当科では糖尿病、高血圧、脂質異常症、肥満・メタボリック症候群などの代謝疾患(生活習慣病)やバセドウ病、慢性甲状腺、甲状腺腫瘍、クッシング症候群、原発性アルドステロン症などに代表される内分泌疾患(ホルモンの病気)の診療や教育研究をおこなっております。また、急性白血病、慢性骨髄性白血病、悪性リンパ腫、多発性骨髄腫、貧血、凝固異常症など血液疾患の診療(新規治療薬を用いた多剤併用化学療法、造血幹細胞移植、細胞免疫療法など)や教育研究を行なっております。

HOME > 研究について > 大規模臨床研究について > JDCS: Japan Diabetes Complications Study

研究について

大規模臨床研究について

TOPICS: Toranomon Hospital Health Management Center Study

概要

当科が東京の虎ノ門病院付属健康管理センター(荒瀬康司センター長)と協力し、人間ドック受診者の大規模データ解析を行っている研究です。糖尿病や様々な生活習慣病の発症予測モデルやリスクファクターの確立などを含めて検討を続けています。

 

研究成果の一部

1: Heianza Y, Arase Y, Saito K, Hsieh SD, Tsuji H, Kodama S, Tanaka S, Ohashi Y,
Shimano H, Yamada N, Hara S, Sone H. Development of a Screening Score for
Undiagnosed Diabetes and Its Application in Estimating Absolute Risk of Future
Type 2 Diabetes in Japan: Toranomon Hospital Health Management Center Study 10
(TOPICS 10). J Clin Endocrinol Metab. 2013 Mar;98(3):1051-60. doi:
10.1210/jc.2012-3092. Epub 2013 Feb 7. PubMed PMID: 23393174.

2: Heianza Y, Arase Y, Saito K, Tsuji H, Fujihara K, Hsieh SD, Kodama S, Shimano
H, Yamada N, Hara S, Sone H. Role of alcohol drinking pattern in type 2 diabetes
in Japanese men: the Toranomon Hospital Health Management Center Study 11 (TOPICS
11). Am J Clin Nutr. 2013 Mar;97(3):561-8. doi: 10.3945/ajcn.112.043364. Epub
2013 Jan 23. PubMed PMID: 23343972.

3: Heianza Y, Arase Y, Tsuji H, Saito K, Amakawa K, Hsieh SD, Kodama S, Shimano
H, Yamada N, Hara S, Sone H. Low lung function and risk of type 2 diabetes in
Japanese men: the Toranomon Hospital Health Management Center Study 9 (TOPICS 9).
Mayo Clin Proc. 2012 Sep;87(9):853-61. doi: 10.1016/j.mayocp.2012.04.016. PubMed
PMID: 22958989; PubMed Central PMCID: PMC3538497.

4: Heianza Y, Arase Y, Hsieh SD, Saito K, Tsuji H, Kodama S, Tanaka S, Ohashi Y,
Shimano H, Yamada N, Hara S, Sone H. Development of a new scoring system for
predicting the 5 year incidence of type 2 diabetes in Japan: the Toranomon
Hospital Health Management Center Study 6 (TOPICS 6). Diabetologia. 2012
Dec;55(12):3213-23. doi: 10.1007/s00125-012-2712-0. Epub 2012 Sep 7. PubMed PMID:
22955996.

5: Heianza Y, Arase Y, Fujihara K, Tsuji H, Saito K, Hsieh SD, Kodama S, Shimano
H, Yamada N, Hara S, Sone H. Screening for pre-diabetes to predict future
diabetes using various cut-off points for HbA(1c) and impaired fasting glucose:
the Toranomon Hospital Health Management Center Study 4 (TOPICS 4). Diabet Med.
2012 Sep;29(9):e279-85. doi: 10.1111/j.1464-5491.2012.03686.x. PubMed PMID:
22510023.

6: Heianza Y, Arase Y, Fujihara K, Tsuji H, Saito K, Hsieh SD, Kodama S, Shimano
H, Yamada N, Hara S, Sone H. High normal HbA(1c) levels were associated with
impaired insulin secretion without escalating insulin resistance in Japanese
individuals: the Toranomon Hospital Health Management Center Study 8 (TOPICS 8).
Diabet Med. 2012 Oct;29(10):1285-90. doi: 10.1111/j.1464-5491.2012.03667.x.
PubMed PMID: 22486679.

7: Heianza Y, Arase Y, Fujihara K, Hsieh SD, Saito K, Tsuji H, Kodama S, Yahagi
N, Shimano H, Yamada N, Hara S, Sone H. Longitudinal trajectories of HbA1c and
fasting plasma glucose levels during the development of type 2 diabetes: the
Toranomon Hospital Health Management Center Study 7 (TOPICS 7). Diabetes Care.
2012 May;35(5):1050-2. doi: 10.2337/dc11-1793. Epub 2012 Mar 28. PubMed PMID:
22456865; PubMed Central PMCID: PMC3329827.

8: Heianza Y, Hara S, Arase Y, Saito K, Tsuji H, Kodama S, Hsieh SD, Mori Y,
Okubo M, Yamada N, Kosaka K, Sone H. Impact of introducing HbA1c into the
diagnostic criteria on prevalence and cardiovascular risk profiles of individuals
with newly diagnosed diabetes in Japan: the Toranomon Hospital Health Management
Center Study 2 (TOPICS 2). Diabetes Res Clin Pract. 2012 Feb;95(2):283-90. doi:
10.1016/j.diabres.2011.10.024. Epub 2011 Nov 21. PubMed PMID: 22104263.

9: Heianza Y, Hara S, Arase Y, Saito K, Fujiwara K, Tsuji H, Kodama S, Hsieh SD,
Mori Y, Shimano H, Yamada N, Kosaka K, Sone H. HbA1c 5•7-6•4% and impaired
fasting plasma glucose for diagnosis of prediabetes and risk of progression to
diabetes in Japan (TOPICS 3): a longitudinal cohort study. Lancet. 2011 Jul
9;378(9786):147-55. doi: 10.1016/S0140-6736(11)60472-8. Epub 2011 Jun 24. PubMed
PMID: 21705064.

10: Heianza Y, Hara S, Arase Y, Saito K, Totsuka K, Tsuji H, Kodama S, Hsieh SD,
Yamada N, Kosaka K, Sone H. Low serum potassium levels and risk of type 2
diabetes: the Toranomon Hospital Health Management Center Study 1 (TOPICS 1).
Diabetologia. 2011 Apr;54(4):762-6. doi: 10.1007/s00125-010-2029-9. Epub 2011 Jan
7. PubMed PMID: 21212932.

 

 

 

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