業　績

業績

原著論文［2024］

Sensory-motor circuit is a therapeutic target for dystonia musculorum mice, a model of hereditary sensory and autonomic neuropathy 6.
Yoshioka N, Kurose M, Sano H, Tran DM, Chiken S, Tainaka K, Yamamura K, Kobayashi K, Nambu A, Takebayashi H.
Sci Adv 10: eadj9335, 2024. [PubMed]

Qki5 safeguards spinal motor neuron function by defining the motor neuron-specific transcriptome via pre-mRNA processing.
Hayakawa-Yano Y, Furukawa T, Matsuo T, Ogasawara T, Nogami M, Yokoyama K, Yugami M, Shinozaki M, Nakamoto C, Sakimura K, Koyama A, Ogi K, Onodera O, Takebayashi H, Okano H, Yano M.
Proc Natl Acad Sci U S A 121: e2401531121, 2024. [PubMed] [Open Access]

Stage-dependent immunity orchestrates AQP4 antibody-guided NMOSD pathology: A role for netting neutrophils with resident memory T cells in situ.
Nakajima A, Yanagimura F, Saji E, Shimizu H, Toyoshima Y, Yanagawa K, Arakawa M, Hokari M, Yokoseki A, Wakasugi T, Okamoto K, Takebayashi H, Fujii C, Itoh K, Takei Y, Ohara S, Yamada M, Takahashi H, Nishizawa M, Igarashi H, Kakita A, Onodera O, Kawachi I.
Acta Neuropathologica 147: 76, 2024. [PubMed]

Analysis of brain, blood, and testis phenotypes lacking the Vps13a gene in C57BL/6N mice.
Pinyomahakul J, Ise M, Kawamura M, Yamada T, Okuyama K, Shibata S, Takizawa J, Abe M, Sakimura K, Takebayashi H.
Int J Mol Sci 25: 7776, 2024. [PubMed]

原著論文［2023］

Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity.
Tran DM, Yoshioka N, Bizen N, Mori-Ochiai Y, Yano M, Yanai S, Hasegawa J, Miyashita S, Hoshino M, Sasaki J, Sasaki T, Takebayashi H.
Dis Model Mech 16: dmm.050169, 2023. [PubMed] [Open Access]

Sbp2l contributes to oligodendrocyte maturation through translational control in Tcf7l2 signaling.
Yugami M, Hayakawa-Yano Y, Ogasawara T, Yokoyama K, Furukawa T, Hara H, Hashikami K, Tsuji I, Takebayashi H, Araki S, Okano H, Yano M.
iScience 26: 108451, 2023. [Open Access]

Brain-specific glycosylation of protein tyrosine phosphatase receptor type Z (PTPRZ) marks a demyelination-associated astrocyte subtype.
Takahashi K, Kanekiyo K, Sakuda K, Muto Y, Iguchi M, Matsuda N, Hashimoto Y, Kanai K, Ogawa H, Hirase H, Kakita A, Bizen N, Takebayashi H, Kawaguchi Y, Uzuki M, Kitazume S.
J Neurochem 166: 547-559, 2023. [PubMed] [Wiley Online Library]

Disruption of the anterior commissure in an Olig2 deficient mouse.
Gotoh H, Maruyama K, Yoshii K, Yamauchi N, Nomura T, Ohtsuka S, Shirasaki R, Takebayashi H, Ono K.
Eur J Neurosci 57: 5-16, 2023. [PubMed] [Wiley Online Library]

・Olig2 KOマウス前脳の組織写真が論文掲載号の表紙を飾りました。

CCP1, a Regulator of Tubulin Post-Translational Modifications, Potentially Plays an Essential Role in Cerebellar Development.
Pang B, Araki A, Zhou L, Takebayashi H, Harada T, Kadota K.
Int J Mol Sci 24: 5335, 2023. [PubMed] [Open Access]

