{"id":5852,"date":"2023-02-24T10:30:03","date_gmt":"2023-02-24T01:30:03","guid":{"rendered":"http:\/\/www.med.niigata-u.ac.jp\/pub\/?p=5852"},"modified":"2023-03-31T19:21:15","modified_gmt":"2023-03-31T10:21:15","slug":"%e6%9c%ac%e9%82%a6%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b2022-2023%e5%b9%b4%e3%82%b7%e3%83%bc%e3%82%ba%e3%83%b3%e3%81%ae%e6%8a%97%e3%82%a4%e3%83%b3%e3%83%95%e3%83%ab%e3%82%a8%e3%83%b3%e3%82%b6%e5%89%a4","status":"publish","type":"post","link":"https:\/\/www.med.niigata-u.ac.jp\/pub\/2023\/02\/24\/%e6%9c%ac%e9%82%a6%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b2022-2023%e5%b9%b4%e3%82%b7%e3%83%bc%e3%82%ba%e3%83%b3%e3%81%ae%e6%8a%97%e3%82%a4%e3%83%b3%e3%83%95%e3%83%ab%e3%82%a8%e3%83%b3%e3%82%b6%e5%89%a4\/","title":{"rendered":"2023\u5e742\u670824\u65e5\u3000\u6297\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u5264\u611f\u53d7\u6027\u4f4e\u4e0b\u682a\u8abf\u67fb\u306e\u7d50\u679c"},"content":{"rendered":"

2022\/23\u5e74\u30b7\u30fc\u30ba\u30f3\u3000\u6297\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u5264\u611f\u53d7\u6027\u4f4e\u4e0b\u682a\u8abf\u67fb\u306e\u7d50\u679c
\n\u65b0\u6f5f\u5927\u5b66\u5927\u5b66\u9662\u533b\u6b6f\u5b66\u7dcf\u5408\u7814\u7a76\u79d1\u30fb\u56fd\u969b\u4fdd\u5065<\/p>\n

\u7d50\u679c\u306e\u6982\u8981
\n2022\/23\u5e74\u30b7\u30fc\u30ba\u30f3\u306f2023\u5e74\u67082\u670824\u65e5\u307e\u3067\u306b\u3001\u53d7\u9818\u3057\u305f\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u7591\u3044\u306e\u691c\u4f53\u306f\u4ee5\u4e0b\u3067\u3042\u308b\u3002
\n\u691c\u4f53\u306e\u5185\u8a33\u306f\u3001\u521d\u8a3a\u664289\u682a\u3001\u518d\u8a3a\u664228\u682a\u3001\u3046\u3061\u30d0\u30ed\u30ad\u30b5\u30d3\u30eb\u6295\u4e0e\u691c\u4f5316\u682a\u3067\u3042\u3063\u305f\uff08\u8868\uff11\uff09\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u3010PA\u907a\u4f1d\u5b50\u306e\u89e3\u6790\u3011
\n\u30b5\u30a4\u30af\u30ea\u30f3\u30b0\u30d7\u30ed\u30fc\u30d6\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0PCR\u6cd5\u306b\u3088\u308a\u3001PA\/I38T\u5909\u7570\u682a\u306e\u691c\u51fa\u3092\u884c\u3063\u305f\uff08\u88682)\u3002<\/p>\n

\"\"<\/a><\/p>\n

PA\/I38T\u5909\u7570\u3042\u308a\u306e\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306f\u3001
\nA(H1Nl)pdm09\u306e\u6d41\u884c\u682a\uff08\u6295\u4e0e\u524d\u682a\uff09\u306f1\u691c\u4f53\u4e2d0\u4ef6\u304cPA\/I38T\u5909\u7570\u967d\u6027(0%)\u3067\u3042\u3063\u305f\u3002\u30d0\u30ed\u30ad\u30b5\u30d3\u30eb\u6295\u4e0e\u5f8c\u306e\u691c\u4f53\u306f\u63a1\u53d6\u3055\u308c\u3066\u3044\u306a\u304b\u3063\u305f\u3002<\/p>\n

A(H3N2)\u306e\u6d41\u884c\u682a\uff08\u6295\u4e0e\u524d\u682a\uff09\u306f77\u691c\u4f53\u4e2d0\u4ef6\u304cPA\/I38T\u5909\u7570\u967d\u6027(0%)\u3067\u3042\u3063\u305f\u3002\u30d0\u30ed\u30ad\u30b5\u30d3\u30eb\u6295\u4e0e\u5f8c\u306e\u5168\u75c7\u4f8b\u306b\u304a\u3044\u306616\u691c\u4f53\u4e2d1\u4ef6\u304cPA\/138T\u5909\u7570\u967d\u6027(6.3%)\u3067\u3042\u3063\u305f\u3002\u518d\u8a3a\u6642RT-PCR\u967d\u6027\u8005\u306e\u307f\u3067\u51fa\u73fe\u983b\u5ea6\u3092\u518d\u8a08\u7b97\u3057\u305f\u5834\u5408\u30017\u691c\u4f53\u4e2d1\u4ef6\u304cPA\/I38T\u5909\u7570\u967d\u6027(14.3%)\u3002\u3053\u306e\u518d\u8a3a\u6642\u306b\u691c\u51fa\u3055\u308c\u305fPA\/I38T\u5909\u7570\u682a\u306f\u3001PA\u5909\u7570\u7121\u3057\u3068\u6709\u308a\u306e\u6df7\u5408\u682a\u3067\u3042\u3063\u305f\u3002<\/p>\n

