© April 2025 Division of Microscopic Anatomy, Graduate School of Medical and Dental Sciences, Niigata University
Microscopic Anatomy, Niigata University

国内特許


1. 特願2024-199014, 発明者:芝田 晋介, 川田治良, 新山瑛理, 寺西知子, 谷口司, 井樋田悟史, 共同出願人:新潟大学, 株式会社Jikisak Bioengineering, シャープ株式会社, 発明の名称:インビトロ疼痛モデル及びそれを用いる疼痛測定方法, 出願日 令和6年11月14日
2. 特願2020-181354, 発明者:芝田 晋介 (1/6), 川田治良, 特許出願人:学校法人慶應義塾, 株式会社Jiksak Bioengineering, 発明の名称:人工軸索束, 整理番号: KP-17895, 提出日:令和2年10月29日
3. 特願2018-248067, 発明者:芝田 晋介 (1/4), 後藤修一, 特許出願人: 学校法人慶應義塾, サンユー電子株式会社, 発明の名称: 電子顕微鏡用試料の作成システム、電子顕微鏡用試料の作成方法およびこれに用いられるプラズマ処理装置、スパッタ装置、テープ搬送機構, 整理番号: S180001, 提出日: 平成30年12月28日, 国際特許分類: G01N 1/28



国内特許


4. 国際特許出願番号: PCT/JP2021/039869, 発明者:芝田 晋介, 木村洋朗, 西島貴之, 信藤知子, 岡野栄之, 川田治良, 特許出願人: 学校法人慶應義塾, 株式会社Jiksak Bioengineering, 発明の名称: 人工軸索束, 提出日: 2021年10月28日, 整理番号: FP4719PCT/P10000003447
5. 国際特許出願番号: PCT/JP2019/051141, 発明者:芝田 晋介 (1/4), 後藤 修一, 権利者: 学校法人慶應義塾, サンユー電子株式会社, 発明の名称: 電子顕微鏡用試料の作成システム、電子顕微鏡用試料の作成方法およびこれに用いられるプラズマ処理装置、スパッタ装置、テープ搬送機構, 提出日: 2019年12月26日, 整理番号: P10000003070



原著論文


2025年


1. Hiraiwa T, Yoshii S, Kawada J, Sugawara T, Kawasaki T, Shibata S, Shindo T, Fujimori K, Umezawa A, Akutsu H. “A human iPSC-Derived myelination model for investigating fetal brain injuries.” Regen Ther. 2025 Mar 13;29:100-107. doi: 10.1016/j.reth.2025.02.014 PMID: 40162018
2. Ariyasu D, Higa D, Tokudome R, Yonemori T, Shimada H, Shibata S, Araki K. “Mice with Heterozygous Deletion of Exon 3 in the Gh Gene Demonstrate Growth Retardation Caused by Reduced Ghrhr mRNA.” Int J Mol Sci. 2025 Jan 26;26(3):1061. doi: 10.3390/ijms26031061. PMID: 39940828
3. Matsuo T, Kimura H, Nishijima T, Kiyota Y, Suzuki T, Nagoshi N, Shibata S, Shindo T, Moritoki N, Sasaki M, Noguchi S, Tamada Y, Nakamura M, Iwamoto T. “Peripheral nerve regeneration using a bioresorbable silk fibroin-based artificial nerve conduit fabricated via a novel freeze-thaw process.” Sci Rep. 2025 Jan 30;15(1):3797. doi: 10.1038/s41598-025-88221-y. PMID: 39885362
4. Tsujisaka R, Suzuki T, Shibata S, Iwamoto T, Taguchi T, Nakamura M.“Effect of Alaska pollock-gelatin sheet on repair strength and regeneration of nerve.” J Hand Surg Eur Vol. 2025 Jan;50(1):76-84. doi: 10.1177/17531934241251670. PMID: 38780096



2024年


5. Ito K, Shinozaki M, Hashimoto S, Saijo Y, Suematsu Y, Tanaka T, Nishi K, Yagi H, Shibata S, Kitagawa Y, Nakamura M, Okano H, Kohyama J, Nagoshi N, “Histological effects of combined therapy involving scar resection, decellularized scaffolds, and human iPSC-NS/PCs transplantation in chronic complete spinal cord injury” Sci Rep. 2024 Dec 28;14(1):31500. doi: 10.1038/s41598-024-82959-7. PMID: 39733145
6. Okada K, Ito D, Morimoto S, Kato C, Oguma Y, Warita H, Suzuki N, Aoki M, Kuramoto J, Kobayashi R, Shinozaki M, Ikawa M, Nakahara J, Takahashi S, Nishimoto Y, Shibata S, Okano H. “Multiple lines of evidence for disruption of nuclear lamina and nucleoporins in FUS amyotrophic lateral sclerosis.” Brain. 2024 Sep 23:awae224. doi: 10.1093/brain/awae224. PMID: 39312484
7. Yan C, Nakajima M, Ikeda-Imafuku M, Yanagawa M, Hayatsu M, Fukuta T, Shibata S, Mitragotri S, Tabeta K. “Choline and geranate ionic liquid for subgingival biofilm control.” Int J Pharm. 2024 Sep 5;662:124544. doi: 10.1016/j.ijpharm.2024.124544. PMID: 39094920
8. Miyaki T, Honma N, Kawasaki Y, Kishi M, Yamaguchi J, Kakuta S, Shindo T, Sugiura M, Trejo JAO, Kaneda H, Omotehara T, Takechi M, Negishi-Koga T, Ishijima M, Aoto K, Iseki S, Kitamura K, Muto S, Amagasa M, Hotchi S, Ogura K, Shibata S, Sakai T, Suzuki Y, Ichimura K. “Ultrastructural analysis of whole glomerulus using array tomography.” J Cell Sci. 2024 Aug 22:jcs.262154. doi: 10.1242/jcs.262154. PMID: 39171439
9. Kinashi Y, Tanaka K, Kimura S, Hirota M, Komiyama S, Shindo T, Hashiguchi A, Takahashi D, Shibata S, Karaki SI, Ohno H, Hase K. “Intestinal epithelium dysfunctions cause IgA deposition in the kidney glomeruli of intestine-specific Ap1m2-deficient mice.” EBioMedicine. 2024 Aug;106:105256. doi: 10.1016/j.ebiom.2024.105256. PMID: 39059316
10. Pinyomahakul J, Ise M, Kawamura M, Yamada T, Okuyama K, Shibata S, Takizawa J, Abe M, Sakimura K, Takebayashi H. “Analysis of Brain, Blood, and Testis Phenotypes Lacking the Vps13a Gene in C57BL/6N Mice.” Int J Mol Sci. 2024 Jul 16;25(14):7776. doi: 10.3390/ijms25147776. PMID: 39063018
11. Ginevskaia T, Innokentev A, Furukawa K, Fukuda T, Hayatsu M, Yamashita SI, Inoue K, Shibata S, Kanki T. “Comprehensive analysis of non-selective and selective autophagy in yeast atg mutants and characterization of autophagic activity in the absence of the Atg8 conjugation system.” J Biochem. 2024 Jun 6: mvae042. doi: 10.1093/jb/mvae042. PMID: 38843068
12. Furukawa K, Hayatsu M, Okuyama K, Fukuda T, Yamashita SI, Inoue K, Shibata S, Kanki T. “Atg44/Mdi1/mitofissin facilitates Dnm1-mediated mitochondrial fission.” Autophagy. 2024 Jun 4:1-9. doi: 10.1080/15548627.2024.2360345. PMID: 38818923
13. Leventoux N, Morimoto S, Ishikawa M, Nakamura S, Ozawa F, Kobayashi R, Watanabe H, Supakul S, Okamoto S, Zhou Z, Kobayashi H, Kato C, Hirokawa Y, Aiba I, Takahashi S, Shibata S, Takao M, Yoshida M, Endo F, Yamanaka K, Kokubo Y, Okano H. “Aberrant CHCHD2-associated mitochondriopathy in Kii ALS/PDC astrocytes” Acta Neuropathol. 2024 May 15;147(1):84. doi: 10.1007/s00401-024-02734-w. PMID: 38750212
14. Wada M, Higa T, Katoh K, Moritoki N, Nakai T, Nishino Y, Miyazawa A, Shibata S, Mineyuki Y. “Chloroplast-actin filaments decide the direction of chloroplast avoidance movement under strong light in Arabidopsis thaliana.” J Plant Res. 2024 Apr 10. doi: 10.1007/s10265-024-01540-5. PMID: 38598067
15. Arai J, Hayakawa Y, Tateno H, Murakami K, Hayashi T, Hata M, Matsushita Y, Kinoshita H, Abe S, Kurokawa K, Oya Y, Tsuboi M, Ihara S, Niikura R, Suzuki N, Iwata Y, Shiokawa T, Shiomi C, Uekura C, Yamamoto K, Fujiwara H, Kawamura S, Nakagawa H, Mizuno S, Kudo T, Takahashi S, Ushiku T, Hirata Y, Fujii C, Nakayama J, Shibata S, Woods S, Worthley DL, Hatakeyama M, Wang TC, Fujishiro M. “Impaired glycosylation of gastric mucins drives gastric tumorigenesis and serves as a novel therapeutic target.” Gastroenterology 2024 Apr 5:S0016-5085(24)00363-9. doi: 10.1053/j.gastro.2024.03.037.
16. Tashiro S, Shibata S, Nagoshi N, Zhang L, Yamada S, Tsuji T, Nakamura M, Okano H. “Do Pharmacological Treatments Act in Collaboration with Rehabilitation in Spinal Cord Injury Treatment? A Review of Preclinical Studies” Cells 2024 Feb 27;13(5):412. doi: 10.3390/cells13050412. PMID: 38474376
17. Supakul S, Murakami R, Oyama C, Shindo T, Hatakeyama Y, Itsuno M, Bannai H, Shibata S, Maeda S, Okano H. “Mutual interaction of neurons and astrocytes derived from iPSCs with APP V717L mutation developed the astrocytic phenotypes of Alzheimer's disease.” Inflamm Regen. 2024 Feb 28;44(1):8. doi: 10.1186/s41232-023-00310-5. PMID: 38419091
18. Saijo Y, Nagoshi N, Kawai M, Kitagawa T, Suematsu Y, Ozaki M, Shinozaki M, Kohyama J, Shibata S, Takeuchi K, Nakamura M, Yuzaki M, Okano H. “Human-induced pluripotent stem cell-derived neural stem/progenitor cell ex vivo gene therapy with synaptic organizer CPTX for spinal cord injury.” Stem Cell Rep. 2024 Mar 12;19(3):383-398. doi: 10.1016/j.stemcr.2024.01.007. PMID: 38366597
19. Nishijima T, Okuyama K, Shibata S*, Kimura H, Shinozaki M, Ouchi T, Mabuchi Y, Ohno T, Nakayama J, Hayatsu M, Uchiyama K, Shindo T, Niiyama E, Toita S, Kawada J, Iwamoto T, Nakamura M, Okano H, Nagoshi N*, “Novel artificial nerve transplantation of human iPSC-derived neurite bundles enhanced nerve regeneration after peripheral nerve injury.” Inflamm Regen. 2024 Feb 13;44(1):6. doi: 10.1186/s41232-024-00319-4. PMID: 38347645 (*co-corresponding author)
20. Yoshida T, Tashiro S, Nagoshi N, Shinozaki M, Shibata T, Inoue M, Ogawa S, Shibata S, Tsuji T, Okano H, Nakamura M. “Chronic Spinal Cord Injury Regeneration with Combined Therapy Comprising Neural Stem/Progenitor Cell Transplantation, Rehabilitation, and Semaphorin 3A Inhibitor.” eNeuro. 2024 Feb 13;11(2):ENEURO.0378-23.2024. doi: 10.1523/ENEURO.0378-23.2024. PMID: 38262737