原著論文［2022］

Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy.
Shinozaki Y, Leung A, Namekata K, Saitoh S, Nguyen HB, Takeda A, Danjo Y, Morizawa YM, Shigetomi E, Sano F, Yoshioka N, Takebayashi H, Ohno N, Segawa T, Miyake K, Kashiwagi K, Harada T, Ohnuma SI, Koizumi S.
Sci Adv 8: eabq1081, 2022. [PubMed] [Open Access] [プレスリリース]
Erratic and blood vessel-guided migration of astrocyte progenitors in the cerebral cortex.
Tabata H, Sasaki M, Agetsuma M, Sano H, Hirota Y, Miyajima M, Hayashi K, Honda T, Nishikawa M, Inaguma Y, Ito H, Takebayashi H, Ema M, Ikenaka K, Nabekura J, Nagata KI, Nakajima K.
Nat Commun 13: 6571, 2022. [PubMed] [Open Access] [プレスリリース]
Isoform-specific mutation in Dystonin-b gene causes late-onset protein aggregate myopathy and cardiomyopathy.
Yoshioka N, Kurose M, Yano M, Tran DM, Okuda S, Mori-Ochiai Y, Horie M, Nagai T, Nishino I, Shibata S, Takebayashi H.
eLife 11: e78419, 2022. [PubMed] [Open Access] [プレスリリース]
A computational study to target necroptosis via RIPK1 inhibition.
Bepari AK, Takebayashi H, Namme JN, Rahman GMS, Reza HM.
J Biomol Struct Dyn doi: 10.1080/07391102.2022.2108900. Epub 2022 Aug 8. [PubMed] [Open Access]
Perturbation of monoamine metabolism and enhanced fear responses in mice defective in the regeneration of tetrahydrobiopterin.
Miyajima K, Sudo Y, Sanechika S, Hara Y, Horiguchi M, Xu F, Suzuki M, Hara S, Tanda K, Inoue K, Takada M, Yoshioka N, Takebayashi H, Mori-Kojima M, Sugimoto M, Sumi-Ichinose C, Kondo K, Takao K, Miyakawa T, Ichinose H.
J Neurochem 161: 129-145, 2022. [PubMed] [Wiley Online Library]
Ddx20, an Olig2 binding factor, governs the survival of neural and oligodendrocyte progenitor cells via proper Mdm2 splicing and p53 suppression.
Bizen N, Bepari AK, Zhou L, Abe M, Sakimura K, Ono K, Takebayashi H.
Cell Death Differ 29: 1028-1041, 2022. [PubMed] [Open Access] [プレスリリース] [Eurekalert]
Nna1, essential for Purkinje cell survival, is also associated with emotion and memory.
Zhou L, Konno K, Yamazaki M, Abe M, Natsume R, Watanabe M, Takebayashi H, Sakimura K.
Int J Mol Sci 23: 12961, 2022. [PubMed] [Open Access]

原著論文［2021］

Ddx20, DEAD box helicase 20, is essential for the differentiation of oligodendrocyte and maintenance of myelin gene expression.
Simankova A, Bizen N, Saitoh S, Shibata S, Ohno N, Abe M, Sakimura K, Takebayashi H.
Glia 69: 2559-2574, 2021. [PubMed] [プレスリリース]
Reduction in miR-219 expression underlies cellular pathogenesis of oligodendrocytes in a mouse model of Krabbe disease.
Inamura N, Go S, Watanabe T, Takase H, Takakura N, Nakayama A, Takebayashi H, Matsuda J, Enokido Y.
Brain Pathol: e12951, 2021. [PubMed] [発達障害研究所プレスリリース]
Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice.
Ito N, Riyadh MA, Ahmad SAI, Hattori S, Kanemura Y, Kiyonari H, Abe T, Furuta Y, Shinmyo Y, Kaneko N, Hirota Y, Lupo G, Hatakeyama J, Abdulhaleem M FA, Anam MB, Yamaguchi M, Takeo T, Takebayashi H, Takebayashi M, Oike Y, Nakagata N, Shimamura K, Holtzman MJ, Takahashi Y, Guillemot F, Miyakawa T, Sawamoto K, Ohta K.
Sci Transl Med 13: eaay7896, 2021. [PubMed] [九州大学プレスリリース]

