{"id":281,"date":"2025-02-04T16:02:12","date_gmt":"2025-02-04T07:02:12","guid":{"rendered":"https:\/\/www.med.niigata-u.ac.jp\/in3\/?post_type=abroad&p=281"},"modified":"2025-02-18T16:33:30","modified_gmt":"2025-02-18T07:33:30","slug":"tominaga3","status":"publish","type":"abroad","link":"https:\/\/www.med.niigata-u.ac.jp\/in3\/abroad\/tominaga3\/","title":{"rendered":"\u30b7\u30f3\u30b7\u30ca\u30c6\u30a3\u5c0f\u5150\u75c5\u9662\u7559\u5b66\u8a18\uff083\uff09"},"content":{"rendered":"\n

\u3000\u7814\u7a76\u958b\u59cb\u304b\u3089\u304a\u3088\u305d\u534a\u5e74\u304c\u7d4c\u904e\u3057\u3001\u7559\u5b66\u8a18\u306e\u57f7\u7b46\u306e\u4f9d\u983c\u3092\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u306e\u3067\u3001\u524d\u534a\u306f\u7814\u7a76\u306b\u3064\u3044\u3066\u3001\u5f8c\u534a\u306b\u65e5\u5e38\u751f\u6d3b\u306b\u3064\u3044\u3066\u5c11\u3057\u8a18\u8f09\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u7814\u7a76\u5185\u5bb9<\/h3>\n\n\n\n

Aim 1. To Generate HIOs Containing Resident Macrophages (Year 1)<\/h5>\n\n\n\n

\u3000\u5f53\u7814\u7a76\u5ba4(James Wells Lab)\u306e\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u6280\u8853\u306f\u3001\u6d88\u5316\u7ba1\u306e\u5168\u3066\u306e\u9818\u57df\u306b\u53ca\u3093\u3067\u3044\u307e\u3059\u304c\u3001\u30af\u30ed\u30fc\u30f3\u75c5\u306a\u3069\u306e\u708e\u75c7\u6027\u75be\u60a3\u306e\u7814\u7a76\u306b\u4e0d\u53ef\u6b20\u306a\u514d\u75ab\u7d30\u80de\u304c\u4e0d\u8db3\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u6700\u8fd1\u306e\u5f53\u7814\u7a76\u5ba4\u306e\u4e88\u5099\u7684\u306a\u30c7\u30fc\u30bf\u3067\u3001\u7d30\u83cc\u306e\u8a98\u56e0\u306b\u5bfe\u3057\u3066\u708e\u75c7\u53cd\u5fdc\u3092\u8d77\u3053\u3057\u3001\u5e38\u5728\u83cc\u3068\u75c5\u539f\u83cc\u3092\u533a\u5225\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u7d44\u7e54\u5e38\u5728\u578b\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3092\u542b\u3080\u30d2\u30c8\u5927\u8178\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\uff08HCO\uff09\u3092\u751f\u6210\u3067\u304d\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u3001\u79c1\u305f\u3061\u306f\u3001\u7d44\u7e54\u5185\u306b\u5e38\u5728\u3059\u308b\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3092\u542b\u3080\u30d2\u30c8\u5c0f\u8178\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\uff08HIO\uff09\u306e\u4f5c\u88fd\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\uff08Fig. 1\uff09
\u3000\u73fe\u5728\u3001\u514d\u75ab\u7d30\u80de\u3067\u3042\u308b\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3092\u5c0f\u8178\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u306b\u5c0e\u5165\u3059\u308b\u65b9\u6cd5\u3068\u3057\u3066\u3001\u5927\u8178\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u306e\u9593\u8449\u7cfb\u7d30\u80de\u3092\u7528\u3044\u305f\u65b9\u6cd5\u3092\u8a66\u307f\u3066\u3044\u308b\u6bb5\u968e\u3067\u3059\u3002\u9593\u8449\u7cfb\u7d30\u80de\u306e\u5265\u96e2\u30fb\u518d\u7d50\u5408\u306e\u6280\u8853\u3092\u78ba\u7acb\u3055\u305b\u3066\u3044\u308b\u540c\u7814\u7a76\u6240\u306eHelmrath Lab\u3068\u3082\u30b3\u30e9\u30dc\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u3057\u3066\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