2023年


21. Tsurisaki E, Nameta M, Shibata S, Hirayama S, Iwai J, Ohashi R, Otani M, Ito Y, Matsumura N, Moriguchi Y, "Cytological Analysis of Male-Sterile MS5 Japanese Cedar (Cryptomeria japonica D. Don) and Comparison with Other Male-Sterile Mutants" Journal of Plant Biology, 23 December 2023, Volume 67, pages 11–23, doi: 10.1007/s12374-023-09415-3
22. Sasaki M, Mitsuhashi T, Goto F, Shibata S, Kubo K, Oku S, Owashi A, Takahashi T. “Maternal immune activation by poly (I:C) exposure causes cerebral cortical dysgenesis through dysregulated cell cycle kinetics of neural stem/progenitor cells” Dev Neurosci. Jun 2023, 45 (3) , pp.115-125, doi: DOI10.1159/000529317
23. Suematsu Y, Nagoshi N, Shinozaki M, Kase Y, Saijo Y, Hashimoto S, Shibata T, Kajikawa K, Kamata Y, Ozaki M, Yasutake K, Shindo T, Shibata S, Matsumoto M, Nakamura M, Okano H. “Hepatocyte growth factor pretreatment boosts functional recovery after spinal cord injury through human iPSC-derived neural stem/progenitor cell transplantation.” Inflamm Regen. 2023 Oct 16;43(1):50. doi: 10.1186/s41232-023-00298-y. PMID: 37845736
24. Iga T, Kobayashi H, Kusumoto D, Sanosaka T, Fujita N, Tai-Nagara I, Ando T, Takahashi T, Matsuo K, Hozumi K, Ito K, Ema M, Miyamoto T, Matsumoto M, Nakamura M, Okano H, Shibata S, Kohyama J, Kim KK, Takubo K, Kubota Y. “Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis” Nat Cell Biol. 2023 Oct;25(10):1415-1425. doi: 10.1038/s41556-023-01240-7. PMID: 37798545
25. Pieczonka K, Nakashima H, Nagoshi N, Yokota K, Hong J, Badner A, Chio JCT, Shibata S, Khazaei M, Fehlings MG. “Human Spinal Oligodendrogenic Neural Progenitor Cells Enhance Pathophysiological Outcomes and Functional Recovery in a Clinically Relevant Cervical Spinal Cord Injury Rat Model.” Stem Cells Transl Med. 2023 Aug 24:szad044. doi: 10.1093/stcltm/szad044. PMID: 37616288
26. Umeda S, Sujino T, Miyamoto K, Yoshimatsu Y, Harada Y, Nishiyama K, Aoto Y, Adachi K, Hayashi N, Amafuji K, Moritoki N, Shibata S, Sasaki N, Mita M, Tanemoto S, Ono K, Mikami Y, Sasabe J, Takabayashi K, Hosoe N, Suzuki T, Sato T, Atarashi K, Teratani T, Ogata H, Nakamoto N, Shiomi D, Ashida H, Kanai T. “D-amino Acids Ameliorate Experimental Colitis and Cholangitis by Inhibiting Growth of Proteobacteria: Potential Therapeutic Role in Inflammatory Bowel Disease.” Cell Mol Gastroenterol Hepatol. 2023 Aug 9:S2352-345X(23)00148-0. doi: 10.1016/j.jcmgh.2023.08.002. PMID: 37567385
27. Kakui H, Ujino-Ihara T, Hasegawa Y, Tsurisaki E, Futamura N, Iwai J, Higuchi Y, Fujino T, Suzuki Y, Kasahara M, Yamaguchi K, Shigenobu S, Otani M, Nakano M, Nameta M, Shibata S, Ueno S, Moriguchi Y. “A single-nucleotide substitution of CjTKPR1 determines pollen production in the gymnosperm plant Cryptomeria japonica.” PNAS Nexus. 2023 Aug 8;2(8): pgad236. doi: 10.1093/pnasnexus/pgad236. eCollection 2023 Aug. PMID: 37559748
28. Takeya H, Itai S, Kimura H, Kurashina Y, Amemiya T, Nagoshi N, Iwamoto T, Sato K, Shibata S, Matsumoto M, Onoe H, Nakamura M. “Schwann cell-encapsulated chitosan-collagen hydrogel nerve conduit promotes peripheral nerve regeneration in rodent sciatic nerve defect models.” Sci Rep. 2023 Jul 24;13(1):11932. doi: 10.1038/s41598-023-39141-2. PMID: 37488180
29. Ansai O, Hayashi R, Katsumi T, Okuyama K, Shibata S, Shinkuma S, Ito M, Abe R. “Atypical epidermolytic palmoplantar keratoderma is a minimal phenotypic variant of epidermolytic ichthyosis: A new insight from ultrastructural findings.” J Eur Acad Dermatol Venereol. 2023 Jul 17. doi: 10.1111/jdv.19357. Online ahead of print. PMID: 37460199
30. Tani H, Kobayashi E, Yagi S, Tanaka K, Kameda-Haga K, Shibata S, Moritoki N, Takatsuna K, Moriwaki T, Sekine O, Umei TC, Morita Y, Soma Y, Kishino Y, Kanazawa H, Fujita J, Hattori S, Fukuda K, Tohyama S. “Heart-derived collagen promotes maturation of engineered heart tissue.” Biomaterials. 2023 Aug;299:122174. doi: 10.1016/j.biomaterials.2023.122174. PMID: 37285642
31. Fukuda T, Furukawa K, Maruyama T, Yamashita SI, Noshiro D, Song C, Ogasawara Y, Okuyama K, Alam JM, Hayatsu M, Saigusa T, Inoue K, Ikeda K, Takai A, Chen L, Lahiri V, Okada Y, Shibata S, Murata K, Klionsky DJ, Noda NN, Kanki T. “The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy.” Mol Cell. 2023 Jun 15;83(12):2045-2058.e9. doi: 10.1016/j.molcel.2023.04.022. PMID: 37192628
32. Hashimoto S, Nagoshi N, Shinozaki M, Nakanishi K, Suematsu Y, Shibata T, Kawai M, Kitagawa T, Ago K, Kamata Y, Yasutake K, Koya I, Ando Y, Minoda A, Shindo T, Shibata S, Matsumoto M, Nakamura M, Okano H. “Microenvironmental modulation in tandem with human stem cell transplantation enhances functional recovery after chronic complete spinal cord injury.” Biomaterials. 2023 Apr ;295:122002. doi: 10.1016/j.biomaterials.2023.122002. PMID: 36736008
33. Mitsuhashi T, Hattori S, Fujimura K, Shibata S, Miyakawa T, Takahashi T. “In utero exposure to valproic acid throughout pregnancy causes phenotypes of autism in offspring mice.” Dev Neurosci. 2023;45(5):223-233. doi: 10.1159/000530452. PMID: 37044070
34. Natsui K, Tsuchiya A, Imamiya R, Osada-Oka M, Ishii Y, Koseki Y, Takeda N, Tomiyoshi K, Yamazaki F, Yoshida Y, Ohashi R, Ling Y, Ueda K, Moritoki N, Sato K, Nakajima T, Hasegawa Y, Okuda S, Shibata S, Terai S. “Escherichia coli-derived outer-membrane vesicles induce immune activation and progression of cirrhosis in mice and humans.” Liver Int. 2023 Feb 8. doi: 10.1111/liv.15539. PMID: 36751961
35. Shibata T, Tashiro S, Shibata S, Shinozaki M, Shindo T, Hashimoto S, Kawai M, Kitagawa T, Ago K, Matsumoto M, Nakamura M, Okano H, Nagoshi N. “Rehabilitative Training Enhances Therapeutic Effect of Human-iPSC-Derived Neural Stem/Progenitor Cells Transplantation in Chronic Spinal Cord Injury.” Stem Cells Transl Med. 2023 Mar 3;12(2):83-96. doi: 10.1093/stcltm/szac089. PMID: 36647673