原著論文［2020］

Disruption of dystonin in Schwann cells results in late-onset neuropathy and sensory ataxia.
Horie M, Yoshioka N, Kusumi S, Sano H, Kurose M, Watanabe-Iida I, Hossain MI, Chiken S, Abe M, Yamamura K, Sakimura K, Nambu A, Shibata M, Takebayashi H.
Glia 68: 2330-2334, 2020. [PubMed]
Retrograde gene transfer into neural pathways mediated by adeno-associated virus (AAV)-AAV receptor interaction.
Sano H, Kobayashi K, Yoshioka N, Takebayashi H, Nambu A.
J Neurosci Methods 345: 108887, 2020. [PubMed]
Olig2-induced semaphorin expression drives corticospinal axon retraction after spinal cord injury.
Ueno M, Nakamura Y, Nakagawa H, Niehaus JK, Maezawa M, Gu Z, Kumanogoh A, Takebayashi H, Lu QR, Takada M, Yoshida Y.
Cereb Cortex 30: 5702-5716, 2020. [PubMed]
Diverse mutations in dystonin gene cause distinct patterns of Dst isoform deficiency and phenotypic heterogeneity in Dystonia musculorum mice.
Yoshioka N, Kabata Y, Kuriyama M, Bizen N, Zhou L, Tran MD, Yano M, Yoshiki A, Ushiki T, Sproule TJ, Abe R, Takebayashi H.
Dis Model Mech 13: dmm041608, 2020. [PubMed] [Open Access] [プレスリリース]
The fornix acts as a permissive corridor for septal neuron migration beyond the diencephalic-telencephalic boundary.
Watanabe K, Takebayashi H, Sato N.
Sci Rep 10: 8315, 2020. [PubMed] [Open Access]
Olig2 regulates terminal differentiation and maturation of peripheral olfactory sensory neurons.
Wang YZ, Fan H, Ji Y, Reynolds K, Gu R, Gan Q, Yamagami T, Zhao T, Hamad S, Bizen N, Takebayashi H, Chen Y, Wu S, Pleasure D, Lam K, Zhou CJ.
Cell Mol Life Sci 77: 3597-3609, 2020. [PubMed]
Glial pathology in a novel spontaneous mutant mouse of the Eif2b5 gene: a vanishing white matter disease model.
Terumitsu-Tsujita M*, Kitaura H, Miura I , Kiyama Y, Goto F, Muraki Y, Ominato S, Hara N, Simankova A, Bizen N, Kashiwagi K, Itoh T, Toyoshima Y, Kakita A, Manabe T, Wakana S, Takebayashi H*, Igarashi H.
J Neurochem 154: 25-40, 2020. [PubMed] [Open Access] [プレスリリース]
Oligodendrogenesis and myelin formation in the forebrain require platelet-derived growth factor receptor-alpha.
Hamashima T, Ishii Y, Linh NQ, Okuno N, Sang Y, Matushima T, Kurashige Y, Takebayashi H, Mori H, Fujimori T, Yamamoto S, Sasahara M.
Neuroscience 436: 11-26, 2020. [PubMed]

Reciprocal connectivity between secondary auditory cortical field and amygdala in mice.
Tsukano H, Hou X, Horie M, Kitaura H, Nishio N, Hishida R, Takahashi K, Kakita A, Takebayashi H, Sugiyama S, Shibuki K.
Sci Rep 9: 19610, 2019. [PubMed] [Open Access]
Acute spatial spread of NO-mediated potentiation during hindpaw ischemia in mice.
Onishi T, Watanabe T, Sasaki M, Kamiya Y, Horie M, Tsukano H, Hishida R, Kohno T, Takebayashi H, Baba H, Shibuki K.
J Physiol 597: 3441-3455, 2019. [PubMed]
Feedback inhibition derived from the posterior parietal cortex regulates the neural properties of the mouse visual cortex.
Horie M, Tsukano H, Tohmi M, Yoshitake K, Meguro R, Takebayashi H, Yanagawa Y, Shibuki K.
Eur J Neurosci 50: 2970-2987, 2019. [PubMed]

