業績 2017-2003 -Bibliographies-

<2017年>

Dumont V, Tolvanen TA, Kuusela S, Wang H, Nyman TA, Lindfors S, Tienari J, Nisen H, Suetsugu S, Plomann M, Kawachi H, Lehtonen S.PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease.FASEB J. 2017 Sep;31(9):3978-3990.

Nishimura H, Yaoita E, Nameta M, Yamaguchi K, Sato M, Ihoriya C, Zhao L, Kawachi H, Sasaki T, Ikezumi Y, Ouchi Y, Kashihara N, Yamamoto T.Restricted nutrition-induced low birth weight, low number of nephrons and glomerular mesangium injury in Japanese quail.J Dev Orig Health Dis. 2017 Jun;8(3):287-300.

<2016年>

Yamazaki M, Fukusumi Y, Kayaba M, Kitazawa Y, Takamura S, Narita I, Kawachi H.Possible role for glomerular-derived angiotensinogen in nephrotic syndrome.J Renin Angiotensin Aldosterone Syst. 2016 Dec 8;17(4).

Wakamatsu A, Fukusumi Y, Hasegawa E, Tomita M, Watanabe T, Narita I, Kawachi H, Role of calcineurin (CN) in kidney glomerular podocyte: CN inhibitor ameliorated proteinuria by inhibiting the redistribution of CN at the slit diaphragm. Physiological Report, 2016 Mar;4(6).

Goto K, Kaneko Y, Sato Y, Otsuka T, Yamamoto S, Goto S, Yamamoto K, Yamamoto T, Kawachi H, Madaio MP, Narita I.Leptin deficiency down-regulates IL-23 production in glomerular podocytes resulting in an attenuated immune response in nephrotoxic serum nephritis.Int Immunol. 2016 Apr;28(4):197-208.

Yaoita E, Nishimura H, Nameta M, Yoshida Y, Takimoto H, Fujinaka H, Kawachi H, Magdeldin S, Zhang Y, Xu B, Oyama T, Nakamura F, Yamamoto T. Avian Podocytes, Which Lack Nephrin, Use Adherens Junction Proteins at Intercellular Junctions. J Histochem Cytochem. 2016  64:67-76.

<2015年>

Maruyama T, Fukuda N, Matsumoto T, Kano K, Endo M, Kazama M, Kazama T, Ikeda J, Matsuda H, Ueno T, Abe M, Okada K, Soma M, Matsumoto K, Kawachi H. Systematic implantation of dedifferentiated fat cells ameliorated monoclonal antibody 1-22-3-induced glomerulonephritis by immunosuppression with increases in TNF-stimulated gene 6. Stem Cell Res Ther. 2015 Apr 16;6(1):80.

Suzuki, Koichi; Fukusumi, Yoshiyasu; Yamazaki, Mihoko; Kaneko, Hiroshi; Tsuruga, Kazushi; Tanaka, Hiroshi; Ito, Etsuro; Matsui, Katsuyuki; Kawachi, Hiroshi Alteration in the podoplanin-ezrin-cytoskeleton linkage is an important initiation event of the podocyte injury in puromycin aminonucleoside nephropathy, a mimic of minimal change nephrotic syndrome. Cell and Tissue Research in press 2015

Fukusumi Y, Wakamatsu A, Takashima N, Hasegawa E, Miyauchi N, Tomita M,Kawachi H. SV2B is essential for the integrity of the glomerular filtration barrier. Lab Invest. 2015 95: 534-545

<2014年>

Takahashi A, Fukusumi Y, Yamazaki M, Kayaba M, Kitazawa Y, Tomita M, Kawachi H. Angiotensin II type 1 receptor blockade ameliorates proteinuria in puromycin aminonucleoside nephropathy by inhibiting the reduction of NEPH1 and nephrin. J Nephrol. 2014 Oct 9.

Yamada S, Nakamura J, Asada M, Takase M, Matsusaka T, Iguchi T, Yamada R, Tanaka M, Higashi AY, Okuda T, Asada N, Fukatsu A, Kawchi H, Graf D, Muso E, Kita T, Kimura T, Pastan I, Economides AN, Yanagita M.Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury. PLoS One. 2014 25;9(2):

Y. Fukusumi, N. Miyauchi, T. Hashimoto, A Saito and H kawachi. Therapeutic target for nephrotic syndrome: Identification of novel slit diaphragm associated molecules. World journal of Nephrology 2014

河内裕、福住好恭 糸球体性蛋白尿の発症機序 Medicina vol.51、No.8、2014 河内裕 糸球体濾過障壁と蛋白尿 腎と透析 76,2014

<2013年>

Wang-Rosenke Y, Khadzhynov D, Loof T, Mika A, Kawchi H, Neumayer HH, Peters H. Tyrosine kinases inhibition by Imatinib slows progression in chronic anti-thy1 glomerulosclerosis of the rat. BMC Nephrol. 2013 14:14 doi: 10.1186/1471-2369-14-223.  