2022年


36. Namiki J, Suzuki S, Shibata S, Kubota Y, Kaneko N, Yoshida K, Yamaguchi R, Matsuzaki Y, Masuda T, Ishihama Y, Sawamoto K, Okano H. “Chitinase-like protein 3: A novel niche factor for mouse neural stem cells.” Stem Cell Rep. 2022 Dec 13;17(12):2704-2717. doi: 10.1016/j.stemcr.2022.10.012. PMID: 36368330
37. Shimada H, Sato Y, Sasaki T, Shimozawa A, Imaizumi K, Shindo T, Miyao S, Kiyama K, Kondo T, Shibata S, Ishii S, Kuromitsu J, Aoyagi H, Ito D, Okano H. “A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer.” Cell Reports Methods. 2022 Sep 8;2(9):100289. doi: 10.1016/j.crmeth.2022.100289. eCollection 2022 Sep 19. PMID: 36160042
38. Ago K, Nagoshi N, Imaizumi K, Kitagawa T, Kawai M, Kajikawa K, Shibata R, Kamata Y, Kojima K, Shinozaki M, Kondo T, Iwano S, Miyawaki A, Ohtsuka M, Bito H, Kobayashi K, Shibata S, Shindo T, Kohyama J, Matsumoto M, Nakamura M, Okano H. “A non-invasive system to monitor in vivo neural graft activity after spinal cord injury.” Commun Biol. 2022 Aug 10;5(1):803. doi: 10.1038/s42003-022-03736-8. PMID: 35948599
39. Yoshioka N, Kurose M, Yano M, Tran DM, Okuda S, Mori-Ochiai Y, Horie M, Nagai T, Nishino I, Shibata S, Takebayashi H. “Isoform-specific mutation in Dystonin-b gene causes late-onset protein aggregate myopathy and cardiomyopathy.” Elife. 2022 Aug 9;11:e78419. doi: 10.7554/eLife.78419. PMID: 35942699
40. Kanzaki S, Shibata S, Nakamura M, Ozaki M, Okano H. “In Vivo Imaging Analysis of an Inner Ear Drug Delivery in Mice: Comparison of Inner Ear Drug Concentrations Over Time.” Methods Mol Biol. 2022 2524:327-332. doi: 10.1007/978-1-0716-2453-1_26. PMID: 35821484
41. Tsuruta S, Kawasaki T, Machida M, Iwatsuki K, Inaba A, Shibata S, Shindo T, Nakabayashi K, Hakamada K, Umezawa A, Akutsu H. “Development of Organoids With Resident Tissue Macrophages as a Model of Intestinal Immune Responses.” Cell Mol Gastroenterol Hepatol. 2022 Jun 26:S2352-345X(22)00149-7. doi: 10.1016/j.jcmgh.2022.06.006. PMID: 35760286
42. Saeki T, Yoshimatsu S, Ishikawa M, Hon CC, Koya I, Shibata S, Hosoya M, Saegusa C, Ogawa K, Shin JW, Fujioka M, Okano H. “Critical roles of FGF, RA, and WNT signalling in the development of the human otic placode and subsequent lineages in a dish.” Regen Ther. 2022 May 16;20:165-186. doi: 10.1016/j.reth.2022.04.008. eCollection 2022 Jun. PMID: 35620640
43. Yanagisawa T, Ouchi T, Shibata S, Negishi T, Okano H. “Glycosaminoglycans promote osteogenesis from human induced pluripotent stem cells via neural crest induction.” Biochem Biophys Res Commun. 2022 Mar 3;603:49-56. doi: 10.1016/j.bbrc.2022.03.002. PMID: 35278879
44. Shibata R, Nagoshi N, Kajikawa K, Ito S, Shibata S, Shindo T, Khazaei M, Nori S, Kohyama J, Fehlings MG, Matsumoto M, Nakamura M, Okano H. “Administration of C5a receptor antagonist improves the efficacy of human iPSCs-derived NS/PC transplantation in the acute phase of spinal cord injury.” J Neurotrauma. 2022 Feb 24. doi: 10.1089/neu.2021.0225. PMID: 35196890
45. Haraguchi T, Koujin T, Shindo T, Bilir Ş, Osakada H, Nishimura K, Hirano Y, Asakawa H, Mori C, Kobayashi S, Okada Y, Chikashige Y, Fukagawa T, Shibata S, Hiraoka Y. “Transfected plasmid DNA is incorporated into the nucleus via nuclear envelope reformation at telophase.” Commun Biol. 2022 Jan 20;5(1):78. doi: 10.1038/s42003-022-03021-8. PMID: 35058555
46. Kitagawa T, Nagoshi N, Kamata Y, Kawai M, Ago K, Kajikawa K, Shibata R, Sato Y, Imaizumi K, Shindo T, Shinozaki M, Kohyama J, Shibata S, Matsumoto M, Nakamura M, Okano H. “Modulation by DREADD reveals the therapeutic effect of human iPSC-derived neuronal activity on functional recovery after spinal cord injury.” Stem Cell Rep 2022 Jan 11;17(1):127-142. doi: 10.1016/j.stemcr.2021.12.005. PMID: 35021049



2021年


47. Sato Y, Atarashi K, Plichta DR, Arai Y, Sasajima S, Kearney SM, Suda W, Takeshita K, Sasaki T, Okamoto S, Skelly AN, Okamura Y, Vlamakis H, Li Y, Tanoue T, Takei H, Nittono H, Narushima S, Irie J, Itoh H, Moriya K, Sugiura Y, Suematsu M, Moritoki N, Shibata S, Littman DR, Fischbach MA, Uwamino Y, Inoue T, Honda A, Hattori M, Murai T, Xavier RJ, Hirose N, Honda K “Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians” Nature. 2021 Nov;599(7885):458-464. doi: 10.1038/s41586-021-03832-5. PMID: 34325466
48. Kawai M, Imaizumi K, Ishikawa M, Shibata S, Shinozaki M, Shibata T, Hashimoto S, Kitagawa T, Ago K, Kajikawa K, Shibata R, Kamata Y, Ushiba J, Koga K, Furue H, Matsumoto M, Nakamura M, Nagoshi N, Okano H. “Long-term selective stimulation of transplanted neural stem/progenitor cells for spinal cord injury improves locomotor function” Cell Rep 2021 Nov 23;37(8):110019. doi: 10.1016/j.celrep.2021.110019. PMID: 34818559
49. Masuda S, Suzuki T, Shibata S, Moritoki N, Abe Y, Chen X, Mizuno Y, Nishiguchi A, Kimura H, Matsumura N, Iwamoto T, Taguchi T, Matsumoto M, Nakamura M. “A Novel Alaska Pollock Gelatin Sealant Shows Higher Bonding Strength and Nerve Regeneration Comparable to That of Fibrin Sealant in a Cadaveric Model and a Rat Model” Plast Reconstr Surg. 2021 Nov 1;148(5):742e-752e. doi: 10.1097/PRS.0000000000008489. PMID: 34705777
50. Yang F, Hayashi I, Sato S, Saijo-Ban Y, Yamane M, Fukui M, Shimizu E, He J, Shibata S, Mukai S, Asai K, Ogawa M, Lan Y, Zeng Q, Hirakata A, Tsubota K, Ogawa Y. “Eyelid blood vessel and meibomian gland changes in a sclerodermatous chronic GVHD mouse model” Ocul Surf. 2021 Oct 26:S1542-0124(21)00123-3. doi: 10.1016/j.jtos.2021.10.006. Online ahead of print. PMID: 34715372
51. Sharp MM, Cassidy J, Thornton T, Lyles J, Keable A, Gatherer M, Yasui M, Abe Y, Shibata S, Weller RO, Górecki DC, Carare RO. “The α-dystrobrevins play a key role in maintaining the structure and function of the extracellular matrix-significance for protein elimination failure arteriopathies.” Acta Neuropathol Commun. 2021 Oct 21;9(1):171. doi: 10.1186/s40478-021-01274-8. PMID: 34674769
52. Li Y, Kanzaki S, Shibata S, Nakamura M, Ozaki M, Okano H, Ogawa K “Comparison of Drug Availability in the Inner Ear After Oral, Transtympanic, and Combined Administration” Front Neurol. 2021 Aug 19;12:641593. doi: 10.3389/fneur.2021.641593. eCollection 2021. PMID: 34497573
53. Simankova A, Bizen N, Saitoh S, Shibata S, Ohno N, Abe M, Sakimura K, Takebayashi H “Ddx20, DEAD box helicase 20, is essential for the differentiation of oligodendrocyte and maintenance of myelin gene expression” Glia. 2021 Jul 7. doi: 10.1002/glia.24058. PMID: 34231259
54. Kamata Y, Isoda M, Sanosaka T, Shibata R, Ito S, Okubo T, Shinozaki M, Inoue M, Koya I, Shibata S, Shindo T, Matsumoto M, Nakamura M, Okano H, Nagoshi N, Kohyama J “A robust culture system to generate neural progenitors with gliogenic competence from clinically relevant induced pluripotent stem cells for treatment of spinal cord injury” Stem Cells Transl Med. 2021 Mar;10(3):398-413. doi: 10.1002/sctm.20-0269. PMID: 33226180
55. Suzuki M, Saito-Adachi M, Arai Y, Fujiwara Y, Takai E, Shibata S, Seki M, Rokutan H, Maeda D, Horie M, Suzuki Y, Shibata T, Kiyono T, Yachida S “E74-like factor 3 is a key regulator of epithelial integrity and immune response genes in biliary tract cancer” Cancer Res. Cancer Res. 2021 Jan 15;81(2):489-500. doi: 10.1158/0008-5472.CAN-19-2988. PMID: 33293429



