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Bibliography in English (for recent 9 years)

Selected journals


1) Hiroki Fujiwara, Narumi Hashikawa-Hobara, Yoshihiro Wake, Shingo Takatori, Mitsuhiro Goda, Hiroshi Higuchi, Yoshito Zamami, Panot Tangsucharit, Yoshihisa Kitamura, Hiromu Kawasaki
Neurogenic vascular responses in mouse mesenteric vascular beds.
J Pharmacol Science, 119, 260-270, 2012

2) Hiroshi Higuchi
Molecular analysis of central feeding regulation by neuropeptide Y (NPY) neurons with NPY receptor small interfering RNAs (siRNAs).
Neurochem Int, 61, 936-941, 2012


1) Hiroki Fujiwara, Narumi Hashikawa-Hobara, Yoshihiro Wake, Shingo Takatori, Mitsuhiro Goda, Hiroshi Higuchi, Yoshito Zamami, Panot Tangsucharit, Yoshihisa Kitamura, Hiromu Kawasaki
Neurogenic vascular responses in mouse mesenteric vascular beds.


1) Hama,Y., Shiraki,K., Yoshida,Y., Maruyama,A., Yasuda,M., Tsuda,M., Honda,M., Takahashi,M., Higuchi,H., Takasaki,I., Daikoku,T., Tsumoto,T.
Antibody to varicella-zoster virus immediate-early protein 62 augments allodynia in zoster via brain-derived neurotrophic factor.
J.Virology 84, 1616-1624, 2010.


1) Yuka Hama, Kimiyasu Shiraki, Yoshihiro Yoshida, Atsushi Maruyama, Makoto Yasuda, Masaaki Tsuda, Mariko Honda, Michiaki Takahashi, Hiroshi Higuchi, Ichiro Takahashi, Tohru Daikoku, Tadaharu Tsumoto
Antibody to Varicella-Zoster virus immediate-early protein 62 augments allodynia in Zoster via brain-derived neurotrophic factor.
J. Virol. 2009 in press.


1) Ohnishi T, Okuda-Ashitaka E, Matsumura S, Katano T, Nishizawa M, Ito S.
Characterization of signaling pathway for the translocation of neuronal nitric oxide synthase to the plasma membrane by PACAP.
J. Neurochem. 105, 2271-2285, 2008.

2) Murase S, Cho C, White JM, Horwitz AF.
ADAM2 promotes migration of neuroblasts in the rostral migratory stream to the olfactory bulb.
Eur. J. Neurosci. 27, 1585-1595, 2008.

3) Higuchi H, Niki T, Shiiya T.
Feeding behavior and gene expression of appetite-related neuropeptides in mice lacking for neuropeptide Y Y5 receptor subclass.
World J. Gastroenterol.14, 6312-6317, 2008.


1) Tsurumaki T, Piao H, Higuchi H.
Synergistic interaction of neuropeptide Y Y1 receptors and alpha1A-adrenoceptors in rat femoral and tail arteries. Eur. J. Pharmacol. in press.

2) Nagai S, Tsurumaki T, Abe H, Higuchi H.
Functional serotonin and histamine receptor subtypes in porcine ciliary artery in comparison with middle cerebral artery. Eur. J. Pharmacol. in press.

3) Piao H, Nagai S, Tsurumaki T, Niki T, Higuchi, H.
Potentiation by neuropeptide Y of histamine H1 receptor-mediated contraction in rat blood vessels. Vascul. Pharmacol. 46, 260-270, 2007..


1) Nagai S, Urayama K, Higuchi H.
Suppression of mental stress-induced change by tandospirone, an anxiolytic, in cardiovascular function. Acta Med. Biol. 54, 103-108, 2006.

2) Tsurumaki TNagai S, Bo X, Toyosato A, Higuchi H.
Potentiation by neuropeptide Y of 5HT2A receptor-mediated contraction in porcine coronary artery. Eur. J. Pharmacol. 544, 111-117, 2006.