Deletion of exons encoding carboxypeptidase domain of Nna1 results in Purkinje cell degeneration (pcd) phenotype.
Zhou L, Hossain MI, Yamazaki M, Abe M, Natsume R, Konno K, Kageyama S, Komatsu M, Watanabe M, Sakimura K, Takebayashi H.
J Neurochem 147: 557-572, 2018. [PubMed] [Open Access]
Direct relay pathways from lemniscal auditory thalamus to secondary auditory field in mice.
Ohga S, Tsukano H, Horie M, Terashima H, Nishio N, Kubota Y, Takahashi K, Hishida R, Takebayashi H, Shibuki K.
Cereb Cortex 28: 4424-4439, 2018. [PubMed] [Open Access] [プレスリリース]
Developmental defects and aberrant accumulation of endogenous psychosine in oligodendrocytes in a murine model of Krabbe disease.
Inamura N, Kito M, Go S, Kishi S, Hosokawa M, Asai K, Takakura N, Takebayashi H, Matsuda J, Enokido Y.
Neurobiol Dis 120: 51-62, 2018. [PubMed]
Motoneuron degeneration in the trigeminal motor nucleus innervating the masseter muscle in Dystonia musculorum mice.
Hossain MI, Horie M, Yoshioka N, Kurose M, Yamamura K, Takebayashi H.
Neurochem Int 119: 159-170, 2018. [PubMed]
Diencephalic progenitors contribute to the posterior septum through rostral migration along the hippocampal axonal pathway.
Watanabe K, Irie K, Hanashima C, Takebayashi H, Sato N.
Sci Rep 8: 11728, 2018. [PubMed] [Open Access]
Locally induced neuronal synchrony precisely propagates to specific cortical areas without rhythm distortion.
Toda H, Kawasaki K, Sato S, Horie M, Nakahara K, Bepari AK, Sawahata H, Suzuki T, Okado H, Takebayashi H, Hasegawa I.
Sci Rep 8: 7678, 2018. [PubMed] [Open Access]
Reduced proliferation of oligodendrocyte progenitor cells in the postnatal brain of dystonia musculorum mice.
Hossain MI, Horie M, Takebayashi H.
Neurochem Res 43: 92-100, 2018. [PubMed]
Histological detection of dynamic glial responses in the dysmyelinating Tabby-jimpy mutant brain.
Ikeda M, Hossain MI, Zhou L, Horie M, Ikenaka K, Horii A, Takebayashi H.
Anat Sci Int 93: 119-127, 2018. [PubMed]

An RNA-binding protein, Qki5, regulates embryonic neural stem cells through pre-mRNA processing in cell adhesion signaling.
Hayakawa-Yano Y, Suyama S, Nogami M, Yugami M, Koya I, Furukawa T, Zhou L, Abe M, Sakimura K, Takebayashi H, Nakanishi A, Okano H, Yano M.
Genes Dev 31 18: 1910-1925, 2017. [PubMed] [Open access]

Hearing loss controlled by optogenetic stimulation of nonexcitable nonglial cells in the cochlea of the inner ear.
Sato MP, Higuchi T, Nin F, Ogata G, Sawamura S, Yoshida T, Ota T, Hori K, Komune S, Uetsuka S, Choi S, Masuda M, Watabe T, Kanzaki S, Ogawa K, Inohara H, Sakamoto S, Takebayashi H, Doi K, Tanaka KF, Hibino H.
Front Mol Neurosci 10: 300, 2017. [PubMed] [Open access]
A novel splice site mutation of myosin VI in mice leads to stereociliary fusion caused by disruption of actin networks in the apical region of inner ear hair cells.
Seki Y, Miyasaka Y, Suzuki S, Wada K, Yasuda SP, Matsuoka K, Ohshiba Y, Endo K, Ishii R, Shitara H, Kitajiri SI, Nakagata N, Takebayashi H, Kikkawa Y.
PLoS ONE 12: e0183477, 2017. [PubMed] [Open access]
Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway.
Morizawa YM, Hirayama Y, Ohno N, Shibata S, Shigetomi E, Sui Y, Nabekura J, Sato K, Okajima F, Takebayashi H, Okano H, Koizumi S.
Nature Commun 8: 28, 2017. [PubMed] [Open access] [山梨大学プレスリリース]
Epidermal growth factor signals attenuate phenotypic and functional development of neocortical GABA neurons.
Namba H, Nagano T, Jodo E, Eifuku S, Horie M, Takebayashi H, Iwakura Y, Sotoyama H, Takei N, Nawa H.
J Neurochem 142: 886-900, 2017. [PubMed] [Open access]
Oligodendrocyte precursor cells in the mouse optic nerve originate in the preoptic area.
Ono K, Yoshii K, Tominaga H, Gotoh H, Nomura T, Takebayashi H, Ikenaka K.
Brain Struct Funct 222: 2441-2448, 2017. [PubMed]
Independent tonotopy and thalamocortical projection patterns in two adjacent parts of the classical primary auditory cortex in mice.
Tsukano H, Horie M, Takahashi K, Hishida R, Takebayashi H, Shibuki K.
Neurosci Lett 637: 26-30, 2017. [PubMed] [Open access]