2020年


56. Nagai N, Kawashima H, Toda E, Homma K, Osada H, Guzman NA, Shibata S, Uchiyama Y, Okano H, Tsubota K, Ozawa Y. “Renin-angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models.” Commun Biol. 2020 Dec 9;3(1):767. doi: 10.1038/s42003-020-01483-2. PMID: 33299105
57. Suzuki T, Adachi S, Kikuguchi C, Shibata S, Nishijima S, Kawamoto Y, Iizuka Y, Koseki H, Okano H, Natsume T, Yamamoto T. “Regulation of Fetal Genes by Transitions among RNA-Binding Proteins during Liver Development.” Int J Mol Sci. 2020 Dec 7;21(23):9319. doi: 10.3390/ijms21239319. PMID: 33297405
58. Kajikawa K, Imaizumi K, Shinozaki M, Shibata S, Shindo T, Kitagawa T, Shibata R, Kamata Y, Kojima K, Nagoshi N, Matsumoto M, Nakamura M, Okano H. “Cell therapy for spinal cord injury by using human iPSC-derived region-specific neural progenitor cells.” Mol Brain. 2020 Sep 3;13(1):120. doi: 10.1186/s13041-020-00662-w. PMID: 32883317
59. Teratani T, Mikami Y, Nakamoto N, Suzuki T, Harada Y, Okabayashi K, Hagihara Y, Taniki N, Kohno K, Shibata S, Miyamoto K, Ishigame H, Chu PS, Sujino T, Suda W, Hattori M, Matsui M, Okada T, Okano H, Inoue M, Yada T, Kitagawa Y, Yoshimura A, Tanida M, Tsuda M, Iwasaki Y, Kanai T. “The liver-brain-gut neural arc maintains the Treg cell niche in the gut.” Nature. 2020 Sep;585(7826):591-596. doi: 10.1038/s41586-020-2425-3. PMID: 32526765
60. Ishiwa S, Kamei K, Tanase-Nakao K, Shibata S, Matsunami K, Takeuchi I, Sato M, Ishikura K, Narumi S. “A girl with MIRAGE syndrome who developed steroid-resistant nephrotic syndrome: a case report.” BMC Nephrol. 2020 Aug 12;21(1):340. doi: 10.1186/s12882-020-02011-4. PMID: 32787808
61. Takahashi M, Misaki M, Shibata S, Iga T, Shindo T, Tai-Nagara I, Hirata A, Ogawa M, Miyamoto T, Nakagawa T, Ema M, Ichiyama Y, Shima DT, Hozumi K, Nishimura S, Kubota Y. “Macrophages fine-tune pupil shape during development.” Dev Biol. 2020 Aug 15;464(2):137-144. doi: 10.1016/j.ydbio.2020.06.004. PMID: 32565279
62. Okazaki I*, Shibata S*, Ando W, Yanagawa T, Yokomori H, Sonoda A, Suzuki N, Yamanouchi E, Okada S, Kamikura S, Hachimura K, Takaki T, Otori K, Suzuki Y, Okano H, Inagaki Y. (*equally contributed first author) “Sequential Matrix Metalloproteinase-1 Expression Triggered by Infiltrating Monocytic Lineage Cells Modulates Pathophysiological Aspects of Human Nonalcoholic Steatohepatitis” Metalloproteinases Med. 2020 Jul 21; Volume 2020:7 Pages 1-13, doi: 10.2147/MNM.S252991
63. Yamane M, Sato S, Shimizu E, Shibata S, Hayano M, Yaguchi T, Kamijuku H, Ogawa M, Suzuki T, Mukai S, Shimmura S, Okano H, Takeuchi T, Kawakami Y, Ogawa Y, Tsubota K. “Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans” FASEB J. 2020 Aug;34(8):10778-10800. doi: 10.1096/fj.201900218R. PMID: 32619061
64. Hirano Y, Kinugasa Y, Osakada H, Shindo T, Kubota Y, Shibata S, Haraguchi T, Hiraoka Y. “Lem2 and Lnp1 maintain the membrane boundary between the nuclear envelope and endoplasmic reticulum.” Commun Biol. 2020 Jun 1;3(1):276. doi: 10.1038/s42003-020-0999-9. PMID: 32483293
65. Yamaguchi T, Higa K, Yagi-Yaguchi Y, Ueda K, Noma H, Shibata S, Nagai T, Tomida D, Yasu-Mimura R, Ibrahim O, Matoba R, Tsubota K, Hamrah P, Yamada J, Kanekura K, Shimazaki J. “Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice.” Science Advances. 2020 May 13;6(20):eaaz5195. doi: 10.1126/sciadv.aaz5195. eCollection 2020 May. PMID: 32426498
66. Tanaka H, Homma H, Fujita K, Kondo K, Yamada S, Jin X, Waragai M, Ohtomo G, Iwata A, Tagawa K, Atsuta N, Katsuno M, Tomita N, Furukawa K, Saito Y, Saito T, Ichise A, Shibata S, Arai H, Saido T, Sudol M, Muramatsu SI, Okano H, Mufson EJ, Sobue G, Murayama S, Okazawa H. “YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology.” Nat Commun. 2020 Jan 24;11(1):507. doi: 10.1038/s41467-020-14353-6. PMID: 31980612
67. Khazaei M, Ahuja CS, Nakashima H, Nagoshi N, Li L, Wang J, Chio J, Badner A, Seligman D, Ichise A, Shibata S, Fehlings MG “GDNF rescues the fate of neural progenitor grafts by attenuating Notch signals in the injured spinal cord in rodents.” Sci Transl Med. 2020 Jan 8;12(525). pii: eaau3538. doi: 10.1126/scitranslmed.aau3538. PMID: 31915299
68. Saeki T, Hosoya M, Shibata S, Okano H, Fujioka M, Ogawa K. “Distribution of tight junctions in the primate cochlear lateral wall.” Neurosci Lett. 2020 Jan 19;717:134686. doi: 10.1016/j.neulet.2019.134686. PMID: 31838016