Babayeva S, Rocque B, Aoudjit L, Zilber Y, Li J, Baldwin C, Kawchi H, Takano T, Torban E. Planar cell polarity pathway regulates nephrin endocytosis in developing podocytes. J Biol Chem. 2013 16;288(33):24035-48.doi: 10.1074/jbc.M113.452904.

Lakshmanan AP, Harima M, Suzuki K, Soetikno V, Nagata M, Nakamura T, Takahashi T, Sone H, Kawachi H, Watanabe K. The hyperglycemia stimulated myo- cardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: a differential role of unfolded protein response (UPR) signaling proteins. Int J Biochem Cell Biol. 45:438-447.2013 doi:10.1016/j.biocel.2012.09.017.

河内裕、高橋彩、山崎美穂子、福住好恭、富田雅之 腎糸球体上皮細胞(ポドサイト)スリット膜の構造と機能-ARBのポドサイト保護作用-Pharma Medica、2013 31:98-100.2013

<2012年>

Sofue T, Kiyomoto H, Kobori H, Urushihara M, Nishijima Y, Kaifu K, Hara T, Matsumoto S, Ichimura A, Ohsaki H, Hitomi H, Kawachi H, Hayden MR, Whaley-Connell A, Sowers JR, Ito S, Kohno M, Nishiyama A.Early Treatment With Olmesartan Prevents Juxtamedullary Glomerular Podocyte Injury and the Onset of Microalbuminuria in Type 2 Diabetic Rats.American Journal of Hypertension.25:604-611, 2012

Toyama K, Morisaki H, Cheng J, Kawachi H, Shimizu F, Ikawa M, Okabe M, Morisaki T.Proteinuria in AMPD2-deficient mice.Genes to Cells 17:28-38, 2012
Sato A, Piao H, Nozawa Y, Morioka T, Kawachi H, Oite T. Local delivery of a direct renin inhibitor into the kidney ameliorates progression of experimental glomerulonephritis.Clinical and Experimental Nephrology 16:539-548, 2012

Ramadan R, Faour D, Awad H, Khateeb E, Cohen R, Yahia A, Torgovicky R, Cohen R, Lazari D, Kawachi H, Abassi Z.Early treatment with everolimus exerts nephroprotective effect in rats with adriamycin-induced nephrotic syndrome.Nephrology Diallysis Transplantation 27:2231-2241, 2012

anabe M, Shimizu A, Masuda Y, Kataoka M, Ishikawa A, Wakamatsu K, Mii A, Fujita E, Higo S, Kaneko T, Kawachi H, Fukuda Y.Development of lymphatic vasculature and morphological characterization in rat kidney.Clinical and Experimental Nephrology in press

Soetikno V, Sari FR, Sukumaran V, Lakshmanan AP, Harima M, Suzuki K, Kawachi H Watanabe K.Curcumin decreases renal triglyceride accumulation through AMPK-SREBP signaling pathway in streptozotocin-induced type 1 diabetic rats.The Journal of Nutritional Biochemistry in press

<2011年>

Ikezumi Y, Suzuki T, Karasawa T, Hasegawa H, Yamada T, Imai N, Narita I, Kawachi H, Polkinghorne KR, Nikolic-Paterson DJ, Uchiyama M.Identification of alternatively activated macrophages in new-onsetpaediatric and adult immunoglobulin A nephropathy: potential role in mesangial matrix expansion.Histopathology 58:198-210, 2011

Saito A, Miyauchi N, Hashimoto T, Karasawa T, Han GD, Kayaba M, Sumi T, Tomita M, Ikezumi Y, Suzuki K, Koitabashi Y, Shimizu F, Kawachi H.         Neurexin-1, a presynaptic adhesion molecule, localizes at the slit diaphragm of the glomerular podocytes in kidneys.American Journal of Physiology Regulatory Integrative Comparative Physiology 300: R340-R348, 2011

Ohtsuka Y, Kanaji T, Nishi M, Sakai N, Sato T, Aoki S, Wakayama K, Nakazato S, Hisano S, Sado Y, Kawachi H, Izuhara K, Hamasaki Y.A notable case report of May-Hegglin anomaly with immune complex-related nephropathy: a genetic and histological analysis.Clinical Nephrology 75:255-262, 2011

Kojima K, Nosaka H, Kishimoto Y, Nishiyama Y, Fukuda S, Shimada M, Kodaka K, Saito F, Matsumura K, Shimizu T, Toda T, Takeda S, Kawachi H, Uchida S.Defective glycosylation of α-dystroglycan contributes to podocyte flattening.Kidney International 79:311-316, 2011

