminus. Journal of molecular and cellular cardiology. 2001;33:197-207<\/li>\r\n
  2. Hosaka Y, Hanawa H, Washizuka T, Chinushi M, Yamashita F, Yoshida T, Komura S, Watanabe H, Aizawa Y. Function, subcellular localization and assembly of a novel mutation of kcnj2 in andersen's syndrome. Journal of molecular and cellular cardiology. 2003;35:409-415<\/li>\r\n
  3. Ikrar T, Hanawa H, Watanabe H, Okada S, Aizawa Y, Ramadan MM, Komura S, Yamashita F, Chinushi M, Aizawa Y. A double-point mutation in the selectivity filter site of the kcnq1 potassium channel results in a severe phenotype, lQT1, of long QT syndrome. J Cardiovasc Electrophysiol. 2008;19:541-549<\/li>\r\n
  4. Sato A, Arimura T, Makita N, Ishikawa T, Aizawa Y, Ushinohama H, Aizawa Y, Kimura A. Novel mechanisms of trafficking defect caused by kcnq1 mutations found in long QT syndrome. J Biol Chem. 2009;284:35122-35133<\/li>\r\n
  5. Watanabe H, Yang T, Stroud DM, Lowe JS, Harris L, Atack TC, Wang DW, Hipkens SB, Leake B, Hall L, Kupershmidt S, Chopra N, Magnuson MA, Tanabe N, Knollmann BC, George AL, Jr., Roden DM. Striking in vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro. Circulation. 2011;124:1001-1011<\/li>\r\n
  6. Makita N, Yagihara N, Crotti L, Johnson CN, Beckmann BM, Roh MS, Shigemizu D, Lichtner P, Ishikawa T, Aiba T, Homfray T, Behr ER, Klug D, Denjoy I, Mastantuono E, Theisen D, Tsunoda T, Satake W, Toda T, Nakagawa H, Tsuji Y, Tsuchiya T, Yamamoto H, Miyamoto Y, Endo N, Kimura A, Ozaki K, Motomura H, Suda K, Tanaka T, Schwartz PJ, Meitinger T, Kaab S, Guicheney P, Shimizu W, Bhuiyan ZA, Watanabe H, Chazin WJ, George AL, Jr. Novel calmodulin mutations associated with congenital arrhythmia susceptibility. Circ Cardiovasc Genet. 2014;7:466-474<\/li>\r\n
  7. Chinushi M, Izumi D, Komura S, Ahara S, Satoh A, Furushima H, Washizuka T, Aizawa Y.Role of autonomic nervous activity in the antiarrhythmic effects of magnesium sulfate in a canine model of polymorphic ventricular tachyarrhythmia associated with prolonged QT interval. J Cardiovasc Pharmacol. 2006;48:121-7<\/li>\r\n
  8. Iijima K, Chinushi M, Izumi D, Ahara S, Furushima H, Komura S, Hosaka Y, Sanada A, Sato A, Aizawa Y. Effect of bepridil in atrial fibrillation inducibility facilitated by vagal nerve stimulation. - prevention of vagal nerve activation-induced shortening of the atrial action potential duration. Circ J. 2010;74:895-902<\/li>\r\n
  9. Izumi D, Chinushi M, Iijima K, Ahara S, Komura S, Furushima H, Hosaka Y, Sanada A, Yagihara N, Aizawa Y. Effects of bepridil versus e-4031 on transmural ventricular repolarization and inducibility of ventricular tachyarrhythmias in the dog. Pacing Clin Electrophysiol. 2010;33:950-959<\/li>\r\n
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