当科では糖尿病、高血圧、脂質異常症、肥満・メタボリック症候群などの代謝疾患(生活習慣病)やバセドウ病、慢性甲状腺、甲状腺腫瘍、クッシング症候群、原発性アルドステロン症などに代表される内分泌疾患(ホルモンの病気)の診療や教育研究をおこなっております。また、急性白血病、慢性骨髄性白血病、悪性リンパ腫、多発性骨髄腫、貧血、凝固異常症など血液疾患の診療(新規治療薬を用いた多剤併用化学療法、造血幹細胞移植、細胞免疫療法など)や教育研究を行なっております。

HOME > 研究について > 大規模臨床研究について > JDCS: Japan Diabetes Complications Study

研究について

大規模臨床研究について

JDCS: Japan Diabetes Complications Study

概要

当科に本部をおき、全国59カ所の糖尿病専門施設外来に通院する、進行合併症を持たない日本人2型糖尿病患者さん約2000名を対象にした大規模臨床研究です。参加施設専門医の先生方の長年のご助力により、対象者の血糖・血圧・血清脂質・生活習慣などの臨床検査と合併症の発症・進展に関するイベントについてデータを収集、解析し、様々な日本人糖尿病患者さんについての科学的エビデンスを提供してきました。

 

研究成果の一部

1: Sone H, Tanaka S, Tanaka S, Suzuki S, Seino H, Hanyu O, Sato A, Toyonaga T,
Okita K, Ishibashi S, Kodama S, Akanuma Y, Yamada N; Japan Diabetes Complications
Study Group. Leisure-time physical activity is a significant predictor of stroke
and total mortality in Japanese patients with type 2 diabetes: analysis from the
Japan Diabetes Complications Study (JDCS). Diabetologia. 2013 May;56(5):1021-30.
doi: 10.1007/s00125-012-2810-z. Epub 2013 Feb 27. PubMed PMID: 23443242.

2: Tanaka S, Tanaka S, Iimuro S, Yamashita H, Katayama S, Akanuma Y, Yamada N,
Araki A, Ito H, Sone H, Ohashi Y; for the Japan Diabetes Complications Study
Group; the Japanese Elderly Diabetes Intervention Trial Group. Predicting Macro-
and Microvascular Complications in Type 2 Diabetes: The Japan Diabetes
Complications Study/the Japanese Elderly Diabetes Intervention Trial risk engine.
Diabetes Care. 2013 Feb 12. [Epub ahead of print] PubMed PMID: 23404305.

3: Kawasaki R, Tanaka S, Tanaka S, Abe S, Sone H, Yokote K, Ishibashi S, Katayama
S, Ohashi Y, Akanuma Y, Yamada N, Yamashita H; for the Japan Diabetes
Complications Study Group. Risk of Cardiovascular Diseases Is Increased Even with
Mild Diabetic Retinopathy: The Japan Diabetes Complications Study. Ophthalmology.
2012 Nov 19. doi:pii: S0161-6420(12)00813-5. 10.1016/j.ophtha.2012.08.029. [Epub
ahead of print] PubMed PMID: 23174397.

4: Sone H, Tanaka S, Tanaka S, Iimuro S, Ishibashi S, Oikawa S, Shimano H,
Katayama S, Ohashi Y, Akanuma Y, Yamada N; Japan Diabetes Complications Study
Group. Comparison of various lipid variables as predictors of coronary heart
disease in Japanese men and women with type 2 diabetes: subanalysis of the Japan
Diabetes Complications Study. Diabetes Care. 2012 May;35(5):1150-7. doi:
10.2337/dc11-1412. Epub 2012 Feb 14. PubMed PMID: 22338107; PubMed Central PMCID:
PMC3329821.

5: Sone H, Tanaka S, Tanaka S, Iimuro S, Oida K, Yamasaki Y, Oikawa S, Ishibashi
S, Katayama S, Ohashi Y, Akanuma Y, Yamada N; Japan Diabetes Complications Study
Group. Serum level of triglycerides is a potent risk factor comparable to LDL
cholesterol for coronary heart disease in Japanese patients with type 2 diabetes:
subanalysis of the Japan Diabetes Complications Study (JDCS). J Clin Endocrinol
Metab. 2011 Nov;96(11):3448-56. doi: 10.1210/jc.2011-0622. Epub 2011 Aug 24.
PubMed PMID: 21865372.

6: Kawasaki R, Tanaka S, Tanaka S, Yamamoto T, Sone H, Ohashi Y, Akanuma Y,
Yamada N, Yamashita H; Japan Diabetes Complications Study Group. Incidence and
progression of diabetic retinopathy in Japanese adults with type 2 diabetes: 8
year follow-up study of the Japan Diabetes Complications Study (JDCS).
Diabetologia. 2011 Sep;54(9):2288-94. doi: 10.1007/s00125-011-2199-0. Epub 2011
Jun 1. PubMed PMID: 21630126.