Suzuki K, Sun X, Nagata M, Kawase T, Yamaguchi H, Sukumaran V, Kawauchi Y, Kawachi H, Nishino T, Watanabe K, Yoneyama H, Asakura H.      Analysis of intestinal fibrosis in chronic colitis in mice induced by dextran sulfate sodium.Pathology International 61:228-238, 2011

Kinoshita Y, Kondo S, Urushihara M, Suga K, Matsuura S, Takamatsu M, Shimizu M, Nishiyama A, Kawachi H, Kagami SAngiotensin II type I receptor blockade suppresses glomerular renin-angiotensin system activation, oxidative stress, and progressive glomerular injury in rat anti-glomerular basement membrane glomerulonephritis.Translational Resseach 158:235-248, 2011

Soetikno V, Sari FR, Veeraveedu PT, Thandavarayan RA, Harima M, Sukumaran V, Lakshmanan AP, Suzuki K, Kawachi H, Watanabe K.Curcumin ameliorates macrophage infiltration by inhibiting NF-κB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy.Nutrition Metabolism 10:35-41, 2011

Miyasato K, Takabatake Y, Kaimori J, Kimura T, Kitamura H, Kawachi H, Li XK, Hünig T, Takahara S, Rakugi H, Isaka Y. CD28 superagonist-induced regulatory T cell expansion amelioratesmesangioproliferative glomerulonephritis in rats. Clinical and Experimental Nephrology 15:50-57, 2011

<2010年>

Urushihara M, Takamatsu M, Shimizu M, Kondo S, Kinoshita Y, Suga K, Kitamura A, Matsuura S, Yoshizumi M, Tamaki T, Kawachi H, Kagami S.ERK5 activation enhances mesangial cell viability and collagen matrix accumulation in rat progressive glomerulonephritis.American Journal of Physiology Renal Physiology 298:F167-F176, 2010

Attias O, Jiang R, Aoudjit L, Kawachi H, Takano T.Rac1 contributes to actin organization in glomerular podocytes.Nephron Experimental Nephrology 114:e93-e106, 2010Zhu J, Attias O, Aoudjit L, Jiang R, Kawachi H, Takano T. p21-activated kinases regulate actin remodeling in glomerular podocytes.American Journal of Physiology Renal Physiology 298:F951-F961, 2010

Ikezumi Y, Suzuki T, Karasawa T, Hasegawa H, Kawachi H, Nikolic-Paterson DJ, Uchiyama M Contrasting effects of steroids and mizoribine on macrophage activation and glomerular lesions in rat thy-1 mesangial proliferative glomerulonephritis. American Journal of Nephrology 31:273-282, 2010

Tanaka M, Asada M, Higashi AY, Nakamura J, Oguchi A, Tomita M, Yamada S, Asada N, Takase M, Okuda T, Kawachi H, Economides AN, Robertson E, Takahashi S, Sakurai T, Goldschmeding R, Muso E, Fukatsu A, Kita T, Yanagita M.Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome.The Journal of Clinical Investigation 120:768-777, 2010

Sun X, Suzuki K, Nagata M, Kawauchi Y, Yano M, Ohkoshi S, Matsuda Y, Kawachi H, Watanabe K, Asakura H, Aoyagi Y. Rectal administration of tranilast ameliorated acute colitis in mice through increased expression of heme oxygenase-1.Pathology International  60:93-101, 2010

Fukuda A, Fujimoto S, Iwatsubo S, Kawachi H, Kitamura K.Effects of mineralocorticoid and angiotensin II receptor blockers on proteinuria and glomerular podocyte protein expression in a model of minimal change nephrotic syndrome. Nephrology  15:321-326, 2010

Tsuda H, Yamahara K, Ishikane S, Otani K, Nakamura A, Sawai K, Ichimaru N, Sada M, Taguchi A, Hosoda H, Tsuji M, Kawachi H, Horio M, Isaka Y, Kangawa K, Takahara S, Ikeda T.Allogenic fetal membrane-derived mesenchymal stem cells contribute to renal repair in experimental glomerulonephritis. American Journal of Physiology Renal Physiology 299:F1004-F1013, 2010

Fan JP, Kim D, Kawachi H, Ha TS, Han GD. Ameliorating effects of L-carnitine on diabetic podocyte injury.Jounal of Medical Food 13:1324-1330, 2010

<2009年>

Okada T, Sakaguchi T, Hatamura I, Saji F, Negi S, Otani H, Muragaki Y, Kawachi H, Shigematsu T.Tolvaptan, a selective oral vasopressin V2 receptor antagonist, ameliorates podocyte injury in puromycinaminonucleoside nephrotic rats.Clinical and Experimental Nephrology 13:438-446, 2009

