2025

1. Chimeric PD‑1 receptor redirects primary T cells against childhood solid tumors but not to PD‑1 ligand‑positive CD80‑coexpressing cells.
   *Shin C, Kawashima H, Ogose A, et al.
   Mol Med Rep　2025；32：243.

2. Comparative surgical invasiveness of internal fixation for pathological fractures in metastatic bone disease versus traumatic fractures: a quantitative analysis of operative time and blood loss.
   *Hayashi K, Kawashima H, et al.
   Jpn J Clin Oncol　2025；55：615-20.

3. Comparison of clinical outcome between surgical treatment and particle beam therapy for pelvic bone sarcomas: A retrospective multicenter study in Japan.
   *Takemori T, Kawashima H, et al.
   J Orthop Sci　2025；30：523-8.

4. Diagnosis of Leptomeningeal Disease in Diffuse Midline Gliomas by Detection of H3F3A K27M Mutation in Circulating Tumor DNA of Cerebrospinal Fluid.
   *Shibuma S, Kawashima H, et al.
   Pediatr Blood Cancer　2025；72：e31535.

5. Heterogeneous c-Met Activation in Osteosarcoma Dictates Synergistic Vulnerability to Combined c-Met Inhibition and Methotrexate Therapy.
   *Li G, Kawashima H, Sasaki T,
   Ariizumi T, Oike N, Ogose A.
   Anticancer Res　2025；45：2791-806.
6. Methotrexate, Doxorubicin, and Cisplatin Versus Methotrexate, Doxorubicin, and Cisplatin + Ifosfamide in Poor Responders to Preoperative Chemotherapy for Newly Diagnosed High-Grade Osteosarcoma (JCOG0905): A Multicenter, Open-Label, Randomized Trial.
   *Hiraga H, Kawashima H, et al.
   J Clin Oncol　2025；43：1886-97.
7. Predictive variables for intraoperative blood loss and surgical time in resection of malignant soft tissue tumors without reconstruction.
   *Nakamura T, Kawashima H, et al.
   Jpn J Clin Oncol　2025；55：610-4.
8. Case Report: Postsurgical hallux varus in which metatarsophalangeal joint arthrodedid was useful.
   Kondo N, Igarashi Y, Inukai T, Kawashima H.
   F1000Research　2024；12：344.
9. Current status of patients with hip fracture in Japan: A nationwide survey
   *Inage K, Kondo N, *Komatsubara S, *Nakamura Y, et al.
   J Orthop Surg　2025；30-Jun：S0949-2658(25)00182-4.
10. Incidence and clinical course of femoral localized periosteal thickening and atypical femoral fracture over 1 10-year period in patients with autoimmune inflammatory rheumatic diseases.
    *Sato H, Kondo N, *Kurosawa Y, *Hasegawa E, Endo N, et al.
    JBMR Plus　2024 Sep；8：ziae090.
11. Excess fibroblast growth factor 23 in alcoholic osteomalacia is derived from the bone
    *Hidaka N, *Oyama Y, *Koga M, Kondo N, et al.
    JBMR Plus　2025；9： ziaf010.
12. Rheumatoid arthritis with rapid destructvie arthropathy of the shoulder due to calcium pyrophosphate deposition.
    Kondo N, Kakutani R, Mochizuki T, Wakui J,
    Hao N, Kinoshita E, Kawashima H.
    Acta Medica Okayama　2025；79：197-203.
13. Primary adenocarcinoma arising from rectal implantation cyst after low anterior resection for rectal cancer 31 years previously.
    *Shimada Y, Ariizumi T, Kawashima H, et al.
    Clin J Gastroenterol　2024；17：899-903.
14. Reevaluating hybrid neurofibroma/schwannoma: Predominance of schwannoma features despite CD34 positivity and initial neurofibroma diagnosis.
    *Katsumi T, Ariizumi T, Ogose A, Kawashima H, et al.
    J Dermatol　2024；51：1461-9.
15. Mixed Reality-Based Navigation for Pedicle Screw Placement: A Preliminary Study Using a 3D-Printed Spine Model
    Ohashi M, Sato M, Tashi H, Minato K,
    Makino T, Kawashima H.
    Cureus　2024；16：e59240
    10.7759/cureus.59240.
16. Neck and shoulder pain in thoracic adolescent idiopathic scoliosis 10 years after posterior spinal fusion
    Ohashi M, Watanabe K, Hirano T, Hasegawa K, Tashi H, Makino T, Minato K, Sato M, Kawashima H.
    Eur Spine J　2024；33：2522-9
    10.1007/s00586-024-08233-6.
17. Ivabradine reduces neuropathic pain after spinal cord injury by inhibiting excitatory synaptic transmission in the spinal dorsal horn.
    Ohashi M, *Hoshino R, *Deguchi H, *Baba H.
    Neurosci Lett　2025；848：138113.
