![\"\"](\"http:\/\/www.med.niigata-u.ac.jp\/pub\/wppublichealth\/wp-content\/uploads\/2023\/03\/report-03.2023-ver421FS17-uploaded-version_Page_4-600x450.jpg\")
<\/a><\/p>\nSummary of Results.
\nDuring 2022\/23 season, samples collected from influenza-like-illness patients as of March 22, 2023 were as below:<\/p>\n
155 samples collected at the first visit, 37 samples at the second visit, 19 samples after baloxavir treatment (Table 1).<\/p>\n
The results of the detection of PA\/I38T substation by cycling probe real-time PCR are shown below (Table 2).<\/p>\n
The percentage of patients with PA\/I38T substitution was:
\nIn A(H1N1)pdm09, no PA\/I38T variant in pre- and post-treatment samples was detected out of 1 sample (0.0%). In A(H3N2), among pre-treatment samples 1 PA\/I38T variant (0.7%) was detected out of 136 samples. Among post baloxavir-treatment samples, 1 PA\/I38T variant (5.5%) and 1 mixed I38&I38T (5.5%) were detected out of 18 samples. If the frequency is calculated based on RT-PCR-positives at the second visit, 1 PA\/I38T variant (12.5%) and 1 mixed I38&I38T (12.5%) were detected out of 8 RT-PCR-positive samples at the second visit.<\/p>\n
In unsubtyped influenza A, pre-treatment samples were 0 positive (0%) PA\/I38T variant out of 7 specimens.<\/p>\n
Influenza B was not detected.<\/p>\n
<\/p>\n
[PA gene analysis]<\/p>\n
In A(H3N2), one PA\/I38M substitution (7.6%) out of 13 paired baloxavir-treated clinical sample was detected by next-generation sequencing (Table 3). This case was identified as mixed I38&I38T by the cycling probe RT-PCR assay but it turned out to be PA\/I38M by NGS. If the denominator is based on 2 samples with successful NGS in the baloxavir-treated group, the frequency of PA variant was 50.0%<\/p>\n
<\/p>\n
[NA gene analysis]<\/p>\n
No substitution in NA gene which confer reduced sensitivity to NAIs was found by next-generation sequencing either in pre-treatment samples (0\/53) or oseltamivir treated samples (0\/25) (Table 4).<\/p>\n","protected":false},"excerpt":{"rendered":"
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<\/a><\/p>\n