Aim 2. To Identify the Impact of VEO-IBD Mutations on HIO (and HCO) Function and Disease Progression (Year 2)<\/h5>\n\n\n\n

\u3000\u4eca\u5f8c\u306f\u3001\u30af\u30ed\u30fc\u30f3\u75c5\u306e\u907a\u4f1d\u7684\u7d20\u56e0\u3092\u6301\u3064\u60a3\u8005\uff08VEO-IBD\uff09\u306e\u75c5\u6c17\u306e\u767a\u751f\u3092\u30e2\u30c7\u30eb\u5316\u3059\u308b\u305f\u3081\u306b\u3053\u308c\u3089\u3092\u4f7f\u7528\u3059\u308b\u4e88\u5b9a\u3067\u3059\u3002\u708e\u75c7\u6027\u8178\u75be\u60a3\u306e\u7814\u7a76\u306b\u3042\u305f\u3063\u3066\u306f\u3001Children\u2019s Hospital\u306e\u6d88\u5316\u5668\u5185\u79d1\u708e\u75c7\u6027\u8178\u75be\u60a3\u6559\u6388\u306eDr. Lee Denson\u3068\u3082\u30b3\u30e9\u30dc\u30ec\u30fc\u30b7\u30e7\u30f3\u3057\u306a\u304c\u3089\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002
\u3000\u307e\u305f\u3053\u306e\u5ea6\u3001Crohn’s & Colitis Foundation\u306eresearch fellowship\u3078\u5fdc\u52df\u3059\u308b\u6a5f\u4f1a\u3092\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002\u5c65\u6b74\u66f8\u3084Research Experience\u66f8\u985e\u306e\u4f5c\u6210\u300110\u6570\u30da\u30fc\u30b8\u306b\u308f\u305f\u308b\u7814\u7a76\u8a08\u753b\u66f8\u306e\u6e96\u5099\u306f\u3068\u3066\u3082\u5927\u5909\u3067\u3057\u305f\u304c\u3001James\u5148\u751f\u306esupport\u3082\u3042\u308a\u3001\u8cb4\u91cd\u306a\u7d4c\u9a13\u3092\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002\u500d\u7387\u306f\u9ad8\u304f\u7372\u5f97\u306f\u96e3\u3057\u3044\u304b\u3068\u306f\u601d\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u5185\u5bb9\u3092\u82f1\u8a9e\u3067\u307e\u3068\u3081\u3001\u3053\u308c\u304b\u3089\u306e\u7814\u7a76\u76ee\u6a19\u3092\u660e\u78ba\u306b\u3057\u3001\u305d\u308c\u3092James\u5148\u751f\u3068\u5171\u6709\u3067\u304d\u305f\u3053\u3068\u306f\u3068\u3066\u3082\u5927\u304d\u306a\u53ce\u7a6b\u3067\u3042\u3063\u305f\u3068\u601d\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