Matsui I, Hamano T, Tomida K, Inoue K, Takabatake Y, Nagasawa Y, Kawada N, Ito T, Kawachi H,Rakugi H, Imai E, Isaka Y.Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycinaminonucleoside-induced nephrosis in rats.Nephrology Diallysis Transplantation 24:2354-2361, 2009

Mii A, Shimizu A, Masuda Y, Ishizaki M, Kawachi H, Iino Y, Katayama Y, Fukuda Y.Angiotensin II receptor blockade inhibits acute glomerular injuries with the alteration of receptorexpression.Laboratory Investigation 89:164-177, 2009Kawachi H, Han GD, Miyauchi N, Hashimoto T, Suzuki K, Shimizu F.Therapeutic targets in the podocyte: findings in anti-slit diaphragm antibody-induced nephropathy.Jounal of Nephrology 22:450-456, 2009

Kawachi H, Suzuki K, Miyauchi N, Hashimoto T, Otaki Y, Shimizu F.Slit diaphragm dysfunction in proteinuric states: identification of novel therapeutic targets for nephrotic syndrome.Clinical and Experimental Nephrology 13:275-280, 2009

<2008年>


Otaki Y, Miyauchi N, Higa M, Takada A, Kuroda T, Gejyo F, Shimizu F, Kawachi H.The dissociation of NEPH1 from nephrin is involved in the development of rat model of focal segmental glomerulosclerosis.Am J Physiol Renal Physiol. 295:F1376-87, 2008

Koop K, Eikmans M, Wehland M, Baelde H, Ijpelaar D, Kreutz R, Kawachi H, Kerjaschki D, de Heer E,Bruijn JA. Selective loss of podoplanin protein expression accompanies proteinuria and precedes alterations in podocyte morphology in a spontaneous proteinuric rat model. Am J Pathol 173:315-26, 2008

Furuichi K, Wada T, Kitajikma S, Toyama T, Okumura T, Hara A, Kawachi H, Shimizu F, Sugaya T, Mukaida N, Narumi S, Matsushima K, Kaneko S. IFN-inducible protein 10 (CXCL10) regulates tubular cell proliferation in renal ischemia-reperfusion injury. Nephron Exp Nephrol. 109: c29-38, 2008;

Wittmann S, Daniel C, Braun A, Vogelbacher R, Shimizu F, Kawachi H, Hugo C. The mTOR inhibitor everolimus attenuates the time course of chronic anti-Thy1 nephritis in the rat. Nephron Exp Nephrol. 108:e45-56, 2008
Uchida K, Suzuki K, Iwamoto M, Kawachi H, Ohno M, Horita S, Nitta K. Decreased tyrosine phosphorylation of nephrin in rat and human nephrosis. Kidney Int. 73:926-32, 2008

Krämer S, Kron S, Wang-Rosenke Y, Loof T, Khadzhynov D, Morgera S, Kawachi H, Shimizu F, Martini S, Neumayer HH, Peters H. Rosuvastatin is additive to high-dose candesartan in slowing progression of experimental mesangioproliferative glomerulosclerosis. Am J Physiol Renal Physiol. 294: F801-11, 2008

Krämer S, Wang-Rosenke Y, Scholl V, Binder E, Loof T, Khadzhynov D, Kawachi H, Shimizu F, Diekmann F, Budde K, Neumayer HH, Peters H. Low-dose mTOR inhibition by rapamycin attenuates progression in anti-thy1-induced chronic glomerulosclerosis of the rat. Am J Physiol Renal Physiol. 294: F440-449, 2008

Nakhoul F, Khankin E, Yaccob A, Kawachi H, Karram T, Awaad H, Nakhoul N, Hoffman A, Abassi Z. Eplerenone potentiates the antiproteinuric effects of enalapril in experimental nephrotic syndrome.Am J Physiol Renal Physiol. 294: F628-637, 2008

Zhu J, Sun N, Aoudjit L, Li H, Kawachi H, Lemay S, Takano T. Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes. Kidney Int. 73:556-566, 2008

Ikezumi Y, Suzuki T, Karasawa T, Kawachi H, Nikolic-Paterson DJ, Uchiyama M. Use of mizoribine as a rescue drug for steroid-resistant pediatric IgA nephropathy. Pediatr Nephrol 23:645-650, 2008

<2007年>

Suzuki K, Han GD, Miyauchi N, Hashimoto T, Nakatsue T, Fujioka Y, Koike H, Shimizu F, Kawachi H. Angiotensin II Type 1 and Type 2 Receptors Play Opposite Roles in Regulating the Barrier Function of Kidney Glomerular Capillary Wall. Am J Pathol. 170: 1841-1853, 2007

