{"id":4633,"date":"2021-06-28T19:23:38","date_gmt":"2021-06-28T10:23:38","guid":{"rendered":"http:\/\/www.med.niigata-u.ac.jp\/pub\/?p=4633"},"modified":"2021-06-29T12:27:54","modified_gmt":"2021-06-29T03:27:54","slug":"%e8%ab%96%e6%96%87%e3%81%8c%e5%85%ac%e9%96%8b%e3%81%95%e3%82%8c%e3%81%be%e3%81%97%e3%81%9f%ef%bc%88wint-wint-phyu%e3%81%95%e3%82%93%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.med.niigata-u.ac.jp\/pub\/2021\/06\/28\/%e8%ab%96%e6%96%87%e3%81%8c%e5%85%ac%e9%96%8b%e3%81%95%e3%82%8c%e3%81%be%e3%81%97%e3%81%9f%ef%bc%88wint-wint-phyu%e3%81%95%e3%82%93%ef%bc%89\/","title":{"rendered":"\u30df\u30e3\u30f3\u30de\u30fc\u306eRS\u30a6\u30a4\u30eb\u30b9\u306e\u8ad6\u6587\u304c\u516c\u958b\u3055\u308c\u307e\u3057\u305f\uff08Wint Wint Phyu\u3055\u3093\uff09"},"content":{"rendered":"

Wint Wint Phyu\u3055\u3093\u306e\u8ad6\u6587\u304c\u3001Infection, Genetics and Evolution\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f<\/p>\n

\u30df\u30e3\u30f3\u30de\u30fc\u306e RS \u30a6\u30a3\u30eb\u30b9\u306e\u907a\u4f1d\u5b50\u9032\u5316\u306b\u3064\u3044\u3066\u306e\u8ad6\u6587\u3067\u3059<\/p>\n

\u56fd\u969b\u8a8c\u3078\u306e\u63b2\u8f09\u306f\u3001\u30df\u30e3\u30f3\u30de\u30fc\u306e RS \u30a6\u30a3\u30eb\u30b9\u306b\u3064\u3044\u3066\u306f\u521d\u3068\u306a\u308a\u307e\u3059<\/p>\n

\u304a\u3081\u3067\u3068\u3046\u3054\u3056\u3044\u307e\u3059\uff01<\/p>\n

https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1567134821002240<\/a><\/p>\n