1) Higuchi H, Hasegawa A, Yamaguchi T.
Transcriptional regulation of NPY gene by leptin and its effect on feeding. J. Pharmacol. Sci. 98, 225-231, 2005.

2) Higuchi H.
Transcriptional regulation of neuronal genes and its effect on neural functions: Preface. J. Pharmacol. Sci. 98, 198-199, 2005.


1) Okada M, Hasegawa A, Higuchi H.
Effect of neuropeptide Y on the T-type Ca2+ channel current expressed in NG108-15 cells. Acta Med. Biol. 52, 103-110, 2004


1) Muraoka O, Xu B, Tsurumaki T, Akira S, Yamaguchi T, Higuchi H.
Leptin-induced transactivation of NPY gene promoter mediated by JAK1, JAK2 and STAT3 in the neural cell lines. Neurochem. Int. 42, 591-601, 2003

2) Watanabe Y, Okada M, Tsurumaki T, Gejyo F, Higuchi H.
The preventive effect of b-blockers, carvedilol and metoprolol, on mental stress-induced changes in cardiovascular functions by a color word conflict test. Acta Med. Biol. 51, 43-48, 2003

3) Tsurumaki T, Muraoka O, Yamaguchi T, Higuchi H.
Neuropeptide Y-induced contraction and its desensitization through the neuropeptide Y receptor subtype in several rat veins. J. Cardiovascular Pharmacol. 41 (Suppl. 1), S23-27, 2003

4) Tsurumaki T, Yamaguchi T, Higuchi H.
Marked neuropeptide Y-induced contractions via NPY-Y1 receptor and its desensitization in rat veins. Vascular Pharmacology, 39, 325-333, 2003

5) Tsurumaki T, Piao HL, Higuchi H.
Neuropeptide Y selectively potentiates a1-adrenoceptor mediated contraction through Y1 receptor subtype in rat femoral artery. J. Cardiovascular Pharmacol. 42 (Suppl. 1), S33-37, 2003


1) Higuchi H, Yamaguchi T, Kaidzu M, Mitomi A, Hasegawa A.
The effect of fasting on NPY receptor gene expression. CINP (Collegium Internationale Neuro-Psychopharmacologium) Regional
Meeting Hiroshima. Abstr. p. 436, Japan (2001)


1) Nagaki, S., Fukamauchi, F., Sakamoto, Y., Higuchi, H., Miki, N., Miki, N., Ono, M., Sadamitsu, M., Kato, N. and Osawa,M.
Upregulation of brain somatostatin and neuropeptide Y following lidocaine-induced kindling in the rat. Brain Res. 852, 470-474, 2000.

2) Katsumata, N., Ma, X. and Higuchi, H.
Protective effect of diltiazem against ishemia-induced decreases in regional myocardial flow in rat heart. Eur. J. Pharmacol. 398, 83-91 2000.

3) Watanabe, K., Ohta, Y., Nakazawa, M., Higuchi, H. Hasagawa, G., Naito, M., Fuse, K., Ito, M., Hirono, S., Tanabe, N., Hanawa, H., Kato, K., Kodama, M. and Aizawa, Y.
Low dose carvedilol inhibits progression of heart failure in rats with dilated cardiomyopathy. Br. J. Pharmacol. 130, 1489-1495, 2000.

4) Niu, S-Y., Kuo, C-H., Taira, E., Muraoka, O., Irie, Y., Do, E., Gan, Y-H., and Miki, N.
Inhibition by naloxone of promoter activity of the neurofilament gene in SK-N-SH cells.
Jpn. J. Pharmacol., 82: 34-39, 2000.