Hashimoto T, Karasawa T, Saito A, Miyauchi N, Han GD, Hayasaka K, Shimizu F, Kawachi H. Ephrin-B1 localizes at the slit diaphragm of the glomerular podocyte. Kidney Int 72:954-64, 2007

Eto N, Wada T, Inagi R, Takano H, Shimizu A, Kato H, Kurihara H, Kawachi H, Shankland SJ, Fujita T, Nangaku M. Podocyte protection by darbepoetin: preservation of the cytoskeleton and nephrin expression. Kidney Int. 72:455-463, 2007

Shibata S, Nagase M, Yoshida S, Kawachi H, Fujita T. Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1. Hypertension 49: 355-364, 2007

Suzuki K, Kawauchi Y, Palaniyandi SS, Veeraveedu PT, Fujii M, Yamagiwa S, Yoneyama H, Han GD, Kawachi H, Okada Y, Ajioka Y, Watanabe K, Hosono M, Asakura H, Aoyagi Y,

Narumi S. Blockade of interferon-gamma-inducible protein-10 attenuates chronic experimental colitis by blocking cellular trafficking and protecting intestinal epithelial cells. Pathol Int 57:413-20, 2007

Hokari M, Matsuda Y, Wakai T, Shirai Y, Sato M, Tsuchiya A, Takamura M, Yamagiwa S, Suzuki K, Ohkoshi S, Ichida T, Kawachi H, Aoyagi Y. Tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 potentates the anchorage-independent growth of human hepatoma HepG2 cells. Life Sci 72:954-64, 2007

Nakaya I, Wada T, Furuichi K, Sakai N, Kitagawa K, Yokoyama H, Ishida Y, Kondo T, Sugaya T, Kawachi H, Shimizu F, Narumi S, Haino M, Gerard C, Matsushima K, Kaneko S. Blockade of IP-10/CXCR3 promotes progressive renal fibrosis. Nephron Exp Nephrol 107:e12-21, 2007

Amazonas RB, Sanita Rde A, Kawachi H, de Faria JB. Prevention of hypertension with or without renin-angiotensin system inhibition precludes nephrin loss in the early stage of experimental diabetes mellitus. Nephron Physiol. 107:57-64, 2007.

Yoneyama H, Kai Y, Koyama J, Suzuki K, Kawachi H, Narumi S, Ichida T. Neutralization of CXCL10 accelerates liver regeneration in carbon tetrachloride-induced acute liver injury. Med Mol Morphol. 40: 191-7, 2007

Ogawa A, Sakatsume M, Wang X, Sakamaki Y, Tsubata Y, Alchi B, Kuroda T, Kawachi H, Narita I, Shimizu F, Gejyo F. SM22alpha: the novel phenotype marker of injured glomerular epithelial cells in anti-glomerular basement membrane nephritis. Nephron Exp Nephrol 106:e77-87, 2007

<2006年>

Han GD, Suzuki K, Koike H, Suzuki K, Yoneyama H, Narumi S, Shimizu F, Kawachi H. IFN-inducible protein-10 plays a pivotal role in maintaining slit-diaphragm function by regulating podocyte cell-cycle balance. J Am Soc Nephrol 17:442-453, 2006

Miyauchi N, Saito A, Karasawa T, Harita Y, Suzuki K, Koike H, Han GD, Shimizu F, Kawachi H. Synaptic vesicle protein 2B is expressed in podocyte, and its expression is altered in proteinuric glomeruli. J Am Soc Nephrol 17: 2748-2759, 2006

Harita Y, Miyauchi N, Karasawa T, Suzuki K, Han GD, Koike H, Igarashi T, Shimizu F, Kawachi H. Altered expression of junctional adhesion molecule 4 in injured podocytes. Am J Physiol Renal Physiol. 290:F335-344, 2006

Macconi D, Bonomelli M, Benigni A, Plati T, Sangalli F, Longaretti L, Conti S, Kawachi H, Hill P, Remuzzi G, Remuzzi A. Pathophysiologic implications of reduced podocyte number in a rat model of progressive glomerular injury. Am J Pathol 168:42-54, 2006

Kondo S, Shimizu M, Urushihara M, Tsuchiya K, Yoshizumi M, Tamaki T, Nishiyama A, Kawachi H, Shimizu F, Quinn MT, Lambeth DJ, Kagami S. Addition of the antioxidant probucol to angiotensin II type I receptor antagonist arrests progressive mesangioproliferative glomerulonephritis in the rat. J Am Soc Nephrol 17:783-794, 2006

