A new beta cell-specific mitophagy reporter mouse shows that metabolic stress leads to accumulation of dysfunctional mitochondria despite increased mitophagy.
Aoyagi K, Yamashita SI, Akimoto Y, Nishiwaki C, Nakamichi Y, Udagawa H, Abe M, Sakimura K, Kanki T, Ohara-Imaizumi M*.
Diabetologia. 2022; Online ahead of print.
Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation.
Varuzhanyan G, Ladinsky MS, Yamashita SI, Abe M, Sakimura K, Kanki T, Chan DC*.
Development. 2021; 148(16): dev199686.
Membrane perturbation by lipidated Atg8 underlies autophagosome biogenesis.
Maruyama T, Alam JM, Fukuda T, Kageyama S, Kirisako H, Ishii Y, Shimada I, Ohsumi Y, Komatsu M, Kanki T, Nakatogawa H, Noda NN*.
Nat Struct Mol Biol. 2021; 28(7): 583-593.
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