Orthopedic Surgery and Rehabilitation

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1.Research Summary and Research Groups

The Department of Orthopedic Surgery performs research and is involved in clinical practice in a wide range of areas, from motor and neurological disorders of the limbs, spine and spinal cord, as well as tumors, infection, connective tissue diseases, congenital abnormalities, and trauma occurring in the same sites. The research and clinical practice activities are performed according to area of specialization: osteoporosis and bone metabolism; rheumatoid arthritis; lower extremity joint surgery (hip, knee, and ankle joints, sports medicine, pediatric orthopedic surgery); spine and spinal cord surgery; bone and soft tissue oncology; and hand microsurgery.

2-1.Osteoporosis and Bone Metabolism Group

Research subjects

In the area of osteochondral metabolism, we introduced bone morphometry for the first time in Japan and have firmly established it as a measure for the assessment of bone dynamics. We have focused on osteoporosis research as well since early in its history and have been conducting ongoing epidemiological field studies of femoral neck fracture and vertebral fracture for as long as 25 years. In addition, we are aggressively investigating gene expression of the cartilage-specific factor chondromodulin.

2-2.Rheumatoid Arthritis

Research subjects

We investigate lymphocytes accumulating specifically in the joint synovium and their relationship with osteoporosis. We are also developing unique joint prostheses and surgical methods for foot deformity.

2-3.Lower Extremity Joint Surgery

We perform unique osteotomy and arthroplasty of hip and knee joints, as well as 3-dimensional biomechanical analyses of hip and knee joints, and are conducting a long-term epidemiological study of knee osteoarthritis without parallel in the world. We also perform surgery using navigation and 3-dimensional devices and evaluate these procedures. In the field of pediatric orthopedic surgery, we conduct surveys and study the establishment of screening systems for congenital hip dislocation and acetabular aplasia.

2-4.Spine and Spinal Cord Surgery

We perform 3-dimensional image analysis, conduct spinal cord functional analysis using the latest MRI, investigate the effects of various drugs on spinal neurons, and analyze spinal instrumentation and biomechanics. We also perform pre-and post-operative imaging and clinical assessments for the following diseases: spinal deformity, such as scoliosis; spinal cord and spinal tumors; dialysis-associated spondylosis; specific diseases, such as ligament ossification.

2-5.Bone and Soft Tissue Oncology

Our activities include: development of anticancer treatment for patients with advanced sarcoma who can be treated on an outpatient basis; identification of specific genes for osteosarcoma and liposarcoma; investigation of the effects of molecular targeted drugs on sarcoma; detection of new tumor-specific genes; development of virus-based gene therapy and unique restoration after tumor resection; and research on regenerative medicine using artificial bones.

2-6.Hand and Microsurgery

We investigate complex tissue transplantation, congenital malformations, nerve regeneration, and so forth by taking advantage of microsurgery.We investigate complex tissue transplantation, congenital malformations, nerve regeneration, and so forth by taking advantage of microsurgery.

2-7.Trauma Group

We are moving forward with analyses of clinical cases, focusing especially on multiple extremity trauma and pelvic fracture.