Ostendorf T, Rong S, Boor P, Wiedemann S, Kunter U, Haubold U, van Roeyen CR, Eitner F, Kawachi H, Starling G, Alvarez E, Smithson G, Floege J. Antagonism of PDGF-D by human antibody CR002 prevents renal scarring in experimental glomerulonephritis. J Am Soc Nephrol. 17:1054-1062, 2006

Tsuji M, Monkawa T, Yoshino J, Asai M, Fukuda S, Kawachi H, Shimizu F, Hayashi M, Saruta T. Microarray analysis of a reversible model and an irreversible model of anti-Thy-1 nephritis. Kidney Int 69:996-1004, 2006

Hara A, Wada T, Furuichi K, Sakai N, Kawachi H, Shimizu F, ShibuyaM, Matsushima K, Yokoyama H. Blockade of VEGF accelerates proteinuria, via decrease in nephrin expression in rat crescentic glomerulonephritis. Kidney Int 69:1986-1995, 2006

Mizui M, Isaka Y, Takabatake Y, Sato Y, Kawachi H, Shimizu F, Takahara S, Ito T, Imai E. Transcription factor Ets-1 is essential for mesangial matrix remodeling. Kidney Int 70:298-305, 2006

Tsubata Y, Sakatsume M, Ogawa A, Alchi B, Kaneko Y, Kuroda T, Kawachi H, Narita I, Yamamoto T, Gejyo F.. Expression of allograft inflammatory factor-1 in kidneys: A novel molecular component of podocyte. Kidney Int 70:1948-1954, 2006

Wang Y, Kramer S, Loof T, Martini S, Kron S, Kawachi H, Shimizu F, Neumayer HH, Peters H. Enhancing cGMP in experimental progressive renal fibrosis: soluble guanylate cyclase stimulation vs. phosphodiesterase inhibition. Am J Physiol Renal Physiol. 290:F167-176, 2006

Ichihara A, Kaneshiro Y, Takemitsu T, Sakoda M, Nakagawa T, Nishiyama A, Kawachi H, Shimizu F, Inagami T. Contribution of nonproteolytically activated prorenin in glomeruli to hypertensive renal damage. J Am Soc Nephrol 17:2495-2503, 2006

Takenaka T, Okada H, Kanno Y, Inoue T, Ryuzaki M, Nakamoto H, Kawachi H, Shimizu F, Suzuki H. Exogenous 5'-nucleotidase improves glomerular autoregulation in Thy-1 nephritic rats. Am J Physiol Renal Physiol. 290:F844-853, 2006

Kawauchi Y, Suzuki K, Watanabe S, Yamagiwa S, Yoneyama H, Han GD, Palaniyandi SS, Veeraveedu PT, Watanabe K, Kawachi H, Okada Y, Shimizu F, Asakura H, Aoyagi Y, Narumi S. Role of IP-10/CXCL10 in the progression of pancreatitis-like injury in mice after murine retroviral infection. Am J Physiol (Gastrointest Liver) 291:G345-354, 2006

Ikezumi Y, Suzuki T, Imai N, Ueno M, Narita I, Kawachi H, Shimizu F, Nikolic-Paterson DJ, Uchiyama M. Histological differences in new-onset IgA nephropathy between children and adults. Nephrol Dial Transplant 21:3466-3474, 2006Li H, Zhu J, Aoudjit L, Latreille M, Kawachi H, Larose L, Takano T. Rat nephrin modulates cell morphology via the adaptor protein Nck. Biochem Biophys Res Commun 349:310-316, 2006

Kagami S, Shimizu M, Kondo S, Kitamura A, Urushihara M, Takamatsu M, Yamaji S, Ishigatsubo Y, Kawachi H, Shimizu F. Up-regulation of integrin-linked kinase activity in rat mesangioproliferative glomerulonephritis. Life Science 78:1794-1800, 2006

<2005年>

Nakatsue T, Koike H, Han GD, Suzuki K, Miyauchi N, Yuan H, Salant DJ, Gejyo F, Shimizu F, Kawachi H. Nephrin and podocin dissociate at the onset of proteinuria in experimental membranous nephropathy. Kidney Int 67:2239-2253, 2005

Suganami T, Mukoyama M, Mori K, Yokoi H, Koshikawa M, Sawai K, Hidaka S, Ebihara K, Tanaka T, Sugawara A, Kawachi H, Vinson C, Ogawa Y, Nakao K. Prevention and reversal of renal injury by leptin in a new mouse model of diabetic nephropathy. The FASEB Journal. 19:127-129, 2005

Uchimura H, Marumo T, Takase O, Kawachi H, Shimizu F, Hayashi M, Saruta T, Hishikawa K, Fujita T. Intrarenal injection of bone marrow-derived angiogenic cells reduces endothelial injury and mesangial cell activation in experimental glomerulonephritis. J Am Soc Nephrol 16:997-1004, 2005