\n
\n

Abstract<\/h2>\n
\n

We studied\u00a0genetic variation<\/a>\u00a0in the second\u00a0hypervariable region<\/a>\u00a0(HVR) of the G gene of\u00a0human respiratory syncytial virus<\/a>\u00a0(HRSV) from 1701\u00a0nasal swab<\/a>\u00a0samples collected from outpatients with acute respiratory infections at two general hospitals in the cities Yangon and Pyinmana in Myanmar from 2015 to 2018. HRSV genotypes were characterized using\u00a0phylogenetic trees<\/a>\u00a0constructed using the\u00a0maximum likelihood method<\/a>. Time-scale\u00a0phylogenetic<\/a>\u00a0tree analyses were performed using the Bayesian\u00a0Markov chain<\/a>\u00a0Monte Carlo method<\/a>. In total, 244 (14.3%) samples were HRSV-positive and were classified as HRSV-A (n<\/em>\u00a0=\u00a084, 34.4%), HRSV-B (n<\/em>\u00a0=\u00a0158, 64.8%), and co-detection of HRSV-A\/HRSV-B (n<\/em>\u00a0=\u00a02, 0.8%). HRSV epidemics occurred seasonally between July (1.9%, 15\/785) and August (10.5%, 108\/1028), with peak infections in September (35.8%, 149\/416) and October (58.2%, 89\/153). HRSV infection rate was higher in children \u22651\u00a0year of age than in those <1\u00a0year of age (70.5% vs. 29.5%). The most common HRSV symptoms in children were cough (80%\u201390%) and\u00a0rhinorrhea<\/a>\u00a0(70%\u2013100%). The predominant genotypes were ON1for HRSV-A (78%) and BA9 for HRSV-B (64%). Time to the most recent common ancestor was 2014 (95% highest posterior density [HPD], 2012\u20132015) for HRSV-A ON1 and 2009 (95% HPD, 2004\u20132012) for HRSV-B BA9. The mean evolutionary rate (substitutions\/site\/year) for HRSV-B (2.12\u00a0\u00d7\u00a010\u22122<\/sup>, 95% HPD, 8.53\u00a0\u00d7\u00a010\u22123<\/sup>\u20133.63\u00a0\u00d7\u00a010\u22122<\/sup>) was slightly higher than that for HRSV-A (1.39\u00a0\u00d7\u00a010\u22122<\/sup>, 95% HPD, 6.03\u00a0\u00d7\u00a010\u22123<\/sup>\u20132.12\u00a0\u00d7\u00a010\u22122<\/sup>). The estimated\u00a0effective population size<\/a>\u00a0(diversity) for HRSV-A increased from 2015 to 2016 and declined in mid-2018, whereas HRSV-B diversity was constant in 2015 and 2016 and increased in mid-2017. In conclusion, the dominant HRSV-A and HRSV-B genotypes in Myanmar were ON1 and BA9, respectively, between 2015 and 2018. HRSV-B evolved slightly faster than HRSV-A and exhibited unique phylogenetic characteristics.<\/p>\n<\/div>\n<\/div>\n<\/div>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Wint Wint Phyu\u3055\u3093\u306e\u8ad6\u6587\u304c\u3001Infection, Genetics and Evolution\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f \u30df\u30e3\u30f3\u30de\u30fc\u306e RS \u30a6\u30a3\u30eb\u30b9\u306e\u907a\u4f1d\u5b50\u9032\u5316\u306b\u3064\u3044\u3066\u306e\u8ad6\u6587\u3067\u3059 \u56fd\u969b\u8a8c\u3078\u306e\u63b2\u8f09\u306f\u3001\u30df\u30e3\u30f3\u30de\u30fc\u306e R …\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":4634,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1,3],"tags":[],"class_list":["post-4633","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-blog"],"jetpack_featured_media_url":"https:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2021\/06\/Phyu-RSV-Myanmar.jpg","jetpack_shortlink":"https:\/\/wp.me\/ph72WZ-1cJ","jetpack-related-posts":[{"id":5778,"url":"https:\/\/www.med.niigata-u.ac.jp\/pub\/2022\/11\/04\/%e3%80%90%e8%ab%96%e6%96%87%e3%80%91phyu%e3%81%95%e3%82%93%ef%bc%9aepidemiology-and-genetic-analysis-of-sars-cov-2-in-myanmar-during-the-community-outbreaks-in-2020\/","url_meta":{"origin":4633,"position":0},"title":"\u3010\u8ad6\u6587\u3011Phyu\u3055\u3093\uff1aEpidemiology and Genetic Analysis of SARS-CoV-2 in Myanmar during the Community Outbreaks in 2020","author":"public-health","date":"2022\u5e7411\u67084\u65e5","format":false,"excerpt":"\u30df\u30e3\u30f3\u30de\u30fc\u304b\u3089\u306e\u7559\u5b66\u751fWint Wint Phyu\u3055\u3093\u306e\u8ad6\u6587\u306e\u7d39\u4ecb\u3067\u3059 Phyu WW, Saito\u2026","rel":"","context":"What\u2019s New","block_context":{"text":"What\u2019s New","link":"https:\/\/www.med.niigata-u.ac.jp\/pub\/category\/news\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2022\/11\/2022-11-04_16-25-24.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2022\/11\/2022-11-04_16-25-24.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2022\/11\/2022-11-04_16-25-24.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2022\/11\/2022-11-04_16-25-24.