18. Anatomical Pelvic Parameters Using the Anterior Pelvic Plane: Relationships with Standing Sagittal Spinal Alignment and Estimated Lumbar Alignment in Healthy Volunteers
    Ohashi M, Hasegawa K, *Hatsushikano S, Imai N,
    Tashi H, Shibuya Y, Minato K, Sato M,
    Sekimoto H, Watanabe K, Kawashima H.
    Spine Surg Relat Res　2025；9(4)：469-76.
19. Natural course of moderate adolescent idiopathic scoliosis: a mean 25-year follow-up study.
    Ohashi M, Watanabe K, Hirano T, Hasegawa K,
    Tashi H, Minato K, Shibuya Y, Sato M,
    Kubota M, Sekimoto H, Kawashima H.
    Eur Spine J　2025；Jul 14. Epub ahead of print.
20. Inhibitory effects of NaF on mitochondrial energy generation in human platelets in vitro
    *Tsujino T, *Kasahara T, *Kawabata H, Mochizuki T, et al.
    Frontiers in Toxicology　2024；6：1421184.
21. Clinical Outcomes and Magnetic Resonance Imaging Evaluation of Autologous Protein Solution Treatment for Knee Osteoarthritis
    *Fangzhou C, Mochizuki T, *Ushiki T, Kawashima H.
    Cureus　2025；17：e84698.
22. Effects of Regular Habitual Exercise on Platelet Energetics in Male Recreational Contact Sports Student-Athletes: A Cross-Sectional Study
    Mochizuki T, *Ushiki T, Koga H, *Suzuki K, *Sato M, et al.
    Health Sci Rep　2025；8：e70784.
23. Mitochondrial Transfer from Human Platelets to Rat Dental Pulp-Derived Fibroblasts in the 2D In Vitro System: Additional Implication in PRP Therapy
    *Nishiyama K, *Kasahara T, *Kawabata H, Mochizuki T, et al.
    Int J Mol Sci　2025；25：5504.
24. The Quadriceps Vector in the Lower Extremity of Indian Patients Is Similar in Caucasian and Japanese Patients
    *Fangzhou C, Takagi S, Mochizuki T,
    Kawashima H, *Malhotra R, *Blaha JD.
    J Arthroplasty　2025；40：S381-4.
25. Incidence of four major osteoporotic fragility fractures among older individuals in Sado, Japan, in 2020
    Imai N, Nozaki A, *Shobugawa Y, Higuchi K, Suda Y,
    Oinuma T, Suzuki H, Horigome Y, Kawashima H.
    J Bone Miner Metab　2024；42：647-52.
26. Motor function is related to the lower phase angle than to muscle mass of the lower limbs in older females with hip osteoarthritis: a cross-sectional observational study
    *Homma D, Imai N, Miyasaka D, *Yamato M,
    *Sugahara T, Horigome Y, Suzuki H, Dohmae Y,
    Endo N, Minato I, Kasashima H.
    BMC Musculoskelet Disord　2024；25：720.
27. Decreased Lower Limb Phase Angle in Older People Is an Indicator of Standing and Gait Function, Regardless of Age
    *Homma D, Norio Imai, Miyasaka D, *Yamato M,
    *Ishisaki M, Horigome Y, Suzuki H, Dohmae Y,
    Endo N, Minato I, Kasashima H.
    J Clin Med　2025；14：1023.
28. Femoral and Global Femoral Offset, but not Anteroposterior Offset, to Improve Postoperative Outcome Following Total Hip Arthroplasty – Considerations Independent of the Contralateral Side –
    Imai N, Hirano Y, Homma D, *Nedo Y,
    Horigome Y, Kawashima H.
    Acta Medica Okayama　2025；79：261-70.
29. Impact of Hip Rotation Angle Following Total Hip Arthroplasty with Leg Lengthening
    Imai N, Hirano Y, Homma D, Komuta Y,
    Horigome Y, Kawashima H.
    J Clin Med　2025；14：1564.
30. Relationship Among Global Femoral Offset, Leg Lengthening, and Tibiofemoral Rotation After Total Hip Arthroplasty
    Imai N, Hirano Y, Homma D, Komuta Y,
    Horigome Y, Kawashima H.
    J Clin Med　2025；14：2893.
31. Short-term clinical outcomes of mirogabalin for carpal tunnel syndrome: A single-center retrospective pilot study
    Suzuki N, Yoda T, Nakadai M, Takano T,
    Oinuma T, Kawashim H.
    J Orthop　2024；64：102-7.
32. The morphology of the femoral posterior condyle affects the external rotation of the femur
    Hijikata H, Osamu Tanifuji, Tomoharu Mochizuki,
    Takashi Sato, Satoshi Watanabe, Ryota Katsumi,
    Sho Hokari, Hiroyuki Kawashima.
    Journal of Experimental Orthopaedics　2023；10：122.]
33. Rotation angle between the femoral and tibial components in varus/valgus stress X-rays following total knee arthroplasty