2019年


69. Mohan S, Coto Hernández I, Selig MK, Shibata S, Jowett N. “Stain-Free Resolution of Unmyelinated Axons in Transgenic Mice Using Fluorescence Microscopy.” J Neuropathol Exp Neurol. 2019 Dec 1;78(12):1178-1180. doi: 10.1093/jnen/nlz099. PMID: 31642916
70. Serizawa T, Isotani A, Matsumura T, Nakanishi K, Nonaka S, Shibata S, Ikawa M, Okano H. “Developmental analyses of mouse embryos and adults using a non-overlapping tracing system for all three germ layers.” Development. 2019 Nov 4;146(21). pii: dev174938. doi: 10.1242/dev.174938. PMID: 31597657
71. Ariyasu D, Kubo E, Higa D, Shibata S, Takaoka Y, Sugimoto M, Imaizumi K, Hasegawa T, Araki K. “Decreased Activity of the Ghrhr and Gh Promoters Causes Dominantly Inherited GH Deficiency in Humanized GH1 Mouse Models.” Endocrinology. 2019 Nov 1;160(11):2673-2691. doi: 10.1210/en.2019-00306. PMID: 31436800
72. Hoshino Y, Nishide K, Nagoshi N, Shibata S, Moritoki N, Kojima K, Tsuji O, Matsumoto M, Kohyama J, Nakamura M, Okano H. “The adeno-associated virus rh10 vector is an effective gene transfer system for chronic spinal cord injury.” Scientific Reports. 2019 Jul 8;9(1):9844. doi: 10.1038/s41598-019-46069-z. PMID: 31285460
73. Li Y, Kanzaki S, Shibata S, Nakamura M, Ozaki M, Okano H, Ogawa K. “Comparison of inner ear drug availbability of combined treatment with systemic or local drug injections alone.” Neurosci Res. 2019 Jul 3. pii: S0168-0102(19)30250-0. doi: 10.1016/j.neures.2019.07.001. PMID: 31278973
74. Shibata S*, Iseda T, Mitsuhashi T, Oka A, Shindo T, Moritoki N, Nagai T, Otsubo S, Inoue T, Sasaki E, Akazawa C, Takahashi T, Schalek R, Lichtman JW, Okano H*, “Large-area fluorescence and electron microscopic correlative imaging with multibeam scanning electron microscopy” Front Neural Circuits, 2019 May 8;13:29. doi: 10.3389/fncir.2019.00029. eCollection 2019. PMID: 31133819 (*co-corresponding author)
75. Kirihara T, Luo Z, Chow SY, Misawa R, Kawada J, Shibata S, Khoyratee F, Vollette CA, Levi T, Fujii T, Ikeuchi Y “A human induced pluripotent stem cell-derived tissue model of a white matter tract connecting two cerebral regions” iScience 2019 Apr 26;14:301-311. doi: 10.1016/j.isci.2019.03.012. PMID: 31006610
76. Yamazaki Y, Abe Y, Shibata S, Shindo T, Fujii S, Ikenaka K, Tanaka KF. “Region- and cell type-specific facilitation of synaptic function at destination synapses induced by oligodendrocyte depolarization.” J Neurosci. 2019 May 22;39(21):4036-4050. doi: 10.1523/JNEUROSCI.1619-18.2019. PMID: 30862665
77. Kinugasa Y, Hirano Y, Sawai M, Ohno Y, Shindo T, Asakawa H, Chikashige Y, Shibata S, Kihara A, Haraguchi T, Hiraoka Y. “Very-long-chain fatty acid elongase Elo2 rescues lethal defects associated with loss of the nuclear barrier function” J Cell Sci. 2019 May 15;132(10). pii: jcs229021. doi: 10.1242/jcs.229021. PMID: 30975915
78. Abe Y, Komaki Y, Seki F, Shibata S, Okano H, Tanaka KF. “Correlative study using structural MRI and super-resolution microscopy to detect structural alterations induced by long-term optogenetic stimulation of striatal medium spiny neurons.” Neurochem Int. 2019 May;125:163-174. doi: 10.1016/j.neuint.2019.02.017. PMID: 30825601
79. Miki F, Maruyama T, Miyazaki K, Takao T, Yoshimasa Y, Katakura S, Hihara H, Uchida S, Masuda H, Uchida H, Nagai T, Shibata S, Tanaka M., “The orientation of a decellularized uterine scaffold determines the tissue topology and architecture of the regenerated uterus in rats” Biol Reprod. 2019 May 1;100(5):1215-1227. doi: 10.1093/biolre/ioz004. PMID: 30649202
80. Suzuki N, Yamaguchi T, Shibata S, Nagai T, Noma H, Tsubota K, Shimazaki J. “Cytokine Levels in the Aqueous Humor Are Associated With Corneal Thickness in Eyes With Bullous Keratopathy.” Am J Ophthalmol. 2019 Feb;198:174-180. doi: 10.1016/j.ajo.2018.10.008. PMID: 30316668



2018年


81. Ito S, Nagoshi N, Tsuji O, Shibata S, Shinozaki M, Kawabata S, Kojima K, Yasutake K, Hirokawa T, Matsumoto M, Takei K, Nakamura M, and Okano H. "LOTUS inhibits neuronal apoptosis and promotes tract regeneration in contusive spinal cord injury model mice" eNeuro. 2018 Dec 14;5(5). pii: ENEURO.0303-18.2018. doi: 10.1523/ENEURO.0303-18.2018. eCollection 2018 Sep-Oct. PMID: 30560203
82. Okubo T, Nagoshi N, Kohyama J, Tsuji O, Shinozaki M, Shibata S, Kase Y, Matsumoto M, Nakamura M, Okano H. “Treatment with a Gamma-Secretase Inhibitor Promotes Functional Recovery in Human iPSC- Derived Transplants for Chronic Spinal Cord Injury.” Stem Cell Reports. 2018 Dec 11;11(6):1416-1432. doi: 10.1016/j.stemcr.2018.10.022. PMID: 30503258
83. Nori S, Khazaei M, Ahuja CS, Yokota K, Ahlfors JE, Liu Y, Wang J, Shibata S, Chio J, Hettiaratchi MH, Führmann T, Shoichet MS, Fehlings MG, “Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury.” Stem Cell Reports. 2018 Dec 11;11(6):1433-1448. doi: 10.1016/j.stemcr.2018.10.017. PMID: 30472009
84. Kojima K, Miyoshi H, Nagoshi N, Kohyama J, Itakura G, Kawabata S, Ozaki M, Iida T, Sugai K, Ito S, Fukuzawa R, Yasutake K, Renault-Mihara F, Shibata S, Matsumoto M, Nakamura M, Okano H. “Selective Ablation of Tumorigenic Cells Following Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation in Spinal Cord Injury.” Stem Cells Transl Med. 2018 Nov 28. doi: 10.1002/sctm.18-0096. PMID: 30485733
85. Matsuo K, Ji S, Miya A, Yoda M, Hamada Y, Tanaka T, Takao-Kawabata R, Kawaai K, Kuroda Y, Shibata S, “Innervation of the tibial epiphysis through the intercondylar foramen.” Bone. 2018 Nov 13;120:297-304. doi: 10.1016/j.bone.2018.11.007. PMID: 30439572
86. Sakai T, Hata J, Ohta H, Shintaku Y, Kimura N, Ogawa Y, Sogabe K, Mori S, Okano HJ, Hamada Y, Shibata S, Okano H, Oishi K, “The Japan Monkey Centre Primates Brain Imaging Repository for comparative neuroscience: an archive of digital records including records for endangered species.” Primates. 2018 Nov;59(6):553-570. doi: 10.1007/s10329-018-0694-3. PMID: 30357587
87. Nagoshi N, Khazaei M, Ahlfors JE, Ahuja CS, Nori S, Wang J, Shibata S, Fehlings MG. "Human spinal oligodendrogenic neural progenitor cells promote functional recovery after spinal cord injury by axonal remyelination and tissue sparing" Stem Cells Transl Med. 2018 Nov;7(11):806-818. doi: 10.1002/sctm.17-0269. PMID: 30085415
88. Kimura H*, Ouchi T*, Shibata S*, Amemiya T, Nagoshi N, Nakagawa T, Matsumoto M, Okano H, Nakamura M, Sato K. “Stem cells purified from human induced pluripotent stem cell-derived neural crest-like cells promote peripheral nerve regeneration.” Scientific Reports. 2018 Jul 3;8(1):10071. doi: 10.1038/s41598-018-27952-7. PMID: 29968745 (*equally contributed first author)
89. Ouchi T, Morikawa S, Shibata S, Takahashi M, Yoshikawa M, Soma T, Miyashita H, Muraoka W, Kameyama K, Kawana H, Arima Y, Saya H, Okano H, Nakagawa T, Asoda S. “Recurrent Spindle Cell Carcinoma Shows Features of Mesenchymal Stem Cells.” J Dent Res. 2018 Jul;97(7):779-786. doi: 10.1177/0022034518759278. PMID: 29494307
90. He J, Yamane M, Shibata S, Fukui M, Shimizu E, Yano T, Mukai S, Kawakami Y, Li S, Tsubota K, Ogawa Y. “Ocular Surface and Tear Film Characteristics in a Sclerodermatous Chronic Graft-Versus-Host Disease Mouse Model.”, Cornea. 2018 Apr;37(4):486-494. doi: 10.1097/ICO.0000000000001487. PMID: 29341972