Koshikawa M, Mukoyama M, Mori K, Suganami T, Sawai K, Yoshioka T, Nagae T, Yokoi H, Kawachi H, Shimizu F, Sugawara A, Nakao K. Role of p38 mitogen-activated protein kinase activation in podocyte injury and proteinuria in experimental nephrotic syndrome. J Am Soc Nephrol 16:2690-2701, 2005

Wang Y, Kramer S, Loof T, Martini S, Kron S, Kawachi H, Shimizu F, Neumayer HH, Peters H. Stimulation of soluble guanylate cyclase slows progression in anti-thy1-induced chronic glomerulosclerosis. Kidney Int 68:47-61, 2005

Takazawa Y, Maeshima Y, Kitayama H, Yamamoto Y, Kawachi H, Shimizu F, Matsui H, Sugiyama H, Yamasaki Y, Makino H. Infusion of angiotensin II reduces loss of glomerular capillary area in the early phase of anti-Thy-1.1 nephritis possibly via regulating angiogenesis-associated factors. Kidney Int. 68:704-722, 2005

Meng Y, Kasai A, Hiramatsu N, Hayakawa K, Takeda M, Shimizu F, Kawachi H, Yao J, Kitamura M. Real-time monitoring of mesangial cell-macrophage cross-talk using SEAP in vitro and ex vivo. Kidney Int 68:886-893, 2005

Tomita M, Sogabe H, Nakazato S, Nakatsuji S, Noto T, Hamada K, Kawachi H, Shimizu F, Matsuo M, Mutoh S. Monoclonal antibody 1-22-3-induced glomerulonephritis in uninephrectomized rats as a model of progressive renal failure. Nephrol Dial Transplant 20:2358-2367, 2005

Ikezumi Y, Suzuki T, Hayafuji S, Okubo S, Nikolic-Paterson DJ, Kawachi H, Shimizu F, Uchiyama M. The sialoadhesin (CD169) expressing a macrophage subset in human proliferative glomerulonephritis. Nephrol Dial Transplant 20:2704-2713, 2005

Meng Y, Kasai A, Hiramatsu N, Hayakawa K, Yamauchi K, Takeda M, Kawachi H, Shimizu F, Yao J, Kitamura M. Continuous, noninvasive monitoring of local microscopic inflammation using a genetically engineered cell-based biosensor. Lab Invest 85:1429-1439, 2005

Hirabayashi S, Mori H, Kansaku A, Kurihara H, Sakai T, Shimizu F, Kawachi H, Hata Y. MAGI-1 is a component of the glomerular slit diaphragm that is tightly associated with nephrin. Lab Invest 85:1528-1543, 2005.
Asai M, Monkawa T, Marumo T, Fukuda S, Tsuji M, Yoshino J, Kawachi H, Shimizu F, Hayashi M, Saruta T. Spironolactone in combination with cilazapril ameliorates proteinuria and renal interstitial fibrosis in rats with anti-Thy-1 irreversible nephritis. Hypertension Research. 27:971-978, 2005

Hino M, Nagase M, Kaname S, Shibata S, Nagase T, Oba S, Funaki M, Kobayashi N, Kawachi H, Mundel P, Fujita T. Expression and regulation of adrenomedullin in renal glomerular podocytes. Biochem Biophys Res Commun 330:178-185, 2005

Kramer S, Loof T, Martini S, Ruckert M, Wang Y, Bohler T, Shimizu F, Kawachi H, Neumayer HH, Peters H. Mycophenolate mofetil slows progression in anti-thy1-induced chronic renal fibrosis but is not additive to a high dose of enalapril. Am J Physiol Renal Physiol. 289:F359-368, 2005

Takabatake Y, Isaka Y, Mizui M, Kawachi H, Shimizu F, Ito T, Hori M, Imai E. Exploring RNA Interference as a therapeutic strategy for renal disease. Gene Therapy. 12:965-973, 2005

Wan Y, Gu L, Suzuki K, Karasawa T, Fujioka Y, Han GD, Koike H, Kawachi H, Shimizu F.Multi-glycoside of Tripterygium wilfordii Hook f. ameliorates proteinuria and acute mesangial injury induced by anti-Thy1.1 monoclonal antibody. Nephron Exp Nephrol 99:e121-129, 2005

<2004年>

Ikezumi Y, Kanno K, Karasawa T, Han GD, Ito Y, Koike H, Toyabe S, Uchiyama M, Shimizu F, Kawachi H: The role of lymphocytes in the experimental progressive glomerulonephritis. Kidney Int 66:1036-1048, 2004
Ma Ji, Matsusaka T, Yang H, Kawachi H, Shimizu F, Isaka Y, Imai E, Kon V, Ichikawa I: Local actions of endogenous angiotensin Ⅱ in injured glomeruli. J Am Soc Nephrol 15:1268-1276, 2004