Endoplasmic reticulum-localized transmembrane protein Dpy19L1 is required for neurite outgrowth.
Watanabe K, Bizen N, Sato N, Takebayashi H.
PLoS ONE 11: e0167985, 2016. [PubMed] [Open access]
Characterization of novel dystonia musculorum mutant mice: implications for central nervous system abnormality.
Horie M, Mekada K, Sano H, Kikkawa Y, Chiken S, Someya T, Saito K, Hossain MD, Nameta M, Abe K, Sakimura K, Ono K, Nambu A, Yoshiki A, Takebayashi H.
Neurobiol Dis 96: 271-283, 2016. [PubMed]
Biallelic variants in UBA5 link dysfunctional UFM1 ubiquitin-like modifier pathway to severe infantile-onset encephalopathy.
Muona M, Ishimura R, Laari A, Ichimura Y, Linnankivi T, Keski-Filppula R, Herva R, Rantala H, Paetau A, Poyhonen M, Obata M, Uemura T, Karhu T, Bizen N, Takebayashi H, McKee S, Parker MJ, Akawi N, McRae J, Hurles ME, the DDD Study, Kuismin O, Kurki MI, Anttonen A-K, Tanaka K, Palotie A, Waguri S, Lehesjoki A-E, Komatsu M.
Am J Hum Genet 99: 683-694, 2016. [PubMed] [Open access] [新潟大学プレスリリース]
Characteristic microglial features in patients with hereditary diffuse leukoencephalopathy with spheroids.
Tada M, Konno T, Tada M, Tezuka T, Miura T, Mezaki N, Okazaki KI, Arakawa M, Itoh K, Yamamoto T, Yokoo H, Yoshikura N, Ishihara K, Horie M, Takebayashi H, Toyoshima Y, Naito M, Onodera O, Nishizawa M, Takahashi H, Ikeuchi T, Kakita A.
Ann Neurol 80: 554-565, 2016. [PubMed]
Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.
Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp JL, Kritzik M, Sicklick JK, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek MA, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T.
Nature 534: 407-411, 2016. [PubMed]
Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sclerosis: Evidence for clinico-pathologic subtypes.
Takeuchi R, Tada M, Shiga A, Toyoshima Y, Konno T, Sato T, Nozaki H, Kato T, Horie M, Shimizu H, Takebayashi H, Onodera O, Nishizawa M, Kakita A, Takahashi H.
Acta Neuropathol Commun 4: 61, 2016. [PubMed] [Open access]
Musashi mediates translational repression of the Drosophila hypoxia inducible factor.
Bertolin AP, Katz MJ, Yano M, Pozzi B, Acevedo JM, Blanco-Obregon D, Gandara L, Sorianello E, Kanda H, Okano H, Srebrow A, Wappner P.
Nucleic Acids Res 44: 7555-7567, 2016. [PubMed]
Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells.
Ichiyanagi N, Fujimori K, Yano M, Ishihara-Fujisaki C, Sone T, Akiyama T, Okada Y, Akamatsu W, Matsumoto T, Ishikawa M, Nishimoto Y, Ishihara Y, Sakuma T, Yamamoto T, Tsuiji H, Suzuki N, Warita H, Aoki M, Okano H.
Stem Cell Rep 6: 496-510, 2016. [PubMed]
Quantitative map of multiple auditory cortical regions with a stereotaxic fine-scale atlas of the mouse brain.
Tsukano H, Horie M, Hishida R, Takahashi K, Takebayashi H, Shibuki K.
Sci Rep 29: 22315, 2016. [PubMed] [Open access]
The dorsoventral boundary of the germinal zone is a specialized niche for the generation of cortical oligodendrocytes during a restricted temporal window.
Naruse M, Ishino Y, Kumar A, Ono K, Takebayashi H, Yamaguchi M, Ishizaki Y, Ikenaka K, Hitoshi S.
Cereb Cortex 26: 2800-2810, 2016. [PubMed]

Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex.
Shinmyo Y, Riyadh MA, Ahmed G, Naser IB, Hossain M, Takebayashi H, Kawasaki H, Ohta K, Tanaka H.
Nature Commun 6: 10232, 2015. [PubMed] [Open access] [金沢大学プレスリリース]
Oligodendrogenesis in the fornix of adult mouse brain; the effect of LPS-induced inflammatory stimulation.
Fukushima S, Nishikawa K, Furube E, Muneoka S, Ono K, Takebayashi H, Miyata S.
Brain Res 1627: 52-69, 2015. [PubMed]
Specific distribution of non-phosphorylated neurofilaments characterizing each subfield in the mouse auditory cortex.
Horie M, Tsukano H, Takebayashi H, Shibuki K.
Neurosci Lett 606: 182-187, 2015. [PubMed]
Acute reduction of neuronal RNA binding Elavl2 protein and Gap43 mRNA in mouse hippocampus after kainic acid treatment.
Ohtsuka T, Yano M, Okano H.
Biochem Biophys Res Commun 466: 46-51, 2015. [PubMed]
Somatic mutations in the MTOR gene cause focal cortical dysplasia type IIb.
Nakashima M, Saitsu H, Takei N, Tohyama J, Kato M, Kitaura H, Shiina M, Shirozu H, Masuda H, Watanabe K, Ohba C, Tsurusaki Y, Miyake N, Zheng Y, Sato T, Takebayashi H, Ogata K, Kameyama S, Kakita A, Matsumoto N.
Ann Neurol 78: 375-386, 2015. [PubMed]
Delineation of a frequency-organized region isolated from the mouse primary auditory cortex.
Tsukano H, Horie M, Bo T, Uchimura A, Hishida R, Kudoh M, Takahashi K, Takebayashi H, Shibuki K.
J Neurophysiol 113: 2900-2920, 2015. [PubMed] [Open access]
Expression of the Olig gene family in the developing mouse inner ear.
Kanaya E, Okano T, Yoshida A, Katsuno T, Takabayashi H, Ito J, Yamamoto N.
Gene Expr Patterns 17: 79-86, 2015. [PubMed]
Alternative role of HuD splicing variants in neuronal differentiation.
Hayashi S, Yano M, Igarashi M, Okano HJ, Okano H.
J Neurosci Res 93: 399-409, 2015. [PubMed]
Impaired clustered protocadherin-α (cPcdh-α) leads to aggregated retinogeniculate terminals and impaired visual acuity in mice.
Meguro R, Hishida R, Tsukano H, Yoshitake K, Imamura R, Tohmi M, Kitsukara T, Hirabayashi T, Yagi T, Takebayashi H, Shibuki K.
J Neurochem 133: 66-72, 2015. [PubMed] [Open access]

Disruption of actin-binding domain-containing dystonin protein causes dystonia musculorum in mice.
Horie M, Watanabe K, Bepari AK, Nashimoto J, Araki K, Sano H, Chiken S, Nambu A, Ono K, Ikenaka K, Kakita K, Yamamura K, Takebayashi H*.
Eur J Neurosci 40: 3458-3471, 2014. [PubMed]
Olig3 is not involved in the ventral patterning of spinal cord.
Liu Z, Hu X, Huang C, Zheng K, Takebayashi H, Cao C, Qiu M.
PLoS One 28: e111076, 2014. [PubMed] [Open access]
Development of the prethalamus is crucial for thalamocortical projection formation and is regulated by Olig2.
Ono K, Clavairoly A, Nomura T, Gotoh H, Uno A, Armant O, Takebayashi H, Zhang Q, Shimamura K, Itohara S, Parras CM, Ikenaka K.
Development 14: 2075-2084, 2014. [PubMed] [Open access]
Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum.
Seto Y, Nakatani T, Masuyama N, Taya S, Kumai M, Minaki Y, Hamaguchi A, Inoue YU, Inoue T, Miyashita S, Fujiyama T, Yamada M, Chapman H, Campbell K, Magnuson MA, Wright CV, Kawaguchi Y, Ikenaka K, Takebayashi H, Ishiwata S, Ono Y, Hoshino M.
Nature Commun 5: 3337, 2014. [PubMed] [Open access]

Age-related deterioration of cortical responses to slow FM sounds in the auditory belt region of adult C57BL/6 mice.
Tsukano H, Horie M, Honma Y, Ohga S, Hishida R, Takebayashi H, Takahashi S, Shibuki K.
Neurosci Lett 556: 204-209, 2013. [PubMed]
Auditory cortical areas activated by slow frequency-modulated sounds in mice.
Honma Y, Tsukano H, Horie M, Ohshima S, Tohmi M, Kubota Y, Takahashi K, Hishida R, Takahashi S, Shibuki K.
PLoS One 17: e68113, 2013. [PubMed] [Open access]
Dual compartments of the ventral division of the medial geniculate body projecting to the core region of the auditory cortex in C57BL/6 mice.
Horie M, Tsukano H, Hishida R, Takebayashi H, Shibuki K.
Neurosci Res 76: 207-212, 2013. [PubMed]
Olig2-lineage cells preferentially differentiate into oligodendrocytes but fail to survive in the chronic demyelinating lesion.
Shimizu T, Tanaka KF, Takebayashi H, Higashi M, Ono K, Hitoshi S, Ikenaka K.
J Neurosci Res 91: 178-186, 2013. [PubMed]
Neuroanatomical study on the tecto-suprageniculate-dorsal auditory cortex pathway in the rat.
Horie M*, Meguro R, Hoshino K, Ishida N, Norita M.
Neuroscience 228: 382-394, 2013. [PubMed]

