業績

■Termination of Palliative Chemotherapy Near the End of Life: A Retrospective Study of Gastrointestinal Cancer Patients.
Yoshifumi Matsumoto, Akito Higuchi, Marika Shiba, Kenta Sasaki, Takuro Saiki, Yujiro Honma, Kazuyoshi Kimura, Qiliang Zhou, Yasuo Saijo
Palliat Med Rep. 2023 Jul 19;4(1):169-174.

■A strategy for low-cost portable monitoring of plasma drug concentrations using a sustainable boron-doped-diamond chip.
Takuro Saiki, Genki Ogata, Seishiro Sawamura, Kai Asai, Olga Razvina, Kota Watanabe, Rito Kato, Qi Zhang, Koei Akiyama, Sasya Madhurantakam, Norzahirah Binti Ahmad, Daisuke Ino, Haruma Nashimoto, Yoshifumi Matsumoto, Masato Moriyama, Arata Horii, Chie Kondo, Ryosuke Ochiai, Hiroyuki Kusuhara, Yasuo Saijo, Yasuaki Einaga, Hiroshi Hibino
Heliyon. 2023 May 9;9(5):e15963.

■Sunitinib therapy for imatinib-resistant and/or intolerant gastrointestinal stromal tumors: comparison of safety and efficacy between standard and reduced dosage regimens.
Kenta Sasaki, Tatsuo Kanda, Yoshifumi Matsumoto, Takashi Ishikawa, Seiichi Hirota, Yasuo Saijo
Jpn J Clin Oncol. 2023 Mar 30;53(4):297-303.

■Efficacy of BRAF inhibitor and anti-EGFR antibody in colorectal neuroendocrine carcinoma.
Mae Nakano, Yoshifumi Shimada, Yoshifumi Matsumoto, Takuro Saiki, Qiliang Zhou, Kenta Sasaki, Masato Moriyama, Kosuke Yoshihara, Manabu Natsumeda, Yoko Kuriyama, Yasumasa Takii, Gen Watanabe, Hajime Umezu, Shujiro Okuda, Takeshi Ikeuchi, Toshifumi Wakai, Yasuo Saijo
Clin J Gastroenterol. 2022 Apr;15(2):413-418.

■Analysis of Pharmacokinetics in the Cochlea of the Inner Ear
Seishiro Sawamura, Genki Ogata, Kai Asai , Olga Razvina, Takeru Ota, Qi Zhang, Sasya Madhurantakam, Koei Akiyama, Daisuke Ino , Sho Kanzaki, Takuro Saiki, Yoshifumi Matsumoto, Masato Moriyama, Yasuo Saijo, Arata Horii, Yasuaki Einaga, Hiroshi Hibino Front Pharmacol. 2021 May 3;12:633505.

■Generation of Thyroid Tissues From Embryonic Stem Cells via Blastocyst Complementation In Vivo.　 Qingsong Ran, Qiliang Zhou, Kanako Oda, Akihiro Yasue, Manabu Abe, Xulu Ye, Yingchun Li, Toshikuni Sasaoka, Kenji Sakimura, Yoichi Ajioka, Yasuo Saijo Front Endocrinol (Lausanne). 2020 Dec 14;11:609697.

■Age-Based Comparison of Hematological Toxicity in Patients with Lung Cancer Yuki Sakai, Qiliang Zhou, Yoshifumi Matsumoto, Takuro Saiki, Masato Moriyama, Akira Toyama, Yasuo Saijo Oncology. 2020;98(11):771-778.

■Generation of Lungs by Blastocyst Complementation in Apneumic Fgf10-Deficient Mice Akihiko Kitahara, Qingsong Ran, Kanako Oda, Akihiro Yasue, Manabu Abe, Xulu Ye, Toshikuni Sasaoka, Masanori Tsuchida, Kenji Sakimura, Yoichi Ajioka, Yasuo Saijo, Qiliang Zhou Cell Rep. 2020 May 12;31(6):107626.