2017年


91. Fukuhara S, Masaoka T, Nishimura S, Nakamura M, Matsuzaki J, Tsugawa H, Miyoshi S, Mori H, Kawase S, Shibata S, Okano H, Kanai T, Suzuki H. “Enteric Glial Dysfunction Evoked by Apolipoprotein E Deficiency Contributes to Delayed Gastric Emptying”, Dig Dis Sci. 2017 Dec;62(12):3359-3369. doi: 10.1007/s10620-017-4820-7. Epub 2017 Nov 2. PMID: 29098550
92. Mori T, Sukeda A, Sekine S, Shibata S, Ryo E, Okano H, Suzuki S, and Hiraoka N. “SOX10 expression as well as BRAF and GNAQ/11 mutations distinguish pigmented ciliary epithelium neoplasms from uveal melanomas”, Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5445-5451. doi: 10.1167/iovs.17-22362. PMID: 29059311
93. Suzuki H, Ahuja CS, Salewski RP, Li L, Satkunendrarajah K, Nagoshi N, Shibata S, Fehlings MG. “Neural stem cell mediated recovery is enhanced by Chondroitinase ABC pretreatment in chronic cervical spinal cord injury.”, PLoS One. 2017 Aug 3;12(8):e0182339. doi: 10.1371/journal.pone.0182339. eCollection 2017. PMID: 28771534
94. Kodo K, Shibata S, Miyagawa-Tomita S, Ong SG, Takahashi H, Kume T, Okano H, Matsuoka R, Yamagishi H. “Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development.” Scientific Reports, 2017 Jul 28;7(1):6771. doi: 10.1038/s41598-017-06964-9. PMID: 28754980
95. Morizawa YM, Hirayama Y, Ohno N, Shibata S, Shigetomi E, Sui Y, Nabekura J, Sato K, Okajima F, Takebayashi H, Okano H, Koizumi S. “Reactive astrocytes function as a phagocyte after brain ischemia via ABCA1-mediated pathway.” Nat Commun. 2017 Jun 22;8(1):28. doi: 10.1038/s41467-017-00037-1. PMID: 28642575
96. Takano M, Kawabata S, Shibata S, Yasuda A, Nori S, Tsuji O, Nagoshi N, Iwanami A, Ebise H, Horiuchi K, Okano H, Nakamura M. “Enhanced Functional Recovery from Spinal Cord Injury in Aged Mice after Stem Cell Transplantation through HGF Induction.” Stem Cell Reports. 2017 Mar 14;8(3):509-518. doi: 10.1016/j.stemcr.2017.01.013. Epub 2017 Feb 16. PMID: 28216143
97. Inagaki E, Hatou S, Higa K, Yoshida S, Shibata S, Okano H, Tsubota K, Shimmura S. “Skin-Derived Precursors as a Source of Progenitors for Corneal Endothelial Regeneration.” Stem Cells Transl Med. 2017 Mar;6(3):788-798. doi: 10.1002/sctm.16-0162. PMID: 28186681
98. Takayama Y, Wakabayashi T, Kushige H, Saito Y, Shibuya Y, Shibata S, Akamatsu W, Okano H, Kida YS. “Brief exposure to small molecules allows induction of mouse embryonic fibroblasts into neural crest-like precursors.” FEBS Lett. 2017 Feb;591(4):590-602. doi: 10.1002/1873-3468.12572. Epub 2017 Feb 9. PMID: 28129669



2016年


99. Shinozaki M, Iwanami A, Fujiyoshi K, Tashiro S, Kitamura K, Shibata S, Fujita H, Nakamura M, Okano H. “Combined treatment with chondroitinase ABC and treadmill rehabilitation for chronic severe spinal cord injury in adult rats.” Neurosci Res. 2016 Dec;113:37-47. doi: 10.1016/j.neures.2016.07.005. PMID: 27497528
100. Ouchi T, Morikawa S, Shibata S, Fukuda K, Okuno H, Fujimura T, Kuroda T, Ohyama M, Akamatsu W, Nakagawa T Okano H. “LNGFR+THY-1+ Human Pluripotent Stem Cell-derived Neural Crest-Like Cells Have the Potential to Develop Into Mesenchymal Stem Cells.” Differentiation. 2016 Dec;92(5):270-280. doi: 10.1016/j.diff.2016.04.003. Epub 2016 May 10. PMID: 27178356
101. Komaki Y, Hikishima K, Shibata S, Konomi T, Seki F, Yamada M, Miyasaka N, Fujiyoshi K, Okano HJ, Nakamura M, *Okano H. “Functional brain mapping using specific sensory-circuit stimulation and a theoretical graph network analysis in mice with neuropathic allodynia.” Scientific Reports, 2016 Nov 29;6:37802. doi: 10.1038/srep37802. PMID: 27898057
102. Futatsugi K, Tokuyama H, Shibata S, Naitoh M, Kanda T, Minakuchi H, Yamaguchi S, Hayashi K, Minamishima YA, Yanagita M, Wakino S, *Itoh H. “Obesity-induced kidney injury is attenuated by amelioration of aberrant PHD2 activation in proximal tubules.” Scientific Reports, 2016 Nov 9;6:36533. doi: 10.1038/srep36533. PMID: 27827416
103. Fujimura K, Mitsuhashi T, Shibata S, Shimozato S, *Takahashi T. “In utero exposure to valproic acid induces neocortical dysgenesis via dysregulation of neural progenitor cell proliferation/differentiation.” J Neurosci.. 2016 Oct 19;36(42):10908-10919. doi: 10.1523/JNEUROSCI.0229-16.2016. PMID: 27798144
104. Narumi S, Amano N, Ishii T, Katsumata N, Muroya K, Adachi M, Toyoshima K, Tanaka Y, Fukuzawa R, Miyako K, Kinjo S, Ohga S, Ihara K, Inoue H, Kinjo T, Hara T, Kohno M, Yamada S, Urano H, Kitagawa Y, Tsugawa K, Higa A, Miyawaki M, Okutani T, Kizaki Z, Hamada H, Kihara M, Shiga K, Yamaguchi T, Kenmochi M, Kitajima H, Fukami M, Shimizu A, Kudoh J, Shibata S, Okano H, Miyake N, Matsumoto N, Hasegawa T. “Syndromic Adrenal Hypoplasia Caused by Activating SAMD9 Mutations” Nature Genetics 2016 Jul;48(7):792-797. doi: 10.1038/ng.3569. Epub 2016 May 16. PMID: 27182967
105. Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp JL, Kritzik M, Sicklick JK, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek MA, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T. “Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.” Nature. 2016 Jun 6;534(7607):407-411. doi: 10.1038/nature17988. PMID: 27281208
106. Inagaki Y, Fujioka M, Kanzaki S, Watanabe K, Oishi N, Itakura G, Yasuda A, Shibata S, Nakamura M, Okano HJ, Okano H, Ogawa K. “Sustained Effect of Hyaluronic Acid in Subcutaneous Administration to the Cochlear Spiral Ganglion.” PLoS One. 2016 Apr 21;11(4):e0153957. doi: 10.1371/journal.pone.0153957. eCollection 2016. PMID: 27099926
107. Fujimura T*, Shibata S*, Shimojima N, Morikawa Y, Okano H, Kuroda T. “Fluorescence Visualization of the Enteric Nervous Network in a Chemically Induced Aganglionosis Model” PLoS One. 2016 Mar 4;11(3):e0150579. doi: 10.1371/journal.pone.0150579. eCollection 2016. PMID: 26943905
(*equally contributed first author)
108. Fujiyoshi K, Hikishima K, Nakahara J, Tsuji O, Hata J, Konomi T, Nagai T, Shibata S, Kaneko S, Iwanami A, Momoshima S, Takahashi S, Jinzaki M, Suzuki N, Toyama Y, Nakamura M, Okano H. “Application of q-Space Diffusion MRI for the Visualization of White Matter” J Neurosci. 2016 Mar 2;36(9):2796-808. doi: 10.1523/JNEUROSCI.1770-15.2016. PMID: 26937016
109. Morikawa S, Ouchi T, Shibata S, Fujimura T, Kawana H, Okano H, Nakagawa T. “Applications of Mesenchymal Stem Cells and Neural Crest Cells in Craniofacial Skeletal Research.” Stem Cells International, 2016; 2016:2849879. doi: 10.1155/2016/2849879. Epub 2016 Feb 24. PMID: 27006661
110. Kawabata S, Takano M, Numasawa-Kuroiwa Y, Itakura G, Kobayashi Y, Nishiyama Y, Sugai K, Nishimura S, Iwai H, Isoda M, Shibata S, Kohyama J, Iwanami A, Toyama Y, Matsumoto M, Nakamura M, Okano H, “Grafted human iPS cell-derived oligodendrocyte precursor cells contribute to robust remyelination of demyelinated axons after spinal cord injury”. Stem Cell Reports. 2016 Jan 12;6(1):1-8. doi: 10.1016/j.stemcr.2015.11.013. PMID: 26724902