5) Chen, J., Wang, Y., Nakajima, T., Iwasawa, K., Hikiji, H., Sunamoto, M., Choi, D-K., Yoshida, Y., Sakai, Y., and Toyo-oka, T.
Autocline action and its underlying mechanism of nitric oxide on intracellular Ca2+ homeostasis in vascular endothelial cells
Journal of Biological Chemistry, 275: 28379-28749, 2000

6) Yamaguchi, T., Takei, N., Araki, K., Ishii, K, Nagano, T., Ichikawa, T., Kumanishi, T. and Nawa, H.
Molecular characterization of a novel gamma-glutamyltranspeptidase homologue found in rat brain.
J.Biochemistry. 128(1), pp101-106, 2000

7) Muraoka, O., Ichikawa, H., Shi, H., Okumura, S., Taira, E., Higuchi, H., Hirano, T., Hibi, H., and Miki, N.
Kheper, a novel ZFH/EF1 family, regulates the development of the neuroectoderm of zebrafish (Danio rerio)
Developmental Biology 228, 29-40, 2000


1) Fujita, S., Yoshida, Y., Islam, M.O., Ma, X., Fujioka, M., Ito, M., Nakano, T., Aizawa Y., Imai, S., and Higuchi, H.
Characterization of major phosphoproteins in cGMP mediated protein phosphorylation system of vascular smooth muscle membranes.
J. Vasc. Res., 36:299-310, 1999

2) Yoshida, Y., Toyosato, A., Islam, M.O., Koga, T., Fujita, S., and Imai, S.
Stimulation of plasma membrane Ca2+-pump ATPase of vascular smooth muscle by cGMP-dependent protein kinase: Functional reconstitution with purified proteins.
Mol. Cell. Biochem., 190: 169-177, 1999

3) Ishibashi, T., Yoshida Y., Imai, S. and Nishio, M.
IP3 production in A10 cells, an established aortic smooth muscle cultured cell line: Effects of agonist administration procedure and culture conditions.
Gen. Pharamcol., 32:115-121, 1999

4) Nakamura M., Ichikawa, K., Ito, M., Yamamori, B., Okinaka, T., Isaka, N., Yoshida, Y., Fujita, S., and Nakano, T.
Effects of the phosphorylation of myosin phosphatase by cyclic GMP-dependent protein kinase.
Cellular Singaling, 11: 671-676, 1999

5) Mitsui, T., Kashem, M.A., Iwabuchi, S., Kamimura, I., Hori, H., and Yoshida, Y.
Involvement of phosphoinositide-signaling on the regulation of a-amylase secretion in suspension-cultured cells of rice (Oryza sative L.).
Bulletin of the Faculty of Agriculture Niigata University, 52:29-40, 1999

6) Kawada, H., Shin, W.S., Nakatsuru, Y., Koizumi, T., Sakamoto, A., Nakajima, T., Okai-Matsuo, Y., Nakazawa, M., Sato, H., and Toyo-oka, T.
Precise identification of gene products in hearts after in vivo gene transfection, using Sendai virus-coated proteoliposomes.
Biochem. Biophys. Res. Commun., 259:408-413, 1999

7) Kawada, T., Nakatsuru, Y., Sakamoto, A., Koizumi, T., Shin, W.S., Okai-Matsuo, Y., Suzuki, J.-I., Uehara, Y., Nakazawa, M., Sato, H., Ishikawa, T., and Toyo-oka, T.
Strain- and age-dependent loss of sarcoglycan complex in cardiomyopathic hamster hearts and its re-pression by d-sarcoglycan gene transfer in vivo.
FEBS Lett., 458:405-408, 1999

8) Watanabe, K., Ohta, Y., Nakazawa, M., Higuchi, H., Hasegawa, G., Naito, M., Nagatomo, T., Fuse, K., Ito, M., Hirono, S., Ohkura, Y., Kato, K., Kodama, M., and Aizawa, Y.
Effects of long-term treatment with carvedilol in rats with dilated cardiomyopathy after myocarditis.
J. Cardivasc. Pharmacol., 34(Suppl. 4):S77-S80, 1999.

9) Taira, E., Nagino, T., Tsukamoto, Y., Okumura, S., Muraoka, O., Sakuma F., and Miki, N.
Cytoplasmic domain is not essential for the cell adhesion activities of gicerin, an Ig-superfamily molecule.
Exp. Cell. Res., 253:697-703, 1999

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