7: Katayama S, Moriya T, Tanaka S, Tanaka S, Yajima Y, Sone H, Iimuro S, Ohashi
Y, Akanuma Y, Yamada N; Japan Diabetes Complications Study Group. Low transition
rate from normo- and low microalbuminuria to proteinuria in Japanese type 2
diabetic individuals: the Japan Diabetes Complications Study (JDCS).
Diabetologia. 2011 May;54(5):1025-31. doi: 10.1007/s00125-010-2025-0. Epub 2011
Feb 1. PubMed PMID: 21286682; PubMed Central PMCID: PMC3071947.

8: Sone H, Tanaka S, Iimuro S, Tanaka S, Oida K, Yamasaki Y, Oikawa S, Ishibashi
S, Katayama S, Yamashita H, Ito H, Yoshimura Y, Ohashi Y, Akanuma Y, Yamada N;
Japan Diabetes Complications Study Group. Long-term lifestyle intervention lowers
the incidence of stroke in Japanese patients with type 2 diabetes: a nationwide
multicentre randomised controlled trial (the Japan Diabetes Complications Study).
Diabetologia. 2010 Mar;53(3):419-28. doi: 10.1007/s00125-009-1622-2. Epub 2010
Jan 7. PubMed PMID: 20054522; PubMed Central PMCID: PMC2815795.

9: Sone H, Tanaka S, Iimuro S, Oida K, Yamasaki Y, Oikawa S, Ishibashi S,
Katayama S, Ito H, Ohashi Y, Akanuma Y, Yamada N. Components of metabolic
syndrome and their combinations as predictors of cardiovascular disease in
Japanese patients with type 2 diabetes. Implications for improved definition.
Analysis from Japan Diabetes Complications Study (JDCS). J Atheroscler Thromb.
2009 Aug;16(4):380-7. Epub 2009 Aug 11. PubMed PMID: 19672033.

10: Sone H, Tanaka S, Iimuro S, Oida K, Yamasaki Y, Ishibashi S, Oikawa S,
Katayama S, Ito H, Ohashi Y, Akanuma Y, Yamada N. Waist circumference as a
cardiovascular and metabolic risk in Japanese patients with type 2 diabetes.
Obesity (Silver Spring). 2009 Mar;17(3):585-92. doi: 10.1038/oby.2008.481. Epub
2008 Nov 20. PubMed PMID: 19023281.

11: Sone H, Tanaka S, Ishibashi S, Yamasaki Y, Oikawa S, Ito H, Saito Y, Ohashi
Y, Akanuma Y, Yamada N; Japan Diabetes Complications Study (JDCS) Group. The new
worldwide definition of metabolic syndrome is not a better diagnostic predictor
of cardiovascular disease in Japanese diabetic patients than the existing
definitions: additional analysis from the Japan Diabetes Complications Study.
Diabetes Care. 2006 Jan;29(1):145-7. PubMed PMID: 16373914.

12: Sone H, Mizuno S, Fujii H, Yoshimura Y, Yamasaki Y, Ishibashi S, Katayama S,
Saito Y, Ito H, Ohashi Y, Akanuma Y, Yamada N; Japan Diabetes Complications
Study. Is the diagnosis of metabolic syndrome useful for predicting
cardiovascular disease in asian diabetic patients? Analysis from the Japan
Diabetes Complications Study. Diabetes Care. 2005 Jun;28(6):1463-71. PubMed PMID:
15920069.

13: Sone H, Mizuno S, Yamada N. Vascular risk factors and diabetic neuropathy. N
Engl J Med. 2005 May 5;352(18):1925-7; author reply 1925-7. PubMed PMID:
15877321.

14: Sone H, Yamada N, Mizuno S, Ohashi Y, Ishibashi S, Yamazaki Y. Requirement
for hypertension and hyperlipidemia medication in U.S. and Japanese patients with
diabetes. Am J Med. 2004 Nov 1;117(9):711-2. PubMed PMID: 15501216.

15: Sone H, Yamada N, Mizuno S, Aida R, Ohashi Y. Alcohol use and diabetes
mellitus. Ann Intern Med. 2004 Sep 7;141(5):408-9; author reply 409. PubMed PMID:
15353438.

16: Sone H, Mizuno S, Ohashi Y, Yamada N. Type 2 diabetes prevalence in Asian
subjects. Diabetes Care. 2004 May;27(5):1251-2; author reply 1252. PubMed PMID:
15111576.

17: Sone H, Yoshimura Y, Ito H, Ohashi Y, Yamada N; Japan Diabetes Complications
Study Group. Energy intake and obesity in Japanese patients with type 2 diabetes.
Lancet. 2004 Jan 17;363(9404):248-9. PubMed PMID: 14738815.

18: Sone H, Ito H, Ohashi Y, Akanuma Y, Yamada N; Japan Diabetes Complication
Study Group. Obesity and type 2 diabetes in Japanese patients. Lancet. 2003 Jan
4;361(9351):85. PubMed PMID: 12517507.
 

 

 

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