2015年


111. Shibata S*, Murota Y, Yoshimura M, Nagai T, Okano H, Siomi MC*. “Immuno-Electron Microscopy and Electron Microscopic In Situ Hybridization for Visualizing piRNA Biogenesis Bodies in Drosophila Ovaries.” Methods in Mol Biol. 2015;1328:163-78. doi: 10.1007/978-1-4939-2851-4_12. PMID: 26324437,
(*co-corresponding author)
112. Kanzaki S, Watanabe K, Fujioka M, Shibata S, Nakamura M, Okano HJ, Okano H, Ogawa K. “Novel in vivo imaging analysis of an inner ear drug delivery system: drug availability in inner ear following different dose of systemic drug injections.” Hearing Research. 2015 Dec;330(Pt A):142-6. doi: 10.1016/j.heares.2015.09.018. PMID: 26435094
113. Nishikawa R, Hotta R, Shimojima N, Shibata S, Nagoshi N, Nakamura M, Matsuzaki Y, Okano HJ, Kuroda T, Okano H, Morikawa Y. “Migration and differentiation of transplanted enteric neural crest-derived cells in murine model of Hirschsprung's disease.” Cytotechnology. 2015 Aug;67(4):661-70. doi: 10.1007/s10616-014-9754-8. PMID: 25230796
114. Iwai H, Shimada H, Nishimura S, Kobayashi Y, Itakura G, Hori K, Hikishima K, Ebise H, Negishi N, Shibata S, Habu S, Toyama Y, Nakamura M, Okano H. ” Allogeneic Neural Stem/Progenitor Cells Derived From Embryonic Stem Cells Promote Functional Recovery After Transplantation Into Injured Spinal Cord of Nonhuman Primates” Stem Cells Transl Med. 2015 Jul;4(7):708-19. doi: 10.5966/sctm.2014-0215. PMID: 26019226
115. Lin ZY, Hirano T, Shibata S, Seki NM, Kitajima R; Sedohara A, Siomi MC, Sasaki E, Siomi H, Imamura M, Okano H. “Gene expression ontogeny of spermatogenesis in the marmoset uncovers primate characteristics during testicular development” Developmental Biology. 2015 Apr 1;400(1):43-58. doi: 10.1016/j.ydbio.2015.01.014. PMID: 25624265
116. Shibata S, Komaki Y, Seki F, Inouye MO, Nagai T, Okano H, “Connectomics: Comprehensive approaches for whole brain mapping” Microscopy. 2015 Feb;64(1):57-67. doi: 10.1093/jmicro/dfu103. pii: dfu103. PMID: 25527636



2014年


117. Nishimura S, Sasaki T, Shimizu A, Yoshida K, Iwai H, Koya I, Kobayashi Y, Itakura G, Shibata S, Ebise H, Horiuchi K, Kudoh J, Toyama Y, Anderson AJ, Okano H, Nakamura M. “Global gene expression analysis following spinal cord injury in non-human primates.” Exp Neurol. 2014 Nov;261:171-179. doi: 10.1016/j.expneurol.2014.05.021. Epub 2014 May 27. PMID: 24873731
118. Murota Y, Ishizu H, Nakagawa S, Iwasaki YW, Shibata S, Kamatani MK, Saito K, Okano H, Siomi H, Siomi MC. “Yb Integrates piRNA Intermediates and Processing Factors into Perinuclear Bodies to Enhance piRISC Assembly.” Cell Report. 2014 Jul 10;8(1):103-13. pii: S2211-1247(14)00437-9. doi: 10.1016/j.celrep.2014.05.043. PMID: 24953657
119. Zhang L, Kaneko S, Kikuchi K, Sano A, Maeda M, Kishino A, Shibata S, Mukaino M, Toyama Y, Liu M, Kimura T, Okano H, Nakamura M. “Rewiring of regenerated axons by combining treadmill training with semaphorin3A inhibition.” Molecular Brain. 2014 Mar 10;7(1):14. doi: 10.1186/1756-6606-7-14. PMID: 24618249
120. Takano M, Kawabata S, Komaki Y, Shibata S, Hikishima K, Toyama Y, Okano H, Nakamura M. “Inflammatory cascades mediate synapse elimination in spinal cord compression.” J of Neuroinflammation. 2014 Mar 4;11(1):40. doi: 10.1186/1742-2094-11-40. PMID: 24589419
121. Kuroiwa-Numasawa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Osaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H. “Involvement of ER stress in dysmyelination of Pelizaeus-Merzbacher disease with PLP1 missense mutations shown by iPSC-derived oligodendrocytes” Stem Cell Reports, 2014 Apr 24;2(5):648-61. doi: 10.1016/j.stemcr.2014.03.007. PMID: 24936452



2013年


122. Ohtomo R, Mori T, Shibata S, Tsuta K, Maeshima M, Akazawa C, Honda K, Yamada T, Yoshimoto S, Asai M, Okano H, Kanai Y, Tsuda H. “Sox10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: A clue to the histogenesis and diagnosis” Modern Pathology 2013, Aug;26(8):1041-50. doi: 10.1038/modpathol.2013.54. PMID: 23558573,
123. Nishimoto Y, Nakagawa S, Hirose T, Okano HJ, Takao M, Shibata S, Suyama S, Kuwako K, Imai T, Murayama S, Suzuki N, Okano H. “The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis.” Molecular Brain. 2013 Jul 8;6:31. doi: 10.1186/1756-6606-6-31. PMID: 23835137,
124. Sato H, Shibata M, Shimizu T, Shibata S, Toriumi H, Ebine T, Kuroi T, Iwashita T, Funakubo M, Kayama Y, Akazawa C, Wajima K, Nakagawa T, Okano H, Suzuki N. “Differential cellular localization of antioxidant enzymes in the trigeminal ganglion.” Neuroscience. 2013 Jun 15;248C:345-358. doi: 10.1016/j.neuroscience.2013.06.010. PMID: 23774632,
125. Fukuda T, Takeda S, Xu R, Ochi H, Sunamura S, Sato T, Shibata S, Yoshida Y, Gu Z, Kimura A, Ma C, Xu C, Bando W, Fujita K, Shinomiya K, Hirai T, Asou Y, Enomoto M, Okano H, Okawa A, Itoh H. “Sema3A regulates bone-mass accrual through sensory innervations.” Nature. 2013 May 23;497(7450):490-3. doi: 10.1038/nature12115. PMID: 23644455,
126. Takahashi T, Suzuki H, Imai T, Shibata S, Tabuchi Y, Tsuchimoto K, Okano H, Hibi T. “Musashi-1 post-transcriptionally enhances phosphotyrosine-binding domain-containing m-Numb protein expression in regenerating gastric mucosa.” PLoS One. 2013;8(1):e53540. doi: 10.1371/journal.pone.0053540. PMID: 23308249



2012年


127. Takagi T, Kimura Y, Shibata S, Saito H, Ishii K, Okano HJ, Toyama Y, Okano H, Tabata Y, Nakamura M. “Sustained bFGF-Release Tubes for Peripheral Nerve Regeneration: Comparison with Autograft.” Plast Reconstr Surg. 2012 Oct;130(4):866-76. doi: 10.1097/PRS.0b013e318262f36e. PMID: 23018697
128. Takano M, Hikishima K, Fujiyoshi K, Shibata S, Yasuda A, Konomi T, Hayashi A, Baba H, Honke K, Toyama Y, Okano H, Nakamura M. “MRI characterization of paranodal junction failure and related spinal cord changes in mice” PLoS One. 2012;7(12):e52904. doi: 10.1371/journal.pone.0052904. PMID: 23300814,
129. Kanzaki S, Fujioka M, Yasuda A, Shibata S, Nakamura M, Okano HJ, Ogawa K, Okano H. “Novel in vivo imaging analysis of an inner ear drug delivery system in mice: Comparison of inner ear drug concentrations over time after transtympanic and systemic injections” PLoS One. 2012;7(12):e48480. doi: 10.1371/journal.pone.0048480. PMID: 23251331
130. Omoto M, Yoshida S, Miyashita H, Kawakita T, Yoshida K, Kishino A, Kimura T, Shibata S, Tsubota K, Okano H, Shimmura S. “The Semaphorin 3A Inhibitor SM-345431 Accelerates Peripheral Nerve Regeneration and Sensitivity in a Murine Corneal Transplantation Model.” PLoS One. 2012;7(11):e47716. doi: 10.1371/journal.pone.0047716. PMID: 23152758
131. Shibata S, Umei M, Kawahara H, Yano M, Makino S, Okano H. “Characterization of the RNA-binding protein Musashi1 in zebrafish.” Brain Research. 2012 Jun 26;1462:162-73. Epub 2012 Feb 3, doi: 10.1016/j.brainres.2012.01.068, PMID: 22429745,