<\/div>\n\n\n\n

\"\"
Fig.1<\/p>\n\n\n\n

<\/div>\n\n\n\n

\u30a2\u30e1\u30ea\u30ab\u3067\u306e\u751f\u6d3b\u30fb\u884c\u4e8b<\/h3>\n\n\n\n

\u3000\u30b3\u30ed\u30ca\u30a6\u30a3\u30eb\u30b9\u306e\u5f71\u97ff\u3067\u306a\u304b\u306a\u304b\u601d\u3046\u3088\u3046\u306b\u51fa\u304b\u3051\u3089\u308c\u306a\u3044\u4e2d\u3001\u898f\u5236\u3082\u305d\u308c\u307b\u3069\u53b3\u3057\u304f\u306a\u304b\u3063\u305f\u6628\u79cb\u306b\u3001\u81ea\u5bb6\u7528\u8eca\u3067\u30ca\u30a4\u30a2\u30ac\u30e9\u3078\u884c\u3063\u3066\u304d\u307e\u3057\u305f\u3002\uff08Fig. 2\u5de6\uff09\u30a2\u30e1\u30ea\u30ab\u306f\u6cd5\u5f8b\u306b\u3088\u308b\u7f70\u5247\u898f\u5b9a\u304c\u3042\u308b\u305f\u3081\u3001\u898f\u5b9a\u306b\u5f93\u3063\u3066\u306e\u884c\u52d5\u3067\u3042\u308c\u3070\u3001\u6bd4\u8f03\u7684\u7686\u81ea\u7531\u306b\u884c\u52d5\u3092\u3057\u3066\u3044\u308b\u5370\u8c61\u3067\u3059\u3002\u5dde\u9593\u306e\u79fb\u52d5\u5236\u9650\u306f\u6bce\u9031\u66f4\u65b0\u3055\u308c\u307e\u3059\u306e\u3067\u3001\u3046\u3063\u304b\u308a\u898f\u5236\u306e\u78ba\u8a8d\u3092\u6020\u308b\u3068\u3001\u5bbf\u6cca\u5148\u306e\u30db\u30c6\u30eb\u3067\u7f70\u91d1\u3092\u79d1\u3055\u308c\u308b\u306e\u3067\u8981\u6ce8\u610f\u3067\u3059\u3002
\u3000\u30cb\u30e5\u30fc\u30e8\u30fc\u30af\u5dde\u306e\u30ca\u30a4\u30a2\u30ac\u30e9\u306f\u30aa\u30cf\u30a4\u30aa\u5dde\u306e\u30b7\u30f3\u30b7\u30ca\u30c6\u30a3\u304b\u3089\u304a\u3088\u305d750km\u5317\u6771\u306b\u4f4d\u7f6e\u3057\u3001\u9014\u4e2d\u306e\u30b3\u30ed\u30f3\u30d0\u30b9\u3084\u30af\u30ea\u30fc\u30d6\u30e9\u30f3\u30c9\u306a\u3069\u306e\u90fd\u5e02\u306b\u5bc4\u308a\u3064\u30647-8\u6642\u9593\u306e\u30c9\u30e9\u30a4\u30d6\u3067\u3057\u305f\u3002\u90fd\u5e02\u9593\u3092\u7e4b\u3050\u30cf\u30a4\u30a6\u30a7\u30a4\u306f\u3001\u65e5\u672c\u306e\u9ad8\u901f\u9053\u8def\u306b\u6bd4\u3079\u308b\u3068\u3001\u307b\u3068\u3093\u3069\u66f2\u304c\u308a\u304f\u306d\u308b\u3053\u3068\u3082\u306a\u304f\u771f\u3063\u3059\u3050\u3067\u3001\u9053\u5e45\u3082\u5e83\u304f\uff08\u5e83\u3044\u3068\u3053\u308d\u3067\u306f\u7247\u90536\u8eca\u7dda\u3042\u308a\uff09\u3001\u6bd4\u8f03\u7684\u30b9\u30c8\u30ec\u30b9\u306a\u304f\u8d70\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u9577\u8ddd\u96e2\u306e\u30c9\u30e9\u30a4\u30d6\u3067\u3057\u305f\u304c\u3001\u305d\u3053\u307e\u3067\u82e6\u306b\u306a\u3089\u305a\u306b\u79fb\u52d5\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u30cf\u30a4\u30a6\u30a7\u30a4\u306f\u3054\u304f\u4e00\u90e8\u3092\u9664\u3044\u3066\u57fa\u672c\u306f\u7121\u6599\u3067\u3001\u30ac\u30bd\u30ea\u30f3\u4fa1\u683c\u3082\u65e5\u672c\u306e\u534a\u5024\u306a\u306e\u3067\u52a9\u304b\u308a\u307e\u3059\u3002
\u3000\u307e\u305f\u3001\u30b7\u30f3\u30b7\u30ca\u30c6\u30a3\u5468\u8fba\u306e\u30a2\u30e1\u30ea\u30ab\u4e2d\u897f\u90e8\u306b\u306f\u3001\u4e16\u754c\u907a\u7523\u306eMammoth Cave National Park\u3084Hocking Hills State Park\uff08Fig. 2\u4e2d\u592e\uff09\u306a\u3069\u306e\u30b9\u30dd\u30c3\u30c8\u304c\u8eca\u3067\u884c\u3051\u308b\u7bc4\u56f2\u306b\u591a\u6570\u3042\u308a\u3001\u5927\u81ea\u7136\u3092\u6e80\u55ab\u3067\u304d\u307e\u3059\u3002
\u3000\u307e\u305f\u3001\uff14\u5927\u30e1\u30b8\u30e3\u30fc\u30b9\u30dd\u30fc\u30c4\u306e\u4e00\u3064\u30a2\u30e1\u30ea\u30ab\u30f3\u30d5\u30c3\u30c8\u30dc\u30fc\u30eb\uff08NFL\uff09\u306f\u4eba\u6570\u5236\u9650\uff08\u5ea7\u5e2d\u6570\u306e\u7d042\u5272\u7a0b\u5ea6\u307e\u3067\uff09\u306e\u4e2d\u3001\u518d\u958b\u3055\u308c\u305f\u305f\u3081\u3001\u5730\u5143\u306e\u30d9\u30f3\u30ac\u30eb\u30ba\u3092\u5fdc\u63f4\u3057\u3066\u304d\u307e\u3057\u305f\uff08Fig. 2\u53f3\uff09\u3002\u524d\u5f8c2-3\u5217\u3001\u5de6\u53f34-5\u5e2d\u4ee5\u4e0a\u306f\u9593\u9694\u304c\u3068\u3089\u308c\u3066\u3044\u305f\u305f\u3081\u5feb\u9069\u306b\u89b3\u6226\u3067\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