Identification of optogenetically activated striatal medium spiny neurons by Npas4 expression.
Bepari AK#, Sano H#, Tamamaki N, Nambu A, Tanaka KF*, Takebayashi H*.
PLoS One 7: e52783, 2012. [# co-first authors] [PubMed] [Open access]
Nkx2.2+ progenitors generate somatic motoneurons in the chick spinal cord.
Gotoh H, Ono K, Nomura T, Takebayashi H, Harada H, Nakamura H, Ikenaka K.
PLoS One 7: e51581, 2012. [PubMed] [Open access]
Visualization of odor-induced neuronal activity by immediate early gene expression.
Bepari AK, Watanabe K, Yamaguchi M, Tamamaki N, Takebayashi H*.
BMC Neurosci 13: 140, 2012. [PubMed] [Open access] Most viewd article (^^)v

Subventricular Zone-Derived Oligodendrogenesis in Injured Neonatal White-matter in Mice Enhanced by a Nonerythropoietic EPO Derivative.
Kako E, Kaneko N, Aoyama M, Hida H, Takebayashi H, Ikenaka K, Asai K, Togari H, Sobue K, Sawamoto K.
Stem Cells 30: 2234-2247, 2012. [PubMed] [Open access]
Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche.
Lee DA, Bedont JL, Wang H, Song J, Miranda-Angulo A, Takiar V, Charubhumi V, Balordi F, Takebayashi H, Aja S, Ford E, Fishell G, Blackshaw S.
Nature Neurosci 15: 700-702, 2012. [PubMed] [Open access]
Role of motoneuron-derived neurotrophin 3 in survival and axonal projection of sensory neurons during neural circuit formation.
Usui N, Watanabe K, Ono K, Tomita K, Tamamaki N, Ikenaka K, Takebayashi H*.
Development 139: 1125-1132, 2012. [PubMed] [Open access] In this Issueに取り上げられました
A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors.
Shinohara R, Thumkeo D, Kamijo H, Kaneko N, Sawamoto K, Watanabe K, Takebayashi H, Kiyonari H, Ishizaki T, Furuyashiki T, Narumiya S.
Nature Neurosci 15: 373-380, 2012. [PubMed] [Open access] [News]

Dpy19l1, a multi-transmembrane protein, regulates radial migration of glutamatergic neurons in the developing cerebral cortex.
Watanabe K*, Takebayashi H*, Bepari AK, Esumi S, Yanagawa Y, Tamamaki N.
Development 138: 4979-4990, 2011. [PubMed] [Open access]
Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia.
Thumkeo D, Shinohara R, Watanabe K, Takebayashi H, Toyoda Y, Tohyama K, Ishizaki T, Furuyashiki T, Narumiya S.
PLoS One 6: e25465, 2011. [PubMed] [Open access]
Olig2-lineage cells generate GABAergic neurons in the prethalamic nuclei, including the zona incerta, ventral lateral geniculate nucleus and reticular thalamic nucleus.
Inamura N, Ono K, Takebayashi H, Zalc B, Ikenaka K.
Dev Neurosci 33: 118-129, 2011. [PubMed]
Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis.
Guo F, Meada Y, Ma J, Delgado M, Sohn J, Miers L, Ko EM, Bannerman P, Xu J, Wang Y, Zhou C, Takebayashi H, Pleasure D.
J Neurosci 31: 11914-11928, 2011. [PubMed] [Open access] [UC Davis News]
Evidence for the spontaneous production but massive programmed cell death of new neurons in the subcallosal zone of the adult mouse brain.
Kim WR, Chun SK, Kim TW, Kim H, Ono K, Takebayashi H, Ikenaka K, Oppenheim RW, Sun W.
Eur J Neurosci 33: 599-611, 2011. [PubMed]
Genetically-defined lineage tracing of Nkx2.2-expressing cells in chick spinal cord.
Goto H, Ono K, Takebayashi H, Harada H, Nakamura H, Ikenaka K.
Dev Biol 349: 504-511, 2011. [PubMed] [Open access]