■A case of severe hepatotoxicity induced by cisplatin and 5-fluorouracil Ayaka Yaegashi, Kensuke Yoshida, Naoto Suzuki, Izumi Shimada, Yusuke Tani, Yasuo Saijo , Akira Toyama Int Cancer Conf J. 2019 Nov 19;9(1):24-27.

■Treatments and outcomes of older patients with esophageal cancer: Comparison with younger patients Yoshifumi Matsumoto, Kazuyoshi Kimura, Qiliang Zhou, Kenta Sasaki, Takuro Saiki, Masato Moriyama, Yasuo Saijo Mol Clin Oncol. 2019 Oct;11(4):383-389.

■Treatment of Gastric and Gastroesophageal Cancer Patients with Hemodialysis by CapeOX Kenta Sasaki, Qiliang Zhou, Yoshifumi Matsumoto, Takuro Saiki, Masato Moriyama, Yasuo Saijo Intern Med. 2019 Oct 1;58(19):2791-2795.

■MicroRNAs control eyelid development through regulating Wnt signaling Takahiro Nagai, Supaluk Trakanant, Maiko Kawasaki, Katsushige Kawasaki, Yurie Yamada, Momoko Watanabe, James Blackburn, Yoko Otsuka-Tanaka, Mitsue Hishinuma, Atsushi Kitatmura, Fumiya Meguro, Akane Yamada, Yasumitsu Kodama, Takeyasu Maeda, Qiliang Zhou, Yasuo Saijo, Akihiro Yasue, Paul T Sharpe, Robert Hindges, Ritsuo Takagi, Atsushi Ohazama Dev Dyn. 2019 Mar;248（3）:201-210.

■Cancers among adolescents and young adults at one institution in Japan Kensuke Kamimura, Yoshifumi Matsumoto, Qiliang Zhou, Masato Moriyama, Yasuo Saijo Oncol Lett. 2018 Dec;16(6):7212-7222.

■Trachea Engineering Using a Centrifugation Method and Mouse-Induced Pluripotent Stem Cells Qiliang Zhou, Xulu Ye, Qingsong Ran, Akihiko Kitahara , Yoshifumi Matsumoto, Masato Moriyama, Yoichi Ajioka, Yasuo Saijo Tissue Eng Part C Methods. 2018 Sep;24(9):524-533.

■The Prognostic Nutrition Index Predicts the Development of Hematological Toxicities in and the Prognosis of Esophageal Cancer Patients Treated with Cisplatin Plus 5-Fluorouracil Chemotherapy Yoshifumi Matsumoto, Qiliang Zhou, Kensuke Kamimura, Masato Moriyama, Yasuo Saijo Nutr Cancer. 2018 Apr;70(3):447-452.

■A highly specific and sensitive massive parallel sequencer-based test for somatic mutations in non-small cell lung cancer Yoshiaki Inoue, Jun Shiihara, Hitoshi Miyazawa, Hiromitsu Ohta, Megumi Higo, Yoshiaki Nagai, Kunihiko Kobayashi, Yasuo Saijo, Masanori Tsuchida, Mitsuo Nakayama, Koichi Hagiwara PLoS One. 2017 Apr 27;12(4):e0176525.

■Randomized Phase II Study of Docetaxel plus Personalized Peptide Vaccination versus Docetaxel plus Placebo for Patients with Previously Treated Advanced Wild Type EGFR Non-Small-Cell Lung Cancer Koichi Takayama, Shunichi Sugawara, Yasuo Saijo, Makoto Maemondo, Atsushi Sato, Shinzo Takamori, Taishi Harada, Tetsuro Sasada, Tatsuyuki Kakuma, Junji Kishimoto, Akira Yamada, Masanori Noguchi, Kyogo Itoh, Yoichi Nakanishi J Immunol Res. 2016;2016:1745108.

■Chromosomal rearrangements in myoepithelial carcinoma of the breast that presented as metachronic double cancer with invasive ductal carcinoma in the ipsilateral breast Hiroyuki Kawashima, Takashi Ariizumi, Yasuo Saijo, Masato Moriyama, Hajime Umezu, Yoshiyuki Ikeda, Akira Ogose, Naoto Endo Cancer Genet. 2016 Nov;209(11):501-505.