<\/div>\n\n\n\n

\"\"
Fig.2 \u5de6\uff1aNiagara Falls \u5411\u304b\u3044\u5074\u306e\u5efa\u7269\u306f\u30ab\u30ca\u30c0\u306e\u9ad8\u5c64\u30db\u30c6\u30eb\u7fa4\u3002\u4e2d\u592e\uff1aHocking Hills State Park\u306e\u7f8e\u3057\u3044\u5730\u5c64\u3002\u53f3\uff1aNFL\u89b3\u6226\u3000\u63a5\u6226\u3067\u6b8b\u308a10\u79d2\u3067\u5730\u5143\u30d9\u30f3\u30ac\u30eb\u30ba\u304c\u9006\u8ee2\u8ca0\u3051\u3057\u305f\u8a66\u5408\u3067\u3057\u305f\u3002<\/p>\n\n\n\n

<\/div>\n\n\n\n

\u3000\u30a2\u30e1\u30ea\u30ab\u3067\u306f\u79cb\u304b\u3089\u51ac\u306b\u304b\u3051\u3066\u3001\u30cf\u30ed\u30a6\u30a3\u30f3\u3001\u30b5\u30f3\u30af\u30b9\u30ae\u30d3\u30f3\u30b0\u3001\u30af\u30ea\u30b9\u30de\u30b9\u3001\u30cb\u30e5\u30fc\u30a4\u30e4\u30fc\u3068\u30db\u30ea\u30c7\u30fc\u30a4\u30d9\u30f3\u30c8\u304c\u7d9a\u304d\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u6628\u5e74\u672b\u306f\u3001\u30b3\u30ed\u30ca\u306e\u5f71\u97ff\u3067\u5927\u898f\u6a21\u306a\u30a4\u30d9\u30f3\u30c8\uff08\u96c6\u307e\u308a\uff09\u306f\u4e2d\u6b62\u3067\u3057\u305f\u306e\u3067\u3001\u898f\u5236\u306e\u7bc4\u56f2\u5185\u3067\u3001\u5c11\u4eba\u6570\u3067\u697d\u3057\u307f\u307e\u3057\u305f\u3002
\u3000\u30cf\u30ed\u30a6\u30a3\u30f3\u3067\u306f\u3001\u304a\u83d3\u5b50\u3092\u3044\u305f\u3060\u304d\u306b\u56de\u308b\u969b\u3082\u30bd\u30fc\u30b7\u30e3\u30eb\u30c7\u30a3\u30b9\u30bf\u30f3\u30b9\u3092\u3068\u3063\u3066\u3067\u3057\u305f\u304c\u3001\u672c\u5834\u30a2\u30e1\u30ea\u30ab\u306e\u30cf\u30ed\u30a6\u30a3\u30f3\u3092\u5473\u308f\u3046\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u30b5\u30f3\u30af\u30b9\u30ae\u30d3\u30f3\u30b0\u306b\u306f\u53cb\u4eba\u5b85\u3067\u3001\u5de8\u5927\u306a\u30bf\u30fc\u30ad\u30fc\u3092\u3075\u308b\u307e\u3063\u3066\u3044\u305f\u3060\u304d\u307e\u3057\u305f\uff08Fig. 3\u5de6\uff09\u3002\u307e\u305f\u3001\u30af\u30ea\u30b9\u30de\u30b9\u306b\u306f\u8857\u306e\u81f3\u308b\u6240\u306b\u5927\u304d\u306a\u30af\u30ea\u30b9\u30de\u30b9\u30c4\u30ea\u30fc\u304c\u98fe\u3089\u308c\uff08Fig. 3\u4e2d\u592e\uff09\u3001\u591c\u306b\u306f\u30e9\u30a4\u30c8\u30a2\u30c3\u30d7\u304c\u884c\u308f\u308c\u3068\u3066\u3082\u7dba\u9e97\u3067\u3059\u3002<\/p>\n\n\n\n