A\u578b\u306e\u6d41\u884c\u682a\uff08\u6295\u4e0e\u524d\u682a\uff09\u306f\uff14\u691c\u4f53\u4e2d0\u4ef6\u304cPA\/I38T\u5909\u7570\u967d\u6027(0%)\u3067\u3042\u3063\u305f\u3002\u30d0\u30ed\u30ad\u30b5\u30d3\u30eb\u6295\u4e0e\u5f8c\u306e\u691c\u4f53\u306f\u63a1\u53d6\u3055\u308c\u306a\u304b\u3063\u305f\u3002<\/p>\n

B\u578b\u306f\u691c\u51fa\u3055\u308c\u306a\u304b\u3063\u305f\u3002<\/p>\n

\u6b21\u4e16\u4ee3\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u306b\u3088\u308bPA\u907a\u4f1d\u5b50\u89e3\u6790\u3068NA\u907a\u4f1d\u5b50\u89e3\u6790\u306f\u307e\u3060\u5b9f\u65bd\u3057\u3066\u3044\u306a\u3044\uff08\u88683,4\uff09<\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

Summary of Results.
\nDuring 2022\/23 season, samples collected from influenza-like-illness patients were as below, as of February 24, 2023.
\nThe breakdown of samples was as follows: 88 samples collected at the first visit, 28 samples at the second visit, 16 samples after baloxavir treatment (Table 1).<\/p>\n

[PA gene analysis]
\nThe results of the detection of PA\/I38T substation by cycling probe real-time PCR are shown below (Table 2).<\/p>\n

The percentage of patients with PA\/138T substitution was;
\nIn A(H1Nl)pdm09, pre-treatment samples were 0 positive (0%) for PA\/I38T variant out of 1 specimen. No specimens were collected after baloxavir administration.<\/p>\n

In A(H3N2), pre-treatment samples were 0 positive (0%) for PA\/I38T variant out of 76 specimens. Among post treatment samples, 1 positive (6.3%) for PA\/I38T variant out of 16 samples in all post-baloxavir-treated patients, 1 positive (14.3%) for PA\/I38T variant out of 7 samples in RT-PCR-positives at the second visit. The PA\/I38T substituted virus detected at the second visit was a mixture of those without and with PA\/I38T substitution.<\/p>\n

In unsubtyped influenza A, pre-treatment samples were 0 positive (0%) PA\/I38T variant out of 4 specimens. No specimens were collected after baloxavir administration.<\/p>\n

Influenza B was not detected.<\/p>\n

PA and NA gene analysis by next-generation sequencing has not yet been performed (Tables 3 and 4).<\/p>\n","protected":false},"excerpt":{"rendered":"

2022\/23\u5e74\u30b7\u30fc\u30ba\u30f3\u3000\u6297\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u5264\u611f\u53d7\u6027\u4f4e\u4e0b\u682a\u8abf\u67fb\u306e\u7d50\u679c \u65b0\u6f5f\u5927\u5b66\u5927\u5b66\u9662\u533b\u6b6f\u5b66\u7dcf\u5408\u7814\u7a76\u79d1\u30fb\u56fd\u969b\u4fdd\u5065 \u7d50\u679c\u306e\u6982\u8981 2022\/23\u5e74\u30b7\u30fc\u30ba\u30f3\u306f2023\u5e74\u67082\u670824\u65e5\u307e\u3067\u306b\u3001\u53d7\u9818\u3057\u305f\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u7591\u3044\u306e\u691c\u4f53\u306f\u4ee5\u4e0b\u3067\u3042 …\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":5859,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1,3,11],"tags":[],"class_list":["post-5852","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-blog","category-influenzasearch"],"jetpack_featured_media_url":"https:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/02\/Table2.jpg","jetpack_shortlink":"https:\/\/wp.me\/ph72WZ-1wo","jetpack-related-posts":[{"id":5880,"url":"https:\/\/www.med.niigata-u.ac.jp\/pub\/2023\/03\/30\/%e6%9c%ac%e9%82%a6%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b2022-2023%e5%b9%b4%e3%82%b7%e3%83%bc%e3%82%ba%e3%83%b3%e3%81%ae%e6%8a%97%e3%82%a4%e3%83%b3%e3%83%95%e3%83%ab%e3%82%a8%e3%83%b3%e3%82%b6%e5%89%a4-2\/","url_meta":{"origin":5852,"position":0},"title":"2023\u5e743\u670823\u65e5\u3000\u6297\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u5264\u611f\u53d7\u6027\u4f4e\u4e0b\u682a\u8abf\u67fb\u306e\u7d50\u679c","author":"public-health","date":"2023\u5e743\u670830\u65e5","format":false,"excerpt":"2022\/23\u5e74\u30b7\u30fc\u30ba\u30f3\u3000\u6297\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u5264\u611f\u53d7\u6027\u4f4e\u4e0b\u682a\u8abf\u67fb\u306e\u7d50\u679c 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