■Inhibition of Glutaminolysis Inhibits Cell Growth via Down-regulating Mtorc1 Signaling in Lung Squamous Cell Carcinoma Xulu Ye, Qiliang Zhou, Yoshifumi Matsumoto, Masato Moriyama, Shun Kageyama, Masaaki Komatsu, Seijiro Satoh, Masanori Tsuchida, Yasuo Saijo Anticancer Res. 2016 Nov;36(11):6021-6029.

■Myelosuppression by chemotherapy in obese patients with gynecological cancers Kensuke Kamimura, Yoshifumi Matsumoto, Qiliang Zhou, Masato Moriyama, Yasuo Saijo Cancer Chemother Pharmacol. 2016 Sep;78(3):633-41.

■Factors associated with a poor response to gefitinib in the NEJ002 study: smoking and the L858R mutation Tatsuro Fukuhara, Makoto Maemondo, Akira Inoue, Kunihiko Kobayashi, Shunichi Sugawara, Satoshi Oizumi, Hiroshi Isobe, Akihiko Gemma, Masao Harada, Hirohisa Yoshizawa, Ichiro Kinoshita, Yuka Fujita, Yasuo Saijo, Koichi Hagiwara, Satoshi Morita, Toshihiro Nukiwa Lung Cancer. 2015 May;88(2):181-6.

■Efficacy of chemotherapy after first-line gefitinib therapy in EGFR mutation-positive advanced non-small cell lung cancer-data from a randomized Phase III study comparing gefitinib with carboplatin plus paclitaxel (NEJ002) Eisaku Miyauchi, Akira Inoue, Kunihiko Kobayashi, Makoto Maemondo, Shunichi Sugawara , Satoshi Oizumi , Hiroshi Isobe, Akihiko Gemma, Yasuo Saijo, Hirohisa Yoshizawa, Koichi Hagiwara, Toshihiro Nukiwa, North-East Japan Study Group Jpn J Clin Oncol. 2015 Jul;45(7):670-6.

■Possible Involvement of Lung Cells Harboring an Abnormal Karyotype in the Pathogenesis of Pulmonary Alveolar Proteinosis Associated with Myelodysplastic Syndrome Masato Moriyama, Toshio Yano, Tatsuo Furukawa, Toshinori Takada, Takashi Ushiki, Masayoshi Masuko, Jun Takizawa, Hirohito Sone,Ryushi Tazawa, Yasuo Saijo, Haruyuki Ishii , Koh Nakata Ann Am Thorac Soc. 2015 Aug;12(8):1251-3.

■A phase II study of erlotinib monotherapy in pre-treated non-small cell lung cancer without EGFR gene mutation who have never/light smoking history: re-evaluation of EGFR gene status (NEJ006/TCOG0903) Yoshifumi Matsumoto, Makoto Maemondo, Yoshiki Ishii, Koichi Okudera, Yoshiki Demura , Kei Takamura, Kunihiko Kobayashi, Naoto Morikawa, Akihiko Gemma, Osamu Ishimoto , Kazuhiro Usui, Masao Harada, Satoru Miura, Yuka Fujita, Ikuro Sato, Yasuo Saijo, North-East Japan Study Group Lung Cancer. 2014 Nov;86(2):195-200.

■Consensus statement for the diagnosis and treatment of drug-induced lung injuries Keishi Kubo, Arata Azuma, Minoru Kanazawa, Hideto Kameda, Masahiko Kusumoto, Akihiko Genma, Yasuo Saijo, Fumikazu Sakai, Yukihiko Sugiyama, Koichiro Tatsumi, Makoto Dohi, Hitoshi Tokuda, Shu Hashimoto, Noboru Hattori, Masayuki Hanaoka, Yuh Fukuda, Japanese Respiratory Society Committee for formulation of Consensus statement for the diagnosis and treatment of drug-induced lung injuries Respir Investig. 2013 Dec;51(4):260-77.