\"\"
Fig.3 \u5de6\uff1a\u91cd\u305510\u338f\u8d85\u3048\u306e\u30bf\u30fc\u30ad\u30fc\u3002\u4e2d\u592e\uff1a\u30cb\u30e5\u30fc\u30dd\u30fc\u30c8\u306b\u98fe\u3089\u308c\u305f\u9ad8\u305510\u30e1\u30fc\u30c8\u30eb\u3092\u8d85\u3048\u308b\u30af\u30ea\u30b9\u30de\u30b9\u30c4\u30ea\u30fc\u3002\u53f3\uff1a\u3053\u306e\u65e5\u306f\u30d7\u30ec\u30b9\u30af\u30fc\u30eb\u306e\u30d1\u30b8\u30e3\u30de\u30c7\u30fc\u3067\u3057\u305f\u304c\u3001\u606f\u5b50\u3060\u3051\u306f\u9811\u306a\u306b\u62d2\u5426\u3057\u30d1\u30b8\u30e3\u30de\u3092\u7740\u307e\u305b\u3093\u3067\u3057\u305f\u30fb\u30fb\u30fb\u3002<\/p>\n\n\n\n

<\/div>\n\n\n\n

\u3000\u65b0\u5e74\u3092\u8fce\u3048\u30012\u6708\u73fe\u5728\u3001\u30a2\u30e1\u30ea\u30ab\u3067\u306f\u30b3\u30ed\u30ca\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3082\u9032\u307f\u3001\u611f\u67d3\u8005\u6570\u306f\u5c11\u3057\u305a\u3064\u843d\u3061\u7740\u3044\u3066\u304d\u3066\u3044\u307e\u3059\u30022\u6b73\u306e\u606f\u5b50\u3082\u30d7\u30ec\u30b9\u30af\u30fc\u30eb\u306b\u3060\u3044\u3076\u6163\u308c\u3066\u304d\u305f\u3088\u3046\u3067\uff08Fig. 3\u53f3\uff09\u3001\u4eca\u306e\u3068\u3053\u308d\u5bb6\u65cf\u7686\u306b\u3068\u3063\u3066\u5145\u5b9f\u3057\u305f\u751f\u6d3b\u304c\u9001\u308c\u3066\u3044\u307e\u3059\u3002
\u3000\u307e\u305f\u3001\u30b3\u30ed\u30ca\u306b\u3088\u308b\u898f\u5236\u306f\u672a\u3060\u3042\u308a\u307e\u3059\u304c\u3001\u7814\u7a76\u306b\u95a2\u3057\u3066\u306f\u5927\u304d\u306a\u652f\u969c\u306a\u304f\u6bce\u65e5\u884c\u3048\u3066\u3044\u307e\u3059\u3002\u6539\u3081\u307e\u3057\u3066\u3001\u5bfa\u4e95\u5148\u751f\u306f\u3058\u3081\u533b\u5c40\u306e\u5148\u751f\u65b9\u3001\u6b66\u90e8\u5148\u751f\u3001James\u5148\u751f\u306b\u611f\u8b1d\u3057\u3001\u5f15\u304d\u7d9a\u304d\u7814\u7a76\u751f\u6d3b\u3092\u9811\u5f35\u308a\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

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