2011年


132. Yasuda A, Tsuji O, Shibata S, Nori S, Takano M, Kobayashi Y, Takahashi Y, Fujiyoshi K, Hara CM, Miyawaki A, Okano HJ, Toyama Y, Nakamura M, Okano H. “Significance of remyelination by neural stem/progenitor cells transplanted into the injured spinal cord.” Stem Cells. 2011 Dec;29(12):1983-94. doi: 10.1002/stem.767. PMID: 22028197
133. Renault-Mihara F, Katoh H, Ikegami T, Iwanami A, Mukaino M, Yasuda A, Nori S, Mabuchi Y, Tada H, Shibata S, Saito K, Matsushita M, Kaibuchi K, Okada S, Toyama Y, Nakamura M, Okano H. “Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase-3 inhibition.” EMBO Molecular Medicine. 2011 Nov;3(11):682-96. doi: 10.1002/emmm.201100179. PMID: 21898827
134. Asada N, Takase M, Nakamura J, Oguchi A, Asada M, Suzuki N, Yamamura K, Nagoshi N, Shibata S, Rao TN, Fehling HJ, Fukatsu A, Minegishi N, Kita T, Kimura T, Okano H, Yamamoto M, Yanagita M. “Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice.” Journal of Clinical Investigation. 2011 Oct;121(10):3981-90. doi: 10.1172/JCI57301. PMID: 21911936
135. Katoh H, Shibata S, Fukuda K, Sato M, Satoh E, Nagoshi N, Minematsu T, Matsuzaki Y, Akazawa C, Toyama Y, Nakamura M, Okano H. “The dual origin of the peripheral olfactory system: placode and neural crest.” Molecular Brain. 2011 Sep 23;4:34. doi: 10.1186/1756-6606-4-34, PMID: 21943152, PMCID: PMC3215936
136. Takagi T, Ishii K, Shibata S, Yasuda A, Sato M, Nagoshi N, Saito H, Okano HJ, Toyama Y, Okano H, Nakamura M. “Schwann-spheres derived from injured peripheral nerves in adult mice--their in vitro characterization and therapeutic potential.” PLoS One. 2011;6(6):e21497. doi: 10.1371/journal.pone.0021497, PMID: 21720551, PMCID: PMC3123355
137. Hosoya M, Fujioka M, Matsuda S, Ohba H, Shibata S, Nakagawa F, Watabe T, Wakabayashi KI, Saga Y, Ogawa K, Okano HJ, Okano H. “Expression and Function of Sox21 During Mouse Cochlea Development.” Neurochem Res. 2011 Jul;36(7):1261-9. doi: 10.1007/s11064-011-0416-3. PMID: 21287267
138. Nagoshi N, Shibata S, Hamanoue M, Mabuchi Y, Matsuzaki Y, Toyama Y, Nakamura M, Okano H. “Schwann cell plasticity after spinal cord injury shown by neural crest lineage tracing.” Glia 2011 May;59(5):771-84. doi: 10.1002/glia.21150. Epub 2011 Feb 23, PMID: 21351159



2010年


139. Shibata S, Yasuda A, Renault-Mihara F, Suyama S, Katoh H, Inoue T, Inoue YU, Nagoshi N, Sato M, Nakamura M, Akazawa C, Okano H. “Sox10-Venus mice: a new tool for real time labelling of neural crest lineage and oligodendrocytes.” Molecular Brain. 2010 Oct 31; 3(1):31. doi: 10.1186/1756-6606-3-31. PMID: 21034515
140. Aihara Y, Hayashi Y, Hirata M, Ariki N, Shibata S, Nagoshi N, Nakanishi M, Ohnuma K, Warashina M, Michiue T, Uchiyama H, Okano H, Asashima M, Furue MK. “Induction of neural crest cells from mouse embryonic stem cells in a serum-free monolayer culture” Int. J. Dev. Biol. 2010;54(8-9):1287-94. doi: 10.1387/ijdb.103173ya. PMID: 20711997,
141. Suzuki S, Namiki J, Shibata S, Mastuzaki Y, Okano H. “The Neural Stem/progenitor Cell Marker Nestin is Expressed in Proliferative Endothelial Cells, but Not in Mature Vasculature” J Histochem Cytochem. 2010 Aug;58(8):721-30. doi: 10.1369/jhc.2010.955609. PMID: 20421592
142. Wakabayashi K, Fujioka M, Kanzaki S, Okano HJ, Shibata S, Yamashita D, Masuda M, Mihara M, Ohsugi Y, Ogawa K, Okano H. “Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea.” Neurosci Res. 2010 Apr;66(4):345-52. doi: 10.1016/j.neures.2009.12.008. PMID: 20026135
143. Tada H, Okano HJ, Takagi H, Shibata S, Yao I, Matsumoto M, Saiga T, Nakayama KI, Kashima H, Takahashi T, Setou M, Okano H. “Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.” J Biol Chem. 2010 Feb 5;285(6):3840-9. doi: 10.1074/jbc.M109.046284. PMID: 19996097



2009年


144. Kumagai G, Okada Y, Yamane J, Nagoshi N, Kitamura K, Mukaino M, Tsuji O, Fujiyoshi K, Katoh H, Okada S, Shibata S, Matsuzaki Y, Toh S, Toyama Y, Nakamura M, Okano H. “Roles of ES cell-derived gliogenic neural stem/progenitor cells in functional recovery after spinal cord injury.” PLoS One. 2009 Nov 6;4(11):e7706. doi: 10.1371/journal.pone.0007706. PMID: 19893739
145. Hamanoue M, Matsuzaki Y, Sato KI, Okano HJ, Shibata S, Sato I, Suzuki S, Ogawara M, Takamatsu K, Okano H. “Cell surface N-glycans mediated isolation of mouse neural stem cells.” Journal of Neurochemistry. 2009 Sep;110(5):1575-84. doi: 10.1111/j.1471-4159.2009.06256.x. PMID: 19573022
146. Nagoshi N, Shibata S, Nakamura M, Matsuzaki Y, Toyama Y, Okano H. “Neural crest-derived stem cells display a wide variety of characteristics” J Cell Biochem. 2009 Aug 15;107(6):1046-52. doi: 10.1002/jcb.22213. PMID: 19479900



2008年


147. Susaki K, Kaneko J, Yamano Y, Nakamura K, Inami W, Yoshikawa T, Ozawa Y, Shibata S, Matsuzaki O, Okano H, Chiba C, “Musashi-1, an RNA-binding protein, is indispensable for survival of photoreceptors” Experimental Eye Research 2009 Mar;88(3):347-55. doi: 10.1016/j.exer.2008.06.019. PMID: 18662689
148. Takagi T, Nakamura M, Yamada M, Hikishima K, Momoshima S, Fujiyoshi K, Shibata S, Okano HJ, Toyama Y, Okano H. “Visualization of peripheral nerve degeneration and regeneration: Monitoring with diffusion tensor tractography.” Neuroimage. 2009 Feb 1;44(3):884-92. doi: 10.1016/j.neuroimage.2008.09.022. PMID: 18948210
149. Renault-Mihara F, Okada S, Shibata S, Nakamura M, Toyama Y, Okano H. “Spinal cord injury: emerging beneficial role of reactive astrocytes' migration.” Int J Biochem Cell Biol. 2008;40(9):1649-53. doi: 10.1016/j.biocel.2008.03.009. PMID: 18434236
150. Nagoshi N, Shibata S, Kubota Y, Nakamura M, Nagai Y, Satoh E, Morikawa S, Okada Y, Mabuchi Y, Katoh H, Okada S, Fukuda K, Suda T, Matsuzaki Y, Toyama Y, Okano H. “Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad.” Cell Stem Cell. 2008 Apr 10;2(4):392-403. doi: 10.1016/j.stem.2008.03.005. PMID: 18397758



2007年


151. Kitamuta K., Iwanami A., Nakamura M., Yamane J, Kota W, Suzuki Y, Miyakawa D, Shibata S, Funakoshi H, Miyatakae S, Coffin R, Nakamura T, Toyama Y, Okano H: “Hepatocyte growth factor promotes endogenous repair and functional recovery after spinal cord injury.” J. Neurosci Res. 2007 Aug 15;85(11):2332-42. DOI: 10.1002/jnr.21372, PMID: 17549731



2006年


152. Kaneko S, Iwanami A, Nakamura M, Kishino A, Kikuchi K, Shibata S, Okano HJ, Ikegami T, Moriya A, Konishi O, Nakayama C, Kumagai K, Kimura T, Sato Y, Goshima Y, Taniguchi M, Ito M, He Z, Toyama Y, Okano H. “A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord.” Nat Med. 2006 Dec;12(12):1380-9. DOI: 10.1038/nm1505, PMID: 17099709
153. Sugiyama-Nakagiri Y, Akiyama M, Shibata S, Okano H, Shimizu H. “Expression of RNA-binding protein Musashi in hair follicle development and hair cycle progression.” Am J Pathology 2006 Jan; 168(1): 80-92. DOI: 10.2353/ajpath.2006.050469, PMID: 16400011



2005年


154. Okano H., Kawahara H., Toriya M., Nakao K., Shibata S. and Imai T. “Function of RNA binding protein Musashi-1 in stem cells.” Exp. Cell Res. 2005 Jun 10;306(2):349-56. DOI: 10.1016/j.yexcr.2005.02.021 PMID: 15925591
155. Akamatsu W, Fujihara H, Mitsuhashi T, Yano M, Shibata S, Hayakawa Y, Okano HJ, Sakakibara SI, Takano H, Takano T, Takahashi T, Noda T, Okano H. “The RNA-binding protein HuD regulates neuronal cell identity and maturation.” Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4625-30. doi: 10.1073/pnas.0407523102. Epub 2005 Mar 11. PMID: 15764704



2002年


156. Sakakibara S, Nakamura Y, Yoshida T, Shibata S, Koike M, Takano H, Ueda S, Uchiyama Y, Noda T, Okano H. “RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation.” Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15194-9. doi: 10.1073/pnas.232087499. Epub 2002 Oct 29. PMID: 12407178PMID: 12407178



2000年


157. Fujino T, Hasegawa M, Shibata S, Kishimoto T, Imai SI, Takano T. “PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis.” Biochem Biophys Res Commun. 2000 May 10;271(2):305-10. doi: 10.1006/bbrc.2000.2614. PMID: 10799292