■Differentiation of mouse induced pluripotent stem cells into alveolar epithelial cells in vitro for use in vivo Qiliang Zhou, Xulu Ye , Ruowen Sun, Yoshifumi Matsumoto , Masato Moriyama, Yoshiya Asano, Yoichi Ajioka, Yasuo Saijo Stem Cells Transl Med. 2014 Jun;3(6):675-85.

■A change in the number of CCSP(pos)/SPC(pos) cells in mouse lung during development, growth, and repair Ruowen Sun, Qiliang Zhou, Xulu Ye, Takenori Takahata, Atsushi Ishiguro, Hiroshi Kijima, Toshihiro Nukiwa, Yasuo Saijo Respir Investig. 2013 Dec;51(4):229-40.

■Randomized phase II trial of uracil/tegafur and cisplatin versus vinorelbine and cisplatin with concurrent thoracic radiotherapy for locally advanced unresectable stage III non-small-cell lung cancer: NJLCG 0601 Shunichi Sugawara, Makoto Maemondo, Motoko Tachihara, Akira Inoue, Osamu Ishimoto, Tomohiro Sakakibara, Kazuhiro Usui, Hiroshi Watanabe, Nobumichi Matsubara, Kana Watanabe, Kenya Kanazawa, Takashi Ishida, Yasuo Saijo, Toshihiro Nukiwa, North Japan Lung Cancer Study Group Lung Cancer. 2013 Jul;81(1):91-6.

■Updated overall survival results from a randomized phase III trial comparing gefitinib with carboplatin-paclitaxel for chemo-naïve non-small cell lung cancer with sensitive EGFR gene mutations (NEJ002) A Inoue, K Kobayashi, M Maemondo, S Sugawara, S Oizumi, H Isobe, A Gemma, M Harada, H Yoshizawa, I Kinoshita, Y Fujita, S Okinaga, H Hirano, K Yoshimori, T Harada, Y Saijo, K Hagiwara, S Morita, T Nukiwa, North-East Japan Study Group Ann Oncol. 2013 Jan;24(1):54-9.

■Quality of life with gefitinib in patients with EGFR-mutated non-small cell lung cancer: quality of life analysis of North East Japan Study Group 002 Trial Satoshi Oizumi, Kunihiko Kobayashi, Akira Inoue, Makoto Maemondo, Shunichi Sugawara, Hirohisa Yoshizawa, Hiroshi Isobe, Masao Harada, Ichiro Kinoshita, Shoji Okinaga, Terufumi Kato, Toshiyuki Harada, Akihiko Gemma, Yasuo Saijo, Yuki Yokomizo, Satoshi Morita, Koichi Hagiwara, Toshihiro Nukiwa Oncologist. 2012;17(6):863-70.

■Methylation of the KEAP1 gene promoter region in human colorectal cancer Naoyuki Hanada, Takenori Takahata, Qiliang Zhou, Xulu Ye, Ruowen Sun, Jugoh Itoh, Atsushi Ishiguro, Hiroshi Kijima, Junsei Mimura, Ken Itoh, Shinsaku Fukuda, Yasuo Saijo BMC Cancer. 2012 Feb 13;12:66.

■Sequential irinotecan hydrochloride/S-1 for S-1-resistant inoperable gastric cancer: A feasibility study Takenori Takahata, Jugoh Itoh, Taroh Satoh, Atsushi Ishiguro, Yoshifumi Matsumoto, Satoshi Tanaka, Soh Saitoh, Hiroshi Tohno, Shinsaku Fukuda, Yasuo Saijo, Yuh Sakata Oncol Lett. 2012 Jan;3(1):89-93.

■Mesenchymal stromal cells protect cancer cells from ROS-induced apoptosis and enhance the Warburg effect by secreting STC1 Shinya Ohkouchi, Gregory J Block, Ahmed M Katsha, Masahiko Kanehira, Masahito Ebina, Toshiaki Kikuchi, Yasuo Saijo, Toshihiro Nukiwa, Darwin J Prockop Mol Ther. 2012 Feb;20(2):417-23.