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2022\/11\/2022-11-04_16-25-24.jpg?resize=1050%2C600&ssl=1 3x"},"classes":[]},{"id":5318,"url":"https:\/\/www.med.niigata-u.ac.jp\/pub\/2022\/01\/05\/2022\/","url_meta":{"origin":4633,"position":1},"title":"2022","author":"public-health","date":"2022\u5e741\u67085\u65e5","format":false,"excerpt":"\u6708\u65e5 \u767a\u8868\u8005 \u30bf\u30a4\u30c8\u30eb \u5b66\u4f1a\u30fb\u4f1a\u8b70\u7b49\u540d\u79f0 \u958b\u50ac\u5730 \u958b\u50ac\u5834\u6240 2022\u5e741\u67087\u65e5 \u9f4b\u85e4\u73b2\u5b50 \u65b0\u578b\u30b3\u30ed\u30ca\u2026","rel":"","context":"\u8b1b\u6f14\u30fb\u5b66\u4f1a\u767a\u8868\u7b49\uff5cPresentations & Lectures","block_context":{"text":"\u8b1b\u6f14\u30fb\u5b66\u4f1a\u767a\u8868\u7b49\uff5cPresentations & Lectures","link":"https:\/\/www.med.niigata-u.ac.jp\/pub\/category\/presentation\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":5891,"url":"https:\/\/www.med.niigata-u.ac.jp\/pub\/2023\/04\/05\/2023%e3%80%80%e8%8b%b1%e6%96%87international-journal\/","url_meta":{"origin":4633,"position":2},"title":"2023\u3000\u82f1\u6587International Journal","author":"public-health","date":"2023\u5e744\u67085\u65e5","format":false,"excerpt":"Sayaka Yoshioka, Wint Wint Phyu, Keita Wagatsuma, \u2026","rel":"","context":"\u8ad6\u6587\uff5cPublications","block_context":{"text":"\u8ad6\u6587\uff5cPublications","link":"https:\/\/www.med.niigata-u.ac.jp\/pub\/category\/paper\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":5552,"url":"https:\/\/www.med.niigata-u.ac.jp\/pub\/2022\/03\/28\/2022%e3%80%80%e8%8b%b1%e6%96%87international-journal\/","url_meta":{"origin":4633,"position":3},"title":"2022\u3000\u82f1\u6587International Journal","author":"public-health","date":"2022\u5e743\u670828\u65e5","format":false,"excerpt":"Wagatsuma K, Yoshioka S, Yamazaki S, Sato R, WW Ph\u2026","rel":"","context":"What\u2019s New","block_context":{"text":"What\u2019s New","link":"https:\/\/www.med.niigata-u.ac.jp\/pub\/category\/news\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":6173,"url":"https:\/\/www.med.niigata-u.ac.jp\/pub\/2024\/04\/01\/2024\/","url_meta":{"origin":4633,"position":4},"title":"2024","author":"public-health","date":"2024\u5e744\u67081\u65e5","format":false,"excerpt":"\u6708\u65e5 \u767a\u8868\u8005 \u30bf\u30a4\u30c8\u30eb \u5b66\u4f1a\u30fb\u4f1a\u8b70\u7b49\u540d\u79f0 \u958b\u50ac\u5730 \u958b\u50ac\u5834\u6240 2024\u5e743\u67087\u65e5 Irina Chon\u2026","rel":"","context":"\u8b1b\u6f14\u30fb\u5b66\u4f1a\u767a\u8868\u7b49\uff5cPresentations & Lectures","block_context":{"text":"\u8b1b\u6f14\u30fb\u5b66\u4f1a\u767a\u8868\u7b49\uff5cPresentations & Lectures","link":"https:\/\/www.med.niigata-u.ac.jp\/pub\/category\/presentation\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2492,"url":"https:\/\/www.med.niigata-u.ac.jp\/pub\/2019\/03\/11\/2019\/","url_meta":{"origin":4633,"position":5},"title":"2019","author":"public-health","date":"2019\u5e743\u670811\u65e5","format":false,"excerpt":"\u6708\u65e5 \u767a\u8868\u8005 \u30bf\u30a4\u30c8\u30eb \u5b66\u4f1a\u30fb\u4f1a\u8b70\u7b49\u540d\u79f0 \u958b\u50ac\u5730 \u958b\u50ac\u5834\u6240 \u00a02019\u5e741\u670810\u65e5 \u00a0\u9f4b\u85e4\u73b2\u5b50 \u00a0\u30df\u2026","rel":"","context":"\u8b1b\u6f14\u30fb\u5b66\u4f1a\u767a\u8868\u7b49\uff5cPresentations & Lectures","block_context":{"text":"\u8b1b\u6f14\u30fb\u5b66\u4f1a\u767a\u8868\u7b49\uff5cPresentations & Lectures","link":"https:\/\/www.med.niigata-u.ac.jp\/pub\/category\/presentation\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.med.niigata-u.ac.jp\/pub\/wp-json\/wp\/v2\/posts\/4633","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.niigata-u.ac.jp\/pub\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.niigata-u.ac.jp\/pub\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.niigata-u.ac.jp\/pub\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.niigata-u.ac.jp\/pub\/wp-json\/wp\/v2\/comments?post=4633"}],"version-history":[{"count":2,"href":"https:\/\/www.med.niigata-u.ac.jp\/pub\/wp-json\/wp\/v2\/posts\/4633\/revisions"}],"predecessor-version":[{"id":4639,"href":"https:\/\/www.med.niigata-u.ac.jp\/pub\/wp-json\/wp\/v2\/posts\/4633\/revisions\/4639"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.niigata-u.ac.jp\/pub\/wp-json\/wp\/v2\/media\/4634"}],"wp:attachment":[{"href":"https:\/\/www.med.niigata-u.ac.jp\/pub\/wp-json\/wp\/v2\/media?parent=4633"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.niigata-u.ac.jp\/pub\/wp-json\/wp\/v2\/categories?post=4633"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.niigata-u.ac.jp\/pub\/wp-json\/wp\/v2\/tags?post=4633"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}