    Hijikata H, Mochizuki T, Maeda K, Tanifuji O,
    Omori G, Yamamoto N, Kawashima H.
    Biomed Mater Eng　2025；36：124-32.
34. The comparison of three dimensional and two dimensional evaluation of varus/valgus stress X-rays following total knee arthroplasty
    Hijikata H, Mochizuki T, Maeda K, Tanifuji O,
    Omori G, Yamamoto N, Kawashima H.
    J Orthop Surg Res　2025；20：326.
35. Analyses of Mesenchymal Progenitors in Skeletal Muscle by Fluorescence-Activated Cell Sorting and Tissue Clearing
    *Ikemoto-Uezumi M, *Kurosawa T, Minato K, *Uezumi A.
    Methods Mol Biol　2023；2640：117-27
    10.1007/978-1-0716-3036-5_9.
36. Tissue-specific functions of MSCs are linked to homeostatic muscle maintenance and alter with aging
    *Kurosawa T, *Ikemoto-Uezumi M, *Yoshimoto Y,
    Minato K, Hase E, et al.
    Aging Cell　2024；23：e14299
    10.1111/acel.14299.
37. Association between preoperative proximal thoracic curve flexibility and postoperative spontaneous correction in Lenke type 1 adolescent idiopathic scoliosis: a retrospective study
    Minato K, Ohashi M, Watanabe K, Hirano T, Hasegawa K,
    Sato M, Makino T, Tashi H, Kawashima H.
    Sci Rep　2025；15：16783
    10.1038/s41598-025-01604-z.
38. Combination of imeglimin and resistance exercise improves mitochondrial function and glucose metabolism in skeletal muscles
    *Ishiguro H, Minato K, *Iwaasa K, *Wu S, et al.
    J Diabetes Complications　2025；39：109145
    10.1016/j.jdiacomp.2025.109145.]
39. A novel method for generating chimeric antigen receptor-transduced primary human natural killer cells by the use of multiple cytokines and anti-CD2 and anti-NKp46 stimulatory antibodies
    *Kubo N, *Baba M, *Shin C, Oike N, et al.
    Biomed Pharmacother　2025；19.
40. IgG4-Related Disease-Like Lesion Arising within a Well-Differentiated Liposarcoma/an Atypical lipomatous tumor: Two Cases Report
    Oike N, *Torigoe T, Ogose A, Ariizumi T, Miyazaki T, Murayama Y, *Homma T, *Umezu H, Kawashima H, et al.
    Frontiers in oncology　2025；in press.
41. Single-Cell RNA Sequencing of Ewing Sarcoma Tumors Demonstrates Transcriptional Heterogeneity and Clonal Evolution
    *A Goodspeed, *A Bodlak, *A B Duffy, Oike N, et al.
    Clin Cancer Res　2025；31：2010-23.
42. Usefulness and limitations of intraoperative pathological diagnosis using frozen sections for spinal cord tumors
    Tanaka Y, Hirano T, Ohashi M, Tashi H, Makino T,
    Minato K, Kawashima H, *Kakita A,
    Hasegawa K, Watanabe K.
    J Orthop Sci　2024；29：1162-7
    10.1016/j.jos.2023.08.011.
43. Primary spinal cord gliomas: Pathologic features associated with prognosis.
    Tanaka Y, *Natsumeda M, Ohashi M, Watanabe K, et al.
    J Neuropathol Exp Neurol　2024；83：1010-9.
44. Image-free robotic-assisted total knee arthroplasty is associated with joint line distalization and improves mid-flexion instability: A prospective cohort study.
    Maeda K, Mchozuki T, Takagi S, Omori G, Yamamoto N, *Kobayashi K, Kawashima H.
    J Exp Orthop.　2025；45760：12.
45. Clinical outcomes of modified Mitchell’s osteotomy and shortening oblique osteotomy for forefoot deformities with hallux valgus due to rheumatoid arthritis: A retrospective analysis
    Hao N, Kondo N, Kakutani R, Kinoshita E, Kawashima H.
    J Orthop Surg Res　2025；20：564.
46. Effective use of ultra-high molecular weight polyethylene cable and Krackow suture for stretched out patellar tendon due to scarring in a case with rheumatoid arthritis post-total knee arthroplasty
    Kinoshita E, Kondo N, Tanifuji O, Kakutani R,
    Hao N, Kawashima H.
    Modern Rheumatol Case Rep　2025；9：rxae074.
47. Delayed paraparesis after posterior spinal fusion for congenital scoliosis: a case report
    Ohtsubo S, Ohashi M, Hirano T, Tashi H, Makino T,
    Minato K, Mitsuma Y, Deguchi H, Hoshino R,
    Ohashi N, Furutani K, Kawashima H, Watanabe K.
    Spinal Cord Ser Cases　2024；10：24
    10.1038/s41394-024-00639-0.