Origin of new glial cells in the intact and injured adult spinal cord.
Barnabe-Heider F, Goritz C, Sabelstrom H, Takebayashi H, Pfrieger FW, Meletis K, Frisen J.
Cell Stem Cell 7: 470-482, 2010. [PubMed] [Open access]
Direct synaptic connections between superior colliculus afferents and thalamo-insular projection neurons in the feline suprageniculate nucleus: A double-labeling study with WGA-HRP and kainic acid.
Hoshino K, Horie M, Nagy A, Berenyi A, Benedek D, Norita M.
Neurosci Res 66: 7-13, 2010. [PubMed]

英文総説

Cofilin Signaling in the CNS Physiology and Neurodegeneration.
Namme JN, Bepari AK, Takebayashi H.
Int J Mol Sci 22: 10727, 2021. [PubMed]
Origin of oligodendrocytes in the optic nerve; Old and new problem.
Ono K, Hirahara Y, Gotoh H, Nomura T, Takebayashi H, Yamada H, Ikenaka K.
Neurochemical Research 43: 186-194, 2018. [PubMed]
BPAG1 in muscles: structure and function in skeletal, cardiac and smooth muscle.
Horie M, Yoshioka N, Takebayashi H.
Semin Cell Dev Biol 69: 26-33, 2017. [PubMed]
Reconsidering Tonotopic Maps in the Auditory Cortex and Lemniscal Auditory Thalamus in Mice.
Tsukano H, Horie M, Ohga S, Takahashi K, Kubota Y, Hishida R, Takebayashi H, Shibuki K.
Frontiers in Neural Circuits 11:14, 2017. [PubMed] [Open access]
RNA regulation went wrong in neurodevelopmental disorders: The example of Msi/Elavl RNA binding proteins.
Yano M, Hayakawa-Yano Y, Okano H.
Int J Dev Neurosci 55: 124-130, 2016. [PubMed]
Oligodendrocyte generation during mouse development.
Takebayashi H, Ikenaka K.
Glia 63: 1350-1356, 2015. [PubMed]
RNA-binding protein research with transcriptome-wide technologies in neural development.
Yano M*, Ohtsuka T, Okano H.
Cell Tissue Res 359: 135-144, 2015. [PubMed] [Open access]
Olig2 transcription factor in the developing and injured forebrain: cell lineage and glial development.

Ono K, Takebayashi H, Ikenaka K.
Mol Cells 27: 397-401, 2009. [PubMed] [Open access]

日本語総説＆論文

神経疾患研究における動物モデルの有用性
竹林浩秀
生物の科学 遺伝 6: 512-519, 2021.

脳はどのようにできているか（第1章）
竹林浩秀
脳神経化学—脳はいま化学の言葉でどこまで語れるか p 2-10, 2018.

ジストニア様の運動症状と感覚神経変性を示すdystonia musculorumマウスの病態解析
竹林浩秀
生化学 89 (5): 756-760, 2017.

単純性表皮水疱症モデルとしての新規Dystonin/Bpag1遺伝子変異マウスの解析
栗山桃奈、吉岡望、加畑雄大、牛木辰男、吉木淳、Thomas J Sproule、阿部理一郎、竹林浩秀
新潟医学会雑誌 131: 655-663, 2017.

ジストニア症状を示す遺伝性神経難病モデルマウスの作製と解析
竹林浩秀、堀江正男
新潟医学会雑誌 129: 491-497, 2015.

グリア細胞発生・分化機構の解析と生体内細胞系譜追跡実験系の確立・応用
竹林浩秀
神経化学 53: 41-46, 2014. [PDF]

ヒト脳病理切片におけるin situ hybridization 法を利用したニューロンおよびグリア細胞の同定
佐藤和彦、堀江正男、竹林浩秀、高橋均、柿田明美
新潟医学会雑誌 128: 625-634, 2014.

神経解剖学を基盤とした神経科学研究の展開
竹林浩秀、堀江正男、Asim K Bepari、渡辺啓介、目黒玲子
新潟医学会雑誌 127: 291-297, 2013.

再生医学と神経発生研究
竹林浩秀
新潟県医師会報 744: 1-4, 2012.

神経発生におけるOlig転写因子の機能解析
竹林浩秀
熊本医学会ニューズレター　第9号: 2011.

グリア発生の研究を起点とした脳研究
竹林浩秀
神経化学 47 (1): 10-18, 2008.

オリゴデンドロサイトと運動ニューロンの発生を制御するOlig2遺伝子
竹林浩秀、池中一裕
細胞工学 22 (4): 406-411, 2003.