研究業績（原著論文）
2024
Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species.
Yamashita SI*, Sugiura Y, Matsuoka Y, Maeda R, Inoue K, Furukawa K, Fukuda T, Chan DC, Kanki T*.
Cell Death Differ. 2024; Online ahead of print.
Imeglimin mitigates the accumulation of dysfunctional mitochondria to restore insulin secretion and suppress apoptosis of pancreatic β-cells from db/db mice.
Aoyagi K, Nishiwaki C, Nakamichi Y, Yamashita SI, Kanki T, Ohara-Imaizumi M*.
Sci Rep. 2024; 14(1): 6178.
2023
Fission Yeast TORC1 Promotes Cell Proliferation through Sfp1, a Transcription Factor Involved in Ribosome Biogenesis.
Tai YT, Fukuda T*, Morozumi Y, Hirai H, Oda AH, Kamada Y, Akikusa Y, Kanki T, Ohta K, Shiozaki K.
Mol Cell Biol. 2023; 43(12): 675-692.
Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity.
Shioda T, Takahashi I, Ikenaka K, Fujita N, Kanki T, Oka T, Mochizuki H, Antebi A, Yoshimori T*, Nakamura S*.
Proc Natl Acad Sci USA. 2023; 120(39): e2221553120.
Hva22, a REEP family protein in fission yeast, promotes reticulophagy in collaboration with a receptor protein.
Fukuda T*, Saigusa T, Furukawa K, Inoue K, Yamashita SI, Kanki T*.
Autophagy. 2023; 19(10): 2657-2667.
The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy.
Fukuda T#, Furukawa K#, Maruyama T#, Yamashita SI, Noshiro D, Song C, Ogasawara Y, Okuyama K, Alam JM, Hayatsu M, Saigusa T, Inoue K, Ikeda K, Takai A, Chen L, Lahiri V, Okada Y, Shibata S, Murata K, Klionsky DJ, Noda NN*, Kanki T*.
Mol Cell. 2023; 83(12): 2045-2058.e9.
#Equal contribution
*Corresponding authors
TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria.
Akabane S, Watanabe K, Kosako H, Yamashita SI, Nishino K, Kato M, Sekine S, Kanki T, Matsuda N, Endo T, Oka T*.
Cell Rep. 2023; 42(5): 112454.
Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry.
Watanabe K, Oka T, Takagi H, Anisimov S, Yamashita SI, Katsuragi Y, Takahashi M, Higuchi M, Kanki T, Saitoh A, Fujii M*.
Nat Commun. 2023; 14(1): 1817.
2022
A new beta cell-specific mitophagy reporter mouse shows that metabolic stress leads to accumulation of dysfunctional mitochondria despite increased mitophagy.
Aoyagi K, Yamashita SI, Akimoto Y, Nishiwaki C, Nakamichi Y, Udagawa H, Abe M, Sakimura K, Kanki T, Ohara-Imaizumi M*.
Diabetologia. 2022; 66(1): 147-162.
2021
Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation.
Varuzhanyan G, Ladinsky MS, Yamashita SI, Abe M, Sakimura K, Kanki T, Chan DC*.
Development. 2021; 148(16): dev199686.