Li H, Lemay S, Aousjit L, Kawachi H, Takano T:Src-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin. J Am Soc Nephrol 15: 3006-3015, 2004
Isaka Y, Nakamura H, Mizui M, Takabatake Y, Horio M, Kawachi H, Shimizu F, Imai E, Hori M: DNAzyme for TGF-beta suppressed extracellular matrix accumulation in experimental glomerulonephritis. Kidney Int 66:586-590, 2004

Watanabe Y, Kobayashi T, Yaoita E, Kawachi H, Yamauchi A, Inoue T, Shimizu F, Yoshida Y, El-Shemi AG, Okada H, Suzuki H, Yamamoto T: Novel expression of sodium/myo-inositol co-transporter in podocytes in puromycin aminonucleoside nephrosis. Nephrol Dial Transplant 19:817822, 2004

Schaier M, Liebler S, Schade K, Shimizu F, Kawachi H, Grone HJ, Chandraratna R, Ritz E, Wagner J: Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat. J Mol Med 82:116-125, 2004

Davis BJ, Forbes JM, Thomas MC, Jerums G, Burns WC, Kawachi H, Allen TJ, Cooper ME:  Superior renoprotective effects of combination therapy with ACE and AGE inhibition in the diabetic spontaneously hypertensive rat. Diabetologia 47:89-95, 2004

<2003年>

Kawachi H, Koike H, Kurihara H, Sakai T, Shimizu F: Cloning of rat homologue of podocin: Expression in proteinuric states and in developing glomeruli. J Am Soc Nephrol 14:46-56, 2003

Han GD, Koike H, Nakatsue T, Suzuki K, Yoneyama H, Narumi S, Kobayashi N, Mundel P, Shimizu F, Kawachi H: IFN-inducible protein-10 has a differential role in podocyte during Thy 1.1 glomerulonephritis. J Am Soc Nephrol 14:3111-3126, 2003

Suzuki A, Ito T, Imai E, Yamato M, Iwatani H, Kawachi H, Hori M: Retinoids regulate the repairing process of the podocytes in puromycin aminonucleoside-induced nephrotic rats. J Am Soc Nephrol 14:981-991, 2003
Koop K, Eikmans M, Baelde HJ, Kawachi H, De Heer E, Paul LC, Bruijn JA: Expression of podocyte-associated molecules in acquired human kidney diseases. J Am Soc Nephrol 14:2063-2071, 2003

Davis BJ, Cao Z, de Gasparo M, Kawachi H, Cooper ME, Allen TJ: Disparate effects of angiotensin II antagonists and calcium channel blockers on albuminuria in experimental diabetes and hypertension: potential role of nephrin. J Hypertens 21:209-216, 2003Higuchi N, Maruyama H, Kuroda T, Kameda S, Iino N, Kawachi H, Nishikawa Y,

Hanawa H, Tahara H, Miyazaki J, Gejyo F: Hydrodynamics-based delivery of the viral interleukin-10 gene suppresses experimental crescentic glomerulonephritis in Wistar-Kyoto rats. Gene Ther 10:1297-1312, 2003

Watanabe S, Suzuki K, Kawauchi Y, Yamagiwa S, Yoneyama H, Kawachi H, Okada Y, Shimizu F, Asakura H, Aoyagi Y: Kinetic analysis of the development of pancreatic lesions in mice infected with a murine retrovirus. Clin Immunol 109:212-223, 2003

Narita I, Goto s, Saito N, Song J, Kondo D, Omori K, Kawachi H, Shimizu F, Sakatsume M, Ueno M, Gejyo F: Genetic polymorphism of NPHS1 modifies the clinical manifestations of IgA nephropathy. Lab Invest 83:1193-1200, 2003

Peters H, Martini S, Woydt R, Ruckert M, Shimizu F, Kawachi H, Liefeldt L, Kramer S, Neumayer HH: Moderate alcohol intake has no impact on acute and chronic progressive anti-Thy-1 glomerulonephritis. Am J Physiol Renal Physiol. 284:F1105-1114, 2003

Kanno K, Kawachi H, Uchida Y, Hara M, Shimizu F, Uchiyama M: Urinary sediment podocalyxin in children with glomerular diseases. Nephron Clin Pract 95:c91-99, 2003Orikasa M, Iwanaga T, Kawachi H, Oyanagi A, Li P, Su Q, Kobayashi H, Nakayama H,

Kikuchi H, Shimizu F: Monoclonal antibody against rat podocyte-derived macrophagic cells reacts with crescent-forming cells in an experimental model. Nephrology 8:217-223, 2003